[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100654741":3},{"organization":4,"outcomesModule":7,"designInfo":83,"detailedDescription":90,"studyPopulation":82,"armGroups":91,"interventions":98,"overallOfficials":104,"centralContacts":112,"locations":120,"responsibleParty":133,"collaborators":82,"id":137,"slug":138,"hasResults":139,"nctId":140,"briefTitle":141,"officialTitle":142,"acronym":82,"eligibilityCriteria":143,"healthyVolunteers":139,"sex":144,"minAge":145,"maxAge":146,"enrollmentInfo":147,"targetDuration":82,"studyType":150,"phases":151,"briefSummary":152,"conditions":153,"keywords":160,"overallStatus":165,"whyStopped":82,"lastUpdateSubmitDate":166,"lastUpdatePostDateStruct":167,"startDateStruct":170,"completionDateStruct":172,"leadSponsor":174,"locationsCount":175},{"fullName":5,"class":6},"University of Zurich","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":82},[9],{"measure":10,"description":11,"timeFrame":12},"Pulmonary resistance (sPAP\u002FCO) after 7 days at sea level","Difference in sPAP\u002FCO by echocardiography between 2850m and Day 5-7 at sea level in patients with pulmonary arterial hypertension","From high altitude (2850m) to day 5-7 at sea level",[14,17,21,24,28,31,34,37,40,43,46,50,53,56,60,63,66,69,73,76,79],{"measure":15,"description":16,"timeFrame":12},"Tricuspid regurgitation velocity TRV after 7 days at sea level","Difference in tricuspid regurgitation velocity TRV between 2850m and Day 5-7 at sea level in patients with pulmonary arterial hypertension",{"measure":18,"description":19,"timeFrame":20},"Cardiac output CO after 7 days at sea level","Difference\u002Fchange in cardiac output CO between 2850m and Day 5-7 at sea level in patients with pulmonary arterial hypertension","From high altitude (2850) to day 5-7 at sea level",{"measure":22,"description":23,"timeFrame":12},"Tricuspid annular plan systolic excursion TAPSE after 7 days at sea level","Difference\u002Fchange in tricuspid annular plan systolic excursion TAPSE between 2850m and Day 5-7 at sea level in patients with pulmonary arterial hypertension",{"measure":25,"description":26,"timeFrame":27},"Right ventricular strain after 7 days at sea level","Difference\u002Fchange in right ventricular strain between 2850m and day 5-7 at sea level in patients with pulmonary arterial hypertension","From high altitude (2850m) to Day 5-7 at sea level",{"measure":29,"description":30,"timeFrame":27},"Right atrial pressure RAP after 7 days at sea level","Difference\u002Fchange in right atrial pressure RAP between 2850m and day 5-7 at sea level in patients with pulmonary arterial hypertension",{"measure":32,"description":33,"timeFrame":27},"Fractional area change FAC after 7 days at sea level","Difference\u002Fchange in fractional area change FAC between 2850m and day 5-7 at sea level in patients with pulmonary arterial hypertension",{"measure":35,"description":36,"timeFrame":20},"PaO2 after 7 days at sea level","Difference\u002Fchange in PaO2 (arterial blood gas analysis) between 2850m and sea level in patients with pulmonary arterial hypertension",{"measure":38,"description":39,"timeFrame":20},"PaCO2 after 7 days at sea level","Difference\u002Fchange in PaCO2 (arterial blood gas analysis) between 2850m and sea level in patients with pulmonary arterial hypertension",{"measure":41,"description":42,"timeFrame":20},"Hemoglobin after 7 days at sea level","Difference\u002Fchange in hemoglobin (arterial blood gas analysis) between 2850m and sea level in patients with pulmonary arterial hypertension",{"measure":44,"description":45,"timeFrame":20},"pH after 7 days at sea level","Difference\u002Fchange in pH(arterial blood gas analysis) between 2850m and sea level in patients with pulmonary arterial hypertension",{"measure":47,"description":48,"timeFrame":49},"Acclimatization-Effect of pulmonary resistance (sPAP\u002FCO) at sea level","Difference\u002Fchange in pulmonary resistance (sPAP\u002FCO) within a stay at sea level of 7 days (after relocation from high altitude)","From Day 2 to Day 5-7 at sea level",{"measure":51,"description":52,"timeFrame":49},"Acclimatization-Effect of tricuspid regurgitation velocity TRV at sea level","Difference\u002Fchange in tricuspid regurgitation velocity TRV within a stay at sea level of 7 days (after relocation from high altitude)",{"measure":54,"description":55,"timeFrame":49},"Acclimatization-Effect of cardiac output CO at sea level","Difference\u002Fchange in cardiac output CO within a stay at sea level of 7 days (after relocation from high altitude)",{"measure":57,"description":58,"timeFrame":59},"Acclimatization-Effect of tricuspid annular plan systolic excursion TAPSE at sea level","Difference\u002Fchange in tricuspid annular plan systolic excursion TAPSE within a stay at sea level for 7 days (after relocation from high altitude)","From Day 2 to day 5-7 at sea level",{"measure":61,"description":62,"timeFrame":49},"Acclimatization-Effect of right ventricular strain at sea level","Difference\u002Fchange in right ventricular strain within a stay at sea level for 7 days (after relocation from high altitude)",{"measure":64,"description":65,"timeFrame":49},"Acclimatization-Effect of right atrial pressure RAP at sea level","Difference\u002Fchange in right atrial pressure RAP within a stay at sea level for 7 days (after relocation from high altitude)",{"measure":67,"description":68,"timeFrame":49},"Acclimatization-Effect of fractional area change FAC at sea level","Difference\u002Fchange in fractional area change FAC within a stay at sea level for 7 days (after relocation from high altitude)",{"measure":70,"description":71,"timeFrame":72},"Acclimatization-Effect of PaO2 at sea level","Difference\u002Fchange in PaO2 (arterial blood gas analysis) within a stay at sea level for 7 days (after relocation from high altitude)","From Day 2 to Day 7 at sea level",{"measure":74,"description":75,"timeFrame":72},"Acclimatization-Effect of PaCO2 at sea level","Difference\u002Fchange in PaCO2 (arterial blood gas analysis) within a stay at sea level for 7 days (after relocation from high altitude)",{"measure":77,"description":78,"timeFrame":72},"Acclimatization-Effect of hemoglobin at sea level","Difference\u002Fchange in hemoglobin (arterial blood gas analysis) within a stay at sea level for 7 days (after relocation from high altitude)",{"measure":80,"description":81,"timeFrame":72},"Acclimatization-Effect of pH at sea level","Difference\u002Fchange in pH (arterial blood gas analysis) within a stay at sea level for 7 days (after relocation from high altitude)",null,{"allocation":84,"interventionModel":85,"interventionModelDescription":86,"primaryPurpose":87,"observationalModel":82,"timePerspective":82,"maskingInfo":88},"NA","SINGLE_GROUP","Patients diagnosed with pulmonary arterial hypertension living permanently \\> 2600m around Quito (Ecuador) will be assessed at 2850m and after relocation to sea level","SUPPORTIVE_CARE",{"masking":89,"maskingDescription":82,"whoMasked":82},"NONE","The aim of this research is to investigate the pulmonary resistance (sPAP\u002FCO) by echocardiography and other hemodynamic outcomes before and after relocation (high altitude near their living altitude vs. sea level) in patients with diagnosed pulmonary arterial hypertension according to guidelines, who permanently live at high altitude over 2600m.",[92],{"label":93,"type":94,"description":95,"interventionNames":96},"Pulmonary resistance (sPAP\u002FCO) at 2850m and at sea level","EXPERIMENTAL","Measurement of pulmonary resistance (sPAP\u002FCO) by echocardiography and other hemodynamic parameters near their resident altitude at 2850m followed by a descent from 2850m to sea level by bus with a stay for 7 days and again measurements by echocardiography",[97],"Behavioral: Descent from 2850m to sea level",[99],{"type":100,"name":101,"description":102,"armGroupLabels":103,"otherNames":82},"BEHAVIORAL","Descent from 2850m to sea level","Descent from 2850m to sea level with a stay for 7 days",[93],[105,109],{"name":106,"affiliation":107,"role":108},"Silvia Ulrich","University Hospital Zurich, Departement of Pulmonology","PRINCIPAL_INVESTIGATOR",{"name":110,"affiliation":111,"role":108},"Rodrigo Hoyos","Hospital Carlos Andrade Marin of Quito, Ecuador",[113,118],{"name":114,"role":115,"phone":116,"phoneExt":82,"email":117},"Silvia Ulrich, Prof. Dr. med.","CONTACT","+41442552220","silvia.ulrich@usz.ch",{"name":119,"role":115,"phone":116,"phoneExt":82,"email":82},"Michael Furian, Prof. Dr. sc. ETH",[121],{"facility":122,"status":82,"city":123,"state":82,"zip":124,"country":125,"countryCode":126,"cosmosGeoPoint":127,"geoPoint":132,"contacts":82},"University Hospital of Zurich","Zurich","8091","Switzerland","CH",{"type":128,"coordinates":129},"Point",[130,131],8.55,47.36667,{"lat":131,"lon":130},{"type":134,"investigatorFullName":135,"investigatorTitle":136,"investigatorAffiliation":5,"oldNameTitle":82,"oldOrganization":82},"SPONSOR_INVESTIGATOR","Silvia Ulrich Somaini","Prof. Dr. med.","100654741","assessment-of-total-pulmonary-resistance-spapco-between-high-altitude-ha-vs-sea-level-la-in-patients-with-pulmonary-arterial-hypertension-pah-100654741",false,"NCT07804524","Assessment of Total Pulmonary Resistance sPAP\u002FCO Between High Altitude HA vs. Sea Level LA in Patients With Pulmonary Arterial Hypertension PAH","Effect of a One-week Descent From 2850m to Sea Level and Re-ascent in Patients With Pulmonary Arterial Hypertension and Healthy Controls Permanently Living > 2600m on Pulmonary Hemodynamics, Exercise Capacity, Blood Oxygenation, Sleep Disordered Breathing and Further Outcomes","Inclusion Criteria:\n\n* Adult patients aged 18-80 years and of all genders\n* Permanent residence \\> 2600 m\n* Diagnosis of pulmonary arterial hypertension PAH (PAHHA-Group) according to guidelines\n* Patients are stable on therapy\n* NYHA (new york heart association) functional class I-III\n* written informed consent to participate in the study\n\nExclusion Criteria:\n\n* Age \\\u003C18 years or \\>80 years\n* unstable condition\n* Patients who cannot follow the study investigations\n* Patient permanently living \\\u003C 2600m.\n* Patients who traveled and stayed overnight at altitudes \\\u003C2000 m in the past 4 weeks.\n* Patients with moderate to severe concomitant lung disease (FEV1\\\u003C70% or forced vital capacity \\\u003C70%), severe parenchymal lung disease, severe smokers (\\>20 cigarettes\u002Fday)\n* Severely hypoxemic patients at 2850m permanently having persistent SpO2 (oxygen saturation by pulseoximetry) \\\u003C80% on ambient air.\n* Patient with a non-corrected ventricular septum defect\n* Relevant concomitant other disease of the heart, kidney, liver, blood (anemia hemoglobin\\\u003C11 g\u002Fdl)","ALL","18 Years","80 Years",{"count":148,"type":149},20,"ESTIMATED","INTERVENTIONAL",[84],"To study the effect of relocation from high altitude (Quito Ecuador: 2850m) to sea level on pulmonary resistance (sPAP\u002FCO) and other hemodynamic outcomes in patients with pulmonary arterial hypertension PAH, who live permanently \\>2600m.",[154,155,156,157,158,159],"Pulmonary Arterial Hypertension (PAH)","Pulmonary Vascular Disease","High Altitude","Echocardiography","Pulmonary Resistance","Hemodynamic Changes",[154,161,156,162,158,163,157,164],"Hypoxia","Pulmonary Hypertension","Pulmonary vascular disease","hemodynamics","NOT_YET_RECRUITING","2026-08-31",{"date":168,"type":169},"2026-09-04","ACTUAL",{"date":171,"type":149},"2026-09-25",{"date":173,"type":149},"2026-12-31",{"name":135,"class":6},1]