[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100658084":3},{"organization":4,"outcomesModule":7,"designInfo":28,"detailedDescription":31,"studyPopulation":32,"armGroups":33,"interventions":27,"overallOfficials":37,"centralContacts":42,"locations":48,"responsibleParty":60,"collaborators":27,"id":64,"slug":65,"hasResults":66,"nctId":67,"briefTitle":68,"officialTitle":69,"acronym":27,"eligibilityCriteria":70,"healthyVolunteers":66,"sex":71,"minAge":72,"maxAge":27,"enrollmentInfo":73,"targetDuration":27,"studyType":76,"phases":27,"briefSummary":77,"conditions":78,"keywords":80,"overallStatus":51,"whyStopped":27,"lastUpdateSubmitDate":89,"lastUpdatePostDateStruct":90,"startDateStruct":93,"completionDateStruct":95,"leadSponsor":97,"locationsCount":98},{"fullName":5,"class":6},"Istanbul Training and Research Hospital","OTHER_GOV",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":27},[9],{"measure":10,"description":11,"timeFrame":12},"Comparison of total visibility scores between polarized dermoscopy and sub-ultraviolet reflectance dermoscopy","For each participant, the index lesion will be evaluated in polarized dermoscopy and sub-ultraviolet reflectance dermoscopy images. Selected lesion morphology items on the finalized scoring form will be scored from 0 to 3, where 0 indicates absent or not visible and 3 indicates clearly visible. A total visibility score will be calculated for each modality, and the paired within-lesion difference between the two modalities will be analyzed.","Day 1",[14,17,20,23],{"measure":15,"description":16,"timeFrame":12},"Visibility scores of individual lesion morphology items across imaging modalities","Individual lesion morphology items on the finalized scoring form will be evaluated using a 0-3 visibility scoring system, where 0 indicates absent or not visible and 3 indicates clearly visible. Scores will be assessed across polarized dermoscopy, sub-ultraviolet reflectance dermoscopy, and ultraviolet fluorescence dermoscopy.",{"measure":18,"description":19,"timeFrame":12},"Detection rates of individual lesion morphology items after dichotomization of visibility scores","Visibility scores will be dichotomized for each lesion morphology item, with a score of 0 defined as not detected and scores of 1, 2, or 3 defined as detected. Detection rates will be calculated and compared across imaging modalities.",{"measure":21,"description":22,"timeFrame":12},"Assessment of ultraviolet and sub-ultraviolet optical findings","Optical findings observed in sub-ultraviolet reflectance dermoscopy and ultraviolet fluorescence dermoscopy will be assessed using the finalized scoring form. Depending on the finalized assessment item, findings may be recorded either as 0-3 visibility scores or as binary detection variables. These findings may include lesion-to-surrounding skin contrast, border visibility, perifollicular optical changes, and intralesional heterogeneity.",{"measure":24,"description":25,"timeFrame":26},"Inter-rater agreement for lesion morphology assessment","Agreement between dermatologist evaluators will be assessed for visibility scores and\u002For binary detection of lesion morphology items using appropriate agreement statistics.","Through completion of image evaluation, up to 6 months",null,{"allocation":27,"interventionModel":27,"interventionModelDescription":27,"primaryPurpose":27,"observationalModel":29,"timePerspective":30,"maskingInfo":27},"CASE_ONLY","CROSS_SECTIONAL","This is a single-center, cross-sectional observational imaging study in patients with clinically diagnosed vitiligo.\n\nDuring a single study visit, demographic and clinical information will be recorded, including disease duration, recent disease course, current treatment status, and patient-reported changes in selected lesions. One to three clinically suitable vitiligo lesions will be included in the main assessment dataset for each participant. Genital lesions will not be evaluated due to practical imaging limitations, hygiene considerations, and participant comfort.\n\nEach selected lesion will be imaged using the Casio DZ-D100-AEA device, which allows simultaneous acquisition of digital contact polarized dermoscopy, digital contact non-polarized dermoscopy, and sub-ultraviolet reflectance dermoscopy images from the same lesion area with a single image capture. This approach is intended to improve within-lesion comparability between polarized dermoscopy and sub-ultraviolet reflectance dermoscopy. Non-polarized images will be obtained as an automatic device output but will not be included in the routine analysis. Ultraviolet fluorescence dermoscopy images will be obtained from the same selected lesion using the DermLite DL5 handheld ultraviolet dermoscope with a smartphone adapter.\n\nFor each participant, one lesion will be designated as the index lesion for the primary analysis. If available, the second and third lesions in the main assessment dataset may be used for secondary and exploratory analyses. In participants with more than three imaged lesions, additional lesion images beyond the lesions retained in the main assessment dataset will be assigned to a separate exploratory\u002Fcalibration image pool and will not be included in the formal main assessment dataset.\n\nThe allocation of lesions to the main assessment dataset or the exploratory\u002Fcalibration pool will be completed before formal image scoring. When more than three lesions are available from a participant, lesions with clearer recent clinical history regarding activity, stability, or repigmentation will be preferentially retained in the main assessment dataset. If several lesions have similarly clear clinical information, allocation will aim to preserve representation of active\u002Fprogressive, stable, and repigmented\u002Fregressive lesions when possible.\n\nThe exploratory\u002Fcalibration image pool will be used for initial exploratory review, refinement of morphological terminology, preparation of evaluator training material, and calibration of scoring rules. These images will not be used as confirmatory evidence for the primary analysis.\n\nMorphological assessment items will be developed from the literature and refined through the calibration process. This process will be used to standardize terminology and scoring rules among dermatologist evaluators before formal image evaluation.\n\nAfter the scoring form is finalized, coded images from the main assessment dataset will be evaluated by dermatologist evaluators using a 0-3 visibility scoring system. To reduce observer bias, images will be presented without participant identity, lesion code, clinical lesion category, treatment information, or clinical history.\n\nComplete blinding to imaging modality may not be possible because the imaging modalities have characteristic color and light features. This will be considered a methodological limitation. However, the coded and randomized image review process is intended to reduce recognition bias, recall bias, and assessment-order bias.","Adult patients with clinically diagnosed vitiligo who attend the dermatology outpatient clinic and have at least one clinically suitable non-genital vitiligo lesion for dermoscopic imaging.",[34],{"label":35,"type":27,"description":36,"interventionNames":27},"Adults With Vitiligo","Adult participants with clinically diagnosed vitiligo who will undergo close-up dermoscopic imaging of one to three clinically suitable vitiligo lesions during a single study visit",[38],{"name":39,"affiliation":40,"role":41},"Ayşe Esra Koku Aksu, Professor","University of Health Sciences Istanbul Training and Research Hospital, Dermatology Department","STUDY_CHAIR",[43],{"name":44,"role":45,"phone":46,"phoneExt":27,"email":47},"Sueda Şanlı Arıkan, Dermatology Resident Physician","CONTACT","+90 5362483355","sueda.sanli.md@gmail.com",[49],{"facility":50,"status":51,"city":52,"state":27,"zip":27,"country":53,"countryCode":27,"cosmosGeoPoint":54,"geoPoint":59,"contacts":27},"University of Health Sciences Istanbul Training and Research Hospital","RECRUITING","Istanbul","Turkey (Türkiye)",{"type":55,"coordinates":56},"Point",[57,58],28.94966,41.01384,{"lat":58,"lon":57},{"type":61,"investigatorFullName":62,"investigatorTitle":63,"investigatorAffiliation":5,"oldNameTitle":27,"oldOrganization":27},"PRINCIPAL_INVESTIGATOR","Sueda Sanli Arikan","Dermatology Resident Physician","100658084","assessment-of-vitiligo-lesions-using-polarized-dermoscopy-sub-ultraviolet-reflectance-dermoscopy-and-ultraviolet-dermoscopy-100658084",false,"NCT07846969","Assessment of Vitiligo Lesions Using Polarized Dermoscopy, Sub-Ultraviolet Reflectance Dermoscopy, and Ultraviolet Dermoscopy","Evaluation of Morphological Findings Related to Activity, Stability, and Repigmentation in Vitiligo Lesions Using Polarized Dermoscopy, Sub-Ultraviolet Reflectance Dermoscopy, and Ultraviolet Fluorescence Dermoscopy: A Cross-Sectional Observational Imaging Study","Inclusion Criteria:\n\n* Adults aged 18 years or older\n* Clinical diagnosis of vitiligo\n* Presence of at least one clinically suitable non-genital vitiligo lesion for dermoscopic imaging\n* Ability and willingness to provide written informed consent\n\nExclusion Criteria:\n\n* Uncertain clinical diagnosis of vitiligo or presence of another hypopigmented or depigmented disorder that may interfere with lesion evaluation\n* Absence of any clinically suitable non-genital vitiligo lesion for imaging\n* Inability to cooperate with the imaging procedure\n* Refusal or inability to provide written informed consent","ALL","18 Years",{"count":74,"type":75},100,"ESTIMATED","OBSERVATIONAL","The goal of this observational study is to learn how different close-up skin imaging methods show vitiligo spots in adults with vitiligo. The study will look at skin changes that may be related to whether a vitiligo spot is active, stable, or gaining color again.\n\nThe main question it aims to answer is: Can special light-based imaging methods show useful details of vitiligo spots differently than regular polarized dermoscopy?\n\nParticipants will have vitiligo spots photographed during one study visit. Researchers will take images using polarized dermoscopy, sub-ultraviolet reflectance imaging, and ultraviolet fluorescence dermoscopy. Dermatologists will later review the coded images and score how clearly selected skin features can be seen.\n\nThe study will not change participants' treatment. It will not include blood tests, biopsy, injections, or any other invasive procedure.",[79],"Vitiligo",[81,82,83,84,85,86,87,88],"Dermoscopy","Sub-ultraviolet reflectance imaging","Ultraviolet fluorescence dermoscopy","Vitiligo activity","Vitiligo stability","Vitiligo morphological findings","Repigmentation","Polarized dermoscopy","2026-09-28",{"date":91,"type":92},"2026-09-29","ACTUAL",{"date":94,"type":92},"2026-07-01",{"date":96,"type":75},"2026-12",{"name":5,"class":6},1]