[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100646441":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":10,"centralContacts":12,"locations":18,"responsibleParty":35,"collaborators":10,"id":39,"slug":40,"hasResults":41,"nctId":42,"briefTitle":43,"officialTitle":44,"acronym":45,"eligibilityCriteria":46,"healthyVolunteers":41,"sex":47,"minAge":48,"maxAge":49,"enrollmentInfo":50,"targetDuration":53,"studyType":54,"phases":10,"briefSummary":55,"conditions":56,"keywords":61,"overallStatus":66,"whyStopped":10,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":71,"completionDateStruct":73,"leadSponsor":74,"locationsCount":75},{"fullName":5,"class":6},"Ukrainian Society of Regional Anesthesia and Pain Therapy","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":10},"Adaptive Support Ventilation With Targeted Fluid Resuscitation",null,"Adult patients with severe burn injury requiring invasive mechanical ventilation who are managed using Adaptive Support Ventilation (ASV) together with targeted fluid resuscitation during the early phase of intensive care. All treatments are delivered as part of routine clinical practice, and clinical, respiratory, hemodynamic, and laboratory data are collected prospectively.",[13],{"name":14,"role":15,"phone":16,"phoneExt":10,"email":17},"Dmytro Dmytriiev, PhD.Professor","CONTACT","+380674309449","dmytrodmytriiev@gmail.com",[19],{"facility":20,"status":10,"city":21,"state":10,"zip":22,"country":23,"countryCode":24,"cosmosGeoPoint":25,"geoPoint":30,"contacts":31},"Vinnitsya Regional Clinical Hospital n.a Pirogov","Vinnytsia","21000","Ukraine","UA",{"type":26,"coordinates":27},"Point",[28,29],28.46871,49.2322,{"lat":29,"lon":28},[32],{"name":33,"role":15,"phone":34,"phoneExt":10,"email":17},"Dmytro Dmytriiev, Phd","0674309449",{"type":36,"investigatorFullName":37,"investigatorTitle":38,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Dmytro Dmytriiev","professor, head of intensive care department","100646441","asv-and-targeted-fluid-resuscitation-in-severe-burns-100646441",false,"NCT07689097","ASV and Targeted Fluid Resuscitation in Severe Burns","Adaptive Support Ventilation and Targeted Fluid Resuscitation in Patients With Severe Burn Injury: A Prospective Cohort Study","BURN-ASV\u002FTFR","Inclusion Criteria:\n\n* Adults aged 18 years or older.\n* Hospital admission with severe burn injury involving ≥20% total body surface area (TBSA).\n* Requirement for invasive mechanical ventilation within 24 hours after admission to the intensive care unit.\n* Expected need for mechanical ventilation for at least 48 hours.\n* Treatment with Adaptive Support Ventilation (ASV) and targeted fluid resuscitation according to institutional protocols.\n* Written informed consent provided by the patient or legally authorized representative, in accordance with local regulations.\n\nExclusion Criteria:\n\n* Age younger than 18 years.\n* Burn injury involving \\\u003C20% TBSA.\n* Mechanical ventilation initiated more than 24 hours after ICU admission.\n* Pregnancy.\n* Pre-existing chronic dependence on invasive mechanical ventilation.\n* Severe traumatic brain injury requiring a specific ventilation strategy.\n* Terminal illness with an expected survival of less than 24 hours.\n* Enrollment in another interventional clinical trial that may influence study outcomes.\n* Inability to obtain essential clinical data required for study analysis.","ALL","18 Years","50 Years",{"count":51,"type":52},100,"ESTIMATED","7 Days","OBSERVATIONAL","This prospective cohort study will evaluate the use of Adaptive Support Ventilation (ASV) together with targeted fluid resuscitation in adult patients with severe burn injuries requiring mechanical ventilation in the intensive care unit.\n\nPatients with extensive burns often develop respiratory failure and require both invasive mechanical ventilation and large-volume fluid resuscitation during the first days after injury. The study will assess whether the combination of ASV and targeted fluid resuscitation is associated with improved oxygenation, respiratory mechanics, fluid balance, and early clinical outcomes during the first 72 hours of intensive care.\n\nClinical data, ventilatory parameters, laboratory results, hemodynamic variables, and fluid resuscitation characteristics will be collected as part of routine clinical care. The findings may help optimize early intensive care management for patients with severe burn injuries and improve future treatment strategies.",[57,58,59,60],"Burn","War-Related Injuries","Mechanical Ventilation","Infusion Fluid",[62,63,64,65],"burns","war - ralated injury","addaptive support ventilation","fluid therapy","NOT_YET_RECRUITING","2026-07-04",{"date":69,"type":70},"2026-07-08","ACTUAL",{"date":72,"type":52},"2026-09-23",{"date":72,"type":52},{"name":5,"class":6},1]