[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100650536":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":21,"centralContacts":26,"locations":32,"responsibleParty":53,"collaborators":55,"id":58,"slug":59,"hasResults":60,"nctId":61,"briefTitle":62,"officialTitle":62,"acronym":63,"eligibilityCriteria":64,"healthyVolunteers":60,"sex":65,"minAge":66,"maxAge":67,"enrollmentInfo":68,"targetDuration":20,"studyType":71,"phases":72,"briefSummary":74,"conditions":75,"keywords":77,"overallStatus":90,"whyStopped":20,"lastUpdateSubmitDate":91,"lastUpdatePostDateStruct":92,"startDateStruct":95,"completionDateStruct":97,"leadSponsor":99,"locationsCount":100},{"fullName":5,"class":6},"Weill Medical College of Cornell University","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Micro-Fragmented Adipose Tissue (MFAT) Injection","EXPERIMENTAL","All participants receive a single, one-time autologous fat grafting procedure (no comparison group). A small volume of abdominal fat (5-15 cc) is harvested by manual liposuction under local anesthesia and concentrated by gentle manual rolling on non-adherent (Telfa) dressings to create micro-fragmented adipose tissue (MFAT). Under ultrasound guidance, the target tendon undergoes percutaneous tenotomy (needle fenestration) to disrupt scar tissue, followed by intratendinous injection of 1-3 cc of concentrated MFAT. Participants are then followed for 12 months with patient-reported pain and function questionnaires and ultrasound imaging. This is a single-arm, open-label study in which each participant serves as their own baseline control.",[13],"Procedure: Micro-Fragmented Adipose Tissue (MFAT) injection",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":20},"PROCEDURE","Micro-Fragmented Adipose Tissue (MFAT) injection","Autologous microfragmented adipose tissue (MFAT), i.e., mechanically concentrated autologous lipoaspirate, prepared and delivered in a single, same-day, point-of-care procedure. Under local anesthesia, 5-15 cc of subcutaneous abdominal fat is harvested by small-volume manual liposuction. The lipoaspirate is sterilely rinsed and concentrated by manual rolling on a non-adherent (Telfa) dressing; no enzymatic (collagenase) digestion, cell isolation, culture, or expansion is performed (minimal manipulation). Under ultrasound guidance, percutaneous tenotomy (needle fenestration) of the target tendon is performed, followed by a single intratendinous injection of 1-3 cc of the concentrated graft into the area of tendinopathy. One-time administration; route is percutaneous intratendinous injection. No exogenous cells, additives, scaffolds, or culture are used; the graft is autologous and delivered within the same surgical procedure.",[9],null,[22],{"name":23,"affiliation":24,"role":25},"Jaspal Singh, MD","Department of Rehabilitation Medicine | Weill Cornell Medicine","PRINCIPAL_INVESTIGATOR",[27],{"name":28,"role":29,"phone":30,"phoneExt":20,"email":31},"Terrence Green","CONTACT","(212) 746-9224","teg7008@med.cornell.edu",[33],{"facility":34,"status":20,"city":35,"state":35,"zip":36,"country":37,"countryCode":38,"cosmosGeoPoint":39,"geoPoint":44,"contacts":45},"Department of Rehabilitation Medicine WCMC","New York","10065","United States","US",{"type":40,"coordinates":41},"Point",[42,43],-74.00597,40.71427,{"lat":43,"lon":42},[46,49,52],{"name":23,"role":29,"phone":47,"phoneExt":20,"email":48},"212-746-1500","Jrs9012@med.cornell.edu",{"name":50,"role":29,"phone":20,"phoneExt":20,"email":51},"Christian Ponce","chp4030@med.cornell.edu",{"name":23,"role":25,"phone":20,"phoneExt":20,"email":20},{"type":54,"investigatorFullName":20,"investigatorTitle":20,"investigatorAffiliation":20,"oldNameTitle":20,"oldOrganization":20},"SPONSOR",[56],{"name":57,"class":6},"The Plastic Surgery Foundation","100650536","autologous-fat-grafting-for-the-treatment-of-chronic-tendinopathy-100650536",false,"NCT07748793","Autologous Fat Grafting for the Treatment of Chronic Tendinopathy","MFAT","Inclusion Criteria\n\n1. Age 18-80 years.\n2. Tendinopathy at any tendon location (e.g., rotator cuff\u002Fsupraspinatus, lateral epicondyle, gluteal\u002Fhip, Achilles, patellar).\n3. Confirmed tendon pathology: pain at the tendon site for \\> 3 months AND pathology confirmed on ultrasound.\n4. Failure of conservative treatment (e.g., activity modification, physical therapy, NSAIDs, corticosteroid injection, and\u002For PRP) for at least 6 weeks.\n5. Able to provide informed consent and complete questionnaires in English.\n\nExclusion Criteria\n\n1. Full-thickness tendon tear.\n2. Prior surgery at the target tendon site.\n3. Injection or other intervention at the target tendon site within the prior 6 months.\n4. Pregnancy or breastfeeding.\n5. Active local or systemic infection, bleeding diathesis or anticoagulation precluding the procedure, or other condition that in the investigator's judgment makes participation unsafe.\n6. Moderate-to-high-grade arthritis in the adjacent joint.","ALL","18 Years","80 Years",{"count":69,"type":70},40,"ESTIMATED","INTERVENTIONAL",[73],"NA","The goal of this clinical trial is to learn whether a one-time injection of a person's own concentrated fat (micro-fragmented adipose tissue, or MFAT) can reduce pain and improve function in adults (ages 18-80) with chronic tendinopathy - tendon pain lasting more than 3 months (for example, in the shoulder, elbow, hip, knee, or Achilles) - that has not improved with usual treatments such as physical therapy, cortisone shots, or platelet-rich plasma.\n\nThe main questions it aims to answer are:\n\n* Does injecting a person's own concentrated fat into a painful tendon reduce tendon pain?\n* Does it improve how well the tendon works, how long does any improvement last, and is the procedure safe?\n\nThis is a single-group study, so there is no separate comparison group; each participant's pain, function, and ultrasound results after treatment are compared with their own measurements taken before treatment.\n\nParticipants will:\n\n* Have a one-time procedure in which a small amount of fat is removed from the abdomen by liposuction (under local numbing), concentrated, and injected into the painful tendon using ultrasound guidance.\n* Complete short pain and function questionnaires and have ultrasound imaging of the tendon at study visits.\n* Be followed for about 12 months, with a phone or video check-in 3-7 days after the procedure, a 2-week skin check of the fat-removal site, and visits at 6 weeks, 3 months, 6 months, and 12 months.",[76],"Chronic Tendinopathy",[78,63,79,80,81,82,83,84,85,86,87,88,89],"Micro-fragmented adipose tissue","autologous fat grafting","adipose-derived stem cells","regenerative medicine","orthobiologics","percutaneous tenotomy,","ultrasound-guided injection","chronic tendinopathy","tendinopathy","lateral epicondylitis","rotator cuff tendinopathy","Achilles tendinopathy","NOT_YET_RECRUITING","2026-07-31",{"date":93,"type":94},"2026-08-06","ACTUAL",{"date":96,"type":70},"2026-08",{"date":98,"type":70},"2028-07",{"name":5,"class":6},1]