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The graft remains at near-normothermic temperature throughout the transition from ex vivo perfusion to in situ implantation, avoiding the conventional cold preservation flush before reperfusion.",[9],null,{"type":22,"name":17,"description":27,"armGroupLabels":28,"otherNames":25},"After completion of normothermic machine perfusion, the liver graft undergoes the standard preservation procedure consisting of a cold preservation solution flush before implantation, resulting in graft recooling prior to reperfusion. 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Sapienza Università di Roma","00161",{"type":50,"coordinates":247},[216,217],{"lat":217,"lon":216},[250,253,255],{"name":251,"role":32,"phone":25,"phoneExt":25,"email":252},"Fabio Melandro","fabio.melandro@uniroma1.it",{"name":254,"role":32,"phone":25,"phoneExt":25,"email":25},"Gianluca Mennini",{"name":251,"role":63,"phone":25,"phoneExt":25,"email":25},{"facility":257,"status":44,"city":212,"state":25,"zip":258,"country":47,"countryCode":48,"cosmosGeoPoint":259,"geoPoint":261,"contacts":262},"Fondazione Policlinico \"Agostino Gemelli\" IRCCS","00168",{"type":50,"coordinates":260},[216,217],{"lat":217,"lon":216},[263,266,269],{"name":264,"role":32,"phone":25,"phoneExt":25,"email":265},"Francesco Frongillo","francesco.frongillo@policlinicogemelli.it",{"name":267,"role":32,"phone":25,"phoneExt":25,"email":268},"Marco Maria Pascale","marcomaria.pascale@policlinicogemelli.it",{"name":264,"role":63,"phone":25,"phoneExt":25,"email":25},{"facility":271,"status":44,"city":272,"state":25,"zip":273,"country":47,"countryCode":48,"cosmosGeoPoint":274,"geoPoint":278,"contacts":279},"Azienda Ospedaliera Universitaria Integrata Verona","Verona","37126",{"type":50,"coordinates":275},[276,277],10.9938,45.43854,{"lat":277,"lon":276},[280,283,285],{"name":281,"role":32,"phone":25,"phoneExt":25,"email":282},"Amedeo Carraro","amedeo.carraro@aovr.veneto.it",{"name":284,"role":32,"phone":25,"phoneExt":25,"email":25},"Alex Borin",{"name":281,"role":63,"phone":25,"phoneExt":25,"email":25},{"type":287,"investigatorFullName":25,"investigatorTitle":25,"investigatorAffiliation":25,"oldNameTitle":25,"oldOrganization":25},"SPONSOR","100645692","avoiding-recooling-after-normothermic-machine-perfusion-in-liver-transplantation-100645692",false,"NCT07692490","Avoiding Recooling After Normothermic Machine Perfusion in Liver Transplantation","Avoiding Recooling After Normothermic Machine Perfusion in Liver Transplantation: a Multicenter, Parallel-group, Open-label, Non-inferiority Randomized Controlled Trial","ARANMP-LT","Inclusion Criteria:\n\n* Age ≥18 years.\n* Listed for primary liver transplantation at the participating institution.\n* Assigned a liver graft preserved with normothermic machine perfusion or sequential hypothermic- normothermic machine perfusion (SHNMP).\n* Signed and dated informed consent prior study inclusion.\n\nExclusion Criteria:\n\n* Pediatric patients (age \\\u003C 18 years)\n* Patients undergoing re-transplantation (history of previous liver transplantation)\n* Patients with acute liver failure\n* Patients undergoing multi-organ transplantation (e.g., liver-kidney, liver-heart)\n* Temporarily unconscious patients\n* Patients unable to freely express consent.","ALL","18 Years",{"count":299,"type":300},170,"ESTIMATED","INTERVENTIONAL",[303],"NA","The ARANMP-LT study is a multicenter, open-label, randomized, parallel-group, non-inferiority clinical trial designed to evaluate whether avoiding graft recooling after normothermic machine perfusion (NMP) improves early outcomes following liver transplantation. Although graft recooling before implantation is common practice, experimental and preliminary clinical evidence suggests that abrupt temperature changes may contribute to ischemia-reperfusion injury.\n\nAdult recipients of deceased-donor liver grafts preserved with NMP or sequential hypothermic-normothermic machine perfusion (SHNMP) will be randomized in a 1:1 ratio to either standard graft implantation with recooling using cold preservation solution (control group) or implantation without recooling using a room-temperature 5% albumin flush immediately before reperfusion (intervention group).\n\nThe primary objective is to compare the incidence of Early Allograft Dysfunction (EAD), defined according to the Olthoff criteria, between the two treatment groups. Secondary objectives include evaluation of histopathological ischemia-reperfusion injury using the Suzuki score, vascular and biliary complications, primary non-function, post-reperfusion syndrome, patient and graft survival, length of intensive care unit and hospital stay, perioperative transfusion requirements, and safety outcomes. A total of 170 participants will be enrolled across multiple Italian liver transplant centers and followed for 90 days after transplantation.",[306,307,308],"Liver Transplantation (LT)","Ischemia-Reperfusion Injury","Early Allograft Dysfunction",[310,311,307,308,312,313],"Liver Transplantation","Normothermic Machine Perfusion","Organ Preservation","Liver Graft","2026-07-10",{"date":316,"type":317},"2026-07-14","ACTUAL",{"date":319,"type":300},"2026-07-07",{"date":321,"type":300},"2028-10-06",{"name":5,"class":6},14]