[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100603719":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":30,"centralContacts":35,"locations":44,"responsibleParty":690,"collaborators":25,"id":692,"slug":693,"hasResults":694,"nctId":695,"briefTitle":696,"officialTitle":697,"acronym":698,"eligibilityCriteria":699,"healthyVolunteers":694,"sex":700,"minAge":701,"maxAge":25,"enrollmentInfo":702,"targetDuration":25,"studyType":705,"phases":706,"briefSummary":708,"conditions":709,"keywords":711,"overallStatus":79,"whyStopped":25,"lastUpdateSubmitDate":722,"lastUpdatePostDateStruct":723,"startDateStruct":726,"completionDateStruct":728,"leadSponsor":730,"locationsCount":731},{"fullName":5,"class":6},"University Hospital, Basel, Switzerland","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Arm A (Control): ALND","ACTIVE_COMPARATOR","1. Surgery: Tailored Axillary Surgery (TAS) includes the sentinel lymph node (SLN) procedure, radiographic confirmation of the removal of previously marked lymph nodes (clip removal), and the targeted excision of palpably suspicious lymph nodes.\n2. Surgery: ALND - current standard of care, with the intention to remove the entire soft tissue within the anatomical borders of the axilla.\n3. Radiotherapy: All patients receive adjuvant breast irradiation following breast-conserving surgery, along with extended regional lymph node irradiation (breast\u002Fchest wall irradiation excluding the axilla).",[13],"Procedure: Axillary lymph node dissection (ALND)",{"label":15,"type":10,"description":16,"interventionNames":17},"Arm B (Investigational): ART","1. Surgery: Tailored Axillary Surgery (TAS) includes the sentinel lymph node (SLN) procedure, radiographic confirmation of the removal of previously marked lymph nodes (clip removal), and the targeted excision of palpably suspicious lymph nodes.\n2. Radiotherapy: All patients receive adjuvant breast irradiation following breast-conserving surgery, along with extended regional lymph node irradiation (breast\u002Fchest wall irradiation excluding the axilla).TAS + breast\u002Fchest wall and axillary irradiation (ART)\n3. Radiotherapy: Axillary radiotherapy (ART).",[18],"Procedure: Axillary radiotherapy (ART)",[20,26],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"PROCEDURE","Axillary lymph node dissection (ALND)","Surgical removal of lymphatic tissue within the anatomical boundaries of the axilla (standard of care in the upfront surgery setting in patients with cN+ BC)",[9],null,{"type":21,"name":27,"description":28,"armGroupLabels":29,"otherNames":25},"Axillary radiotherapy (ART)","Axillary irradiation",[15],[31],{"name":32,"affiliation":33,"role":34},"Walter P. Weber, Prof. Dr. med.","Breast Surgery Service, University Hospital Basel","PRINCIPAL_INVESTIGATOR",[36,40],{"name":32,"role":37,"phone":38,"phoneExt":25,"email":39},"CONTACT","+41 61 328 61 49","walter.weber@usb.ch",{"name":41,"role":37,"phone":42,"phoneExt":25,"email":43},"OPBC project management team","+41 61 55 65134","noax.trial@usb.ch",[45,63,77,92,106,120,132,144,156,168,177,191,205,220,228,239,251,265,277,289,299,311,320,329,338,350,364,376,390,404,415,427,440,452,465,477,489,501,511,523,532,544,556,568,577,589,601,613,625,637,650,659,668,681],{"facility":46,"status":47,"city":48,"state":49,"zip":50,"country":51,"countryCode":52,"cosmosGeoPoint":53,"geoPoint":58,"contacts":59},"Walter Reed National Military Medical Center","NOT_YET_RECRUITING","Bethesda","Maryland","20814","United States","US",{"type":54,"coordinates":55},"Point",[56,57],-77.10026,38.98067,{"lat":57,"lon":56},[60],{"name":61,"role":37,"phone":25,"phoneExt":25,"email":62},"Annesley Copeland","annesley.w.copeland.civ@health.mil",{"facility":64,"status":47,"city":65,"state":66,"zip":67,"country":51,"countryCode":52,"cosmosGeoPoint":68,"geoPoint":72,"contacts":73},"Duke University\u002FDuke Cancer Center","Durham","North Carolina","27710",{"type":54,"coordinates":69},[70,71],-78.89862,35.99403,{"lat":71,"lon":70},[74],{"name":75,"role":37,"phone":25,"phoneExt":25,"email":76},"Maggie DiNome","maggie.dinome@duke.edu",{"facility":78,"status":79,"city":80,"state":81,"zip":82,"country":51,"countryCode":52,"cosmosGeoPoint":83,"geoPoint":87,"contacts":88},"Fox Chase Cancer Center","RECRUITING","Philadelphia","Pennsylvania","19111",{"type":54,"coordinates":84},[85,86],-75.16362,39.95238,{"lat":86,"lon":85},[89],{"name":90,"role":37,"phone":25,"phoneExt":25,"email":91},"Austin Williams","austin.williams@fccc.edu",{"facility":93,"status":47,"city":94,"state":95,"zip":96,"country":51,"countryCode":52,"cosmosGeoPoint":97,"geoPoint":101,"contacts":102},"Swedish Cancer Institute","Seattle","Washington","98104",{"type":54,"coordinates":98},[99,100],-122.33207,47.60621,{"lat":100,"lon":99},[103],{"name":104,"role":37,"phone":25,"phoneExt":25,"email":105},"Laura Lazarus","laura.lazarus@swedish.org",{"facility":107,"status":79,"city":108,"state":25,"zip":25,"country":109,"countryCode":110,"cosmosGeoPoint":111,"geoPoint":115,"contacts":116},"KH Dornbirn","Dornbirn","Austria","AT",{"type":54,"coordinates":112},[113,114],9.74195,47.41427,{"lat":114,"lon":113},[117],{"name":118,"role":37,"phone":25,"phoneExt":25,"email":119},"Christopher Hager","christopher.hager@dornbirn.at",{"facility":121,"status":79,"city":122,"state":25,"zip":25,"country":109,"countryCode":110,"cosmosGeoPoint":123,"geoPoint":127,"contacts":128},"LKH Feldkirch","Feldkirch",{"type":54,"coordinates":124},[125,126],9.59734,47.23645,{"lat":126,"lon":125},[129],{"name":130,"role":37,"phone":25,"phoneExt":25,"email":131},"Angelika Wolfrum","angelika.wolfrum@lkhf.at",{"facility":133,"status":79,"city":134,"state":25,"zip":25,"country":109,"countryCode":110,"cosmosGeoPoint":135,"geoPoint":139,"contacts":140},"MUI - Univ. Klinik f. Frauenheilkunde Innsbruck","Innsbruck",{"type":54,"coordinates":136},[137,138],11.39454,47.26266,{"lat":138,"lon":137},[141],{"name":142,"role":37,"phone":25,"phoneExt":25,"email":143},"Daniel Egle","daniel.egle@tirol-kliniken.at",{"facility":145,"status":79,"city":146,"state":25,"zip":25,"country":109,"countryCode":110,"cosmosGeoPoint":147,"geoPoint":151,"contacts":152},"Ordensklinikum Linz","Linz",{"type":54,"coordinates":148},[149,150],14.28611,48.30639,{"lat":150,"lon":149},[153],{"name":154,"role":37,"phone":25,"phoneExt":25,"email":155},"Markus Acko","markus.acko@ordensklinikum.at",{"facility":157,"status":47,"city":158,"state":25,"zip":25,"country":109,"countryCode":110,"cosmosGeoPoint":159,"geoPoint":163,"contacts":164},"Medical University Vienna, Department of Gynecology","Vienna",{"type":54,"coordinates":160},[161,162],16.37208,48.20849,{"lat":162,"lon":161},[165],{"name":166,"role":37,"phone":25,"phoneExt":25,"email":167},"Christian Singer","christian.singer@meduniwien.ac.at",{"facility":169,"status":79,"city":158,"state":25,"zip":25,"country":109,"countryCode":110,"cosmosGeoPoint":170,"geoPoint":172,"contacts":173},"Medical University Vienna, Department of Surgery",{"type":54,"coordinates":171},[161,162],{"lat":162,"lon":161},[174],{"name":175,"role":37,"phone":25,"phoneExt":25,"email":176},"Ruth Exner","ruth.exner@meduniwien.ac.at",{"facility":178,"status":79,"city":179,"state":25,"zip":25,"country":180,"countryCode":181,"cosmosGeoPoint":182,"geoPoint":186,"contacts":187},"CIUSSS du Centre Ouest-de-l 'Ile-de-Montréal","Montreal","Canada","CA",{"type":54,"coordinates":183},[184,185],-73.58781,45.50884,{"lat":185,"lon":184},[188],{"name":189,"role":37,"phone":25,"phoneExt":25,"email":190},"Stephanie Wong","sm.wong@mcgill.ca",{"facility":192,"status":47,"city":193,"state":25,"zip":25,"country":194,"countryCode":195,"cosmosGeoPoint":196,"geoPoint":200,"contacts":201},"Breast Centre of Clinical Hospital, Rijeka","Rijeka","Croatia","HR",{"type":54,"coordinates":197},[198,199],14.44241,45.32673,{"lat":199,"lon":198},[202],{"name":203,"role":37,"phone":25,"phoneExt":25,"email":204},"Ana Car Peterko Car Peterko","anacarpeterko@gmail.com",{"facility":206,"status":79,"city":207,"state":25,"zip":208,"country":209,"countryCode":210,"cosmosGeoPoint":211,"geoPoint":215,"contacts":216},"University Hospital Heidelberg, Women's Clinic","Heidelberg","69120","Germany","DE",{"type":54,"coordinates":212},[213,214],8.69079,49.40768,{"lat":214,"lon":213},[217],{"name":218,"role":37,"phone":25,"phoneExt":25,"email":219},"Jörg Heil","joerg.heil@med.uni-heidelberg.de",{"facility":221,"status":79,"city":207,"state":25,"zip":25,"country":209,"countryCode":210,"cosmosGeoPoint":222,"geoPoint":224,"contacts":225},"Brustzentrum Heidelberg Klinik St. Elisabeth GmbH",{"type":54,"coordinates":223},[213,214],{"lat":214,"lon":213},[226],{"name":218,"role":37,"phone":25,"phoneExt":25,"email":227},"joerg.heil@kse-hd.de",{"facility":229,"status":79,"city":230,"state":25,"zip":25,"country":209,"countryCode":210,"cosmosGeoPoint":231,"geoPoint":235,"contacts":236},"Breast Center Osnabrück","Osnabrück",{"type":54,"coordinates":232},[233,234],8.0498,52.27264,{"lat":234,"lon":233},[237],{"name":238,"role":37,"phone":25,"phoneExt":25,"email":25},"Thorsten Heilmann",{"facility":240,"status":47,"city":241,"state":25,"zip":25,"country":209,"countryCode":210,"cosmosGeoPoint":242,"geoPoint":246,"contacts":247},"HELIOS Universitätsklinikum Wuppertal","Wuppertal",{"type":54,"coordinates":243},[244,245],7.14816,51.25627,{"lat":245,"lon":244},[248],{"name":249,"role":37,"phone":25,"phoneExt":25,"email":250},"Vesna Bjelic-Radisic","Vesna.Bjelic-Radisic@helios-gesundheit.de",{"facility":252,"status":47,"city":253,"state":25,"zip":25,"country":254,"countryCode":255,"cosmosGeoPoint":256,"geoPoint":260,"contacts":261},"\"Alexandra\" Hospital, Athens","Athens","Greece","GR",{"type":54,"coordinates":257},[258,259],23.72784,37.98376,{"lat":259,"lon":258},[262],{"name":263,"role":37,"phone":25,"phoneExt":25,"email":264},"George Pissakas","pissakasg@gmail.com",{"facility":266,"status":47,"city":267,"state":25,"zip":25,"country":254,"countryCode":255,"cosmosGeoPoint":268,"geoPoint":272,"contacts":273},"University Hospital of Heraklion","Heraklion",{"type":54,"coordinates":269},[270,271],25.14341,35.32787,{"lat":271,"lon":270},[274],{"name":275,"role":37,"phone":25,"phoneExt":25,"email":276},"Eelco de Bree","debree@med.uoc.gr",{"facility":278,"status":47,"city":279,"state":25,"zip":25,"country":254,"countryCode":255,"cosmosGeoPoint":280,"geoPoint":284,"contacts":285},"University Hospital of Larissa","Larissa",{"type":54,"coordinates":281},[282,283],22.42112,39.62847,{"lat":283,"lon":282},[286],{"name":287,"role":37,"phone":25,"phoneExt":25,"email":288},"Antigoni Poultsidi","apoultsidi@uth.gr",{"facility":290,"status":47,"city":291,"state":25,"zip":25,"country":292,"countryCode":293,"cosmosGeoPoint":294,"geoPoint":298,"contacts":25},"Cork University Hospital","Cork","Ireland","IE",{"type":54,"coordinates":295},[296,297],-8.47061,51.89797,{"lat":297,"lon":296},{"facility":300,"status":47,"city":301,"state":25,"zip":25,"country":292,"countryCode":293,"cosmosGeoPoint":302,"geoPoint":306,"contacts":307},"Beaumont Hospital Dublin","Dublin",{"type":54,"coordinates":303},[304,305],-6.24889,53.33306,{"lat":305,"lon":304},[308],{"name":309,"role":37,"phone":25,"phoneExt":25,"email":310},"Arnold Hill","adkhill@rcsi.ie",{"facility":312,"status":47,"city":301,"state":25,"zip":25,"country":292,"countryCode":293,"cosmosGeoPoint":313,"geoPoint":315,"contacts":316},"St- Luke's Hospital Dublin",{"type":54,"coordinates":314},[304,305],{"lat":305,"lon":304},[317],{"name":318,"role":37,"phone":25,"phoneExt":25,"email":319},"Frances Duane","fran.duane@slh.ie",{"facility":321,"status":47,"city":301,"state":25,"zip":25,"country":292,"countryCode":293,"cosmosGeoPoint":322,"geoPoint":324,"contacts":325},"St. James's Hospital Dublin",{"type":54,"coordinates":323},[304,305],{"lat":305,"lon":304},[326],{"name":327,"role":37,"phone":25,"phoneExt":25,"email":328},"Elizabeth Connolly","emconnolly@stjames.ie",{"facility":330,"status":47,"city":301,"state":25,"zip":25,"country":292,"countryCode":293,"cosmosGeoPoint":331,"geoPoint":333,"contacts":334},"St. Vincent's University Hospital",{"type":54,"coordinates":332},[304,305],{"lat":305,"lon":304},[335],{"name":336,"role":37,"phone":25,"phoneExt":25,"email":337},"Michael Boland","michaelboland@rcsi.ie",{"facility":339,"status":79,"city":340,"state":25,"zip":25,"country":292,"countryCode":293,"cosmosGeoPoint":341,"geoPoint":345,"contacts":346},"University Hospital Galway","Galway",{"type":54,"coordinates":342},[343,344],-9.05095,53.27245,{"lat":344,"lon":343},[347],{"name":348,"role":37,"phone":25,"phoneExt":25,"email":349},"Aoife Lowery","alowery@universityofgalway.ie",{"facility":351,"status":47,"city":352,"state":25,"zip":25,"country":353,"countryCode":354,"cosmosGeoPoint":355,"geoPoint":359,"contacts":360},"Istituto Oncologico Veneto IRCCS","Padova","Italy","IT",{"type":54,"coordinates":356},[357,358],11.14261,44.38225,{"lat":358,"lon":357},[361],{"name":362,"role":37,"phone":25,"phoneExt":25,"email":363},"Massimo Ferrucci","massimoferrucci@gmail.com",{"facility":365,"status":47,"city":366,"state":25,"zip":25,"country":353,"countryCode":354,"cosmosGeoPoint":367,"geoPoint":371,"contacts":372},"Policlinico Universitario \"Agostino Gemelli","Rome",{"type":54,"coordinates":368},[369,370],12.51133,41.89193,{"lat":370,"lon":369},[373],{"name":374,"role":37,"phone":25,"phoneExt":25,"email":375},"Gianluca Franceschini","gianlucafranceschini70@gmail.com",{"facility":377,"status":79,"city":378,"state":25,"zip":25,"country":379,"countryCode":380,"cosmosGeoPoint":381,"geoPoint":385,"contacts":386},"Pauls Stradiņš Clinical University Hospital","Riga","Latvia","LV",{"type":54,"coordinates":382},[383,384],24.10589,56.946,{"lat":384,"lon":383},[387],{"name":388,"role":37,"phone":25,"phoneExt":25,"email":389},"Jelena Maksimenko","Jelena.Maksimenko@stradini.lv",{"facility":391,"status":79,"city":392,"state":25,"zip":25,"country":393,"countryCode":394,"cosmosGeoPoint":395,"geoPoint":399,"contacts":400},"Kantonsspital Baden","Baden","Switzerland","CH",{"type":54,"coordinates":396},[397,398],8.30592,47.47333,{"lat":398,"lon":397},[401],{"name":402,"role":37,"phone":25,"phoneExt":25,"email":403},"Cornelia Leo","cornelia.leo@ksb.ch",{"facility":33,"status":79,"city":405,"state":25,"zip":406,"country":393,"countryCode":394,"cosmosGeoPoint":407,"geoPoint":411,"contacts":412},"Basel","4031",{"type":54,"coordinates":408},[409,410],7.57327,47.55839,{"lat":410,"lon":409},[413,414],{"name":32,"role":37,"phone":38,"phoneExt":25,"email":39},{"name":32,"role":34,"phone":25,"phoneExt":25,"email":25},{"facility":416,"status":47,"city":417,"state":25,"zip":25,"country":393,"countryCode":394,"cosmosGeoPoint":418,"geoPoint":422,"contacts":423},"University Hospital of Bern (Inselspital)","Bern",{"type":54,"coordinates":419},[420,421],7.44744,46.94809,{"lat":421,"lon":420},[424],{"name":425,"role":37,"phone":25,"phoneExt":25,"email":426},"Anneke Heverhagen","anneke.heverhagen@insel.ch",{"facility":428,"status":79,"city":429,"state":25,"zip":430,"country":393,"countryCode":394,"cosmosGeoPoint":431,"geoPoint":435,"contacts":436},"Clinique des Grangettes","Chêne-Bougeries","1224",{"type":54,"coordinates":432},[433,434],6.18642,46.19843,{"lat":434,"lon":433},[437],{"name":438,"role":37,"phone":25,"phoneExt":25,"email":439},"conny Vrieling","conny.vrieling@grangettes.ch",{"facility":441,"status":79,"city":442,"state":25,"zip":25,"country":393,"countryCode":394,"cosmosGeoPoint":443,"geoPoint":447,"contacts":448},"Graubünden Cantonal Hospital","Chur",{"type":54,"coordinates":444},[445,446],9.53287,46.84986,{"lat":446,"lon":445},[449],{"name":450,"role":37,"phone":25,"phoneExt":25,"email":451},"Martina Maranta","martina.maranta@ksgr.ch",{"facility":453,"status":79,"city":454,"state":25,"zip":455,"country":393,"countryCode":394,"cosmosGeoPoint":456,"geoPoint":460,"contacts":461},"Spital Thurgau","Frauenfeld","8500",{"type":54,"coordinates":457},[458,459],8.89893,47.55776,{"lat":459,"lon":458},[462],{"name":463,"role":37,"phone":25,"phoneExt":25,"email":464},"Mathias Fehr","mathias.fehr@stgag.ch",{"facility":466,"status":79,"city":467,"state":25,"zip":25,"country":393,"countryCode":394,"cosmosGeoPoint":468,"geoPoint":472,"contacts":473},"Hôpitaux Universitaires de Genève","Geneva",{"type":54,"coordinates":469},[470,471],6.14569,46.20222,{"lat":471,"lon":470},[474],{"name":475,"role":37,"phone":25,"phoneExt":25,"email":476},"Giang Thanh Lam","giang.t.lam@hcuge.ch",{"facility":478,"status":79,"city":479,"state":25,"zip":25,"country":393,"countryCode":394,"cosmosGeoPoint":480,"geoPoint":484,"contacts":485},"Clinique de Genolier","Genolier",{"type":54,"coordinates":481},[482,483],6.21809,46.43537,{"lat":483,"lon":482},[486],{"name":487,"role":37,"phone":25,"phoneExt":25,"email":488},"Magdalena Kohlik","mkohlik@genolier.net",{"facility":490,"status":79,"city":491,"state":25,"zip":25,"country":393,"countryCode":394,"cosmosGeoPoint":492,"geoPoint":496,"contacts":497},"Hirslandenklinik St. Anna","Lucerne",{"type":54,"coordinates":493},[494,495],8.30635,47.05048,{"lat":495,"lon":494},[498],{"name":499,"role":37,"phone":25,"phoneExt":25,"email":500},"Peter Dubsky","peter.dubsky@hirslanden.ch",{"facility":502,"status":79,"city":491,"state":25,"zip":25,"country":393,"countryCode":394,"cosmosGeoPoint":503,"geoPoint":505,"contacts":506},"Kantonsspital Luzern",{"type":54,"coordinates":504},[494,495],{"lat":495,"lon":494},[507],{"name":508,"role":37,"phone":509,"phoneExt":25,"email":510},"Susanne Bucher","0041 41 205 62 70","susanne.bucher@luks.ch",{"facility":512,"status":79,"city":513,"state":25,"zip":25,"country":393,"countryCode":394,"cosmosGeoPoint":514,"geoPoint":518,"contacts":519},"Centro di Senologia della Svizzera Italiana","Lugano",{"type":54,"coordinates":515},[516,517],8.96004,46.01008,{"lat":517,"lon":516},[520],{"name":521,"role":37,"phone":25,"phoneExt":25,"email":522},"Maria Luisa Gasparri","MariaLuisa.Gasparri@eoc.ch",{"facility":524,"status":47,"city":513,"state":25,"zip":25,"country":393,"countryCode":394,"cosmosGeoPoint":525,"geoPoint":527,"contacts":528},"Ticino Breast Center",{"type":54,"coordinates":526},[516,517],{"lat":517,"lon":516},[529],{"name":530,"role":37,"phone":25,"phoneExt":25,"email":531},"Damire De Monaco","damir.demonaco@affidea.ch",{"facility":533,"status":79,"city":534,"state":25,"zip":25,"country":393,"countryCode":394,"cosmosGeoPoint":535,"geoPoint":539,"contacts":540},"Hôpital Neuchâtelois","Neuchâtel",{"type":54,"coordinates":536},[537,538],6.931,46.99179,{"lat":538,"lon":537},[541],{"name":542,"role":37,"phone":25,"phoneExt":25,"email":543},"Alexis Léger","alexis.leger@rhne.ch",{"facility":545,"status":79,"city":546,"state":25,"zip":25,"country":393,"countryCode":394,"cosmosGeoPoint":547,"geoPoint":551,"contacts":552},"Bethesda Hospital Basel","Pratteln",{"type":54,"coordinates":548},[549,550],7.69356,47.52071,{"lat":550,"lon":549},[553],{"name":554,"role":37,"phone":25,"phoneExt":25,"email":555},"Dieter Müller","dmueller@muellerhess.com",{"facility":557,"status":79,"city":558,"state":25,"zip":25,"country":393,"countryCode":394,"cosmosGeoPoint":559,"geoPoint":563,"contacts":564},"Kantonsspital St. Gallen","Sankt Gallen",{"type":54,"coordinates":560},[561,562],9.37477,47.42391,{"lat":562,"lon":561},[565],{"name":566,"role":37,"phone":25,"phoneExt":25,"email":567},"Inga Bekes","inga.bekes@kssg.ch",{"facility":569,"status":79,"city":558,"state":25,"zip":25,"country":393,"countryCode":394,"cosmosGeoPoint":570,"geoPoint":572,"contacts":573},"Tumor-& Brustzentrum Ostschweiz St. Gallen",{"type":54,"coordinates":571},[561,562],{"lat":562,"lon":561},[574],{"name":575,"role":37,"phone":25,"phoneExt":25,"email":576},"Michael Knauer","michael.knauer@tbz-ost.ch",{"facility":578,"status":79,"city":579,"state":25,"zip":25,"country":393,"countryCode":394,"cosmosGeoPoint":580,"geoPoint":584,"contacts":585},"Schaffhausen Cantonal Hospital","Schaffhausen",{"type":54,"coordinates":581},[582,583],8.63493,47.69732,{"lat":583,"lon":582},[586],{"name":587,"role":37,"phone":25,"phoneExt":25,"email":588},"Deborah Admaty","Deborah.Admaty@spitaeler-sh.ch",{"facility":590,"status":79,"city":591,"state":25,"zip":25,"country":393,"countryCode":394,"cosmosGeoPoint":592,"geoPoint":596,"contacts":597},"Spital Limmattal","Schlieren",{"type":54,"coordinates":593},[594,595],8.44763,47.39668,{"lat":595,"lon":594},[598],{"name":599,"role":37,"phone":25,"phoneExt":25,"email":600},"Kathrin Kimmig","Kathrin.Kimmig@spital-limmattal.ch",{"facility":602,"status":79,"city":603,"state":25,"zip":25,"country":393,"countryCode":394,"cosmosGeoPoint":604,"geoPoint":608,"contacts":609},"Hôpital du Valais, Hôpital de Sion","Sion",{"type":54,"coordinates":605},[606,607],7.35559,46.22739,{"lat":607,"lon":606},[610],{"name":611,"role":37,"phone":25,"phoneExt":25,"email":612},"Colin Simonson","colin.simonson@hopitalvs.ch",{"facility":614,"status":79,"city":615,"state":25,"zip":25,"country":393,"countryCode":394,"cosmosGeoPoint":616,"geoPoint":620,"contacts":621},"Kantonsspital Winterthur","Winterthur",{"type":54,"coordinates":617},[618,619],8.72413,47.50564,{"lat":619,"lon":618},[622],{"name":623,"role":37,"phone":25,"phoneExt":25,"email":624},"Denise Vorburger","denise.vorburger@ksw.ch",{"facility":626,"status":79,"city":627,"state":25,"zip":25,"country":393,"countryCode":394,"cosmosGeoPoint":628,"geoPoint":632,"contacts":633},"Spital Zollikerberg","Zollikerberg",{"type":54,"coordinates":629},[630,631],8.60088,47.3451,{"lat":631,"lon":630},[634],{"name":635,"role":37,"phone":25,"phoneExt":25,"email":636},"Hisham Fansa","hisham.fansa@spitalzollikerberg.ch",{"facility":638,"status":79,"city":639,"state":25,"zip":640,"country":393,"countryCode":394,"cosmosGeoPoint":641,"geoPoint":645,"contacts":646},"Brustzentrum Zürich (Seefeld)","Zurich","8008",{"type":54,"coordinates":642},[643,644],8.55,47.36667,{"lat":644,"lon":643},[647],{"name":648,"role":37,"phone":25,"phoneExt":25,"email":649},"Christoph Tausch","christoph.tausch@brust-zentrum.ch",{"facility":651,"status":79,"city":639,"state":25,"zip":25,"country":393,"countryCode":394,"cosmosGeoPoint":652,"geoPoint":654,"contacts":655},"Stadtspital Triemli",{"type":54,"coordinates":653},[643,644],{"lat":644,"lon":643},[656],{"name":657,"role":37,"phone":25,"phoneExt":25,"email":658},"Heike Ruth Passmann Kegel","Heike.Passmann@stadtspital.ch",{"facility":660,"status":47,"city":639,"state":25,"zip":25,"country":393,"countryCode":394,"cosmosGeoPoint":661,"geoPoint":663,"contacts":664},"University Hospital Zürich",{"type":54,"coordinates":662},[643,644],{"lat":644,"lon":643},[665],{"name":666,"role":37,"phone":25,"phoneExt":25,"email":667},"Heike Frauchiger-Heuer","Heike.Frauchiger-Heuer@usz.ch",{"facility":669,"status":47,"city":670,"state":25,"zip":25,"country":671,"countryCode":25,"cosmosGeoPoint":672,"geoPoint":676,"contacts":677},"İstanbul Bağcılar Training and Research Hospital","Istanbul","Turkey (Türkiye)",{"type":54,"coordinates":673},[674,675],28.94966,41.01384,{"lat":675,"lon":674},[678],{"name":679,"role":37,"phone":25,"phoneExt":25,"email":680},"Merve Tokoçin","mervetokocin@gmail.com",{"facility":682,"status":47,"city":670,"state":25,"zip":25,"country":671,"countryCode":25,"cosmosGeoPoint":683,"geoPoint":685,"contacts":686},"Sancaktepe Şehit Prof. Dr. İlhan Varank Training and Research Hospital",{"type":54,"coordinates":684},[674,675],{"lat":675,"lon":674},[687],{"name":688,"role":37,"phone":25,"phoneExt":25,"email":689},"Adnan Gündoğdu","adnangundogdu89@gmail.com",{"type":691,"investigatorFullName":25,"investigatorTitle":25,"investigatorAffiliation":25,"oldNameTitle":25,"oldOrganization":25},"SPONSOR","100603719","axillary-radiotherapy-or-axillary-lymph-node-dissection-in-patients-with-clinically-node--positive-breast-cancer-undergoing-upfront-tailored-axillary-surgery-100603719",false,"NCT07140172","Axillary Radiotherapy or Axillary Lymph Node Dissection in Patients With Clinically Node- Positive Breast Cancer Undergoing Upfront Tailored Axillary Surgery","Axillary Radiotherapy or Axillary Lymph Node Dissection in Patients With Clinically Node- Positive Breast Cancer Undergoing Upfront Tailored Axillary Surgery: An International, Randomized Superiority Trial (OPBC-10\u002F NOAX)","OPBC-10\u002F NOAX","Inclusion Criteria at screening:\n\n* Written informed consent according to ICH\u002FGCP regulations prior to any trial specific procedures.\n* Patients ≥ 18 years of age.\n* Node-positive breast cancer (histologically or cytologically proven both in primary tumor and in lymph node) American Joint Committee on Cancer\u002F International Union Against Cancer (AJCC\u002FUICC) stage II-III (all molecular subtypes allowed).\n* Node-positivity detected by imaging and non-palpable (iN+) and confirmed by pathology.\n* Node-positivity palpable (cN1-3) and confirmed by pathology.\n* Occult breast cancer is allowed, if biopsy-proven axillary lymphatic metastasis is present.\n* Eligible for primary ALND or SLN procedure and either:\n\n  * Newly diagnosed.\n  * Isolated in-breast recurrence or second ipsilateral breast cancer after previous breast conserving surgery and sentinel procedure and at least 3 years disease free and no prior axillary dissection or axillary RT.\n* Upfront surgery setting.\n* Most suspicious axillary lymph node clipped. (If clipping is not part of the routine, this should be done after consent of the patient as a study procedure.)\n* Ability to complete the QoL questionnaires.\n* WHO performance status 0-2\n* Adequate condition for general anesthesia, breast cancer surgery and radiotherapy.\n* Adult patients (≥18 years of age).\n* Women of child-bearing potential are using effective contraception (condom, diaphragm, intrauterine device), are not pregnant or lactating and agree not to become pregnant during trial treatment (until end of RT) and thereafter during the time recommended by the guidelines - also for adjuvant systemic therapies. A negative pregnancy test before registration is required for all women of child-bearing potential.\n* Men agree not to father a child during trial treatment and for 6 months afterward.\n\nExclusion criteria at screening:\n\n* Stage IV breast cancer.\n* Clinical N3c breast cancer without axillary disease (clinical N3a and clinical N3b are allowed).\n* Clinical N2b breast cancer (clinical N2a is allowed).\n* Contralateral breast cancer within 3 years.\n* Prior axillary surgery (except prior sentinel node procedure in case of in-breast recurrence).\n* Prior regional radiotherapy.\n* Neoadjuvant treatment with the exception of bridging therapy given for less than 3 months.\n* History of hematologic or primary solid tumor malignancy, unless in remission for at least 3 years from pre-registration with the exception of adequately treated cervical carcinoma in situ or localized non-melanoma skin cancer.\n* Any other serious underlying medical, psychiatric, psychological, familial or geographical condition, which in the judgment of the investigator may interfere with the planned staging, treatment and follow-up, affect patient compliance or place the patient at high risk from treatment-related complications.\n\nExclusion criteria at randomization (intraoperatively):\n\n* Absence of clip in the specimen radiography.\n* Palpable disease left behind in the axilla after TAS.\n* No SLN identified in the axilla.","ALL","18 Years",{"count":703,"type":704},1060,"ESTIMATED","INTERVENTIONAL",[707],"NA","This trial is to investigate if in patients with clinically node positive breast cancer undergoing upfront surgery, treatment with TAS and ART is superior to ALND in terms of arm-related Quality of Life (QoL) and occurrence of lymphedema two years after randomization.",[710],"Breast Cancer",[712,713,714,715,716,717,718,719,720,721],"axillary lymph node dissection (ALND)","axillary radiotherapy (ART)","tailored axillary surgery (TAS)","clinically node positive breast cancer (cN+ BC)","sentinel lymph node biopsy (SLNB)","Breast cancer-specific survival (BCSS)","NOAX","OPBC-10","Lymphedema","Quality of life (QoL)","2026-08-06",{"date":724,"type":725},"2026-08-07","ACTUAL",{"date":727,"type":725},"2026-01-01",{"date":729,"type":704},"2037-12",{"name":5,"class":6},54]