[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100611998":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":35,"centralContacts":36,"locations":46,"responsibleParty":65,"collaborators":35,"id":69,"slug":70,"hasResults":71,"nctId":72,"briefTitle":73,"officialTitle":74,"acronym":75,"eligibilityCriteria":76,"healthyVolunteers":71,"sex":77,"minAge":78,"maxAge":35,"enrollmentInfo":79,"targetDuration":35,"studyType":82,"phases":83,"briefSummary":85,"conditions":86,"keywords":88,"overallStatus":49,"whyStopped":35,"lastUpdateSubmitDate":92,"lastUpdatePostDateStruct":93,"startDateStruct":96,"completionDateStruct":98,"leadSponsor":100,"locationsCount":101},{"fullName":5,"class":6},"Beijing Anzhen Hospital","OTHER",[8,15],{"label":9,"type":10,"description":11,"interventionNames":12},"Combined Protection Group (BGC + Filter)","EXPERIMENTAL","Patients in this group will undergo carotid artery stenting (CAS) using a Balloon Guide Catheter (BGC) for proximal protection combined with a distal filter protection device.",[13,14],"Device: Balloon Guide Catheter","Device: Distal Filter Protection Device",{"label":16,"type":17,"description":18,"interventionNames":19},"Standard Protection Group (Filter Alone)","ACTIVE_COMPARATOR","Patients in this group will undergo carotid artery stenting (CAS) using a standard guiding catheter and a distal filter protection device alone.",[14],[21,28],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DEVICE","Balloon Guide Catheter","A catheter with a balloon at the distal tip, used to temporarily arrest flow and aspirate debris during the stenting procedure.",[9],[27],"BGC",{"type":22,"name":29,"description":30,"armGroupLabels":31,"otherNames":32},"Distal Filter Protection Device","A mesh-type device deployed distally to the stenosis to capture embolic debris during the procedure.",[9,16],[33,34],"Embolic Protection Device","EPD",null,[37,42],{"name":38,"role":39,"phone":40,"phoneExt":35,"email":41},"Xiaochuan Huo, Doctor, Doctor","CONTACT","+86 13716292262","hxc810909@163.com",{"name":43,"role":39,"phone":44,"phoneExt":35,"email":45},"Xin Tong, Doctor","+86 17810651085","tomice123@foxmail.com",[47],{"facility":48,"status":49,"city":50,"state":51,"zip":52,"country":53,"countryCode":54,"cosmosGeoPoint":55,"geoPoint":60,"contacts":61},"Beijing Anzhen Hospital Affiliated to Capital Medical University","RECRUITING","Beijing","Beijing Municipality","101118","China","CN",{"type":56,"coordinates":57},"Point",[58,59],116.39723,39.9075,{"lat":59,"lon":58},[62,64],{"name":63,"role":39,"phone":40,"phoneExt":35,"email":41},"Xiaochuan Huo, Doctor",{"name":43,"role":39,"phone":44,"phoneExt":35,"email":45},{"type":66,"investigatorFullName":67,"investigatorTitle":68,"investigatorAffiliation":5,"oldNameTitle":35,"oldOrganization":35},"PRINCIPAL_INVESTIGATOR","Xiaochuan Huo","Director","100611998","balloon-guide-catheter-combined-with-filter-protection-for-carotid-artery-stenting-100611998",false,"NCT07247864","Balloon Guide Catheter Combined With Filter Protection for Carotid Artery Stenting","A Comparative Study of Carotid Artery Stenosis Stenting With Balloon Guide Catheter Combined With Distal Filter Versus Distal Filter Alone-A Multicenter, Prospective, Open-label, Endpoint-blinded, Randomized Controlled Study","ANGEL-BEACON","1. Occlusion or severe stenosis (70% or greater) of the intracranial segment of the ipsilateral internal carotid artery system;\n2. Occlusion or severe stenosis (70% or greater) of the contralateral common carotid artery or internal carotid artery;\n3. History of stenting in the head and neck vessels within 3 months;\n4. Coexisting other cerebrovascular diseases, such as intracranial aneurysms greater than 5 mm or cerebrovascular malformations;\n5. Onset of stroke within 7 days;\n6. Large old infarctions from previous stroke that may confound the evaluation of endpoints;\n7. Contraindications to magnetic resonance imaging (MRI);\n8. Definite risk of cardiogenic embolism (e.g., atrial fibrillation, atrial flutter, intracardiac thrombus) or clear indications for anticoagulation therapy;\n9. Absolute or relative contraindications to antiplatelet therapy;\n10. Pregnant or lactating women;\n11. Allergy or hypersensitivity to contrast media or stent materials (e.g., Nitinol);\n12. Life expectancy less than 1 year;\n13. Pre-existing neurological or psychiatric disorders (e.g., severe dementia) that would confound neurological assessments;\n14. Severe renal insufficiency (eGFR less than 30 mL\u002Fmin).","ALL","18 Years",{"count":80,"type":81},296,"ESTIMATED","INTERVENTIONAL",[84],"NA","This multicenter, randomized, controlled trial evaluates a combined embolic protection strategy during carotid artery stenting (CAS). Carotid artery stenosis is a major cause of stroke. While stenting is an effective treatment, the procedure itself carries a risk of dislodging plaque debris, which can travel to the brain and cause new strokes or silent brain infarctions.\n\nCurrently, a distal filter (protection device) is standardly used to catch debris. However, it may not capture all particles. This study investigates whether adding a Balloon Guide Catheter (BGC)-which temporarily stops blood flow and allows for aspiration-to the standard filter protection is more effective than using the filter alone.\n\nPatients with symptomatic (≥50% stenosis) or asymptomatic (≥70% stenosis) carotid artery stenosis who are scheduled for stenting will be randomly assigned to one of two groups:\n\n1. Combined Protection Group: Receiving CAS using a Balloon Guide Catheter combined with a distal filter.\n2. Standard Protection Group: Receiving CAS using a distal filter alone. The primary goal is to determine if the combined approach reduces the number of new ischemic lesions detected on brain MRI within 72 hours post-procedure. The study will also assess clinical stroke events over a 90-day follow-up period.",[87],"Carotid Artery Stenosis",[89,90,23,33,91],"Carotid artery stenosis","Carotid Artery Stenting","New Ischemic Lesions","2026-07-02",{"date":94,"type":95},"2026-07-06","ACTUAL",{"date":97,"type":95},"2025-12-03",{"date":99,"type":81},"2027-12-01",{"name":5,"class":6},1]