[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100657733":3},{"organization":4,"outcomesModule":7,"designInfo":30,"detailedDescription":33,"studyPopulation":34,"armGroups":35,"interventions":29,"overallOfficials":39,"centralContacts":46,"locations":29,"responsibleParty":52,"collaborators":29,"id":56,"slug":57,"hasResults":58,"nctId":59,"briefTitle":60,"officialTitle":61,"acronym":29,"eligibilityCriteria":62,"healthyVolunteers":58,"sex":63,"minAge":64,"maxAge":29,"enrollmentInfo":65,"targetDuration":29,"studyType":68,"phases":29,"briefSummary":69,"conditions":70,"keywords":75,"overallStatus":81,"whyStopped":29,"lastUpdateSubmitDate":82,"lastUpdatePostDateStruct":83,"startDateStruct":86,"completionDateStruct":88,"leadSponsor":90,"locationsCount":29},{"fullName":5,"class":6},"Assiut University","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":29},[9],{"measure":10,"description":11,"timeFrame":12},"Prevalence of esophageal varices","Proportion of patients with esophageal varices detected by upper gastrointestinal endoscopy among those with liver stiffness measurement 15-25 kPa.","Baseline",[14,17,20,23,26],{"measure":15,"description":16,"timeFrame":12},"Prevalence of varices needing treatment","Proportion of patients with varices needing treatment (VNT) on upper gastrointestinal endoscopy.",{"measure":18,"description":19,"timeFrame":12},"Mean liver stiffness measurement","Mean liver stiffness value in kPa measured by vibration-controlled transient elastography.",{"measure":21,"description":22,"timeFrame":12},"Mean platelet count","Mean platelet count (×10⁹\u002FL).",{"measure":24,"description":25,"timeFrame":12},"Diagnostic performance of ANTICIPATE model","Sensitivity, specificity, and area under the ROC curve of the ANTICIPATE model for detecting esophageal varices.",{"measure":27,"description":28,"timeFrame":12},"Proportion of patients meeting Baveno VIII rule-out criteria","Proportion of patients with liver stiffness ≤15 kPa and platelet count ≥150×10⁹\u002FL.",null,{"allocation":29,"interventionModel":29,"interventionModelDescription":29,"primaryPurpose":29,"observationalModel":31,"timePerspective":32,"maskingInfo":29},"COHORT","PROSPECTIVE","Non-invasive criteria based on liver stiffness measurement and platelet count are recommended for identifying clinically significant portal hypertension. Patients with liver stiffness between 15 and 25 kPa represent an indeterminate group.\n\nThis observational study will include adult patients with compensated advanced chronic liver disease and liver stiffness measurement of 15-25 kPa. All eligible participants will undergo upper gastrointestinal endoscopy to detect esophageal varices. The performance of Baveno VIII criteria and additional clinical predictors will be evaluated.","Adult patients with compensated advanced chronic liver disease attending Al-Rajhi Liver Hospital, Assiut University.",[36],{"label":37,"type":29,"description":38,"interventionNames":29},"Single cohort: Patients with cACLD and LSM 15-25 kPa","Adult patients with compensated advanced chronic liver disease and liver stiffness measurement between 15 and 25 kPa who will undergo upper gastrointestinal endoscopy.",[40,44],{"name":41,"affiliation":42,"role":43},"Hanan m nafeh, prof","Tropical Medicine & Gastroenterology Department, Assiut University Hospitals","STUDY_CHAIR",{"name":45,"affiliation":42,"role":43},"Mohamed A Medhat, Prof",[47],{"name":48,"role":49,"phone":50,"phoneExt":29,"email":51},"Marven J Louis, Resident","CONTACT","01551357988","marvin.18313586@med.aun.edu.eg",{"type":53,"investigatorFullName":54,"investigatorTitle":55,"investigatorAffiliation":5,"oldNameTitle":29,"oldOrganization":29},"PRINCIPAL_INVESTIGATOR","Marven Joseph Louis Agrabas","Resident Physician, Department of Tropical Medicine & Gastroenterology","100657733","baveno-viii-criteria-for-portal-hypertension-in-egyptian-patients-100657733",false,"NCT07842666","Baveno VIII Criteria for Portal Hypertension in Egyptian Patients","Cost-Effectiveness and Validation of Baveno VIII Criteria for Detecting Clinically Significant Portal Hypertension in Egyptian Patients With Compensated Advanced Chronic Liver Disease","Inclusion Criteria:\n\n* \\- Age 18 years or older\n* Compensated advanced chronic liver disease (cACLD)\n* Liver stiffness measurement by VCTE under fasting conditions\n* Liver stiffness measurement between 15 and 25 kPa\n* Eligible for upper gastrointestinal endoscopy\n* Written informed consent\n\nExclusion Criteria:\n\n* \\- Previous variceal bleeding or band ligation\n* TIPS, hepatocellular carcinoma, or portal vein thrombosis\n* Acute liver failure\n* Overt hepatic encephalopathy\n* Severe ascites affecting LSM reliability\n* Concurrent viral hepatitis and MASLD\n* Pregnancy or refusal to undergo endoscopy","ALL","18 Years",{"count":66,"type":67},125,"ESTIMATED","OBSERVATIONAL","This prospective observational study aims to validate Baveno VIII criteria for detection of clinically significant portal hypertension and to evaluate additional predictors of esophageal varices in Egyptian patients with compensated advanced chronic liver disease and liver stiffness measurement between 15 and 25 kPa.",[71,72,73,74],"Compensated Liver Disease","Esophageal Varices","Portal Hypertension","Chronic Liver Disease",[76,77,78,79,80],"FibroScan","Baveno VIII","Assiut","Liver stiffness","Clinically significant portal hypertension","NOT_YET_RECRUITING","2026-09-21",{"date":84,"type":85},"2026-09-25","ACTUAL",{"date":87,"type":67},"2026-09-26",{"date":89,"type":67},"2028-03-20",{"name":5,"class":6}]