[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100649139":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":20,"centralContacts":21,"locations":20,"responsibleParty":30,"collaborators":20,"id":32,"slug":33,"hasResults":34,"nctId":35,"briefTitle":36,"officialTitle":37,"acronym":38,"eligibilityCriteria":39,"healthyVolunteers":34,"sex":40,"minAge":41,"maxAge":20,"enrollmentInfo":42,"targetDuration":20,"studyType":45,"phases":46,"briefSummary":48,"conditions":49,"keywords":51,"overallStatus":56,"whyStopped":20,"lastUpdateSubmitDate":57,"lastUpdatePostDateStruct":58,"startDateStruct":61,"completionDateStruct":63,"leadSponsor":65,"locationsCount":20},{"fullName":5,"class":6},"Maastricht University Medical Center","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Standard atrial pacing (80-120 bpm) before and after a routine 500 mL fluid bolus.","EXPERIMENTAL","No therapeutic intervention will take place. A pacemaker wire is routinely placed by the cardiac surgeon after the surgery, as part of the standard care that occurs with every surgery. As part of the study protocol, an atrial pacing protocol is performed, starting with pacing at 80 bpm, then increasing by 10 beats per minute until reaching 120 bpm, followed by a gradual decrease back to 80 bpm. This protocol is repeated after the administration of the 500 mL fluid bolus.",[13],"Procedure: Pacing protocol via routinely placed surgical pacemaker wire",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":20},"PROCEDURE","Pacing protocol via routinely placed surgical pacemaker wire","A pacemaker wire is routinely placed by the cardiac surgeon after the surgery, as part of the standard care that occurs with every surgery. As part of the study protocol, an atrial pacing protocol is performed, starting with pacing at 80 bpm, then increasing by 10 beats per minute until reaching 120 bpm, followed by a gradual decrease back to 80 bpm. This protocol is repeated after the administration of the 500 mL fluid bolus. Additionally: As part of routine care, the intensivist frequently adjusts the pacemaker in this manner to test its function.",[9],null,[22,27],{"name":23,"role":24,"phone":25,"phoneExt":20,"email":26},"Rob Driessen, MD, PhD","CONTACT","+31653821055","rob.driessen@mumc.nl",{"name":28,"role":24,"phone":20,"phoneExt":20,"email":29},"Bas van Bussel, MD, PhD","bas.van.bussel@mumc.nl",{"type":31,"investigatorFullName":20,"investigatorTitle":20,"investigatorAffiliation":20,"oldNameTitle":20,"oldOrganization":20},"SPONSOR","100649139","beat-to-beat-evaluation-of-atrial-pacing-to-test-fluid-responsiveness-100649139",false,"NCT07730242","Beat-to-beat Evaluation of Atrial Pacing to Test Fluid Responsiveness","BEAT- FR Beat-to-beat Evaluation of Atrial Pacing to Test Fluid Responsiveness","BEAT-FR","Inclusion Criteria:\n\n* Aged 18 years or older.\n* Underwent CABG surgery, without concomitant valve surgery.\n* Admitted to the ICU during the first postoperative day.\n* Equipped with surgically placed temporary atrial pacemaker wire.\n* Scheduled for a 500 mL bolus of balanced solution (Ringer's lactate) within the first two postoperative hours for clinical reasons.\n* Able to provide preoperative consent at the outpatient clinic before the surgery takes place.\n* Assessed by the attending intensivist as hemodynamically stable and (thereby) eligible for the study.\n\nExclusion Criteria:\n\n* Presence of atrial fibrillation or other arrhythmias precluding atrial pacing.\n* Absence of atrial pacemaker wire.\n* Suspected cardiac tamponade or significant postoperative bleeding (e.g., \\>400 mL blood loss in the first hour postoperatively).\n* Use of extracorporeal life support (ECLS) during the observation period.\n* Acute changes in vasopressor or inotrope dosage within the observation period.\n* Significant changes in body position, ventilator settings, or pacing mode during the study protocol.\n* Known contraindications to echocardiographic monitoring or arterial wave form analysis.","ALL","18 Years",{"count":43,"type":44},18,"ESTIMATED","INTERVENTIONAL",[47],"NA","The goal of this observational study is to learn whether atrial pacing-induced preload variation can identify fluid responsiveness in adult patients admitted to the intensive care unit after cardiac surgery.\n\nThe main questions it aims to answer are:\n\nCan beat-to-beat atrial pacing induce measurable changes in stroke volume that predict fluid responsiveness? Do stroke volume changes measured by transthoracic echocardiography (LVOT VTI) and arterial waveform analysis identify patients who respond to a 500 mL fluid bolus?\n\nResearchers will compare fluid responders and non-responders, defined by a ≥10% increase in stroke volume after a 500 mL Ringer's lactate fluid bolus, to determine whether pacing-induced hemodynamic changes predict fluid responsiveness.\n\nParticipants will:\n\nUndergo a standardized atrial pacing protocol (80-120 bpm in 10 bpm increments) before and after a routine 500 mL Ringer's lactate fluid bolus.\n\nUndergo transthoracic echocardiography and continuous arterial pressure monitoring during the pacing protocol.\n\nHave routine ICU hemodynamic data collected during their admission.",[50],"Evaluate Whether Beat-to-beat Ramped Atrial Pacing is Related to Fluid Responsiveness in Postcardiac Surgery Patients",[52,53,54,55],"fluid responsiveness","intensive care","atrial pacing","fluid bolus","NOT_YET_RECRUITING","2026-07-23",{"date":59,"type":60},"2026-07-28","ACTUAL",{"date":62,"type":44},"2027-01",{"date":64,"type":44},"2029-01",{"name":5,"class":6}]