[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100652345":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":12,"centralContacts":18,"locations":23,"responsibleParty":39,"collaborators":41,"id":49,"slug":50,"hasResults":51,"nctId":52,"briefTitle":53,"officialTitle":54,"acronym":55,"eligibilityCriteria":56,"healthyVolunteers":51,"sex":57,"minAge":58,"maxAge":59,"enrollmentInfo":60,"targetDuration":10,"studyType":63,"phases":10,"briefSummary":64,"conditions":65,"keywords":73,"overallStatus":84,"whyStopped":10,"lastUpdateSubmitDate":85,"lastUpdatePostDateStruct":86,"startDateStruct":89,"completionDateStruct":91,"leadSponsor":93,"locationsCount":94},{"fullName":5,"class":6},"Virginia Commonwealth University","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":10},"Children undergoing clinically indicated head CT for suspected ABI in the pediatric ED and PICU",null,"Combined ED + PICU sampling enriches for CT-positive cases and supplies the serial-imaging subset.",[13,16],{"name":14,"affiliation":5,"role":15},"Aarti Sarwal, MD","PRINCIPAL_INVESTIGATOR",{"name":17,"affiliation":5,"role":15},"Alia Marie O'Meara, MD",[19],{"name":14,"role":20,"phone":21,"phoneExt":10,"email":22},"CONTACT","804-828-9499","aarti.sarwal@vcuhealth.org",[24],{"facility":5,"status":10,"city":25,"state":26,"zip":27,"country":28,"countryCode":29,"cosmosGeoPoint":30,"geoPoint":35,"contacts":36},"Richmond","Virginia","23298","United States","US",{"type":31,"coordinates":32},"Point",[33,34],-77.46026,37.55376,{"lat":34,"lon":33},[37,38],{"name":14,"role":20,"phone":21,"phoneExt":10,"email":22},{"name":17,"role":20,"phone":21,"phoneExt":10,"email":22},{"type":40,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR",[42,45,47],{"name":43,"class":44},"UMass Chan Medical School","UNKNOWN",{"name":46,"class":44},"Atrium Health Levine Children's Hospital",{"name":48,"class":44},"Children's Hospital of Richmond at VCU","100652345","bedside-cranial-ultrasound-for-risk-stratified-imaging-in-pediatric-acute-brain-injury-100652345",false,"NCT07772323","Bedside Cranial Ultrasound for Risk-Stratified Imaging in Pediatric Acute Brain Injury","Bedside Cranial Point-of-Care Ultrasound (cPOCUS) for Risk-Stratified Imaging in Pediatric Acute Brain Injury: A Prospective Diagnostic-Accuracy and Longitudinal Biomarker Cohort Study (CUPID-Peds)","CUPID-Peds","Inclusion Criteria:\n\n* Children 2 to 17 years of age\n* Undergoing a clinically indicated (standard-of-care) head CT for suspected acute brain injury (including trauma, headache with neurologic findings, altered mental status, focal deficit, seizure, post-cardiac-arrest, oncologic neurologic emergency, or intracranial infection)\n* Seen in the pediatric Emergency Department or Pediatric Intensive Care Unit at the Children's Hospital of Richmond at VCU (CHoR-VCU)\n* Consent obtainable from a legally authorized representative (LAR)\n* Cranial ultrasound feasible within the protocol time window (within 6 hours of head CT)\n\nExclusion Criteria:\n\n* Open skull fracture\n* Prior hemicraniectomy\n* Cranial surgical defect at the insonation site\n* Anticipated transition to comfort-only care\n* Any clinical condition in which cranial ultrasound would delay a time-critical intervention","ALL","2 Years","17 Years",{"count":61,"type":62},220,"ESTIMATED","OBSERVATIONAL","Acute brain injury (ABI) is a leading cause of death and long-term disability in children. Diagnosis depends on fast neuroimaging, and head computed tomography (CT) is the bedside reference standard despite exposing the developing brain to ionizing radiation. A safe, portable, radiation-free bedside tool is needed to help decide which children need a head CT, to speed CT when injury is present, and to safely monitor injured children between scans. This study evaluates B-mode cranial point-of-care ultrasound (cPOCUS) performed through the temporal (and frontal) bone windows in children undergoing a clinically indicated head CT in the pediatric emergency department (ED) and pediatric intensive care unit (PICU). Children's thin skulls provide adequate acoustic windows in more than 95% of cases. cPOCUS is acquired by trained research scanners within 6 hours of head CT and interpreted offline by two blinded expert readers; the radiology CT report is the diagnostic gold standard. This is a prospective observational study; cPOCUS results are not returned to the clinical team in real time and do not change clinical care.",[66,67,68,69,70,71,72],"Acute Brain Injury","Traumatic Brain Injury","Intracranial Hemorrhage","Hydrocephalus","Stroke","Brain Neoplasm","Hypoxia-Ischemia, Brain",[74,75,76,77,78,79,80,81,82,83],"cranial ultrasound","point-of-care ultrasound","cPOCUS","transcranial B-mode ultrasound","pediatric neuroimaging","head CT","midline shift","diagnostic accuracy","radiation reduction","neurocritical care","NOT_YET_RECRUITING","2026-08-13",{"date":87,"type":88},"2026-08-19","ACTUAL",{"date":90,"type":62},"2026-11-30",{"date":92,"type":62},"2028-11-30",{"name":5,"class":6},1]