[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100651686":3},{"organization":4,"armGroups":7,"interventions":13,"overallOfficials":10,"centralContacts":18,"locations":10,"responsibleParty":24,"collaborators":10,"id":28,"slug":29,"hasResults":30,"nctId":31,"briefTitle":32,"officialTitle":33,"acronym":10,"eligibilityCriteria":34,"healthyVolunteers":30,"sex":35,"minAge":36,"maxAge":10,"enrollmentInfo":37,"targetDuration":40,"studyType":41,"phases":10,"briefSummary":42,"conditions":43,"keywords":45,"overallStatus":48,"whyStopped":10,"lastUpdateSubmitDate":49,"lastUpdatePostDateStruct":50,"startDateStruct":53,"completionDateStruct":55,"leadSponsor":57,"locationsCount":10},{"fullName":5,"class":6},"West China Hospital","OTHER",[8],{"label":9,"type":10,"description":10,"interventionNames":11},"Acute Decompensated Heart Failure Cohort",null,[12],"Other: Serial NT-proBNP Measurement",[14],{"type":6,"name":15,"description":16,"armGroupLabels":17,"otherNames":10},"Serial NT-proBNP Measurement","Serial NT-proBNP measurements will be performed during hospitalization to assess dynamic changes in NT-proBNP levels in patients with acute decompensated heart failure receiving standard guideline-directed medical treatment. NT-proBNP measurements are collected for observational analysis only and will not determine or modify clinical treatment decisions.",[9],[19],{"name":20,"role":21,"phone":22,"phoneExt":10,"email":23},"Si Wang, MD","CONTACT","+86-18980602792","si.wang@scu.edu.cn",{"type":25,"investigatorFullName":26,"investigatorTitle":27,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"SPONSOR_INVESTIGATOR","Mao Chen","Director of Department of Cardiology","100651686","bedside-nt-probnp-monitoring-in-acute-heart-failure-100651686",false,"NCT07762521","Bedside NT-proBNP Monitoring in Acute Heart Failure","Impact of Serial Point-of-Care NT-proBNP Monitoring on Decongestion in Acute Decompensated Heart Failure: A Prospective Controlled Study","Inclusion Criteria:\n\n* Adults aged ≥18 years.\n* Patients hospitalized in the cardiac intensive care unit (CCU) with a diagnosis of acute decompensated heart failure (ADHF).\n* Presence of clinical evidence of congestion at admission, including at least one of the following:\n* Symptoms or signs of volume overload (e.g., dyspnea, orthopnea, peripheral edema, elevated jugular venous pressure).\n* Pulmonary congestion based on physical examination or imaging findings.\n* Other clinically recognized evidence of congestion judged by the treating physician.\n* Patients receiving standard guideline-directed medical treatment for acute decompensated heart failure, including intravenous diuretic therapy according to clinical practice.\n* Ability to provide informed consent or availability of a legally authorized representative to provide consent.\n\nExclusion Criteria:\n\n* Cardiogenic shock or requirement for immediate mechanical circulatory support.\n* End-stage kidney disease requiring maintenance dialysis or renal replacement therapy at admission.\n* Acute conditions requiring urgent intervention that may interfere with study assessments, including acute coronary syndrome requiring immediate revascularization or acute pulmonary embolism.\n* Clinical conditions in which NT-proBNP interpretation is considered unreliable or inappropriate by the investigator.\n* Expected survival of less than 72 hours, early transfer from the CCU, or inability to complete the core observation period.\n* Any other condition considered inappropriate for participation by the investigator.","ALL","18 Years",{"count":38,"type":39},50,"ESTIMATED","30 Days","OBSERVATIONAL","The goal of this observational study is to investigate the association between dynamic changes in NT-proBNP levels and clinical decongestion status in patients with acute decompensated heart failure (ADHF) receiving guideline-directed standard medical treatment.\n\nThe main question it aims to answer is:\n\nAmong patients with acute decompensated heart failure treated according to current clinical guidelines, are changes in NT-proBNP levels during hospitalization associated with successful clinical decongestion?\n\nParticipants will receive standard-of-care treatment for ADHF according to treating physicians' clinical decisions and current guideline recommendations. During hospitalization, serial NT-proBNP measurements and repeated assessments of congestion status will be performed to evaluate the relationship between NT-proBNP dynamics and the process of decongestion.\n\nThis study is purely observational and will not assign treatments or modify clinical management. The findings may improve understanding of the role of NT-proBNP dynamics as a marker of treatment response and provide preliminary evidence for future studies on individualized management of acute heart failure.",[44],"Acute Decompensated Heart Failure (ADHF)",[46,47],"ADHF","POCT NT-proBNP","NOT_YET_RECRUITING","2026-08-08",{"date":51,"type":52},"2026-08-13","ACTUAL",{"date":54,"type":39},"2026-08-15",{"date":56,"type":39},"2026-12-30",{"name":26,"class":6}]