[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100650913":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":25,"centralContacts":29,"locations":25,"responsibleParty":35,"collaborators":25,"id":37,"slug":38,"hasResults":39,"nctId":40,"briefTitle":41,"officialTitle":42,"acronym":43,"eligibilityCriteria":44,"healthyVolunteers":39,"sex":45,"minAge":46,"maxAge":47,"enrollmentInfo":48,"targetDuration":25,"studyType":51,"phases":52,"briefSummary":54,"conditions":55,"keywords":57,"overallStatus":59,"whyStopped":25,"lastUpdateSubmitDate":60,"lastUpdatePostDateStruct":61,"startDateStruct":64,"completionDateStruct":66,"leadSponsor":68,"locationsCount":25},{"fullName":5,"class":6},"Braveheart Bio, Inc.","INDUSTRY",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"BHB-1893","EXPERIMENTAL","Participants will receive BHB-1893 twice daily and matching placebo for metoprolol once daily.",[13],"Drug: BHB-1893",{"label":15,"type":16,"description":17,"interventionNames":18},"Metoprolol","ACTIVE_COMPARATOR","Participants will receive metoprolol once daily and matching placebo for BHB-1893 twice daily.",[19],"Drug: Metoprolol",[21,26],{"type":22,"name":9,"description":23,"armGroupLabels":24,"otherNames":25},"DRUG","Tablets for oral use",[9],null,{"type":22,"name":15,"description":27,"armGroupLabels":28,"otherNames":25},"Capsules for oral use",[15],[30],{"name":31,"role":32,"phone":33,"phoneExt":25,"email":34},"Study Director","CONTACT","(415) 707-6312","info@braveheart.bio",{"type":36,"investigatorFullName":25,"investigatorTitle":25,"investigatorAffiliation":25,"oldNameTitle":25,"oldOrganization":25},"SPONSOR","100650913","bhb-1893-versus-metoprolol-for-symptomatic-obstructive-hypertrophic-cardiomyopathy-100650913",false,"NCT07755904","BHB-1893 Versus Metoprolol for Symptomatic Obstructive Hypertrophic Cardiomyopathy","A Phase 3, Multi-region, Multi-center, Randomized, Double-blind, Active-Comparator-Controlled Trial to Evaluate the Efficacy and Safety of BHB-1893 Compared to Metoprolol in Adults With Symptomatic Obstructive Hypertrophic Cardiomyopathy","LIONHEART-HCM","Key Inclusion Criteria:\n\n* Diagnosed with oHCM per the protocol specified criteria\n* NYHA Class II or III at screening visits\n* KCCQ-CSS that meets the protocol specified criteria at screening visits\n* Adequate acoustic windows for echocardiography\n\nKey Exclusion Criteria:\n\n* Medical indication for either β-blocker or calcium-channel blocker therapy, other than oHCM, prohibiting drug discontinuation\n* History of intolerance or medical contraindication to β-blocker therapy\n* Resting systolic blood pressure (SBP) of \\>160 millimeters of mercury (mmHg) at screening visits\n* Resting heart rate of \\>100 beats per minute (bpm) at screening visits\n* Significant valvular heart disease, defined as:\n\n  * Moderate to severe valvular aortic stenosis or fixed subaortic obstruction;\n  * Mitral regurgitation not due to systolic anterior motion of the mitral valve (per Investigator's judgment)\n\nOther protocol-defined criteria apply.","ALL","18 Years","85 Years",{"count":49,"type":50},210,"ESTIMATED","INTERVENTIONAL",[53],"PHASE3","The main purpose of this trial is to find out whether BHB-1893 works better than metoprolol in adults with symptoms of obstructive hypertrophic cardiomyopathy (oHCM). The trial includes adults who are currently being treated for oHCM or who have not yet been treated.",[56],"Cardiomyopathy, Hypertrophic Obstructive",[58,9],"oHCM","NOT_YET_RECRUITING","2026-08-05",{"date":62,"type":63},"2026-08-10","ACTUAL",{"date":65,"type":50},"2026-10",{"date":67,"type":50},"2028-11",{"name":5,"class":6}]