[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100524209":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":20,"centralContacts":24,"locations":32,"responsibleParty":117,"collaborators":121,"id":124,"slug":125,"hasResults":126,"nctId":127,"briefTitle":128,"officialTitle":129,"acronym":19,"eligibilityCriteria":130,"healthyVolunteers":131,"sex":132,"minAge":133,"maxAge":134,"enrollmentInfo":135,"targetDuration":19,"studyType":138,"phases":139,"briefSummary":141,"conditions":142,"keywords":147,"overallStatus":35,"whyStopped":19,"lastUpdateSubmitDate":151,"lastUpdatePostDateStruct":152,"startDateStruct":155,"completionDateStruct":157,"leadSponsor":159,"locationsCount":160},{"fullName":5,"class":6},"University of Pittsburgh","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"contrast-enhanced mammography","EXPERIMENTAL","Enrolled participants will receive a baseline contrast-enhanced mammography exam for breast cancer screening, along with their scheduled 3D mammography exam, then they will receive another CEM exam for breast cancer screening at 24 months after their baseline CEM exam, and then again at 48 months. All the while, participants will still receive their annual 3D mammography exam as per their usual routine care.",[13],"Device: contrast-enhanced mammography",[15],{"type":16,"name":9,"description":17,"armGroupLabels":18,"otherNames":19},"DEVICE","Contrast-enhanced mammography (CEM) is a new FDA-approved exam that is similar to magnetic resonance imaging (MRI) in depicting breast cancers due to increased and leaky blood vessels. Contrast-enhanced mammography is used as an adjunct following mammography and\u002For ultrasound examinations to localize a known or suspected lesion.",[9],null,[21],{"name":22,"affiliation":5,"role":23},"Wendie Berg, MD, PhD","PRINCIPAL_INVESTIGATOR",[25,29],{"name":22,"role":26,"phone":27,"phoneExt":19,"email":28},"CONTACT","412-641-8278","bergwa@upmc.edu",{"name":30,"role":26,"phone":27,"phoneExt":19,"email":31},"McKenna Rigling, MS","riglingmm@upmc.edu",[33,54,67,80,93,103],{"facility":34,"status":35,"city":36,"state":37,"zip":38,"country":39,"countryCode":40,"cosmosGeoPoint":41,"geoPoint":46,"contacts":47},"UPMC Magee-Womens Imaging - Bethel Park","RECRUITING","Bethel Park","Pennsylvania","15102","United States","US",{"type":42,"coordinates":43},"Point",[44,45],-80.0395,40.32757,{"lat":45,"lon":44},[48,49,53],{"name":30,"role":26,"phone":27,"phoneExt":19,"email":31},{"name":50,"role":26,"phone":51,"phoneExt":19,"email":52},"Maegan Johnson, RN","412-641-8283","johnsonme15@upmc.edu",{"name":22,"role":23,"phone":19,"phoneExt":19,"email":19},{"facility":55,"status":35,"city":56,"state":37,"zip":57,"country":39,"countryCode":40,"cosmosGeoPoint":58,"geoPoint":62,"contacts":63},"UPMC Magee at the Lemieux Sports Complex","Cranberry Township","16066",{"type":42,"coordinates":59},[60,61],-80.10714,40.68496,{"lat":61,"lon":60},[64,65,66],{"name":30,"role":26,"phone":27,"phoneExt":19,"email":31},{"name":50,"role":26,"phone":51,"phoneExt":19,"email":52},{"name":22,"role":23,"phone":19,"phoneExt":19,"email":19},{"facility":68,"status":35,"city":69,"state":37,"zip":70,"country":39,"countryCode":40,"cosmosGeoPoint":71,"geoPoint":75,"contacts":76},"Magee Womancare Monroeville","Monroeville","15146",{"type":42,"coordinates":72},[73,74],-79.7881,40.42118,{"lat":74,"lon":73},[77,78,79],{"name":30,"role":26,"phone":27,"phoneExt":19,"email":31},{"name":50,"role":26,"phone":51,"phoneExt":19,"email":52},{"name":22,"role":23,"phone":19,"phoneExt":19,"email":19},{"facility":81,"status":35,"city":82,"state":37,"zip":83,"country":39,"countryCode":40,"cosmosGeoPoint":84,"geoPoint":88,"contacts":89},"Magee-Womens Hospital","Pittsburgh","15213",{"type":42,"coordinates":85},[86,87],-79.99589,40.44062,{"lat":87,"lon":86},[90,91,92],{"name":30,"role":26,"phone":27,"phoneExt":19,"email":31},{"name":50,"role":26,"phone":51,"phoneExt":19,"email":52},{"name":22,"role":23,"phone":19,"phoneExt":19,"email":19},{"facility":94,"status":35,"city":82,"state":37,"zip":95,"country":39,"countryCode":40,"cosmosGeoPoint":96,"geoPoint":98,"contacts":99},"Hillman Cancer Center at Shadyside","15232",{"type":42,"coordinates":97},[86,87],{"lat":87,"lon":86},[100,101,102],{"name":30,"role":26,"phone":27,"phoneExt":19,"email":31},{"name":50,"role":26,"phone":51,"phoneExt":19,"email":52},{"name":22,"role":23,"phone":19,"phoneExt":19,"email":19},{"facility":104,"status":35,"city":105,"state":37,"zip":106,"country":39,"countryCode":40,"cosmosGeoPoint":107,"geoPoint":111,"contacts":112},"UPMC West Mifflin Outpatient Center","West Mifflin","15236",{"type":42,"coordinates":108},[109,110],-79.86644,40.3634,{"lat":110,"lon":109},[113,115,116],{"name":30,"role":26,"phone":114,"phoneExt":19,"email":31},"412-941-8278",{"name":50,"role":26,"phone":51,"phoneExt":19,"email":52},{"name":22,"role":23,"phone":19,"phoneExt":19,"email":19},{"type":118,"investigatorFullName":119,"investigatorTitle":120,"investigatorAffiliation":5,"oldNameTitle":19,"oldOrganization":19},"SPONSOR_INVESTIGATOR","Wendie Berg","Professor of Radiology",[122],{"name":123,"class":6},"Breast Cancer Research Foundation","100524209","biennial-cem-in-women-with-a-personal-history-of-breast-cancer-100524209",false,"NCT06105749","Biennial CEM in Women With a Personal History of Breast Cancer","Outcome of Biennial Screening Contrast-Enhanced Mammography (CEM) in Women With a Personal History of Breast Cancer (PHBC)","Inclusion Criteria:\n\n* Asymptomatic women, ages 30-79, with a personal history of breast cancer who are at least one year out from any breast cancer surgery and\u002For treatment and are scheduled to have a routine annual mammogram with tomosynthesis (DBT).\n\nExclusion Criteria:\n\n* Women with a history of prior moderate or severe iodinated contrast reaction \\[only those with a prior mild reaction that can be managed by pre-medication AND with and a strong desire to participate will be allowed to participate. However, among these women with a mild sensitivity, if they are allergic to Benadryl (one of the premedications), they will be excluded\\].\n* Women with implant(s) in the breasts to be screened (as this creates artifacts and diagnostic performance of imaging in women with implants likely does not generalize to those without implants, and the sample size with implants would be too small to infer conclusions.\n* Women who have had bilateral mastectomy\n* Women with a history of kidney failure or estimated glomerular filtration rate (eGFR) \\\u003C 30 mL\u002Fmin\n* Pregnancy or lactation\n* Women actively being treated for cancer of any type with chemotherapy.\n* Women with stage 4 metastasis to visceral areas or brain\n* Women with known personal history of breast cancer who have a screening breast MRI exam within 24 months prior to the current round of CEM.\n* Women with known personal history of breast cancer who had a CEM exam within the prior 23 months",true,"FEMALE","30 Years","79 Years",{"count":136,"type":137},1600,"ESTIMATED","INTERVENTIONAL",[140],"NA","This is a prospective clinical trial that will examine if biennial contrast-enhanced mammography added to annual 3D mammography (tomosynthesis) substantially improves breast cancer detection with minimal increase in false-positives, in women with a personal history of breast cancer.",[143,144,145,146],"Breast Cancer","Breast Neoplasms","Breast Cancer Female","Neoplasms",[148,149,150],"Breast cancer screening","Digital Breast Tomosynthesis","Contrast-Enhanced Mammogram","2026-08-17",{"date":153,"type":154},"2026-08-19","ACTUAL",{"date":156,"type":154},"2023-11-08",{"date":158,"type":137},"2031-04",{"name":119,"class":6},6]