[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100647876":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":10,"centralContacts":29,"locations":35,"responsibleParty":52,"collaborators":10,"id":56,"slug":57,"hasResults":58,"nctId":59,"briefTitle":60,"officialTitle":61,"acronym":10,"eligibilityCriteria":62,"healthyVolunteers":63,"sex":64,"minAge":65,"maxAge":66,"enrollmentInfo":67,"targetDuration":10,"studyType":70,"phases":10,"briefSummary":71,"conditions":72,"keywords":74,"overallStatus":37,"whyStopped":10,"lastUpdateSubmitDate":79,"lastUpdatePostDateStruct":80,"startDateStruct":83,"completionDateStruct":85,"leadSponsor":87,"locationsCount":88},{"fullName":5,"class":6},"Trio Fertility","OTHER",[8,15],{"label":9,"type":10,"description":11,"interventionNames":12},"Endometriosis Group",null,"Patients who have been diagnosed with Endometriosis",[13,14],"Diagnostic Test: SNCG Protein","Diagnostic Test: BCL-6 Protein",{"label":16,"type":10,"description":17,"interventionNames":18},"Control Group","Patients who have not been diagnosed with Endometriosis",[13,14],[20,25],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":10},"DIAGNOSTIC_TEST","SNCG Protein","Synuclein gamma (SNCG), a member of the synuclein family of neuronal proteins, is involved in cellular proliferation by interacting with the mitotic checkpoint kinase BubR1, and inhibiting its regulatory role on cellular proliferation. During the last decade, several studies have demonstrated that SNCG is correlated with poor outcome of breast cancer, ovarian cancer, colon cancer and pancreatic cancer. Interestingly, SNCG has previously been shown to have elevated expression ranging from 5- to 53-fold in ovarian endothelial cells of endometriosis lesions compared with eutopic endometrium from the same individual.",[16,9],{"type":21,"name":26,"description":27,"armGroupLabels":28,"otherNames":10},"BCL-6 Protein","B-Cell Lymphoma 6 (BCL6) protein is encoded by the BCL6 oncogene and is a zinc finger transcription factor that regulates the transcription of signal transducer and activators of transcription (STAT)-dependent IL-4 responses of B-cells. Previously, BCL6 was shown to express in the endometrial epithelial cells and B-cells in lymph node germinal centers. In addition, over-expression of BCL6 has been reported in endometrial biopsies and has been linked to the progesterone resistance and pathogenesis of endometriosis",[16,9],[30],{"name":31,"role":32,"phone":33,"phoneExt":10,"email":34},"Yasaman Sadeghi, M.Sc.","CONTACT","4165060804","yasamans@triofertility.com",[36],{"facility":5,"status":37,"city":38,"state":39,"zip":40,"country":41,"countryCode":42,"cosmosGeoPoint":43,"geoPoint":48,"contacts":49},"RECRUITING","Toronto","Ontario","M5G 2K4","Canada","CA",{"type":44,"coordinates":45},"Point",[46,47],-79.39864,43.70643,{"lat":47,"lon":46},[50],{"name":51,"role":32,"phone":33,"phoneExt":10,"email":34},"Yasaman Sadeghi",{"type":53,"investigatorFullName":54,"investigatorTitle":55,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Dr. Robert F. Casper","Principal Investigator","100647876","biomarkers-for-endometriosis-100647876",false,"NCT07713797","Biomarkers for Endometriosis","A Prospective, Observational and Multicentric Study to Evaluate the Performance and Clinical Utility of EndoID ELISA Kit to Determine Circulating Synuclein Gamma (SNCG) and B-cell Lymphoma-6 (BCL6) Levels as Potential Biomarkers for Endometriosis\"","Inclusion Criteria for Endometriosis Group:\n\n* Women of reproductive age group (18Y-45Y).\n* Women with active endometriosis diagnosed by ultrasound\u002FMRI\u002Flaparoscopy.\n\nExclusion Criteria for Endometriosis Group:\n\n* Women \\\u003C18Y and \\>45Y.\n* Women with endometriosis during stimulation with gonadotropins.\n* Current or prior history of uterine, ovarian, colon, pancreatic, breast or any other type of cancer.\n* Any prior history of chronic illness.\n* Pregnant women.\n\nInclusion Criteria for Control Group:\n\n* Women of reproductive age group (18Y-45Y).\n* Women without endometriosis and any other gynaecological problem.\n\nExclusion Criteria for Endometriosis Group:\n\n* Women \\\u003C18Y and \\>45Y\n* Prior history of any disease including cancer or chronic illness.\n* Pregnant women.",true,"FEMALE","18 Years","45 Years",{"count":68,"type":69},100,"ESTIMATED","OBSERVATIONAL","Endometriosis is a condition in which tissue similar to the lining of the uterus grows outside the uterus, often causing pain and infertility. Currently, endometriosis can only be definitively diagnosed through invasive procedures like laparoscopy and biopsy.\n\nThe purpose of this study is to investigate whether the proteins Synuclein Gamma (SNCG) and B-Cell Lymphoma 6 (BCL6), measurable in blood and menstrual fluid, can serve as non-invasive biomarkers to diagnose or monitor endometriosis.",[73],"Endometriosis",[75,76,77,78],"endometriosis","biomarkers","BCL6","SNCG","2026-07-30",{"date":81,"type":82},"2026-08-03","ACTUAL",{"date":84,"type":82},"2026-01-16",{"date":86,"type":69},"2027-09-01",{"name":5,"class":6},1]