[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100472368":3},{"organization":4,"outcomesModule":7,"designInfo":24,"detailedDescription":26,"studyPopulation":27,"armGroups":23,"interventions":23,"overallOfficials":28,"centralContacts":36,"locations":44,"responsibleParty":382,"collaborators":23,"id":384,"slug":385,"hasResults":386,"nctId":387,"briefTitle":388,"officialTitle":388,"acronym":23,"eligibilityCriteria":389,"healthyVolunteers":386,"sex":390,"minAge":23,"maxAge":23,"enrollmentInfo":391,"targetDuration":394,"studyType":395,"phases":23,"briefSummary":396,"conditions":397,"keywords":23,"overallStatus":47,"whyStopped":23,"lastUpdateSubmitDate":399,"lastUpdatePostDateStruct":400,"startDateStruct":403,"completionDateStruct":405,"leadSponsor":407,"locationsCount":408},{"fullName":5,"class":6},"Immune Oncology Research Institute","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":23},[9],{"measure":10,"description":11,"timeFrame":12},"Overall survival","Time from diagnosis to death","5 years",[14,17,20],{"measure":15,"description":16,"timeFrame":12},"Complete remission rate","The proportion of patients with complete remission",{"measure":18,"description":19,"timeFrame":12},"Mean duration of the first remission","Time from first remission to disease progression or death",{"measure":21,"description":22,"timeFrame":12},"Event-free survival","Time from diagnosis to occurrence of a complication",null,{"allocation":23,"interventionModel":23,"interventionModelDescription":23,"primaryPurpose":23,"observationalModel":25,"timePerspective":6,"maskingInfo":23},"CASE_ONLY","Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare hematologic malignancy. In 2008, it was recognized by the WHO as a distinct entity and separately listed in the group of acute myeloid leukemias and related precursor neoplasms.\n\nThe final diagnosis of BPDCN relies on a compatible immunophenotype. The triple positive CD4+CD56+CD123+ phenotype associated with negativity for lineage-specific markers is a minimum requirement for defining BPDCN. The highly specific marker BDCA2\u002FCD303, as well as other plasmacytoid dendritic cell-associated antigens (e.g. TCL1 and CD2AP), might be of great support to exclude potential mimickers of BPDCN (acute myeloid and monocytic leukemias, precursor lymphoblastic T-cell leukemia\u002Flymphomas and T- and NK\u002FT cell lymphomas.\n\nAt present, there is no consensus on the optimal treatment of BPDCN. The majority of patients receive multi-agent chemotherapy with AML or ALL treatment regimens, while a few patients undergo allogeneic haematopoietic stem cell transplantation (HSCT). In recent years, different novel and innovative therapies are in development to target surface molecules in BPDCN. The patients are still in need of better treatments and the optimal therapy of disease remains to be determined.\n\nThis is a multicenter, international prospective and retrospective registry with the aim of collecting data of patients with a diagnosis of BPDCN globally.\n\nPatients will be recruited directly by the national study groups \u002F participating centers.\n\nParticipating centers will collect and verify informed consent of all prospective patients enrolled at their center.\n\nThe following data will be collected through questionnaires:\n\n1. Patient characteristics\n2. BPDCN characteristics\n3. Treatment details\n4. Outcomes\n5. Cause of death\n6. End of data collection\n\nQuality control and data management will be conducted by the Immune Oncology Research Institute.","All patients with BPDCN diagnosed since 01.01.2010",[29,33],{"name":30,"affiliation":31,"role":32},"Astghik Voskanyan, MD","Immune Oncology Research Institute, Yerevan, Armenia","PRINCIPAL_INVESTIGATOR",{"name":34,"affiliation":31,"role":35},"Gevorg Tamamyan, MD, PhD, DSc","STUDY_DIRECTOR",[37,41],{"name":30,"role":38,"phone":39,"phoneExt":23,"email":40},"CONTACT","+374 10 28 38 00","astghikvos@gmail.com",{"name":42,"role":38,"phone":39,"phoneExt":23,"email":43},"Davit Melkonyan","davit.melkonyan@immonc.org",[45,66,79,93,115,131,145,160,175,190,204,222,237,250,265,281,298,315,329,342,352,368],{"facility":46,"status":47,"city":48,"state":49,"zip":50,"country":51,"countryCode":52,"cosmosGeoPoint":53,"geoPoint":58,"contacts":59},"Sylvester Comprehensive Cancer Center, University of Miami","RECRUITING","Miami","Florida","33136","United States","US",{"type":54,"coordinates":55},"Point",[56,57],-80.19366,25.77427,{"lat":57,"lon":56},[60,63],{"name":61,"role":38,"phone":23,"phoneExt":23,"email":62},"Dickran Kazandjian, MD","dkazandjian@miami.edu",{"name":64,"role":38,"phone":23,"phoneExt":23,"email":65},"Alvaro Alencar, MD","aalencar@med.miami.edu",{"facility":67,"status":47,"city":68,"state":49,"zip":69,"country":51,"countryCode":52,"cosmosGeoPoint":70,"geoPoint":74,"contacts":75},"Moffitt Cancer Center","Tampa","33612",{"type":54,"coordinates":71},[72,73],-82.45843,27.94752,{"lat":73,"lon":72},[76],{"name":77,"role":38,"phone":23,"phoneExt":23,"email":78},"Rami Komrokji, MD","rami.komrokji@moffitt.org",{"facility":80,"status":47,"city":81,"state":82,"zip":83,"country":51,"countryCode":52,"cosmosGeoPoint":84,"geoPoint":88,"contacts":89},"Seattle Children's Cancer and Blood Disorders Center","Seattle","Washington","98145",{"type":54,"coordinates":85},[86,87],-122.33207,47.60621,{"lat":87,"lon":86},[90],{"name":91,"role":38,"phone":23,"phoneExt":23,"email":92},"Adam Lamble, MD","adam.lamble@seattlechildrens.org",{"facility":94,"status":47,"city":95,"state":23,"zip":96,"country":97,"countryCode":98,"cosmosGeoPoint":99,"geoPoint":103,"contacts":104},"Hematology Center named after prof. R. Yeolyan","Yerevan","0014","Armenia","AM",{"type":54,"coordinates":100},[101,102],44.5126,40.17765,{"lat":102,"lon":101},[105,107,110,113],{"name":30,"role":38,"phone":106,"phoneExt":23,"email":40},"+374 10 283800",{"name":108,"role":38,"phone":106,"phoneExt":23,"email":109},"Gevorg Tamamyan, PhD","gevorgtamamyan@gmail.com",{"name":111,"role":112,"phone":23,"phoneExt":23,"email":23},"Shushan Hovsepyan, MD","SUB_INVESTIGATOR",{"name":114,"role":112,"phone":23,"phoneExt":23,"email":23},"Nerses Ghahramanyan, MD",{"facility":116,"status":47,"city":117,"state":118,"zip":119,"country":120,"countryCode":121,"cosmosGeoPoint":122,"geoPoint":126,"contacts":127},"University of Calgary","Calgary","Alberta","T2N 1N4","Canada","CA",{"type":54,"coordinates":123},[124,125],-114.08529,51.05011,{"lat":125,"lon":124},[128],{"name":129,"role":38,"phone":23,"phoneExt":23,"email":130},"Carolyn Owen, MD","carolyn.owen@ahs.ca",{"facility":132,"status":47,"city":133,"state":134,"zip":135,"country":120,"countryCode":121,"cosmosGeoPoint":136,"geoPoint":140,"contacts":141},"Children's Hospital of Eastern Ontario, University of Ottawa","Ottawa","Ontario","K1H 8L1",{"type":54,"coordinates":137},[138,139],-75.69812,45.41117,{"lat":139,"lon":138},[142],{"name":143,"role":38,"phone":23,"phoneExt":23,"email":144},"Consolato Sergi, MD, PhD","csergi@cheo.on.ca",{"facility":146,"status":47,"city":147,"state":23,"zip":148,"country":149,"countryCode":150,"cosmosGeoPoint":151,"geoPoint":155,"contacts":156},"Cyprus Society of Haematology","Nicosia","2019","Cyprus","CY",{"type":54,"coordinates":152},[153,154],33.35397,35.17284,{"lat":154,"lon":153},[157],{"name":158,"role":38,"phone":23,"phoneExt":23,"email":159},"Michalis Michael, MD","mixalis.maxail@gmail.com",{"facility":161,"status":47,"city":162,"state":23,"zip":163,"country":164,"countryCode":165,"cosmosGeoPoint":166,"geoPoint":170,"contacts":171},"Oncology Center, Mansoura University Faculty of Medicine","Al Mansurah","7650030","Egypt","EG",{"type":54,"coordinates":167},[168,169],31.38069,31.03637,{"lat":169,"lon":168},[172],{"name":173,"role":38,"phone":23,"phoneExt":23,"email":174},"Shaimaa El-Ashwah, MD","shaimaasaber@mans.edu.eg",{"facility":176,"status":47,"city":177,"state":23,"zip":178,"country":179,"countryCode":180,"cosmosGeoPoint":181,"geoPoint":185,"contacts":186},"M. Iashvili Children's Central Hospital","Tbilisi","0159","Georgia","GE",{"type":54,"coordinates":182},[183,184],44.83412,41.69143,{"lat":184,"lon":183},[187],{"name":188,"role":38,"phone":23,"phoneExt":23,"email":189},"Nino Totogashvili, MD","nino_totogashvili@yahoo.com",{"facility":191,"status":47,"city":192,"state":23,"zip":193,"country":194,"countryCode":195,"cosmosGeoPoint":196,"geoPoint":200,"contacts":201},"Department of Medical Oncology, Dr. B.R.A Institute Rotary Cancer Hospital, All India Institute of Medical Sciences","New Delhi","110029","India","IN",{"type":54,"coordinates":197},[198,199],77.2148,28.62137,{"lat":199,"lon":198},[202],{"name":203,"role":38,"phone":23,"phoneExt":23,"email":23},"Sameer Bakhshi, MBBS, MD, DM",{"facility":205,"status":47,"city":206,"state":23,"zip":207,"country":208,"countryCode":209,"cosmosGeoPoint":210,"geoPoint":214,"contacts":215},"Pediatric Hematology Oncology, Children's Welfare Teaching Hospital, Medical City, College of Medicine, University of Baghdad","Baghdad","61023","Iraq","IQ",{"type":54,"coordinates":211},[212,213],44.40088,33.34058,{"lat":213,"lon":212},[216,219],{"name":217,"role":38,"phone":23,"phoneExt":23,"email":218},"Mazin Faisal Al-Jadiry, MD","mazinaljadiry@yahoo.com",{"name":220,"role":38,"phone":23,"phoneExt":23,"email":221},"Hasanein Habeeb Ghali, MD","hasaneinghali@gmail.com",{"facility":223,"status":47,"city":224,"state":23,"zip":225,"country":226,"countryCode":227,"cosmosGeoPoint":228,"geoPoint":232,"contacts":233},"University of Perugia - Azienda Ospedaliera Perugia","Perugia","06129","Italy","IT",{"type":54,"coordinates":229},[230,231],12.38878,43.1122,{"lat":231,"lon":230},[234],{"name":235,"role":38,"phone":23,"phoneExt":23,"email":236},"Maria Paola Martelli, MD, PhD","maria.martelli@unipg.it",{"facility":238,"status":47,"city":239,"state":23,"zip":240,"country":226,"countryCode":227,"cosmosGeoPoint":241,"geoPoint":245,"contacts":246},"Department of Biomedicine and Prevention, University of Rome Tor Vergata","Roma","00133",{"type":54,"coordinates":242},[243,244],11.10642,44.99364,{"lat":244,"lon":243},[247],{"name":248,"role":38,"phone":23,"phoneExt":23,"email":249},"Maria Teresa Voso, MD","voso@med.uniroma2.it",{"facility":251,"status":47,"city":252,"state":23,"zip":253,"country":254,"countryCode":255,"cosmosGeoPoint":256,"geoPoint":260,"contacts":261},"King Hussein Cancer Center (KHCC)","Amman","11941","Jordan","JO",{"type":54,"coordinates":257},[258,259],35.94503,31.95522,{"lat":259,"lon":258},[262],{"name":263,"role":38,"phone":23,"phoneExt":23,"email":264},"Zaid Abdel Rahman, MD","za.11040@khcc.jo",{"facility":266,"status":47,"city":267,"state":23,"zip":268,"country":269,"countryCode":270,"cosmosGeoPoint":271,"geoPoint":275,"contacts":276},"Department of hematology, Kuwait Cancer Control Center","Kuwait City","42262","Kuwait","KW",{"type":54,"coordinates":272},[273,274],47.97429,29.367,{"lat":274,"lon":273},[277],{"name":278,"role":38,"phone":279,"phoneExt":280,"email":23},"Ahmad Alhuraiji, MD, MRCP(UK)","+965 24849100","24002",{"facility":282,"status":47,"city":283,"state":23,"zip":284,"country":285,"countryCode":286,"cosmosGeoPoint":287,"geoPoint":291,"contacts":292},"Fundeni Clinical Institute, Department of Acute Leukemia","Bucharest","022328","Romania","RO",{"type":54,"coordinates":288},[289,290],26.10626,44.43225,{"lat":290,"lon":289},[293,296],{"name":294,"role":38,"phone":295,"phoneExt":23,"email":23},"Maria Camelia Stancioaica, MD","+40740959904",{"name":297,"role":38,"phone":23,"phoneExt":23,"email":23},"Daniel Coriu, MD, PhD",{"facility":299,"status":47,"city":300,"state":23,"zip":301,"country":302,"countryCode":303,"cosmosGeoPoint":304,"geoPoint":308,"contacts":309},"China Medical University Children's Hospital","Taichung","40447","Taiwan","TW",{"type":54,"coordinates":305},[306,307],120.6839,24.1469,{"lat":307,"lon":306},[310,313],{"name":311,"role":38,"phone":23,"phoneExt":23,"email":312},"Min-Yu Su, MD","035515@tool.caaumed.org.tw",{"name":314,"role":38,"phone":23,"phoneExt":23,"email":23},"Ching-Tien Peng, MD",{"facility":316,"status":47,"city":317,"state":23,"zip":318,"country":319,"countryCode":23,"cosmosGeoPoint":320,"geoPoint":324,"contacts":325},"Turkish Pediatric Cancer Registry","Ankara","06690","Turkey (Türkiye)",{"type":54,"coordinates":321},[322,323],32.85427,39.91987,{"lat":323,"lon":322},[326],{"name":327,"role":38,"phone":23,"phoneExt":23,"email":328},"Tezer Kutluk, MD, PhD","tezerkutluk@gmail.com",{"facility":330,"status":47,"city":331,"state":23,"zip":332,"country":319,"countryCode":23,"cosmosGeoPoint":333,"geoPoint":337,"contacts":338},"Istanbul University, Oncology Institute","Istanbul","34093",{"type":54,"coordinates":334},[335,336],28.94966,41.01384,{"lat":336,"lon":335},[339],{"name":340,"role":38,"phone":23,"phoneExt":23,"email":341},"Rejin Kebudi, MD","rejinkebudi@yahoo.com",{"facility":343,"status":47,"city":331,"state":23,"zip":344,"country":319,"countryCode":23,"cosmosGeoPoint":345,"geoPoint":347,"contacts":348},"University of Health Sciences, Umraniye Research and Education Hospital, Pediatric Hematology and Oncology Department, Pediatric Bone Marrow Transplantation Unit","34766",{"type":54,"coordinates":346},[335,336],{"lat":336,"lon":335},[349],{"name":350,"role":38,"phone":23,"phoneExt":23,"email":351},"Funda Tekkesin, MD","tekkesinfunda@gmail.com",{"facility":353,"status":47,"city":354,"state":355,"zip":356,"country":357,"countryCode":358,"cosmosGeoPoint":359,"geoPoint":363,"contacts":364},"Broomfield Hospital, Haematology Mid and South Essex University Hospitals Group","Chelmsford","Essex","CM1 7ET","United Kingdom","UK",{"type":54,"coordinates":360},[361,362],0.46958,51.73575,{"lat":362,"lon":361},[365],{"name":366,"role":38,"phone":23,"phoneExt":23,"email":367},"Pavel P Kotoucek, PhD, FRCPath","pavel.kotoucek@nhs.net",{"facility":369,"status":47,"city":370,"state":371,"zip":372,"country":357,"countryCode":358,"cosmosGeoPoint":373,"geoPoint":377,"contacts":378},"United Lincolnshire Teaching Hospital NHS Trust","Lincoln","Lincolnshire","LN2 5QY",{"type":54,"coordinates":374},[375,376],-0.53792,53.22683,{"lat":376,"lon":375},[379],{"name":380,"role":38,"phone":23,"phoneExt":23,"email":381},"Marios Tsoutsoukis, MD","marios.tsoutsoukis@nhs.net",{"type":383,"investigatorFullName":23,"investigatorTitle":23,"investigatorAffiliation":23,"oldNameTitle":23,"oldOrganization":23},"SPONSOR","100472368","blastic-plasmacytoid-dendritic-cell-neoplasm-bpdcn-international-registry-100472368",false,"NCT05430971","Blastic Plasmacytoid Dendritic Cell Neoplasm (BPDCN) International Registry","Inclusion Criteria:\n\n* Diagnosis of BPDCN\n* Signed informed consent form for prospective patients\n\nExclusion Criteria:\n\n\\-","ALL",{"count":392,"type":393},200,"ESTIMATED","5 Years","OBSERVATIONAL","Blastic Plasmacytoid Dendritic Cell Neoplasm (BPDCN) is a very rare hematologic malignancy. Despite recent advances, at present there is no consensus on the optimal treatment of BPDCN. The optimal therapy of disease remains to be determined, and due to the rarity of cases, there is a need for international collaboration to collect data on BPDCN clinical presentations, diagnostics, treatment regimens and outcomes. Therefore, the objectives of this study are: (1) to build a large database of patients with BPDCN, (2) to investigate the characteristics and outcome of the disease with different treatment regimens, (3) to evaluate prognostic factors, and (4) to generate data-based prospective treatment recommendations.",[398],"Blastic Plasmacytoid Dendritic Cell Neoplasm (BPDCN)","2026-06-04",{"date":401,"type":402},"2026-06-05","ACTUAL",{"date":404,"type":402},"2022-07-01",{"date":406,"type":393},"2032-07",{"name":5,"class":6},22]