[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100651624":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":18,"centralContacts":22,"locations":10,"responsibleParty":27,"collaborators":10,"id":30,"slug":31,"hasResults":32,"nctId":33,"briefTitle":34,"officialTitle":35,"acronym":10,"eligibilityCriteria":36,"healthyVolunteers":37,"sex":38,"minAge":39,"maxAge":10,"enrollmentInfo":40,"targetDuration":43,"studyType":44,"phases":10,"briefSummary":45,"conditions":46,"keywords":48,"overallStatus":53,"whyStopped":10,"lastUpdateSubmitDate":54,"lastUpdatePostDateStruct":55,"startDateStruct":58,"completionDateStruct":60,"leadSponsor":62,"locationsCount":10},{"fullName":5,"class":6},"Changhai Hospital","OTHER",[8,12,15],{"label":9,"type":10,"description":11,"interventionNames":10},"Healthy Controls",null,"Healthy volunteers without chronic pancreatitis or pancreatic cancer will be enrolled as the reference cohort for comparison with the chronic pancreatitis and pancreatic ductal adenocarcinoma cohorts.",{"label":13,"type":10,"description":14,"interventionNames":10},"Chronic Pancreatitis","Participants with chronic pancreatitis will be enrolled as the main longitudinal cohort. This cohort will be followed over time to evaluate clinical, imaging, genetic, and immune features associated with pancreatic cancer risk.",{"label":16,"type":10,"description":17,"interventionNames":10},"Pancreatic Ductal Adenocarcinoma","Participants with newly diagnosed pancreatic ductal adenocarcinoma will be enrolled as the pancreatic cancer cohort for comparison with the healthy control and chronic pancreatitis cohorts.",[19],{"name":20,"affiliation":5,"role":21},"Zhuan Liao, PhD","PRINCIPAL_INVESTIGATOR",[23],{"name":20,"role":24,"phone":25,"phoneExt":10,"email":26},"CONTACT","+86-21-31161001","zhuanleo@126.com",{"type":21,"investigatorFullName":28,"investigatorTitle":29,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"Zhuan Liao","Professor and Chief Physician","100651624","blood-biomarkers-and-gut-microbiota-for-pancreatic-cancer-risk-in-chronic-pancreatitis-100651624",false,"NCT07762950","Blood Biomarkers and Gut Microbiota for Pancreatic Cancer Risk in Chronic Pancreatitis","Immune Repertoire Decoding Enables Dynamic Risk Stratification During Chronic Pancreatitis-to-Pancreatic Cancer Transition","Inclusion Criteria:\n\n* Adults aged 18 years or older.\n* Able to understand the study procedures and provide written informed consent.\n* Healthy controls: participants without a known history of chronic pancreatitis or pancreatic cancer.\n* Chronic pancreatitis cohort: participants diagnosed with chronic pancreatitis according to clinical guidelines, based on clinical, imaging, and\u002For genetic information.\n* Pancreatic ductal adenocarcinoma cohort: participants with newly diagnosed pancreatic ductal adenocarcinoma based on clinical, imaging, and\u002For pathological evaluation.\n* Willing to provide blood samples and relevant clinical information.\n* For participants with chronic pancreatitis, willing to undergo longitudinal follow-up approximately every 6 to 12 months.\n\nExclusion Criteria:\n\n* Unable or unwilling to provide written informed consent.\n* Unable to provide required clinical information or biological samples.\n* Prior diagnosis of another active malignant tumor, except adequately treated non-melanoma skin cancer or carcinoma in situ, if considered not to affect study participation by the investigator.\n* Current severe acute infection or other serious medical condition that, in the investigator's judgment, may interfere with study participation or interpretation of immune-related analyses.\n* Use of systemic immunosuppressive therapy or immunotherapy within a period considered clinically relevant by the investigator.\n* Any condition that, in the investigator's judgment, makes the participant unsuitable for this study.",true,"ALL","18 Years",{"count":41,"type":42},800,"ESTIMATED","28 Months","OBSERVATIONAL","The goal of this observational study is to learn more about pancreatic cancer risk in people with chronic pancreatitis. Researchers will study blood markers and gut microorganisms, which are bacteria and other microbes living in the intestine.\n\nResearchers will compare healthy participants, participants with chronic pancreatitis, and participants with newly diagnosed pancreatic cancer. The study will examine whether blood markers and gut microorganisms differ among these groups. It will also study how these features change over time and whether they may help identify people with chronic pancreatitis who are at higher risk of pancreatic cancer.\n\nParticipants will provide blood and stool samples. Researchers will also collect health information, laboratory test results, and abdominal scan results. Participants with chronic pancreatitis will be followed about every 6 to 12 months. Participants with pancreatic cancer will also be followed according to their routine medical care schedule. Researchers will collect information about their treatment, disease changes, test results, scans, and survival status.\n\nSome participants with chronic pancreatitis or pancreatic cancer may be asked to provide additional blood or stool samples. Their permission will be confirmed before each additional sample is collected. Refusing an additional sample will not affect their routine medical care or continued follow-up in the study.\n\nNo treatment will be assigned as part of this study. The findings may help improve future methods for assessing pancreatic cancer risk in people with chronic pancreatitis.",[13,47],"Pancreatic Cancer",[16,49,50,51,52],"Serum Biomarkers","Gut Microbiota","Microbial Translocation","Risk Stratification","NOT_YET_RECRUITING","2026-08-09",{"date":56,"type":57},"2026-08-13","ACTUAL",{"date":59,"type":42},"2026-08-01",{"date":61,"type":42},"2028-12-31",{"name":5,"class":6}]