[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100657265":3},{"organization":4,"outcomesModule":7,"designInfo":27,"detailedDescription":26,"studyPopulation":26,"armGroups":36,"interventions":49,"overallOfficials":26,"centralContacts":61,"locations":67,"responsibleParty":86,"collaborators":26,"id":89,"slug":90,"hasResults":91,"nctId":92,"briefTitle":93,"officialTitle":94,"acronym":26,"eligibilityCriteria":95,"healthyVolunteers":91,"sex":96,"minAge":97,"maxAge":98,"enrollmentInfo":99,"targetDuration":26,"studyType":102,"phases":103,"briefSummary":105,"conditions":106,"keywords":110,"overallStatus":113,"whyStopped":26,"lastUpdateSubmitDate":114,"lastUpdatePostDateStruct":115,"startDateStruct":118,"completionDateStruct":120,"leadSponsor":122,"locationsCount":123},{"fullName":5,"class":6},"The Affiliated Hospital Of Southwest Medical University","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":26},[9],{"measure":10,"description":11,"timeFrame":12},"H-reflex Hmax\u002FMmax Ratio","H-reflex is a validated neurophysiological indicator for evaluating spinal-level AMI after knee surgery which is applied to assess resting spinal reflex excitability of the knee extensor motor pool vastus medialis.\n\nUnit of Measure: Ratio (dimensionless)","From enrollment to the end of treatment at 12 weeks.",[14,17,20,23],{"measure":15,"description":16,"timeFrame":12},"Knee Joint Position Sense (JPS) Accuracy","Knee proprioceptive acuity was evaluated using a calibrated isokinetic dynamometer. Participants were blindfolded to exclude visual interference and seated with the tested lower limb securely strapped to the dynamometer lever arm. The knee was passively positioned at three target flexion angles (30°, 60°, and 90°). After passive positioning and a 3-second holding phase, participants actively reproduced the perceived target angle independently. Absolute angular error was calculated as the absolute discrepancy between the preset target angle and the actively reproduced angle.\n\nUnit of Measure: Degrees (°)",{"measure":18,"description":19,"timeFrame":12},"Somatosensory Evoked Potential (SEP) P40 Latency","Cortical somatosensory afferent function was assessed via tibial nerve somatosensory evoked potentials (SEP). The P40 latency was defined as the time interval from stimulus onset to the occurrence of the P40 positive wave, representing the conduction efficiency and temporal characteristics of peripheral proprioceptive signals transmitting to the primary somatosensory cortex.\n\nUnit of Measure: Milliseconds (ms)",{"measure":21,"description":22,"timeFrame":12},"Somatosensory Evoked Potential (SEP) N45-P40 Peak-to-peak Amplitude","Central sensory integration plasticity was assessed via tibial nerve somatosensory evoked potentials (SEP). The N45-P40 peak-to-peak amplitude was calculated to evaluate cortical sensory gain and central inhibitory\u002Fexcitatory balance.\n\nUnit of Measure: Microvolts (μV)",{"measure":24,"description":25,"timeFrame":12},"Quadriceps rapid torque development rate (RTD)","Quadriceps rapid torque development rate (RTD) was measured to quantify the efficiency of central motor unit recruitment and neuromuscular rapid-driving capability. Quadriceps RTD was calculated as the rate of torque increase within the early contraction phase, reflecting the recruitment efficacy of high-threshold type II muscle fibers and synchronous firing of motor units.\n\nUnit of Measure: Nm\u002Fs",null,{"allocation":28,"interventionModel":29,"interventionModelDescription":26,"primaryPurpose":30,"observationalModel":26,"timePerspective":26,"maskingInfo":31},"RANDOMIZED","PARALLEL","TREATMENT",{"masking":32,"maskingDescription":26,"whoMasked":33},"DOUBLE",[34,35],"PARTICIPANT","OUTCOMES_ASSESSOR",[37,43],{"label":38,"type":39,"description":40,"interventionNames":41},"Blood flow restriction training group","EXPERIMENTAL","Progressive BFRT exercises with 60%-80% of arterial occlusion pressure. The BFRT protocol was individualized based on limb circumference and tolerance, with pressure settings determined using the limb occlusion pressure method. For lower extremity training, pressure was set at 60%-80% of arterial occlusion pressure (approximately 140-220 mmHg depending on individual limb characteristics).",[42],"Other: Blood flow restriction training with 60%-80% occlusion",{"label":44,"type":45,"description":46,"interventionNames":47},"Control group","SHAM_COMPARATOR","Participants in CON group with sham BFRT completed 3 sets of 10 repetitions for each exercise with the sham unit set to 20 mmHg. The restriction pressure was based on prior work which shows that 20 mmHg is well below the threshold for either arterial or venous occlusion.",[48],"Other: Standard postoperative knee rehabilitation with sham BFRT",[50,57],{"type":6,"name":51,"description":52,"armGroupLabels":53,"otherNames":54},"Blood flow restriction training with 60%-80% occlusion","A personalized constant-pressure system served as the active BFRT unit, with restrictive pressure set at 60%-80% of limb arterial occlusion pressure; it auto-inflates to maintain constant pressure and automatically monitors, assesses, and adjusts pressure during training.",[38],[55,56],"KAATSU Training","Occlusion Training",{"type":6,"name":58,"description":59,"armGroupLabels":60,"otherNames":26},"Standard postoperative knee rehabilitation with sham BFRT","Standard postoperative rehabilitation protocol after knee arthroscopic surgery, without blood flow restriction training. The rehabilitation program includes range of motion exercises, muscle strength training, balance training and functional activity training, with the same schedule, frequency and duration as the experimental group.",[44],[62],{"name":63,"role":64,"phone":65,"phoneExt":26,"email":66},"Yuxiu Ji","CONTACT","86+0830-8950771","1062111370@qq.com",[68],{"facility":69,"status":26,"city":70,"state":71,"zip":72,"country":73,"countryCode":74,"cosmosGeoPoint":75,"geoPoint":80,"contacts":81},"The Affiliated Hospital of Southwest Medical University","Luzhou","Sichuan","646000","China","CN",{"type":76,"coordinates":77},"Point",[78,79],105.42575,28.8903,{"lat":79,"lon":78},[82],{"name":83,"role":64,"phone":84,"phoneExt":26,"email":85},"Chi Zhang","86+13082566763","chizhang0123@swmu.edu.cn",{"type":87,"investigatorFullName":63,"investigatorTitle":88,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"SPONSOR_INVESTIGATOR","Attending Physician, Department of Rehabilitation Medicine, Principal Investigator","100657265","blood-flow-restriction-training-in-knee-arthropathy-100657265",false,"NCT07837154","Blood Flow Restriction Training in Knee Arthropathy","Effects of Blood Flow Restriction Training on Lower Limb Muscle Strength and Atrophy in Patients With Knee Arthropathy: A Randomized Controlled Trial","Inclusion Criteria:\n\n1. Knee arthroscopy;\n2. Age 18-60 years;\n3. Ability to provide informed consent;\n4. Availability for follow-up assessments;\n5. Written informed consent.\n\nExclusion Criteria:\n\n1. Neurological disorders affecting lower extremity function;\n2. Vascular disease or coagulopathy;\n3. Contralateral knee pathology;\n4. Previous knee surgery;\n5. inability to comply with rehabilitation protocols;\n6. pregnancy.","ALL","18 Years","60 Years",{"count":100,"type":101},56,"ESTIMATED","INTERVENTIONAL",[104],"NA","Arthrogenic muscle inhibition (AMI) is the key neurophysiological cause of impeding quadriceps activation following anterior cruciate ligament reconstruction (ACLR). Blood flow restriction training (BFRT) may induce neuroplasticity whereas the neurophysiological responses remain uncertain. In this study, we aimed to explore the effects of constant pressure blood flow restriction training (CP-BFRT) on neurophysiological responses and physical function. Patients will receive the same standardized progressive physical rehabilitation for 2 weeks after the surgery and then start the BRFT or sham BRFT intervention for the following 12 weeks.",[107,108,109],"Knee Arthroscopic Surgery","Arthrogenic Muscle Inhibition","Quadriceps Muscle Weakness",[111,112,107],"Arthrogenic muscle inhibition","Blood flow restriction training","NOT_YET_RECRUITING","2026-09-22",{"date":116,"type":117},"2026-09-23","ACTUAL",{"date":119,"type":101},"2026-09-01",{"date":121,"type":101},"2026-12-31",{"name":63,"class":6},1]