[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100625598":3},{"organization":4,"outcomesModule":7,"designInfo":14,"detailedDescription":22,"studyPopulation":13,"armGroups":23,"interventions":36,"overallOfficials":13,"centralContacts":13,"locations":47,"responsibleParty":62,"collaborators":13,"id":66,"slug":67,"hasResults":68,"nctId":69,"briefTitle":70,"officialTitle":71,"acronym":72,"eligibilityCriteria":73,"healthyVolunteers":68,"sex":74,"minAge":75,"maxAge":76,"enrollmentInfo":77,"targetDuration":13,"studyType":80,"phases":81,"briefSummary":83,"conditions":84,"keywords":88,"overallStatus":50,"whyStopped":13,"lastUpdateSubmitDate":97,"lastUpdatePostDateStruct":98,"startDateStruct":101,"completionDateStruct":103,"leadSponsor":105,"locationsCount":106},{"fullName":5,"class":6},"Sana'a University","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":13},[9],{"measure":10,"description":11,"timeFrame":12},"Radiographic bone regeneration in cystic defects following enucleation","The amount of bone regeneration will be evaluated radiographically using CBCT imaging to measure the percentage of defect fill and bone density changes at 6 months postoperatively.","6 months after surgery",null,{"allocation":15,"interventionModel":16,"interventionModelDescription":17,"primaryPurpose":18,"observationalModel":13,"timePerspective":13,"maskingInfo":19},"RANDOMIZED","PARALLEL","Participants will be randomly allocated into two parallel groups. The intervention group will receive autologous platelet-rich fibrin (PRF) following cystic enucleation.\n\nThe control group will undergo cystic enucleation without PRF application (standard management).\n\nOutcomes related to bone regeneration will be assessed and compared between the two groups.","TREATMENT",{"masking":20,"maskingDescription":21,"whoMasked":13},"NONE","This is an open-label study. Participants, care providers, and investigators are aware of the assigned intervention (PRF or control). No masking is used.","This study is designed as a randomized controlled clinical trial to evaluate the effectiveness of autologous platelet-rich fibrin (PRF) in enhancing bone regeneration after cystic enucleation in the jaws.\n\nPRF is an autologous biomaterial rich in growth factors that may enhance bone healing and tissue regeneration. Participants undergoing cystic enucleation will be randomly assigned to either a PRF-treated group or a control group receiving conventional treatment without PRF.\n\nClinical and radiographic assessments will be performed to evaluate bone regeneration, healing rate, and postoperative outcomes. If PRF demonstrates significant improvement in osseous regeneration, it may represent a minimally invasive and cost-effective alternative to traditional bone grafting procedures.\n\nEthical approval will be obtained from the Ethical Committee of the Faculty of Medicine and Health Sciences, Sana'a University, Yemen.",[24,30],{"label":25,"type":26,"description":27,"interventionNames":28},"PRF Group","EXPERIMENTAL","Participants undergoing cystic enucleation in the jaws will receive autologous Platelet-Rich Fibrin (PRF) placed into the osseous defect immediately after surgical enucleation.",[29],"Biological: Autologous Platelet-Rich Fibrin (PRF)",{"label":31,"type":32,"description":33,"interventionNames":34},"Control Group","ACTIVE_COMPARATOR","Participants undergoing cystic enucleation of jaw cysts will receive conventional surgical management without the application of platelet-rich fibrin (PRF). The osseous defect will be left to heal naturally following standard enucleation and wound closure procedures.",[35],"Procedure: Conventional Surgical Management",[37,42],{"type":38,"name":39,"description":40,"armGroupLabels":41,"otherNames":13},"BIOLOGICAL","Autologous Platelet-Rich Fibrin (PRF)","Autologous platelet-rich fibrin (PRF) prepared from the participant's own venous blood will be placed into the osseous defect immediately after cystic enucleation. PRF will be prepared using standard centrifugation protocols and applied to promote bone regeneration.",[25],{"type":43,"name":44,"description":45,"armGroupLabels":46,"otherNames":13},"PROCEDURE","Conventional Surgical Management","Conventional cystic enucleation will be performed without the use of platelet-rich fibrin (PRF). The osseous defect will be managed according to standard surgical protocol and allowed to heal naturally.",[31],[48],{"facility":49,"status":50,"city":51,"state":52,"zip":53,"country":54,"countryCode":55,"cosmosGeoPoint":13,"geoPoint":13,"contacts":56},"Faculty of Medicine and Health Sciences - Sana'a University","RECRUITING","Sanaa","Sanaa Governorate","00000","Yemen","YE",[57],{"name":58,"role":59,"phone":60,"phoneExt":13,"email":61},"lamees F Alareeki, BDS","CONTACT","+967772377003","lamis.alarigi@su.edu.ye",{"type":63,"investigatorFullName":64,"investigatorTitle":65,"investigatorAffiliation":5,"oldNameTitle":13,"oldOrganization":13},"PRINCIPAL_INVESTIGATOR","Lamees Fozi Alareeki","Master's Degree Candidate, Faculty of Dentistry, Sana'a University","100625598","bone-regeneration-using-prf-after-cyst-enucleation-100625598",false,"NCT07424716","Bone Regeneration Using PRF After Cyst Enucleation","Clinical Efficacy of Platelet-Rich Fibrin in Osseous Regeneration After Cystic Enucleation","PRF-Bone","Inclusion Criteria:\n\n* Patients diagnosed with odontogenic cysts requiring surgical enucleation.\n* Presence of a postoperative osseous defect in the jaws after cyst enucleation.\n* Age ≥ 18 years.\n* Systemically healthy patients (ASA I or II).\n* Patients willing to participate and sign informed consent.\n\nExclusion Criteria:\n\n* Patients with systemic diseases affecting bone healing (e.g., uncontrolled diabetes, osteoporosis).\n* Patients receiving bisphosphonates or long-term corticosteroid therapy.\n* Smokers (\\>10 cigarettes\u002Fday).\n* Pregnant or lactating women.\n* Patients with acute infection at the surgical site.\n* Patients unwilling to participate or unable to attend follow-up visits.","ALL","18 Years","80 Years",{"count":78,"type":79},20,"ESTIMATED","INTERVENTIONAL",[82],"NA","This randomized controlled clinical trial aims to evaluate the clinical efficacy of autologous platelet-rich fibrin (PRF) in promoting osseous regeneration following cystic enucleation in the jaws. The study will assess bone healing outcomes and compare PRF application with conventional management methods.",[85,86,87],"Odontogenic Cyst","Jaw Cysts","Osseous Defect After Cyst Enucleation",[89,90,91,92,93,94,95,96],"Platelet-Rich Fibrin","PRF","Cyst Enucleation","Bone Regeneration","Randomized Controlled Trial","Oral Surgery","Osseous Healing","Jaw Bone Defect","2026-02-14",{"date":99,"type":100},"2026-02-20","ACTUAL",{"date":102,"type":100},"2025-05-19",{"date":104,"type":79},"2026-10-19",{"name":5,"class":6},1]