[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100470274":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":22,"centralContacts":27,"locations":36,"responsibleParty":60,"collaborators":62,"id":72,"slug":73,"hasResults":74,"nctId":75,"briefTitle":76,"officialTitle":77,"acronym":78,"eligibilityCriteria":79,"healthyVolunteers":74,"sex":80,"minAge":81,"maxAge":82,"enrollmentInfo":83,"targetDuration":10,"studyType":86,"phases":10,"briefSummary":87,"conditions":88,"keywords":10,"overallStatus":39,"whyStopped":10,"lastUpdateSubmitDate":91,"lastUpdatePostDateStruct":92,"startDateStruct":95,"completionDateStruct":97,"leadSponsor":99,"locationsCount":100},{"fullName":5,"class":6},"University of Massachusetts, Worcester","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"single group assignment",null,"men or women between the ages of 18-75 who have an established diagnosis of Hidradenitis Suppurativa",[13],"Drug: Botulinum toxin",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":20},"DRUG","Botulinum toxin","Administration of botulinum toxin (50 units\u002F100cm2 injected intradermally) into lesional skin",[9],[21],"Botox",[23],{"name":24,"affiliation":25,"role":26},"Sarah K Whitley, MD PhD","Assistant Professor of Dermatology","PRINCIPAL_INVESTIGATOR",[28,32],{"name":24,"role":29,"phone":30,"phoneExt":10,"email":31},"CONTACT","(508)856-4086","sarah.whitley@umassmed.edu",{"name":33,"role":29,"phone":34,"phoneExt":10,"email":35},"Deborah White, Deborah Peduzzi","(508)856-2664","deborah.white@umassmed.edu",[37],{"facility":38,"status":39,"city":40,"state":41,"zip":42,"country":43,"countryCode":44,"cosmosGeoPoint":45,"geoPoint":50,"contacts":51},"University of Massachusetts Chan Medical School","RECRUITING","Worcester","Massachusetts","01605","United States","US",{"type":46,"coordinates":47},"Point",[48,49],-71.80229,42.26259,{"lat":49,"lon":48},[52,56],{"name":53,"role":29,"phone":54,"phoneExt":10,"email":55},"Sidney Leno, MD","774-455-4087","hsresearch@umassmed.edu",{"name":57,"role":29,"phone":58,"phoneExt":10,"email":59},"Terrie Lamarche","508-856-5386","terrie.lamarche@umassmed.edu",{"type":26,"investigatorFullName":61,"investigatorTitle":25,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"Sarah Whitley",[63,66,69],{"name":64,"class":65},"Hidradenitis Suppurativa Foundation","UNKNOWN",{"name":67,"class":68},"National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)","NIH",{"name":70,"class":71},"AbbVie","INDUSTRY","100470274","botulinum-toxin-therapy-in-hidradenitis-suppurativa-100470274",false,"NCT05403710","Botulinum Toxin Therapy in Hidradenitis Suppurativa","Targeting Nociceptors in Hidradenitis Suppurativa","HS","Inclusion:\n\n* Adults between ages 18 and 75 years with established diagnosis of hidradenitis suppurativa (HS)\n* HS skin lesions of duration at least 1 year, HS skin lesions in at least two different body areas\n\nExclusion:\n\n* Age \\\u003C 18 years or \\> 75 years\n* pregnant or breastfeeding\n* neuromuscular disorder (ex. ALS, myasthenia gravis, Lambert-Eaton syndrome, myopathy)\n* medical co-morbidity that is a relative contraindication to skin biopsy procedure (ex. end stage congestive heart failure or coagulopathy)\n* active bacterial, fungal, or viral infection in the treatment area\n* known hypersensitivity to botulinum toxin A preparations or any of their components (human albumin, saline, lactose, sodium succinate)\n* prisoners\n* adults unable to consent for themselves.","ALL","18 Years","75 Years",{"count":84,"type":85},20,"ESTIMATED","OBSERVATIONAL","This study will build on data from mice and humans implicating TRPV1 nociceptors in the pathogenesis of the type-17 chronic inflammatory skin disease Hidradenitis Suppurativa (HS). In this study, the investigators will test the hypothesis that inhibiting neuropeptide activity with botulinum toxin reduces pathogenic inflammation.",[89,90],"Hidradenitis Suppurativa","Hyperhidrosis","2026-08-04",{"date":93,"type":94},"2026-08-07","ACTUAL",{"date":96,"type":94},"2022-06-07",{"date":98,"type":85},"2028-04-30",{"name":5,"class":6},1]