[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100520674":3},{"organization":4,"outcomesModule":7,"designInfo":18,"detailedDescription":28,"studyPopulation":17,"armGroups":29,"interventions":42,"overallOfficials":54,"centralContacts":62,"locations":71,"responsibleParty":1195,"collaborators":1197,"id":1200,"slug":1201,"hasResults":1202,"nctId":1203,"briefTitle":1204,"officialTitle":1204,"acronym":1205,"eligibilityCriteria":1206,"healthyVolunteers":1202,"sex":1207,"minAge":1208,"maxAge":17,"enrollmentInfo":1209,"targetDuration":17,"studyType":1212,"phases":1213,"briefSummary":1215,"conditions":1216,"keywords":17,"overallStatus":74,"whyStopped":17,"lastUpdateSubmitDate":1220,"lastUpdatePostDateStruct":1221,"startDateStruct":1224,"completionDateStruct":1226,"leadSponsor":1228,"locationsCount":1229},{"fullName":5,"class":6},"Orchestra BioMed, Inc","INDUSTRY",{"primaryOutcomes":8,"secondaryOutcomes":17,"otherOutcomes":17},[9,13],{"measure":10,"description":11,"timeFrame":12},"Change from Baseline in the Mean 24-hour ambulatory systolic blood pressure (aSBP) at 3 Months","Between group difference in the change of mean 24-hour ambulatory systolic blood pressure (aSBP) from baseline to 3 months post randomization","Baseline and 3 months post randomization",{"measure":14,"description":15,"timeFrame":16},"Freedom from Unanticipated Serious Adverse Device Effects (USADE)","Freedom from Unanticipated Serious Adverse Device Effects (USADE) in the treatment group at 3 months.","3 months post randomization",null,{"allocation":19,"interventionModel":20,"interventionModelDescription":17,"primaryPurpose":21,"observationalModel":17,"timePerspective":17,"maskingInfo":22},"RANDOMIZED","PARALLEL","TREATMENT",{"masking":23,"maskingDescription":17,"whoMasked":24},"TRIPLE",[25,26,27],"PARTICIPANT","INVESTIGATOR","OUTCOMES_ASSESSOR","The study will be conducted in three phases: 1) Screening Phase, 2) Double-blind Randomized Phase (1 year), and 3) Unblinded Phase (2 years). Patients scheduled for implantation of an Astra\u002FAzure pacemaker, or those who already have one implanted, who also have hypertension, may be screened for inclusion into this study. Subjects meeting randomization eligibility criteria will have the investigational AVIM Therapy RAMware downloaded into the Astra\u002FAzure pacemaker and be randomized 1:1 to either have AVIM therapy turned ON or turned OFF. All subjects will continue to receive antihypertensive drug therapy.",[30,36],{"label":31,"type":32,"description":33,"interventionNames":34},"Treatment Group","EXPERIMENTAL","AVIM therapy activated with continued stable antihypertensive drug therapy",[35],"Device: Medtronic Astra\u002FAzure DR MRI IPG with AVIM therapy Activated",{"label":37,"type":38,"description":39,"interventionNames":40},"Control Group","SHAM_COMPARATOR","AVIM therapy deactivated with continued stable antihypertensive drug therapy",[41],"Device: Medtronic Astra\u002FAzure DR MRI IPG with AVIM therapy Deactivated",[43,50],{"type":44,"name":45,"description":46,"armGroupLabels":47,"otherNames":48},"DEVICE","Medtronic Astra\u002FAzure DR MRI IPG with AVIM therapy Activated","Antihypertensive therapy utilizing atrioventricular interval modulation.",[31],[49],"BackBeat CNT",{"type":44,"name":51,"description":52,"armGroupLabels":53,"otherNames":17},"Medtronic Astra\u002FAzure DR MRI IPG with AVIM therapy Deactivated","AVIM therapy is deactivated",[37],[55,59],{"name":56,"affiliation":57,"role":58},"David Kandzari, MD","Piedmont Heart Institute","PRINCIPAL_INVESTIGATOR",{"name":60,"affiliation":61,"role":58},"Andrea Russo, MD","Cooper University",[63,68],{"name":64,"role":65,"phone":66,"phoneExt":17,"email":67},"Hans-Peter Stoll, MD, PhD","CONTACT","646-956-2161","hpstoll@orchestrabiomed.com",{"name":69,"role":65,"phone":17,"phoneExt":17,"email":70},"Angela Stagg","astagg@orchestrabiomed.com",[72,86,96,105,114,123,132,142,151,156,165,175,185,194,203,212,221,230,239,248,257,266,276,285,295,305,315,324,329,339,349,359,365,375,381,387,397,406,415,425,434,443,453,463,472,481,490,500,510,521,529,538,548,557,566,576,585,591,601,607,613,623,632,641,646,656,666,675,685,694,704,714,724,736,746,754,762,767,775,787,796,801,806,816,824,832,840,848,858,866,874,882,890,898,906,914,922,932,937,945,953,963,971,979,984,994,1002,1010,1022,1032,1040,1048,1056,1064,1072,1080,1088,1096,1106,1114,1122,1130,1140,1148,1156,1164,1174,1179,1184,1192],{"facility":73,"status":74,"city":75,"state":76,"zip":77,"country":78,"countryCode":79,"cosmosGeoPoint":80,"geoPoint":85,"contacts":17},"HonorHealth","RECRUITING","Scottsdale","Arizona","85258","United States","US",{"type":81,"coordinates":82},"Point",[83,84],-111.89903,33.50921,{"lat":84,"lon":83},{"facility":87,"status":74,"city":88,"state":89,"zip":90,"country":78,"countryCode":79,"cosmosGeoPoint":91,"geoPoint":95,"contacts":17},"Adventist Health Glendale","Glendale","California","91206",{"type":81,"coordinates":92},[93,94],-118.25508,34.14251,{"lat":94,"lon":93},{"facility":97,"status":74,"city":98,"state":89,"zip":99,"country":78,"countryCode":79,"cosmosGeoPoint":100,"geoPoint":104,"contacts":17},"Hoag Memorial Hospital Presbyterian","Newport Beach","92633",{"type":81,"coordinates":101},[102,103],-117.92895,33.61891,{"lat":103,"lon":102},{"facility":106,"status":74,"city":107,"state":89,"zip":108,"country":78,"countryCode":79,"cosmosGeoPoint":109,"geoPoint":113,"contacts":17},"Stanford","Redwood City","94063",{"type":81,"coordinates":110},[111,112],-122.23635,37.48522,{"lat":112,"lon":111},{"facility":115,"status":74,"city":116,"state":89,"zip":117,"country":78,"countryCode":79,"cosmosGeoPoint":118,"geoPoint":122,"contacts":17},"Scripps Clinic","San Diego","92121",{"type":81,"coordinates":119},[120,121],-117.16472,32.71571,{"lat":121,"lon":120},{"facility":124,"status":74,"city":125,"state":89,"zip":126,"country":78,"countryCode":79,"cosmosGeoPoint":127,"geoPoint":131,"contacts":17},"Sutter Valley Hospitals","San Francisco","94109",{"type":81,"coordinates":128},[129,130],-122.41942,37.77493,{"lat":130,"lon":129},{"facility":133,"status":74,"city":134,"state":135,"zip":136,"country":78,"countryCode":79,"cosmosGeoPoint":137,"geoPoint":141,"contacts":17},"South Denver Cardiology","Denver","Colorado","80210",{"type":81,"coordinates":138},[139,140],-104.9847,39.73915,{"lat":140,"lon":139},{"facility":143,"status":74,"city":144,"state":135,"zip":145,"country":78,"countryCode":79,"cosmosGeoPoint":146,"geoPoint":150,"contacts":17},"Colorado Heart and Vascular","Golden","80401",{"type":81,"coordinates":147},[148,149],-105.2211,39.75554,{"lat":149,"lon":148},{"facility":152,"status":74,"city":144,"state":135,"zip":145,"country":78,"countryCode":79,"cosmosGeoPoint":153,"geoPoint":155,"contacts":17},"Intermountain Health Lutheran Hospital",{"type":81,"coordinates":154},[148,149],{"lat":149,"lon":148},{"facility":157,"status":74,"city":158,"state":135,"zip":159,"country":78,"countryCode":79,"cosmosGeoPoint":160,"geoPoint":164,"contacts":17},"UCHealth Medical Center of the Rockies","Loveland","80538",{"type":81,"coordinates":161},[162,163],-105.07498,40.39776,{"lat":163,"lon":162},{"facility":166,"status":74,"city":167,"state":168,"zip":169,"country":78,"countryCode":79,"cosmosGeoPoint":170,"geoPoint":174,"contacts":17},"MedStar Washington Hospital Center","Washington D.C.","District of Columbia","20010",{"type":81,"coordinates":171},[172,173],-77.03637,38.89511,{"lat":173,"lon":172},{"facility":176,"status":74,"city":177,"state":178,"zip":179,"country":78,"countryCode":79,"cosmosGeoPoint":180,"geoPoint":184,"contacts":17},"HCA Florida JFK Hospital","Atlantis","Florida","33462",{"type":81,"coordinates":181},[182,183],-80.10088,26.5909,{"lat":183,"lon":182},{"facility":186,"status":74,"city":187,"state":178,"zip":188,"country":78,"countryCode":79,"cosmosGeoPoint":189,"geoPoint":193,"contacts":17},"Cardiovascular Research Solutions (MyCardiologist)","Celebration","34747",{"type":81,"coordinates":190},[191,192],-81.53313,28.32529,{"lat":192,"lon":191},{"facility":195,"status":74,"city":196,"state":178,"zip":197,"country":78,"countryCode":79,"cosmosGeoPoint":198,"geoPoint":202,"contacts":17},"Clearwater Cardiovascular Consultants","Clearwater","33756",{"type":81,"coordinates":199},[200,201],-82.8001,27.96585,{"lat":201,"lon":200},{"facility":204,"status":74,"city":205,"state":178,"zip":206,"country":78,"countryCode":79,"cosmosGeoPoint":207,"geoPoint":211,"contacts":17},"Citrus Cardiology Consultants","Crystal River","34429",{"type":81,"coordinates":208},[209,210],-82.5926,28.90248,{"lat":210,"lon":209},{"facility":213,"status":74,"city":214,"state":178,"zip":215,"country":78,"countryCode":79,"cosmosGeoPoint":216,"geoPoint":220,"contacts":17},"The Cardiac and Vascular Institute","Gainesville","32605",{"type":81,"coordinates":217},[218,219],-82.32483,29.65163,{"lat":219,"lon":218},{"facility":222,"status":74,"city":223,"state":178,"zip":224,"country":78,"countryCode":79,"cosmosGeoPoint":225,"geoPoint":229,"contacts":17},"Memorial Healthcare System","Hollywood","33021",{"type":81,"coordinates":226},[227,228],-80.14949,26.0112,{"lat":228,"lon":227},{"facility":231,"status":74,"city":232,"state":178,"zip":233,"country":78,"countryCode":79,"cosmosGeoPoint":234,"geoPoint":238,"contacts":17},"Baptist Health Jacksonville","Jacksonville","32207",{"type":81,"coordinates":235},[236,237],-81.65565,30.33218,{"lat":237,"lon":236},{"facility":240,"status":74,"city":241,"state":178,"zip":242,"country":78,"countryCode":79,"cosmosGeoPoint":243,"geoPoint":247,"contacts":17},"Baptist Health South Florida","Miami","33176",{"type":81,"coordinates":244},[245,246],-80.19366,25.77427,{"lat":246,"lon":245},{"facility":249,"status":74,"city":250,"state":178,"zip":251,"country":78,"countryCode":79,"cosmosGeoPoint":252,"geoPoint":256,"contacts":17},"Mount Sinai Medical Center of Florida","Miami Beach","33140",{"type":81,"coordinates":253},[254,255],-80.13005,25.79065,{"lat":255,"lon":254},{"facility":258,"status":74,"city":259,"state":178,"zip":260,"country":78,"countryCode":79,"cosmosGeoPoint":261,"geoPoint":265,"contacts":17},"Sarasota Memorial Hospital","Sarasota","34239",{"type":81,"coordinates":262},[263,264],-82.53065,27.33643,{"lat":264,"lon":263},{"facility":267,"status":74,"city":268,"state":269,"zip":270,"country":78,"countryCode":79,"cosmosGeoPoint":271,"geoPoint":275,"contacts":17},"Piedmont Healthcare, Inc.","Atlanta","Georgia","30309",{"type":81,"coordinates":272},[273,274],-84.38798,33.749,{"lat":274,"lon":273},{"facility":277,"status":74,"city":278,"state":269,"zip":279,"country":78,"countryCode":79,"cosmosGeoPoint":280,"geoPoint":284,"contacts":17},"Wellstar Research Institute","Marietta","30060",{"type":81,"coordinates":281},[282,283],-84.54993,33.9526,{"lat":283,"lon":282},{"facility":286,"status":74,"city":287,"state":288,"zip":289,"country":78,"countryCode":79,"cosmosGeoPoint":290,"geoPoint":294,"contacts":17},"St. Luke's Idaho Cardiology","Boise","Idaho","83712",{"type":81,"coordinates":291},[292,293],-116.20345,43.6135,{"lat":293,"lon":292},{"facility":296,"status":74,"city":297,"state":298,"zip":299,"country":78,"countryCode":79,"cosmosGeoPoint":300,"geoPoint":304,"contacts":17},"University of Chicago","Chicago","Illinois","60637",{"type":81,"coordinates":301},[302,303],-87.65005,41.85003,{"lat":303,"lon":302},{"facility":306,"status":74,"city":307,"state":308,"zip":309,"country":78,"countryCode":79,"cosmosGeoPoint":310,"geoPoint":314,"contacts":17},"University of Kansas Medical Center","Kansas City","Kansas","66160",{"type":81,"coordinates":311},[312,313],-94.62746,39.11417,{"lat":313,"lon":312},{"facility":316,"status":74,"city":317,"state":308,"zip":318,"country":78,"countryCode":79,"cosmosGeoPoint":319,"geoPoint":323,"contacts":17},"Cardiovascular Research Institute of Kansas","Wichita","67226",{"type":81,"coordinates":320},[321,322],-97.33754,37.69224,{"lat":322,"lon":321},{"facility":325,"status":74,"city":317,"state":308,"zip":318,"country":78,"countryCode":79,"cosmosGeoPoint":326,"geoPoint":328,"contacts":17},"West Houston Area Clinical Trial Consultants (Wichita, KS)",{"type":81,"coordinates":327},[321,322],{"lat":322,"lon":321},{"facility":330,"status":74,"city":331,"state":332,"zip":333,"country":78,"countryCode":79,"cosmosGeoPoint":334,"geoPoint":338,"contacts":17},"Baptist Health Lexington","Lexington","Kentucky","40503",{"type":81,"coordinates":335},[336,337],-84.47772,37.98869,{"lat":337,"lon":336},{"facility":340,"status":74,"city":341,"state":342,"zip":343,"country":78,"countryCode":79,"cosmosGeoPoint":344,"geoPoint":348,"contacts":17},"Ochsner Medical Center","New Orleans","Louisiana","70121",{"type":81,"coordinates":345},[346,347],-90.07507,29.95465,{"lat":347,"lon":346},{"facility":350,"status":74,"city":351,"state":352,"zip":353,"country":78,"countryCode":79,"cosmosGeoPoint":354,"geoPoint":358,"contacts":17},"The Johns Hopkins University","Baltimore","Maryland","21205",{"type":81,"coordinates":355},[356,357],-76.61219,39.29038,{"lat":357,"lon":356},{"facility":360,"status":74,"city":351,"state":352,"zip":361,"country":78,"countryCode":79,"cosmosGeoPoint":362,"geoPoint":364,"contacts":17},"Medstar Union Memorial Hospital","21218",{"type":81,"coordinates":363},[356,357],{"lat":357,"lon":356},{"facility":366,"status":74,"city":367,"state":368,"zip":369,"country":78,"countryCode":79,"cosmosGeoPoint":370,"geoPoint":374,"contacts":17},"The Brigham and Women's Hospital","Boston","Massachusetts","02115",{"type":81,"coordinates":371},[372,373],-71.05977,42.35843,{"lat":373,"lon":372},{"facility":376,"status":74,"city":367,"state":368,"zip":377,"country":78,"countryCode":79,"cosmosGeoPoint":378,"geoPoint":380,"contacts":17},"St. Elizabeth's Medical Center","02135",{"type":81,"coordinates":379},[372,373],{"lat":373,"lon":372},{"facility":382,"status":74,"city":367,"state":368,"zip":383,"country":78,"countryCode":79,"cosmosGeoPoint":384,"geoPoint":386,"contacts":17},"Beth Israel Deaconess Medical Center","02215",{"type":81,"coordinates":385},[372,373],{"lat":373,"lon":372},{"facility":388,"status":74,"city":389,"state":390,"zip":391,"country":78,"countryCode":79,"cosmosGeoPoint":392,"geoPoint":396,"contacts":17},"Henry Ford Health","Detroit","Michigan","48202-2689",{"type":81,"coordinates":393},[394,395],-83.04575,42.33143,{"lat":395,"lon":394},{"facility":398,"status":74,"city":399,"state":390,"zip":400,"country":78,"countryCode":79,"cosmosGeoPoint":401,"geoPoint":405,"contacts":17},"UMH-Sparrow Clinical Research","Lansing","48912",{"type":81,"coordinates":402},[403,404],-84.55553,42.73253,{"lat":404,"lon":403},{"facility":407,"status":74,"city":408,"state":390,"zip":409,"country":78,"countryCode":79,"cosmosGeoPoint":410,"geoPoint":414,"contacts":17},"Michigan Heart","Ypsilanti","48197",{"type":81,"coordinates":411},[412,413],-83.61299,42.24115,{"lat":413,"lon":412},{"facility":416,"status":74,"city":417,"state":418,"zip":419,"country":78,"countryCode":79,"cosmosGeoPoint":420,"geoPoint":424,"contacts":17},"Health Partners Institute (Methodist Heart and Vascular Center)","Bloomington","Minnesota","55425",{"type":81,"coordinates":421},[422,423],-93.29828,44.8408,{"lat":423,"lon":422},{"facility":426,"status":74,"city":427,"state":418,"zip":428,"country":78,"countryCode":79,"cosmosGeoPoint":429,"geoPoint":433,"contacts":17},"Minneapolis Heart Institute","Minneapolis","55407",{"type":81,"coordinates":430},[431,432],-93.26384,44.97997,{"lat":432,"lon":431},{"facility":435,"status":74,"city":436,"state":418,"zip":437,"country":78,"countryCode":79,"cosmosGeoPoint":438,"geoPoint":442,"contacts":17},"Mayo Clinic","Rochester","55905",{"type":81,"coordinates":439},[440,441],-92.4699,44.02163,{"lat":441,"lon":440},{"facility":444,"status":74,"city":445,"state":446,"zip":447,"country":78,"countryCode":79,"cosmosGeoPoint":448,"geoPoint":452,"contacts":17},"Washington University St. Louis","St Louis","Missouri","63130",{"type":81,"coordinates":449},[450,451],-90.19789,38.62727,{"lat":451,"lon":450},{"facility":454,"status":74,"city":455,"state":456,"zip":457,"country":78,"countryCode":79,"cosmosGeoPoint":458,"geoPoint":462,"contacts":17},"The Cooper Health System","Camden","New Jersey","08103",{"type":81,"coordinates":459},[460,461],-75.11962,39.92595,{"lat":461,"lon":460},{"facility":464,"status":74,"city":465,"state":456,"zip":466,"country":78,"countryCode":79,"cosmosGeoPoint":467,"geoPoint":471,"contacts":17},"Hackensack University Medical Center","Hackensack","07601",{"type":81,"coordinates":468},[469,470],-74.04347,40.88593,{"lat":470,"lon":469},{"facility":473,"status":74,"city":474,"state":456,"zip":475,"country":78,"countryCode":79,"cosmosGeoPoint":476,"geoPoint":480,"contacts":17},"Virtua Medical Group, P.A.","Marlton","08053",{"type":81,"coordinates":477},[478,479],-74.92183,39.89122,{"lat":479,"lon":478},{"facility":482,"status":74,"city":483,"state":456,"zip":484,"country":78,"countryCode":79,"cosmosGeoPoint":485,"geoPoint":489,"contacts":17},"Jersey Shore University Medical Center","Neptune City","07753",{"type":81,"coordinates":486},[487,488],-74.02792,40.20011,{"lat":488,"lon":487},{"facility":491,"status":492,"city":493,"state":456,"zip":494,"country":78,"countryCode":79,"cosmosGeoPoint":495,"geoPoint":499,"contacts":17},"The Valley Hospital","TERMINATED","Ridgewood","07450",{"type":81,"coordinates":496},[497,498],-74.11653,40.97926,{"lat":498,"lon":497},{"facility":501,"status":74,"city":502,"state":503,"zip":504,"country":78,"countryCode":79,"cosmosGeoPoint":505,"geoPoint":509,"contacts":17},"Lovelace Medical Center (New Mexico Heart Institute)","Albuquerque","New Mexico","87110",{"type":81,"coordinates":506},[507,508],-106.65114,35.08449,{"lat":508,"lon":507},{"facility":511,"status":512,"city":513,"state":514,"zip":515,"country":78,"countryCode":79,"cosmosGeoPoint":516,"geoPoint":520,"contacts":17},"Northwell Health, Inc.","WITHDRAWN","New Hyde Park","New York","11042",{"type":81,"coordinates":517},[518,519],-73.68791,40.7351,{"lat":519,"lon":518},{"facility":522,"status":74,"city":514,"state":514,"zip":523,"country":78,"countryCode":79,"cosmosGeoPoint":524,"geoPoint":528,"contacts":17},"Icahn School of Medicine at Mount Sinai","10029",{"type":81,"coordinates":525},[526,527],-74.00597,40.71427,{"lat":527,"lon":526},{"facility":530,"status":531,"city":436,"state":514,"zip":532,"country":78,"countryCode":79,"cosmosGeoPoint":533,"geoPoint":537,"contacts":17},"University of Rochester - Cardiology CCTU","NOT_YET_RECRUITING","14642",{"type":81,"coordinates":534},[535,536],-77.61556,43.15478,{"lat":536,"lon":535},{"facility":539,"status":74,"city":540,"state":541,"zip":542,"country":78,"countryCode":79,"cosmosGeoPoint":543,"geoPoint":547,"contacts":17},"HCA Asheville Cardiology Associates","Asheville","North Carolina","28801",{"type":81,"coordinates":544},[545,546],-82.55402,35.60095,{"lat":546,"lon":545},{"facility":549,"status":74,"city":550,"state":541,"zip":551,"country":78,"countryCode":79,"cosmosGeoPoint":552,"geoPoint":556,"contacts":17},"Atrium Health - Sanger Heart","Charlotte","28210",{"type":81,"coordinates":553},[554,555],-80.84313,35.22709,{"lat":555,"lon":554},{"facility":558,"status":74,"city":559,"state":541,"zip":560,"country":78,"countryCode":79,"cosmosGeoPoint":561,"geoPoint":565,"contacts":17},"WakeMed","Raleigh","27610",{"type":81,"coordinates":562},[563,564],-78.63861,35.7721,{"lat":564,"lon":563},{"facility":567,"status":74,"city":568,"state":569,"zip":570,"country":78,"countryCode":79,"cosmosGeoPoint":571,"geoPoint":575,"contacts":17},"The Lindner Research Center","Cincinnati","Ohio","45219",{"type":81,"coordinates":572},[573,574],-84.51439,39.12711,{"lat":574,"lon":573},{"facility":577,"status":74,"city":578,"state":569,"zip":579,"country":78,"countryCode":79,"cosmosGeoPoint":580,"geoPoint":584,"contacts":17},"The Ohio State University","Columbus","43210",{"type":81,"coordinates":581},[582,583],-82.99879,39.96118,{"lat":583,"lon":582},{"facility":586,"status":74,"city":578,"state":569,"zip":587,"country":78,"countryCode":79,"cosmosGeoPoint":588,"geoPoint":590,"contacts":17},"OhioHealth Corporation","43214",{"type":81,"coordinates":589},[582,583],{"lat":583,"lon":582},{"facility":592,"status":74,"city":593,"state":594,"zip":595,"country":78,"countryCode":79,"cosmosGeoPoint":596,"geoPoint":600,"contacts":17},"University of Oklahoma","Oklahoma City","Oklahoma","73019",{"type":81,"coordinates":597},[598,599],-97.51643,35.46756,{"lat":599,"lon":598},{"facility":602,"status":74,"city":593,"state":594,"zip":603,"country":78,"countryCode":79,"cosmosGeoPoint":604,"geoPoint":606,"contacts":17},"Hightower Clinical Trials","73102",{"type":81,"coordinates":605},[598,599],{"lat":599,"lon":598},{"facility":608,"status":74,"city":593,"state":594,"zip":609,"country":78,"countryCode":79,"cosmosGeoPoint":610,"geoPoint":612,"contacts":17},"South Oklahoma Heart Research","73135",{"type":81,"coordinates":611},[598,599],{"lat":599,"lon":598},{"facility":614,"status":74,"city":615,"state":616,"zip":617,"country":78,"countryCode":79,"cosmosGeoPoint":618,"geoPoint":622,"contacts":17},"Penn Medicine at Doylestown Health Cardiology","Doylestown","Pennsylvania","18901",{"type":81,"coordinates":619},[620,621],-75.12989,40.31011,{"lat":621,"lon":620},{"facility":624,"status":74,"city":625,"state":616,"zip":626,"country":78,"countryCode":79,"cosmosGeoPoint":627,"geoPoint":631,"contacts":17},"Penn Medicine Lancaster General Health","Lancaster","17602",{"type":81,"coordinates":628},[629,630],-76.30551,40.03788,{"lat":630,"lon":629},{"facility":633,"status":74,"city":634,"state":616,"zip":635,"country":78,"countryCode":79,"cosmosGeoPoint":636,"geoPoint":640,"contacts":17},"Hospital of the University of Pennsylvania","Philadelphia","19104",{"type":81,"coordinates":637},[638,639],-75.16362,39.95238,{"lat":639,"lon":638},{"facility":642,"status":74,"city":634,"state":616,"zip":635,"country":78,"countryCode":79,"cosmosGeoPoint":643,"geoPoint":645,"contacts":17},"Penn Presbyterian Medical Center",{"type":81,"coordinates":644},[638,639],{"lat":639,"lon":638},{"facility":647,"status":74,"city":648,"state":649,"zip":650,"country":78,"countryCode":79,"cosmosGeoPoint":651,"geoPoint":655,"contacts":17},"Medical University of South Carolina","Charleston","South Carolina","29425",{"type":81,"coordinates":652},[653,654],-79.93275,32.77632,{"lat":654,"lon":653},{"facility":657,"status":74,"city":658,"state":659,"zip":660,"country":78,"countryCode":79,"cosmosGeoPoint":661,"geoPoint":665,"contacts":17},"Stern Cardiovascular Foundation, Inc.","Germantown","Tennessee","38138",{"type":81,"coordinates":662},[663,664],-89.81009,35.08676,{"lat":664,"lon":663},{"facility":667,"status":74,"city":668,"state":659,"zip":669,"country":78,"countryCode":79,"cosmosGeoPoint":670,"geoPoint":674,"contacts":17},"Ascension St. Thomas Hospital","Nashville","37203",{"type":81,"coordinates":671},[672,673],-86.78444,36.16589,{"lat":673,"lon":672},{"facility":676,"status":74,"city":677,"state":678,"zip":679,"country":78,"countryCode":79,"cosmosGeoPoint":680,"geoPoint":684,"contacts":17},"Ascension Seton","Austin","Texas","78723",{"type":81,"coordinates":681},[682,683],-97.74306,30.26715,{"lat":683,"lon":682},{"facility":686,"status":74,"city":687,"state":678,"zip":688,"country":78,"countryCode":79,"cosmosGeoPoint":689,"geoPoint":693,"contacts":17},"Baylor Scott & White Research Institute","Dallas","75204",{"type":81,"coordinates":690},[691,692],-96.80667,32.78306,{"lat":692,"lon":691},{"facility":695,"status":74,"city":696,"state":697,"zip":698,"country":78,"countryCode":79,"cosmosGeoPoint":699,"geoPoint":703,"contacts":17},"Centra Health dba Stroobants Cardiovascular Center","Lynchburg","Virginia","24501",{"type":81,"coordinates":700},[701,702],-79.14225,37.41375,{"lat":702,"lon":701},{"facility":705,"status":74,"city":706,"state":707,"zip":708,"country":78,"countryCode":79,"cosmosGeoPoint":709,"geoPoint":713,"contacts":17},"West Virginia University","Morgantown","West Virginia","26506",{"type":81,"coordinates":710},[711,712],-79.9559,39.62953,{"lat":712,"lon":711},{"facility":715,"status":74,"city":716,"state":717,"zip":718,"country":78,"countryCode":79,"cosmosGeoPoint":719,"geoPoint":723,"contacts":17},"Advocate Aurora Research Institute, LLC","Milwaukee","Wisconsin","53233",{"type":81,"coordinates":720},[721,722],-87.90647,43.0389,{"lat":722,"lon":721},{"facility":725,"status":531,"city":726,"state":727,"zip":728,"country":729,"countryCode":730,"cosmosGeoPoint":731,"geoPoint":735,"contacts":17},"Lyell McEwin Hospital","Elizabeth Vale","South Australia","5112","Australia","AU",{"type":81,"coordinates":732},[733,734],138.66819,-34.74857,{"lat":734,"lon":733},{"facility":737,"status":512,"city":738,"state":17,"zip":17,"country":739,"countryCode":740,"cosmosGeoPoint":741,"geoPoint":745,"contacts":17},"OLV Ziekenhuis","Aalst","Belgium","BE",{"type":81,"coordinates":742},[743,744],4.0355,50.93604,{"lat":744,"lon":743},{"facility":747,"status":74,"city":748,"state":17,"zip":17,"country":739,"countryCode":740,"cosmosGeoPoint":749,"geoPoint":753,"contacts":17},"Middelheim Ziekenhuis","Antwerp",{"type":81,"coordinates":750},[751,752],4.40026,51.22047,{"lat":752,"lon":751},{"facility":755,"status":74,"city":756,"state":17,"zip":17,"country":739,"countryCode":740,"cosmosGeoPoint":757,"geoPoint":761,"contacts":17},"Universite Libre de Bruxelles-Erasme Hospital","Brussels",{"type":81,"coordinates":758},[759,760],4.34878,50.85045,{"lat":760,"lon":759},{"facility":763,"status":512,"city":756,"state":17,"zip":17,"country":739,"countryCode":740,"cosmosGeoPoint":764,"geoPoint":766,"contacts":17},"UZ Brussel",{"type":81,"coordinates":765},[759,760],{"lat":760,"lon":759},{"facility":768,"status":74,"city":769,"state":17,"zip":17,"country":739,"countryCode":740,"cosmosGeoPoint":770,"geoPoint":774,"contacts":17},"UZ Leuven","Leuven",{"type":81,"coordinates":771},[772,773],4.70093,50.87959,{"lat":773,"lon":772},{"facility":776,"status":74,"city":777,"state":778,"zip":779,"country":780,"countryCode":781,"cosmosGeoPoint":782,"geoPoint":786,"contacts":17},"Nanjing Drum Tower Hospital","Nanjing","Jiangsu","210008","China","CN",{"type":81,"coordinates":783},[784,785],118.77778,32.06167,{"lat":785,"lon":784},{"facility":788,"status":74,"city":789,"state":17,"zip":17,"country":790,"countryCode":17,"cosmosGeoPoint":791,"geoPoint":795,"contacts":17},"Fakultní nemocnice Královské Vinohrady (FNKV)","Prague","Czechia",{"type":81,"coordinates":792},[793,794],14.42076,50.08804,{"lat":794,"lon":793},{"facility":797,"status":74,"city":789,"state":17,"zip":17,"country":790,"countryCode":17,"cosmosGeoPoint":798,"geoPoint":800,"contacts":17},"Institute for Clinical and Experimental Medicine (IKEM)",{"type":81,"coordinates":799},[793,794],{"lat":794,"lon":793},{"facility":802,"status":74,"city":789,"state":17,"zip":17,"country":790,"countryCode":17,"cosmosGeoPoint":803,"geoPoint":805,"contacts":17},"Na Homolce Hospital",{"type":81,"coordinates":804},[793,794],{"lat":794,"lon":793},{"facility":807,"status":74,"city":808,"state":17,"zip":17,"country":809,"countryCode":810,"cosmosGeoPoint":811,"geoPoint":815,"contacts":17},"CHU Grenoble","Grenoble","France","FR",{"type":81,"coordinates":812},[813,814],5.71479,45.17869,{"lat":814,"lon":813},{"facility":817,"status":74,"city":818,"state":17,"zip":17,"country":809,"countryCode":810,"cosmosGeoPoint":819,"geoPoint":823,"contacts":17},"Hospices Civils de Lyon (HCL)","Lyon",{"type":81,"coordinates":820},[821,822],4.84789,45.74906,{"lat":822,"lon":821},{"facility":825,"status":74,"city":826,"state":17,"zip":17,"country":809,"countryCode":810,"cosmosGeoPoint":827,"geoPoint":831,"contacts":17},"CHU de Nantes","Nantes",{"type":81,"coordinates":828},[829,830],-1.55336,47.21725,{"lat":830,"lon":829},{"facility":833,"status":74,"city":834,"state":17,"zip":17,"country":809,"countryCode":810,"cosmosGeoPoint":835,"geoPoint":839,"contacts":17},"AP-HP Hôpital Pitié Salpêtrière","Paris",{"type":81,"coordinates":836},[837,838],2.3488,48.85341,{"lat":838,"lon":837},{"facility":841,"status":74,"city":842,"state":17,"zip":17,"country":809,"countryCode":810,"cosmosGeoPoint":843,"geoPoint":847,"contacts":17},"CHRU Tours","Tours",{"type":81,"coordinates":844},[845,846],0.70398,47.39484,{"lat":846,"lon":845},{"facility":849,"status":74,"city":850,"state":17,"zip":17,"country":851,"countryCode":852,"cosmosGeoPoint":853,"geoPoint":857,"contacts":17},"Universitätsmedizin Berlin, Deutsches Herzzentrum der Charité (DHZC)","Berlin","Germany","DE",{"type":81,"coordinates":854},[855,856],13.41053,52.52437,{"lat":856,"lon":855},{"facility":859,"status":74,"city":860,"state":17,"zip":17,"country":851,"countryCode":852,"cosmosGeoPoint":861,"geoPoint":865,"contacts":17},"Herzzentrum Bonn am Universitätsklinikum Bonn","Bonn",{"type":81,"coordinates":862},[863,864],7.09549,50.73438,{"lat":864,"lon":863},{"facility":867,"status":74,"city":868,"state":17,"zip":17,"country":851,"countryCode":852,"cosmosGeoPoint":869,"geoPoint":873,"contacts":17},"Cardioangiologisches Centrum Bethanien (CCB) am AGAPLESION Markus Krankenhaus","Frankfurt",{"type":81,"coordinates":870},[871,872],10.53333,49.68333,{"lat":872,"lon":871},{"facility":875,"status":74,"city":876,"state":17,"zip":17,"country":851,"countryCode":852,"cosmosGeoPoint":877,"geoPoint":881,"contacts":17},"Universitätsklinikum Hamburg-Eppendorf","Hamburg",{"type":81,"coordinates":878},[879,880],9.99302,53.55073,{"lat":880,"lon":879},{"facility":883,"status":531,"city":884,"state":17,"zip":17,"country":851,"countryCode":852,"cosmosGeoPoint":885,"geoPoint":889,"contacts":17},"Herzzentrum Leipzig","Leipzig",{"type":81,"coordinates":886},[887,888],12.37129,51.33962,{"lat":888,"lon":887},{"facility":891,"status":74,"city":892,"state":17,"zip":17,"country":851,"countryCode":852,"cosmosGeoPoint":893,"geoPoint":897,"contacts":17},"University Hospital Luebeck","Lübeck",{"type":81,"coordinates":894},[895,896],10.68729,53.86893,{"lat":896,"lon":895},{"facility":899,"status":74,"city":900,"state":17,"zip":17,"country":851,"countryCode":852,"cosmosGeoPoint":901,"geoPoint":905,"contacts":17},"University Medical Centre Mannheim","Mannheim",{"type":81,"coordinates":902},[903,904],8.46694,49.4891,{"lat":904,"lon":903},{"facility":907,"status":74,"city":908,"state":17,"zip":17,"country":851,"countryCode":852,"cosmosGeoPoint":909,"geoPoint":913,"contacts":17},"Saarland University Hospital","Saarbrücken",{"type":81,"coordinates":910},[911,912],7.00982,49.23262,{"lat":912,"lon":911},{"facility":915,"status":74,"city":916,"state":17,"zip":17,"country":851,"countryCode":852,"cosmosGeoPoint":917,"geoPoint":921,"contacts":17},"Krankenhaus der Barmherzigen Brüder Trier","Trier",{"type":81,"coordinates":918},[919,920],6.63935,49.75565,{"lat":920,"lon":919},{"facility":923,"status":74,"city":924,"state":17,"zip":17,"country":925,"countryCode":926,"cosmosGeoPoint":927,"geoPoint":931,"contacts":17},"Central Hospital of Northern Pest - Military Hospital","Budapest","Hungary","HU",{"type":81,"coordinates":928},[929,930],19.04045,47.49835,{"lat":930,"lon":929},{"facility":933,"status":74,"city":924,"state":17,"zip":17,"country":925,"countryCode":926,"cosmosGeoPoint":934,"geoPoint":936,"contacts":17},"Semmelweis University",{"type":81,"coordinates":935},[929,930],{"lat":930,"lon":929},{"facility":938,"status":74,"city":939,"state":17,"zip":17,"country":925,"countryCode":926,"cosmosGeoPoint":940,"geoPoint":944,"contacts":17},"University of Debrecen","Debrecen",{"type":81,"coordinates":941},[942,943],21.62444,47.53167,{"lat":943,"lon":942},{"facility":946,"status":74,"city":947,"state":17,"zip":17,"country":925,"countryCode":926,"cosmosGeoPoint":948,"geoPoint":952,"contacts":17},"University of Szeged","Szeged",{"type":81,"coordinates":949},[950,951],20.14824,46.253,{"lat":951,"lon":950},{"facility":954,"status":74,"city":955,"state":17,"zip":17,"country":956,"countryCode":957,"cosmosGeoPoint":958,"geoPoint":962,"contacts":17},"Policlinico Di Sant Orsola Malpighi","Bologna","Italy","IT",{"type":81,"coordinates":959},[960,961],11.33875,44.49381,{"lat":961,"lon":960},{"facility":964,"status":74,"city":965,"state":17,"zip":17,"country":956,"countryCode":957,"cosmosGeoPoint":966,"geoPoint":970,"contacts":17},"Campus Bio-Medico University Hospital","Rome",{"type":81,"coordinates":967},[968,969],12.51133,41.89193,{"lat":969,"lon":968},{"facility":972,"status":74,"city":973,"state":17,"zip":17,"country":956,"countryCode":957,"cosmosGeoPoint":974,"geoPoint":978,"contacts":17},"Azienda Ospedaliera Universitaria Integrata Verona","Verona",{"type":81,"coordinates":975},[976,977],10.9938,45.43854,{"lat":977,"lon":976},{"facility":980,"status":74,"city":973,"state":17,"zip":17,"country":956,"countryCode":957,"cosmosGeoPoint":981,"geoPoint":983,"contacts":17},"IRCCS Sacro Cuore Don Calabria",{"type":81,"coordinates":982},[976,977],{"lat":977,"lon":976},{"facility":985,"status":74,"city":986,"state":17,"zip":17,"country":987,"countryCode":988,"cosmosGeoPoint":989,"geoPoint":993,"contacts":17},"Amsterdam University Medical Centre","Amsterdam","Netherlands","NL",{"type":81,"coordinates":990},[991,992],4.88969,52.37403,{"lat":992,"lon":991},{"facility":995,"status":74,"city":996,"state":17,"zip":17,"country":987,"countryCode":988,"cosmosGeoPoint":997,"geoPoint":1001,"contacts":17},"Maastricht UMC+","Maastricht",{"type":81,"coordinates":998},[999,1000],5.68889,50.84833,{"lat":1000,"lon":999},{"facility":1003,"status":74,"city":1004,"state":17,"zip":17,"country":987,"countryCode":988,"cosmosGeoPoint":1005,"geoPoint":1009,"contacts":17},"Isala Klinieken","Zwolle",{"type":81,"coordinates":1006},[1007,1008],6.09444,52.5125,{"lat":1008,"lon":1007},{"facility":1011,"status":531,"city":1012,"state":1013,"zip":1014,"country":1015,"countryCode":1016,"cosmosGeoPoint":1017,"geoPoint":1021,"contacts":17},"ChristChurch Hospital","Christchurch","Canterbury","8140","New Zealand","NZ",{"type":81,"coordinates":1018},[1019,1020],172.63333,-43.53333,{"lat":1020,"lon":1019},{"facility":1023,"status":74,"city":1024,"state":17,"zip":17,"country":1025,"countryCode":1026,"cosmosGeoPoint":1027,"geoPoint":1031,"contacts":17},"Górnośląskie Centrum Medyczne im prof Leszka Gieca Śląskiego Uniwersytetu Medycznego w Katowicach","Katowice","Poland","PL",{"type":81,"coordinates":1028},[1029,1030],19.02173,50.2597,{"lat":1030,"lon":1029},{"facility":1033,"status":74,"city":1034,"state":17,"zip":17,"country":1025,"countryCode":1026,"cosmosGeoPoint":1035,"geoPoint":1039,"contacts":17},"Jagiellonian University Hospital","Krakow",{"type":81,"coordinates":1036},[1037,1038],19.93658,50.06143,{"lat":1038,"lon":1037},{"facility":1041,"status":531,"city":1042,"state":17,"zip":17,"country":1025,"countryCode":1026,"cosmosGeoPoint":1043,"geoPoint":1047,"contacts":17},"Centralny Szpital Kliniczny Uniwersytetu Medycznego w Łodzi","Lodz",{"type":81,"coordinates":1044},[1045,1046],19.47395,51.77058,{"lat":1046,"lon":1045},{"facility":1049,"status":74,"city":1050,"state":17,"zip":17,"country":1025,"countryCode":1026,"cosmosGeoPoint":1051,"geoPoint":1055,"contacts":17},"Wojewódzki Szpital Specjalistyczny im. Stefana Kardynała Wyszyńskiego","Lublin",{"type":81,"coordinates":1052},[1053,1054],22.57009,51.25058,{"lat":1054,"lon":1053},{"facility":1057,"status":74,"city":1058,"state":17,"zip":17,"country":1025,"countryCode":1026,"cosmosGeoPoint":1059,"geoPoint":1063,"contacts":17},"Uniwersytecki Szpital Kliniczny w Poznaniu","Poznan",{"type":81,"coordinates":1060},[1061,1062],16.92993,52.40692,{"lat":1062,"lon":1061},{"facility":1065,"status":74,"city":1066,"state":17,"zip":17,"country":1025,"countryCode":1026,"cosmosGeoPoint":1067,"geoPoint":1071,"contacts":17},"Uniwersytecki Szpital Kliniczny nr 2 PUM","Szczecin",{"type":81,"coordinates":1068},[1069,1070],14.55302,53.42894,{"lat":1070,"lon":1069},{"facility":1073,"status":74,"city":1074,"state":17,"zip":17,"country":1025,"countryCode":1026,"cosmosGeoPoint":1075,"geoPoint":1079,"contacts":17},"Uniwersyteckie Centrum Kliniczne Warszawskiego Uniwersytetu Medycznego","Warsaw",{"type":81,"coordinates":1076},[1077,1078],21.01178,52.22977,{"lat":1078,"lon":1077},{"facility":1081,"status":74,"city":1082,"state":17,"zip":17,"country":1025,"countryCode":1026,"cosmosGeoPoint":1083,"geoPoint":1087,"contacts":17},"Uniwersytecki Szpital Kliniczny im. Jana Mikulicza-Radeckiego we Wrocławiu","Wroclaw",{"type":81,"coordinates":1084},[1085,1086],17.03006,51.10286,{"lat":1086,"lon":1085},{"facility":1089,"status":74,"city":1090,"state":17,"zip":17,"country":1025,"countryCode":1026,"cosmosGeoPoint":1091,"geoPoint":1095,"contacts":17},"Silesian Center for Heart Diseases","Zabrze",{"type":81,"coordinates":1092},[1093,1094],18.78576,50.32492,{"lat":1094,"lon":1093},{"facility":1097,"status":74,"city":1098,"state":17,"zip":17,"country":1099,"countryCode":1100,"cosmosGeoPoint":1101,"geoPoint":1105,"contacts":17},"Hospital Germans Trias i Pujol","Badalona","Spain","ES",{"type":81,"coordinates":1102},[1103,1104],2.24741,41.45004,{"lat":1104,"lon":1103},{"facility":1107,"status":74,"city":1108,"state":17,"zip":17,"country":1099,"countryCode":1100,"cosmosGeoPoint":1109,"geoPoint":1113,"contacts":17},"Hospital Clínico de Barcelona","Barcelona",{"type":81,"coordinates":1110},[1111,1112],2.15899,41.38879,{"lat":1112,"lon":1111},{"facility":1115,"status":74,"city":1116,"state":17,"zip":17,"country":1099,"countryCode":1100,"cosmosGeoPoint":1117,"geoPoint":1121,"contacts":17},"La Paz University Hospital","Madrid",{"type":81,"coordinates":1118},[1119,1120],-3.70256,40.4165,{"lat":1120,"lon":1119},{"facility":1123,"status":74,"city":1124,"state":17,"zip":17,"country":1099,"countryCode":1100,"cosmosGeoPoint":1125,"geoPoint":1129,"contacts":17},"Hospital Universitario Nuestra Señora de Candelaria","Santa Cruz de Tenerife",{"type":81,"coordinates":1126},[1127,1128],-16.25462,28.46824,{"lat":1128,"lon":1127},{"facility":1131,"status":74,"city":1132,"state":17,"zip":17,"country":1133,"countryCode":1134,"cosmosGeoPoint":1135,"geoPoint":1139,"contacts":17},"Universitaetsspital Basel","Basel","Switzerland","CH",{"type":81,"coordinates":1136},[1137,1138],7.57327,47.55839,{"lat":1138,"lon":1137},{"facility":1141,"status":74,"city":1142,"state":17,"zip":17,"country":1133,"countryCode":1134,"cosmosGeoPoint":1143,"geoPoint":1147,"contacts":17},"Universitaetsspital Bern","Bern",{"type":81,"coordinates":1144},[1145,1146],7.44744,46.94809,{"lat":1146,"lon":1145},{"facility":1149,"status":74,"city":1150,"state":17,"zip":17,"country":1133,"countryCode":1134,"cosmosGeoPoint":1151,"geoPoint":1155,"contacts":17},"Hôpitaux Universitaires de Genève","Geneva",{"type":81,"coordinates":1152},[1153,1154],6.14569,46.20222,{"lat":1154,"lon":1153},{"facility":1157,"status":74,"city":1158,"state":17,"zip":17,"country":1133,"countryCode":1134,"cosmosGeoPoint":1159,"geoPoint":1163,"contacts":17},"Cardiocentro Ticino Lugano","Lugano",{"type":81,"coordinates":1160},[1161,1162],8.96004,46.01008,{"lat":1162,"lon":1161},{"facility":1165,"status":74,"city":1166,"state":17,"zip":17,"country":1167,"countryCode":1168,"cosmosGeoPoint":1169,"geoPoint":1173,"contacts":17},"Royal Brompton","London","United Kingdom","UK",{"type":81,"coordinates":1170},[1171,1172],-0.12574,51.50853,{"lat":1172,"lon":1171},{"facility":1175,"status":74,"city":1166,"state":17,"zip":17,"country":1167,"countryCode":1168,"cosmosGeoPoint":1176,"geoPoint":1178,"contacts":17},"St. Bartholomew's Hospital",{"type":81,"coordinates":1177},[1171,1172],{"lat":1172,"lon":1171},{"facility":1180,"status":74,"city":1166,"state":17,"zip":17,"country":1167,"countryCode":1168,"cosmosGeoPoint":1181,"geoPoint":1183,"contacts":17},"St. Thomas Hospital",{"type":81,"coordinates":1182},[1171,1172],{"lat":1172,"lon":1171},{"facility":1185,"status":74,"city":1186,"state":17,"zip":17,"country":1167,"countryCode":1168,"cosmosGeoPoint":1187,"geoPoint":1191,"contacts":17},"John Radcliffe Hospital","Oxford",{"type":81,"coordinates":1188},[1189,1190],-1.25596,51.75222,{"lat":1190,"lon":1189},{"facility":1193,"status":74,"city":1194,"state":17,"zip":17,"country":1167,"countryCode":1168,"cosmosGeoPoint":17,"geoPoint":17,"contacts":17},"Southampton General Hospital","Southhampton",{"type":1196,"investigatorFullName":17,"investigatorTitle":17,"investigatorAffiliation":17,"oldNameTitle":17,"oldOrganization":17},"SPONSOR",[1198],{"name":1199,"class":6},"Medtronic","100520674","bradycardia-pacemaker-with-av-interval-modulation-for-blood-pressure-treatment-100520674",false,"NCT06059638","BradycArdia paCemaKer With AV Interval Modulation for Blood prEssure treAtmenT","BACKBEAT","Inclusion Criteria:\n\n1. Patient has or is indicated for a dual-chamber pacemaker. Visit 1 can be performed within 30 days prior to a planned implant of a Medtronic Astra\u002FAzure dual-chamber pacemaker system or at any time thereafter\n2. On a stable antihypertension treatment regimen with at least 1 class of antihypertensive drug\n3. Office SBP ≥135 mmHg and \\\u003C180 mmHg\n4. Average 24-Hour aSBP ≥130 mmHg and \\\u003C170 mmHg\n\nExclusion Criteria:\n\n1. LVEF \\\u003C50%\n2. NYHA Class III-IV\n3. History of cerebrovascular accident (CVA) or transient ischemic attack (TIA) within 6 months\n4. Myocardial infarction (MI) within 3 months\n5. Prior percutaneous or surgical coronary, carotid, or endovascular intervention within 3 months\n6. Permanent atrial fibrillation\n7. Mitral valve regurgitation greater than or equal to grade 3\n8. Aortic stenosis with a valve area less than 1.5 cm2\n9. Has an active or prior device-based anti-hypertensive treatment (e.g., renal denervation procedure, baroreflex activation therapy)\n10. Has an existing active cardiac device or neurostimulator other than the recent Astra\u002FAzure pacemaker implant","ALL","18 Years",{"count":1210,"type":1211},500,"ESTIMATED","INTERVENTIONAL",[1214],"NA","A prospective, multinational, randomized, double-blind, clinical trial evaluating the safety and effectiveness of a novel atrioventricular interval modulation (AVIM) algorithm downloaded into a dual-chamber Medtronic Astra\u002FAzure pacemaker.",[1217,1218,1219],"Hypertension","Hypertension, Systolic","Hypertension, Essential","2026-08-24",{"date":1222,"type":1223},"2026-08-25","ACTUAL",{"date":1225,"type":1223},"2023-12-27",{"date":1227,"type":1211},"2029-08",{"name":5,"class":6},130]