[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100080584":3},{"organization":4,"armGroups":7,"interventions":7,"overallOfficials":8,"centralContacts":16,"locations":22,"responsibleParty":45,"collaborators":47,"id":52,"slug":53,"hasResults":54,"nctId":55,"briefTitle":56,"officialTitle":57,"acronym":7,"eligibilityCriteria":58,"healthyVolunteers":54,"sex":59,"minAge":7,"maxAge":7,"enrollmentInfo":60,"targetDuration":7,"studyType":63,"phases":7,"briefSummary":64,"conditions":65,"keywords":68,"overallStatus":25,"whyStopped":7,"lastUpdateSubmitDate":80,"lastUpdatePostDateStruct":81,"startDateStruct":84,"completionDateStruct":86,"leadSponsor":88,"locationsCount":89},{"fullName":5,"class":6},"University of California, San Francisco","OTHER",null,[9,12,14],{"name":10,"affiliation":5,"role":11},"Elliott H Sherr, MD, PhD","PRINCIPAL_INVESTIGATOR",{"name":13,"affiliation":5,"role":11},"James Barkovich, MD",{"name":15,"affiliation":5,"role":11},"Pratik Mukherjee, MD, PhD",[17],{"name":18,"role":19,"phone":20,"phoneExt":7,"email":21},"Carolyn Le, BA, BS","CONTACT","415-502-8039","Carolyn.Le@ucsf.edu",[23],{"facility":24,"status":25,"city":26,"state":27,"zip":28,"country":29,"countryCode":30,"cosmosGeoPoint":31,"geoPoint":36,"contacts":37},"University of California, San francisco","RECRUITING","San Francisco","California","94143","United States","US",{"type":32,"coordinates":33},"Point",[34,35],-122.41942,37.77493,{"lat":35,"lon":34},[38,41,43],{"name":39,"role":40,"phone":7,"phoneExt":7,"email":7},"Anne Slavotinek, MD","SUB_INVESTIGATOR",{"name":42,"role":40,"phone":7,"phoneExt":7,"email":7},"Elysa Marco, MD",{"name":44,"role":40,"phone":7,"phoneExt":7,"email":7},"Rita J Jeremy, PhD",{"type":46,"investigatorFullName":7,"investigatorTitle":7,"investigatorAffiliation":7,"oldNameTitle":7,"oldOrganization":7},"SPONSOR",[48,50],{"name":49,"class":6},"University of Washington",{"name":51,"class":6},"California Institute of Technology","100080584","brain-development-research-program-100080584",false,"NCT00305305","Brain Development Research Program","Disorders of Cerebral Development: A Phenotypic and Genetic Analysis","Inclusion Criteria:\n\n* Clinical diagnosis of agenesis or dysgenesis of the corpus callosum, polymicrogyria, or Dandy-Walker malformation\n* Should be confirmed by an MRI (Magnetic Resonance Imaging) of the brain\n\nExclusion Criteria:\n\n* Fully formed but hypoplastic corpus callosum","ALL",{"count":61,"type":62},2000,"ESTIMATED","OBSERVATIONAL","Dr. Elliott Sherr and his collaborators at University of California, San Francisco (UCSF) are studying the genetic causes of disorders of cognition and epilepsy, in particular disorders of brain development that affect the corpus callosum, such as Aicardi syndrome, as well as two additional brain malformations, polymicrogyria and Dandy-Walker malformation. The goal of the investigators' research is to use a better understanding of the underlying genetic causes as a foundation to develop better treatments for these groups of patients.",[66,67],"Brain Disorders","Aicardi Syndrome",[69,70,71,72,73,74,75,76,77,78,79],"Agenesis Corpus Callosum","Polymicrogyria","Dandy-Walker","Brain Malformation","Autism","Epilepsy","Mental Retardation","MRI","Agenesis of the Corpus Callosum (complete or partial)","Confirmed by a brain MRI.","Aicardi Syndrome.","2026-08-13",{"date":82,"type":83},"2026-08-17","ACTUAL",{"date":85,"type":83},"2003-08",{"date":87,"type":62},"2027-01",{"name":5,"class":6},1]