[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100651587":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":31,"centralContacts":35,"locations":43,"responsibleParty":61,"collaborators":26,"id":63,"slug":64,"hasResults":65,"nctId":66,"briefTitle":67,"officialTitle":68,"acronym":26,"eligibilityCriteria":69,"healthyVolunteers":70,"sex":71,"minAge":72,"maxAge":26,"enrollmentInfo":73,"targetDuration":26,"studyType":76,"phases":77,"briefSummary":79,"conditions":80,"keywords":83,"overallStatus":46,"whyStopped":26,"lastUpdateSubmitDate":92,"lastUpdatePostDateStruct":93,"startDateStruct":96,"completionDateStruct":98,"leadSponsor":100,"locationsCount":101},{"fullName":5,"class":6},"General Neuro Inc.","INDUSTRY",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Active Stimulation","EXPERIMENTAL","Participants receive active transcranial electrical stimulation delivered through a non-invasive scalp-mounted headset while completing structured language-learning content. Stimulation amplitude and session duration are selected per cohort from the declared parameter envelope, with current ramping at session start and end. Sessions are typically 20 to 30 minutes.",[13],"Device: Active transcranial electrical stimulation (tES)",{"label":15,"type":16,"description":17,"interventionNames":18},"Sham Stimulation","SHAM_COMPARATOR","Participants receive sham stimulation through the same non-invasive scalp-mounted headset while completing the same structured language-learning content. Sham provides the sensory experience of stimulation onset without sustained current delivery. The specific validated sham approach is selected and documented per cohort.",[19],"Device: Sham transcranial electrical stimulation (tES)",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DEVICE","Active transcranial electrical stimulation (tES)","Non-invasive transcranial electrical stimulation delivered by a scalp-mounted headset within the LOTES-2023 limited-output envelope, paired with structured language-learning content. Adult declared range 0 to 4 mA average absolute current, maximum current density 2 mA\u002Fcm2 at the electrode contact area, and maximum session duration 60 minutes subject to a 6000 mC per-session total charge limit. Electrodes are placed in standard cephalic or extracephalic montages targeting the left perisylvian region and adjacent association cortex.",[9],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"Sham transcranial electrical stimulation (tES)","Sham stimulation delivered by the same scalp-mounted headset, providing the initial cutaneous sensory experience of stimulation onset without sustained current delivery, paired with the same structured language-learning content. The specific validated sham approach is selected per cohort and documented in the corresponding cohort plan.",[15],[32],{"name":33,"affiliation":5,"role":34},"Alec Sheffield, PhD","PRINCIPAL_INVESTIGATOR",[36,40],{"name":33,"role":37,"phone":38,"phoneExt":26,"email":39},"CONTACT","617-657-3348","alec@generalneuro.com",{"name":41,"role":37,"phone":26,"phoneExt":26,"email":42},"Luke Knoble","luke@generalneuro.com",[44],{"facility":45,"status":46,"city":47,"state":48,"zip":49,"country":50,"countryCode":51,"cosmosGeoPoint":52,"geoPoint":57,"contacts":58},"General Neuro, Inc.","RECRUITING","Boston","Massachusetts","02131","United States","US",{"type":53,"coordinates":54},"Point",[55,56],-71.05977,42.35843,{"lat":56,"lon":55},[59],{"name":33,"role":37,"phone":38,"phoneExt":26,"email":60},"info@generalneuro.com",{"type":62,"investigatorFullName":26,"investigatorTitle":26,"investigatorAffiliation":26,"oldNameTitle":26,"oldOrganization":26},"SPONSOR","100651587","brain-stimulation-paired-with-structured-language-learning-in-adults-100651587",false,"NCT07762118","Brain Stimulation Paired With Structured Language Learning in Adults","A Study of Transcranial Electrical Stimulation (tES) Paired With Structured Learning Protocols for Accelerated Skill Acquisition: Sub-Protocol A (Adult Language Learning)","Inclusion Criteria:\n\n* Adults aged 18 years or older\n* Able to understand the consent materials and the informed consent process in English, or in another language for which an IRB-approved consent form is available\n* Willing and able to participate in structured language-learning activities for the duration of the intervention period\n* Able to provide written informed consent\n\nExclusion Criteria:\n\n* History of epilepsy or any seizure disorder\n* Active skin disease, open wounds, or significant skin irritation at electrode contact sites\n* Implanted electronic medical devices where stimulation would be contraindicated per device manufacturer guidance or investigator judgment after individual risk assessment\n* Significant cognitive impairment that would interfere with informed consent or study participation\n* Any other condition that, in the investigator's judgment, would compromise participant safety or the integrity of the study data",true,"ALL","18 Years",{"count":74,"type":75},60,"ESTIMATED","INTERVENTIONAL",[78],"NA","This study investigates whether transcranial electrical stimulation (tES) delivered during structured language-learning sessions affects the rate and quality of second-language acquisition in adults.\n\nAdults who are learning or planning to learn a new language are randomly assigned in equal numbers to receive either active stimulation or sham (placebo) stimulation while completing structured language-learning content. Participants wear a non-invasive transcranial electrical stimulation headset that delivers a low-level electrical current through electrodes resting on the scalp, targeting cortical regions associated with language. Sessions typically last 20 to 30 minutes and may be completed at home or in person at a participating language program.\n\nLanguage proficiency is measured with a standardized assessment before and after the intervention period, with additional app-derived performance metrics and participant-reported measures collected throughout. A follow-up assessment may be conducted up to 12 months after the intervention ends to evaluate whether any observed effects persist.\n\nIn this study the device is applied as a learning aid in healthy adults. It is not used to diagnose, treat, cure, or prevent any disease.",[81,82],"Language Development","Learning",[84,85,86,87,88,89,90,91],"transcranial electrical stimulation","tES","transcranial direct current stimulation","tDCS","second language acquisition","language learning","neuromodulation","healthy volunteers","2026-08-07",{"date":94,"type":95},"2026-08-13","ACTUAL",{"date":97,"type":75},"2026-09-01",{"date":99,"type":75},"2032-06-01",{"name":5,"class":6},1]