[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100614164":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":21,"centralContacts":25,"locations":34,"responsibleParty":49,"collaborators":53,"id":57,"slug":58,"hasResults":59,"nctId":60,"briefTitle":61,"officialTitle":62,"acronym":20,"eligibilityCriteria":63,"healthyVolunteers":64,"sex":65,"minAge":66,"maxAge":67,"enrollmentInfo":68,"targetDuration":20,"studyType":71,"phases":72,"briefSummary":74,"conditions":75,"keywords":77,"overallStatus":37,"whyStopped":20,"lastUpdateSubmitDate":79,"lastUpdatePostDateStruct":80,"startDateStruct":83,"completionDateStruct":85,"leadSponsor":87,"locationsCount":88},{"fullName":5,"class":6},"University of Pittsburgh","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Healthy subjects and CNVS subjects","EXPERIMENTAL","Subjects without gastric problems and subjects with Chronic Nausea and Vomiting (CNVS)",[13],"Device: Transcranial Magnetic Stimulation, TMS",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":20},"DEVICE","Transcranial Magnetic Stimulation, TMS","The best location for evoking an electromyographic (EMG) response of the first dorsal interosseus (FDI) muscle in left and right hand to stimulation of the primary (M1) motor cortex and the minimum stimulation intensity required to evoke a certain EMG response amplitude (Motor Threshold, MT) are determined. This serves as a reference to determine the best location and stimulation parameters to evoke GMEPs from M1 and pre-motor cortical areas.\n\nAfter identification of the GMEP hot-spot, a stomach filling task (water load test or test meal) is administered and changes in the electrogastrogram (EGG) are monitored.\n\nIn subsequent study visits, the stomach filling task is preceded by application of neuromodulatory repetitive TMS (rTMS), targeted to the GMEP hotspot.",[9],null,[22],{"name":23,"affiliation":5,"role":24},"David J Levinthal, MD PhD","PRINCIPAL_INVESTIGATOR",[26,31],{"name":27,"role":28,"phone":29,"phoneExt":20,"email":30},"Elijah D Wright","CONTACT","412-647-1228","edw87@pitt.edu",{"name":23,"role":28,"phone":32,"phoneExt":20,"email":33},"412-303-0525","levinthald@upmc.edu",[35],{"facility":36,"status":37,"city":38,"state":39,"zip":40,"country":41,"countryCode":42,"cosmosGeoPoint":43,"geoPoint":48,"contacts":20},"University of Pittsburgh Medical Center","RECRUITING","Pittsburgh","Pennsylvania","15232","United States","US",{"type":44,"coordinates":45},"Point",[46,47],-79.99589,40.44062,{"lat":47,"lon":46},{"type":50,"investigatorFullName":51,"investigatorTitle":52,"investigatorAffiliation":5,"oldNameTitle":20,"oldOrganization":20},"SPONSOR_INVESTIGATOR","David Levinthal","Associate Professor",[54],{"name":55,"class":56},"National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)","NIH","100614164","brain-stomach-circuits-in-chronic-nausea-100614164",false,"NCT07276035","Brain-Stomach Circuits in Chronic Nausea","TMS Neuromodulation of Brain-to-Stomach Circuits in Chronic Nausea","Inclusion Criteria:\n\n* Adults between ages 21-60 years old, with and without CNVS diagnosis per self-report.\n\nExclusion Criteria:\n\n* body mass index (BMI) \\> 30\n* pregnancy or intention to become pregnant\n* past or present chemotherapy\n* diagnosis of gastric (stomach) cancer\n* any kind of gastric (stomach) surgery\n* current use of GLP-1 receptor agonists (e.g. Ozempic, Trulicity)\n* medications which significantly lower seizure thresholds (e.g. bupropion (Wellbutrin), fluoxetine (Prozac), or tramadol (Ultram))\n* implantable devices, such as a pacemakers or nerve stimulators\n* history of head injury that required hospitalization, metal in the skull, or neurologic disease such as stroke, history of seizures or history of syncope (fainting or passing out)\n* neurodegenerative disease (Multiple Sclerosis, Parkinson's or Alzheimer's Disease)\n* ongoing psychosis or altered cognitive status status (e.g. hearing sounds or seeing visions that are not there, or feeling confused or suffering from memory lapses)\n* history of cardiovascular (i.e., heart attack), pulmonary (i.e., need for supplemental oxygen), or endocrine disease (e.g. diabetes)\n* current enrollment in another study using Transcranial Magnetic Stimulation (TMS)\n* current use of drugs such as amphetamines, methamphetamine, Ecstasy, Ketamine, Angel Dust\u002FPCP, cocaine, or drinking 3 or more alcoholic drinks per day\n* For healthy subjects only: chronic history of gastrointestinal symptoms (e.g., nausea, indigestion, bloating, abdominal pain)\n* For CNVS subjects only: diagnosis of gastric motility disorder (e.g. gastroparesis\u002Fslow stomach emptying) or history of bowel obstruction (i.e., chronic partial small bowel obstruction)",true,"ALL","21 Years","60 Years",{"count":69,"type":70},219,"ESTIMATED","INTERVENTIONAL",[73],"NA","The goal of this study is to determine whether stimulation of the brain-stomach connection can influence stomach activity in healthy adults and in individuals suffering from chronic nausea. The main questions it aims to answer are:\n\n* What are the best brain sites to influence the stomach?\n* What are the effects of different stimulation patterns on stomach activity?\n* Does the stimulation affect the sensation of nausea in participants suffering from chronic nausea?\n\nResearchers will use a non-invasive method of brain stimulation called Transcranial Magnetic Stimulation (TMS) and will record stomach responses with skin electrodes on the abdomen.\n\nParticipants will:\n\n* Visit the clinic at least once, and for up to 9 times more over the course of several months.\n* Receive TMS while sitting in a chair similar to a dentist's chair.\n* Drink water or consume a test meal during each study visit.",[76],"Chronic Nausea and Vomiting Syndrome",[78],"Chronic unexplained nausea and vomiting","2026-07-22",{"date":81,"type":82},"2026-07-24","ACTUAL",{"date":84,"type":82},"2026-01-28",{"date":86,"type":70},"2031-07",{"name":51,"class":6},1]