[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100647926":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":24,"centralContacts":28,"locations":34,"responsibleParty":123,"collaborators":125,"id":142,"slug":143,"hasResults":144,"nctId":145,"briefTitle":146,"officialTitle":146,"acronym":147,"eligibilityCriteria":148,"healthyVolunteers":144,"sex":149,"minAge":150,"maxAge":10,"enrollmentInfo":151,"targetDuration":10,"studyType":154,"phases":10,"briefSummary":155,"conditions":156,"keywords":164,"overallStatus":172,"whyStopped":10,"lastUpdateSubmitDate":173,"lastUpdatePostDateStruct":174,"startDateStruct":177,"completionDateStruct":179,"leadSponsor":181,"locationsCount":182},{"fullName":5,"class":6},"Imperial College London","OTHER",[8,12,15,18,21],{"label":9,"type":10,"description":11,"interventionNames":10},"Oesophagogastric Arm",null,"Cases will be patients with histology-confirmed, treatment naïve oesophageal (OAC) or gastric adenocarcinoma (GAC) and controls will be patients who have a normal upper GI tract or benign condition as diagnosed on the reference test (upper GI endoscopy). All eligible patients will be invited to participate.\n\nParticipants will attend a one off research visit, after having fasted for 6 hours (water permitted) and sign a consent form. They will rinse their mouth with water, provide a baseline breath sample and consume an oral stimulant drink (a nutrient supplement). A further breath sample will be collected after 15 minutes, and an additional environment sample will also be collected.\n\nParticipants will answer questions about their medical and drug history.",{"label":13,"type":10,"description":14,"interventionNames":10},"Oesophageal SCC Arm","Cases will be patients with histology-confirmed, treatment naive Oesophageal Squamous Cell Carcinoma (OSCC) and controls will be patients who have a normal upper GI tract or benign condition as diagnosed on the reference test (upper GI endoscopy). All eligible patients will be invited to participate.\n\nParticipants will attend a one-off research visit, after having fasted for 6 hours (water permitted) and sign a consent form. They will rinse their mouth with water and provide a breath sample. An additional environment sample will also be collected.\n\nParticipants will answer questions about their medical and drug history.",{"label":16,"type":10,"description":17,"interventionNames":10},"Pancreatic Arm","Cases will be patients with histology-confirmed, treatment naïve pancreatic ductal adenocarcinoma (PDAC) and controls will be patients with non-specific abdominal symptoms and a radiologically-normal pancreas as diagnosed on the reference test (ultrasound, MRI, CT, PET-CT and endoscopic ultrasound). All eligible patients will be invited to participate.\n\nParticipants will attend a one-off research visit, after having fasted for 6 hours (water permitted) and sign a consent form. They will rinse their mouth with water and provide a breath sample. An additional environment sample will also be collected.\n\nParticipants will answer questions about their medical and drug history.",{"label":19,"type":10,"description":20,"interventionNames":10},"Liver Arm","Cases will be patients with histology-confirmed, treatment naïve hepatocellular carcinoma (HCC) and cholangiocarcinoma (CCC) and controls will be patients with non-specific abdominal symptoms with a radiologically-normal liver as diagnosed on the reference test (ultrasound, MRI, CT and PET-CT). All eligible patients will be invited to participate.\n\nParticipants will attend a one-off research visit, after having fasted for 6 hours (water permitted) and sign a consent form. They will rinse their mouth with water and provide a breath sample. An additional environment sample will also be collected.\n\nParticipants will answer questions about their medical and drug history.",{"label":22,"type":10,"description":23,"interventionNames":10},"Colorectal Arm","Cases will be patients with histology-confirmed, treatment naïve colorectal adenocarcinoma (CRC) and controls will be patients with non-specific abdominal symptoms with a normal lower GI tract or benign condition of the colon as diagnosed on the reference test (colonoscopy). All eligible patients will be invited to participate.\n\nParticipants will attend a one-off research visit, after having fasted for 6 hours (water permitted) and sign a consent form. They will rinse their mouth with water and provide a breath sample. An additional environment sample will also be collected.\n\nParticipants will answer questions about their medical and drug history.",[25],{"name":26,"affiliation":5,"role":27},"George Hanna, MBBS; PhD; FRSC","PRINCIPAL_INVESTIGATOR",[29],{"name":30,"role":31,"phone":32,"phoneExt":10,"email":33},"Jessie S McClymont, Medical Biosciences BSc","CONTACT","+44 7434937543","brave-study@imperial.ac.uk",[35,55,71,86,98,113],{"facility":36,"status":10,"city":37,"state":38,"zip":39,"country":40,"countryCode":41,"cosmosGeoPoint":42,"geoPoint":47,"contacts":48},"Maidstone and Tunbridge Wells NHS Trust","Maidstone","Kent","ME16 9QQ","United Kingdom","UK",{"type":43,"coordinates":44},"Point",[45,46],0.51667,51.26667,{"lat":46,"lon":45},[49,53],{"name":50,"role":31,"phone":51,"phoneExt":10,"email":52},"Samantha Forner, MBBS; MRCP","01622 477714","samantha.forner@nhs.net",{"name":54,"role":27,"phone":10,"phoneExt":10,"email":10},"Samantha Forner, MBBS; MRSCP",{"facility":56,"status":10,"city":57,"state":58,"zip":59,"country":40,"countryCode":41,"cosmosGeoPoint":60,"geoPoint":64,"contacts":65},"Liverpool University Hospitals NHS Foundation Trust","Liverpool","Merseyside","L7 8XP",{"type":43,"coordinates":61},[62,63],-2.97794,53.41058,{"lat":63,"lon":62},[66,70],{"name":67,"role":31,"phone":68,"phoneExt":10,"email":69},"Andrew Moore, MBBS; MRCP","0151 706 2000","andrew.moore@liverpoolft.nhs.uk",{"name":67,"role":27,"phone":10,"phoneExt":10,"email":10},{"facility":72,"status":10,"city":73,"state":10,"zip":74,"country":40,"countryCode":41,"cosmosGeoPoint":75,"geoPoint":79,"contacts":80},"NHS Greater Glasgow and Clyde","Glasgow","G12 0XH",{"type":43,"coordinates":76},[77,78],-4.25763,55.86515,{"lat":78,"lon":77},[81,85],{"name":82,"role":31,"phone":83,"phoneExt":10,"email":84},"Gary Nicholson, MBBS; FRCS","0141 201 3000","Gary.Nicholson2@nhs.scot",{"name":82,"role":27,"phone":10,"phoneExt":10,"email":10},{"facility":87,"status":10,"city":57,"state":10,"zip":88,"country":40,"countryCode":41,"cosmosGeoPoint":89,"geoPoint":91,"contacts":92},"The Clatterbridge Cancer Centre NHS Foundation Trust","L7 8YA",{"type":43,"coordinates":90},[62,63],{"lat":63,"lon":62},[93,97],{"name":94,"role":31,"phone":95,"phoneExt":10,"email":96},"Alia Alchawaf, MBBS; MRCP","0151 556 5000","aliaalchawaf@nhs.net",{"name":94,"role":27,"phone":10,"phoneExt":10,"email":10},{"facility":99,"status":10,"city":100,"state":10,"zip":101,"country":40,"countryCode":41,"cosmosGeoPoint":102,"geoPoint":106,"contacts":107},"Royal Free London NHS Foundation Trust","London","NW3 2QG",{"type":43,"coordinates":103},[104,105],-0.12574,51.50853,{"lat":105,"lon":104},[108,112],{"name":109,"role":31,"phone":110,"phoneExt":10,"email":111},"Georgia Woodfield, MBBS; MRCP","020 7472 6446","georgia.woodfield@nhs.net",{"name":109,"role":27,"phone":10,"phoneExt":10,"email":10},{"facility":114,"status":10,"city":100,"state":10,"zip":115,"country":40,"countryCode":41,"cosmosGeoPoint":116,"geoPoint":118,"contacts":119},"Imperial College Healthcare NHS Trust","W12 0NN",{"type":43,"coordinates":117},[104,105],{"lat":105,"lon":104},[120,122],{"name":121,"role":31,"phone":32,"phoneExt":10,"email":33},"Jessie S McClymont, BSc",{"name":26,"role":27,"phone":10,"phoneExt":10,"email":10},{"type":124,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR",[126,127,129,132,133,135,137,138,140],{"name":114,"class":6},{"name":128,"class":6},"Maidstone & Tunbridge Wells NHS Trust",{"name":130,"class":131},"Royal Liverpool University Hospital","OTHER_GOV",{"name":87,"class":6},{"name":134,"class":131},"Hull University Teaching Hospitals NHS Trust",{"name":99,"class":136},"UNKNOWN",{"name":72,"class":6},{"name":139,"class":6},"Chelsea and Westminster NHS Foundation Trust",{"name":141,"class":6},"St George's Healthcare NHS Trust","100647926","breath-research-narrow-validation-for-gastrointestinal-cancer-detection-100647926",false,"NCT07714538","Breath Research Narrow Validation for Gastrointestinal Cancer Detection","BRAVE","Inclusion Criteria:\n\nAdult participants ≥ 18 years old who meet at least one of the following criteria\n\nColorectal arm:\n\n1. Cancer: Histologically-confirmed CRC\\*\n2. Control: Non-specific abdominal symptoms with normal or benign colonoscopy findings\n\nPancreatic arm:\n\n1. Cancer: Histologically-confirmed PDAC\\*\n2. Control: Non-specific abdominal symptoms with a radiologically-normal pancreas\n\nOesophagogastric arm:\n\n1. Cancer: Histologically-confirmed OGC\\*\n2. Control: Non-specific abdominal symptoms with normal or benign upper gastrointestinal endoscopy findings\n\nOesophageal squamous arm:\n\n1. Cancer: Histologically-confirmed OSCC\\*\n2. Control: Non-specific abdominal symptoms with normal or benign upper gastrointestinal endoscopy findings\n\nLiver arm:\n\n1. Cancer: Histologically- or radiologically-confirmed HCC or CCC\\*\n2. Control: Non-specific abdominal symptoms with a radiologically-normal liver\n\n   * Patients with suspected cancer (e.g. based on imaging) but who do not have histological confirmation prior to participating in the study may still be recruited and followed up to determine whether or not a diagnosis of cancer was subsequently confirmed.\n\nExclusion Criteria:\n\n* Patients who have already received chemotherapy, radiotherapy or surgery for their cancer\n* History of another cancer (other than non-melanoma skin cancers) within three years\n* Participants with co-morbidities preventing breath collection\n* Unable or unwilling to provide informed consent\n* (For Oesophagogastric arm only): Allergies to any of the constituents of the nutrient drink including glucose, glycerol, iron sulphate, Maltodextrin (Corn, Potato), Xanthan Gum, Potassium Chloride, tyrosine, phenylalanine, and glutamic acid\n* (For Colorectal arm only): Participants receiving bowel prep in the previous 7 days","ALL","18 Years",{"count":152,"type":153},1000,"ESTIMATED","OBSERVATIONAL","The investigators of this study are developing a simple breath test to help detect gastrointestinal (gut) cancers earlier, including cancers of the oesophagus (food pipe), stomach, pancreas, liver and bowel. These cancers often cause non-specific symptoms that are similar to benign conditions, making early diagnosis difficult. Delays between the onset of symptoms and referral for a diagnostic test such as an endoscopy or a scan, can allow the cancer to progress.\n\nThe breath test detects small molecules called volatile organic compounds (VOCs) that are released in exhaled breath. Some of these VOCs are strongly associated with these cancers and may help identify high-risk patients who require urgent investigation.\n\nIn practice, patients who come to their GP with concerning symptoms will be offered the breath test. If the test is positive, patients can be referred promptly for a diagnostic test, while those with a negative result can be reassured and offered re-testing if symptoms persist. Earlier diagnosis could improve access to curative treatment while reducing unnecessary invasive investigations.\n\nPrevious studies have identified a panel of VOCs that appear to distinguish patients with gastrointestinal cancers from those without cancer. This study aims to confirm these findings in a new group of participants to determine whether the same biomarkers can be reliably identified.\n\nParticipants will provide a breath sample, usually before a hospital procedure they are already scheduled to undergo, and complete a short questionnaire about their medical history and medications. Some participants will also be asked to drink a nutritional supplement before providing a second breath sample. The results will help determine whether the breath test is reliable enough for further clinical evaluation",[157,158,159,160,161,162,163],"Oesophageal Squamous Cell Carcinoma","Oesophageal Adenocarcinoma","Gastric Adenocarcinoma","Pancreatic Ductal Adenocarcinoma (PDAC)","Cholangiocarcinoma","Hepatocellular Carcinoma (HCC)","Colorectal Adenocarcinoma",[165,166,167,168,169,170,171],"Early Detection","Volatile Organic Compunds","Oesophageal Cancer","Gastric Cancer","Colorectal Cancer","Liver Cancer","Pancreatic Cancer","NOT_YET_RECRUITING","2026-07-21",{"date":175,"type":176},"2026-07-23","ACTUAL",{"date":178,"type":153},"2026-07-20",{"date":180,"type":153},"2028-08-02",{"name":5,"class":6},6]