[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100647255":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":33,"centralContacts":34,"locations":44,"responsibleParty":59,"collaborators":63,"id":65,"slug":66,"hasResults":67,"nctId":68,"briefTitle":69,"officialTitle":70,"acronym":71,"eligibilityCriteria":72,"healthyVolunteers":67,"sex":73,"minAge":74,"maxAge":33,"enrollmentInfo":75,"targetDuration":33,"studyType":78,"phases":79,"briefSummary":81,"conditions":82,"keywords":87,"overallStatus":47,"whyStopped":33,"lastUpdateSubmitDate":97,"lastUpdatePostDateStruct":98,"startDateStruct":101,"completionDateStruct":102,"leadSponsor":103,"locationsCount":104},{"fullName":5,"class":6},"University Hospital, Basel, Switzerland","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Airway Exchange Catheter","ACTIVE_COMPARATOR","The body donors will undergo a tube exchange with the conventional airway exchange catheter-guided technique",[13],"Procedure: Airway Exchange Catheter-Guided Endotracheal Tube Exchange",{"label":15,"type":16,"description":17,"interventionNames":18},"Bronchoscopic tube exchange","EXPERIMENTAL","The body donors will undergo a tube exchange with the bronchoscopic tube-exchange technique",[19],"Procedure: Bronchoscope-Guided Endotracheal Tube Exchange",[21,28],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"PROCEDURE","Airway Exchange Catheter-Guided Endotracheal Tube Exchange","The existing tube fixation is released. A Cook airway exchange catheter is advanced through the in-situ endotracheal tube into the tracheobronchial tree. Ventilation is interrupted, the cuff is deflated, and the old tube is removed over the catheter. A new endotracheal tube is advanced over the catheter, the catheter is removed, the cuff is inflated, ventilation is resumed, and tube position is verified by lung auscultation.",[9],[27],"Cook Catheter Tube Exchange",{"type":22,"name":29,"description":30,"armGroupLabels":31,"otherNames":32},"Bronchoscope-Guided Endotracheal Tube Exchange","The replacement tube is preloaded onto a therapeutic flexible bronchoscope. The bronchoscope is advanced alongside the in-situ tube through the larynx into the trachea, and proximal tracheal secretions are suctioned. Ventilation is interrupted and the old tube is removed. The replacement tube is advanced over the bronchoscope into the trachea under direct visual control. The bronchoscope is removed, the cuff is inflated, and ventilation is resumed.",[15],[15],null,[35,40],{"name":36,"role":37,"phone":38,"phoneExt":33,"email":39},"Léo Franchetti, MD","CONTACT","+41 61 265 25 25","leo.franchetti@usb.ch",{"name":41,"role":37,"phone":42,"phoneExt":33,"email":43},"Prof. Jürgen Hetzel, MD","+41 61 328 61 95","juergen.hetzel@usb.ch",[45],{"facility":46,"status":47,"city":48,"state":33,"zip":33,"country":49,"countryCode":50,"cosmosGeoPoint":51,"geoPoint":56,"contacts":57},"Unversity Hospital of Basel","RECRUITING","Basel","Switzerland","CH",{"type":52,"coordinates":53},"Point",[54,55],7.57327,47.55839,{"lat":55,"lon":54},[58],{"name":36,"role":37,"phone":33,"phoneExt":33,"email":33},{"type":60,"investigatorFullName":61,"investigatorTitle":62,"investigatorAffiliation":5,"oldNameTitle":33,"oldOrganization":33},"SPONSOR_INVESTIGATOR","Léo Franchetti","Physician, Department of Pneumology, University Hospital Basel",[64],{"name":5,"class":6},"100647255","bronchoscopic-versus-airway-exchange-catheter-guided-endotracheal-tube-exchange-100647255",false,"NCT07706309","Bronchoscopic Versus Airway Exchange Catheter-Guided Endotracheal Tube Exchange","Bronchoscopic Endotracheal Tube Exchange as an Alternative to Airway Exchange Catheter-Guided Tube Exchange: A Prospective Study","Bronchex","Inclusion Criteria:\n\n* Human body donor preserved using the Thiel embalming method.\n* Intact trachea without relevant postmortem or preparation-related lesions.\n* Documented consent for scientific use of the body and confirmation of anatomical suitability by the Institute of Anatomy.\n* Sufficient mobility of the neck, jaw, and laryngeal region to permit realistic tube-exchange maneuvers.\n\nExclusion Criteria:\n\n* Tumor or stenosis involving the larynx, trachea, or central airways.\n* Previous surgery or radiotherapy involving the larynx or oral cavity.\n* Previous pneumonectomy.\n* Previous tracheotomy or laryngectomy.\n* Inability to achieve safe or standardized positioning of the cadaver.\n* Incomplete consent documentation or unclear provenance.\n* Preservation using a fixation method other than the Thiel method.","ALL","18 Years",{"count":76,"type":77},2,"ESTIMATED","INTERVENTIONAL",[80],"NA","This prospective experimental study compares two methods for replacing an endotracheal tube in Thiel-embalmed body donors. The conventional method uses an airway exchange catheter based on the Seldinger technique, whereas the investigational method uses a flexible bronchoscope to provide direct visual guidance throughout the exchange.\n\nThe primary outcome is the duration of interrupted ventilation, measured from cessation of ventilation until ventilation is resumed through a correctly positioned replacement tube. Secondary outcomes include unsuccessful tube exchange requiring complete reintubation, duration of individual procedural steps, procedures lasting more than 60 seconds, use of additional rescue equipment, and unforeseen technical difficulties.\n\nBoth techniques will be performed in two Thiel-embalmed donated human bodies using an alternating sequence. Four experienced physicians will perform 40 tube exchanges per technique, resulting in a total of 80 procedures.",[83,84,85,86],"Endotracheal Tube Exchange","Airway Management","Endotracheal Intubation","Reintubation",[88,89,90,91,92,93,94,95,96],"Airway exchange catheter","bronchoscopy","interventional pneumology","tube exchange","reintubation","endotracheal tube exchange","apnea time","airway management","critical care","2026-07-10",{"date":99,"type":100},"2026-07-15","ACTUAL",{"date":97,"type":100},{"date":97,"type":77},{"name":61,"class":6},1]