[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100651006":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":25,"centralContacts":26,"locations":25,"responsibleParty":32,"collaborators":25,"id":36,"slug":37,"hasResults":38,"nctId":39,"briefTitle":40,"officialTitle":41,"acronym":25,"eligibilityCriteria":42,"healthyVolunteers":43,"sex":44,"minAge":45,"maxAge":25,"enrollmentInfo":46,"targetDuration":25,"studyType":49,"phases":50,"briefSummary":52,"conditions":53,"keywords":54,"overallStatus":56,"whyStopped":25,"lastUpdateSubmitDate":57,"lastUpdatePostDateStruct":58,"startDateStruct":61,"completionDateStruct":63,"leadSponsor":65,"locationsCount":25},{"fullName":5,"class":6},"South Valley University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Intervention Group","EXPERIMENTAL","Intervention Group (35 participants) will receive\n\nBuerger's Exercises + Proprioceptive Drills, 3 times\u002Fweek for 8 weeks:\n\n* Buerger's Exercises:\n\n  * Leg elevation at 45° for 2 min until blanching\n  * Dependent sitting for 3 min until hyperemia\n  * Supine rest for 5 min\n  * 3 cycles per session\n* Proprioceptive Drills:\n\n  * Single-leg stance\n  * Tandem stance\u002Fwalking\n  * Heel-to-toe walking\n  * Anterior-posterior and lateral weight shifts\n  * Mini-squats on foam\n  * Ankle alphabet\n  * Progressively increased difficulty Sessions supervised by trained physiotherapists.",[13],"Combination Product: Buerger's Exercises",{"label":15,"type":16,"description":17,"interventionNames":18},"Control Group","ACTIVE_COMPARATOR","Control Group (35 participants) will receive Standard care with educational leaflets and physical activity advice.",[13],[20],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"COMBINATION_PRODUCT","Buerger's Exercises","Buerger's Exercises + Proprioceptive Drills, 3 times\u002Fweek for 8 weeks:\n\n* Buerger's Exercises:\n\n  * Leg elevation at 45° for 2 min until blanching\n  * Dependent sitting for 3 min until hyperemia\n  * Supine rest for 5 min\n  * 3 cycles per session\n* Proprioceptive Drills:\n\n  * Single-leg stance\n  * Tandem stance\u002Fwalking\n  * Heel-to-toe walking\n  * Anterior-posterior and lateral weight shifts\n  * Mini-squats on foam\n  * Ankle alphabet\n  * Progressively increased difficulty Sessions supervised by trained physiotherapists.",[15,9],null,[27],{"name":28,"role":29,"phone":30,"phoneExt":25,"email":31},"ibrahim abuzaid, Assistant professor","CONTACT","01006512160","ibrahim_ismail_2011@svu.edu.eg",{"type":33,"investigatorFullName":34,"investigatorTitle":35,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"PRINCIPAL_INVESTIGATOR","Ibrahim Abuzaid","Head of department physical therapy for cardiovascular\u002FRespiratory disorders and Geriatrics","100651006","buergers-exercises-and-proprioceptive-drills-on-postural-stability-and-foot-perfusion-in-elderly-patients-with-chemotherapy-100651006",false,"NCT07756073","Buerger's Exercises and Proprioceptive Drills on Postural Stability and Foot Perfusion in Elderly Patients With Chemotherapy","Combined Effect of Buerger's Exercises and Proprioceptive Drills on Postural Stability and Foot Perfusion in Elderly Patients With Chemotherapy-Induced Peripheral Neuropathy Randomized Controlled Trial","Inclusion Criteria:\n\n* Aged 65 years or older\n* Diagnosed with CIPN for at least 3 months\n* Demonstrating impaired postural stability (BBS ≤ 48 or ≥2 falls in the past year)\n* Medically cleared for exercise\n* Cognitively intact (MMSE ≥ 24)\n* Willing and able to give consent\n\nExclusion Criteria:\n\n* Severe peripheral arterial disease (ABI \\\u003C 0.5)\n* Severe postural hypotension or positional syncope\n* Recent orthopedic procedures or fractures (past 6 months)\n* Vestibular or cerebellar disorders\n* Uncontrolled systemic diseases\n* Cognitive impairment (MMSE \\\u003C 24)\n* Concurrent participation in another structured balance or vascular program\n* Lower limb ulcers or active infection\n* Severe visual impairment\n* Intolerance to positional exercises",true,"ALL","65 Years",{"count":47,"type":48},70,"ESTIMATED","INTERVENTIONAL",[51],"NA","Chemotherapy-induced peripheral neuropathy (CIPN) is a common, dose-limiting side effect of neurotoxic chemotherapy agents, characterized by sensory loss, impaired proprioception, and muscle weakness, predominantly affecting the lower limbs. These impairments significantly contribute to postural instability and increase fall risk in elderly patients. Additionally, CIPN-associated microvascular changes can compromise peripheral circulation, further exacerbating neuromotor dysfunction and balance deficits.\n\nWhile pharmacological options for CIPN are limited and often inadequate, exercise-based interventions have shown promise in mitigating functional impairments. Buerger's exercises, a vascular stimulation technique, are known to enhance peripheral blood flow, whereas proprioceptive drills can improve neuromuscular coordination and postural control. However, their combined effect on both postural stability and foot perfusion in elderly patients with CIPN has not been systematically studied.",[40],[55],"Buerger's Exercises - Proprioceptive Drills - Postural Stability -Foot Perfusion - Elderly Patients - Chemotherapy-Induced Peripheral Neuropathy","NOT_YET_RECRUITING","2026-08-04",{"date":59,"type":60},"2026-08-10","ACTUAL",{"date":62,"type":48},"2026-07-25",{"date":64,"type":48},"2026-12-01",{"name":5,"class":6}]