[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100658643":3},{"organization":4,"outcomesModule":7,"designInfo":26,"detailedDescription":25,"studyPopulation":29,"armGroups":25,"interventions":30,"overallOfficials":25,"centralContacts":40,"locations":46,"responsibleParty":68,"collaborators":25,"id":70,"slug":71,"hasResults":72,"nctId":73,"briefTitle":74,"officialTitle":74,"acronym":75,"eligibilityCriteria":76,"healthyVolunteers":72,"sex":77,"minAge":78,"maxAge":25,"enrollmentInfo":79,"targetDuration":82,"studyType":83,"phases":25,"briefSummary":84,"conditions":85,"keywords":92,"overallStatus":49,"whyStopped":25,"lastUpdateSubmitDate":97,"lastUpdatePostDateStruct":98,"startDateStruct":101,"completionDateStruct":103,"leadSponsor":105,"locationsCount":106},{"fullName":5,"class":6},"Centre Hospitalier Universitaire, Amiens","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":25},[9],{"measure":10,"description":11,"timeFrame":12},"association between placental cadmium levels and fetal growth","investigate the association between placental cadmium levels and fetal growth.","at 2 months",[14,17,20,23],{"measure":15,"description":16,"timeFrame":12},"Association between maternal urinary cadmium concentration and fetal growth","Association between maternal urinary cadmium concentration (adjusted for creatinine) and fetal growth, assessed by birth weight adjusted for gestational age (z-score).",{"measure":18,"description":19,"timeFrame":12},"Association between maternal blood cadmium concentration and fetal growth","Association between maternal blood cadmium concentration and fetal growth, assessed by birth weight adjusted for gestational age (z-score).",{"measure":21,"description":22,"timeFrame":12},"Association between placental cadmium concentration and placental efficiency","Association between placental cadmium concentration and placental efficiency, defined as the fetal-to-placental weight ratio",{"measure":24,"description":24,"timeFrame":12},"Association between maternal dietary patterns and estimated dietary cadmium intake and cadmium concentrations measured in placental tissue",null,{"allocation":25,"interventionModel":25,"interventionModelDescription":25,"primaryPurpose":25,"observationalModel":27,"timePerspective":28,"maskingInfo":25},"CASE_ONLY","PROSPECTIVE","Women delivering at term or preterm who are patients at Amiens University Hospital,",[31,34,37],{"type":6,"name":32,"description":33,"armGroupLabels":25,"otherNames":25},"maternal blood samples","maternal blood samples are collected at admission for delivery as part of standard obstetric care.",{"type":6,"name":35,"description":36,"armGroupLabels":25,"otherNames":25},"Placental tissue samples","Placental tissue samples are collected at delivery,",{"type":6,"name":38,"description":39,"armGroupLabels":25,"otherNames":25},"maternal urine samples","maternal urine samples are obtained during routine prenatal visits,",[41],{"name":42,"role":43,"phone":44,"phoneExt":25,"email":45},"Rosalie CABRY, Pr","CONTACT","33+3 22 08 73 70","cabry.rosalie@chu-amiens.fr",[47],{"facility":48,"status":49,"city":50,"state":25,"zip":25,"country":51,"countryCode":52,"cosmosGeoPoint":53,"geoPoint":58,"contacts":59},"CHU Amiens Picardie","RECRUITING","Amiens","France","FR",{"type":54,"coordinates":55},"Point",[56,57],2.3,49.9,{"lat":57,"lon":56},[60,63,66],{"name":61,"role":43,"phone":25,"phoneExt":25,"email":62},"Rosalie Cabry, Pr","Cabry.Rosalie@chu-amiens.fr",{"name":64,"role":65,"phone":25,"phoneExt":25,"email":25},"Fabrice Sergent, Pr","SUB_INVESTIGATOR",{"name":67,"role":65,"phone":25,"phoneExt":25,"email":25},"Karen CHARDON, Pr",{"type":69,"investigatorFullName":25,"investigatorTitle":25,"investigatorAffiliation":25,"oldNameTitle":25,"oldOrganization":25},"SPONSOR","100658643","cadmium-exposure-during-pregnancy-and-fetal-growth-100658643",false,"NCT07855237","Cadmium Exposure During Pregnancy and Fetal Growth","CADNAT","Inclusion Criteria:\n\n* Pregnant women aged 18 years or older\n* Singleton pregnancy\n* Planned delivery at the maternity unit of Amiens University Hospital (CHU Amiens)\n* Ability to receive study information and provide informed non-opposition\u002Fconsent according to French regulations for non-interventional research\n\nExclusion Criteria:\n\n* Women under legal protection measures, including guardianship, curatorship, or judicial safeguard\n* Inability to understand the study objectives or the constraints of the protocol (language barrier, cognitive impairment, or other reasons)\n* Lack of affiliation to a social security system, as required by French regulations","FEMALE","18 Years",{"count":80,"type":81},50,"ESTIMATED","2 Months","OBSERVATIONAL","Cadmium is a toxic heavy metal naturally present in the environment, whose human exposure has increased over recent decades due to diffuse anthropogenic contamination, particularly related to industrial activities and the use of mineral phosphate fertilizers in agriculture.\n\nCadmium is characterized by its bioaccumulative properties and well-established toxicity, including renal and bone damage and carcinogenic effects. In pregnant women, several animal and human cohort studies have shown that cadmium can cross the placental barrier and accumulate in placental tissue. Placental cadmium exposure has been associated with impaired placental function and adverse perinatal outcomes, including fetal growth restriction and increased neonatal morbidity. In the general population without occupational exposure, diet represents the main source of cadmium exposure, apart from tobacco smoking. Fetal growth, commonly assessed through birth weight adjusted for gestational age, is a major determinant of neonatal and long-term health outcomes. This monocentric prospective pilot study aims to assess fetal exposure to cadmium during pregnancy using placental cadmium concentration as a biomarker. Placental samples will be collected at delivery from women giving birth at Amiens University Hospital, and cadmium levels will be measured using inductively coupled plasma mass spectrometry. The association between placental cadmium concentration and fetal growth will be explored. Fetal growth will be evaluated using birth weight adjusted for gestational age, expressed as a standardized z-score. Maternal urinary and blood cadmium concentrations will also be measured to characterize maternal exposure and explore correlations between biological matrices. Placental efficiency, defined as the fetal-to-placental weight ratio, will be assessed as an indicator of placental function. The results of this pilot study will provide preliminary data to inform future larger-scale epidemiological and mechanistic studies on prenatal cadmium exposure and pregnancy outcomes.",[86,87,88,89,90,91],"Cadmium","Placenta","Fetal Growth","Birth Weight","Environmental Exposure","Biomonitoring",[93,94,95,96,87,86],"biomonitoring","environmental exposure","birth weight","fetal growth","2026-09-28",{"date":99,"type":100},"2026-10-02","ACTUAL",{"date":102,"type":100},"2026-09-21",{"date":104,"type":81},"2026-12",{"name":5,"class":6},1]