[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100658073":3},{"organization":4,"outcomesModule":7,"designInfo":14,"detailedDescription":17,"studyPopulation":18,"armGroups":19,"interventions":13,"overallOfficials":13,"centralContacts":13,"locations":28,"responsibleParty":73,"collaborators":13,"id":77,"slug":78,"hasResults":79,"nctId":80,"briefTitle":81,"officialTitle":81,"acronym":82,"eligibilityCriteria":83,"healthyVolunteers":79,"sex":84,"minAge":85,"maxAge":86,"enrollmentInfo":87,"targetDuration":90,"studyType":91,"phases":13,"briefSummary":92,"conditions":93,"keywords":96,"overallStatus":31,"whyStopped":13,"lastUpdateSubmitDate":104,"lastUpdatePostDateStruct":105,"startDateStruct":108,"completionDateStruct":110,"leadSponsor":112,"locationsCount":113},{"fullName":5,"class":6},"University of Pisa","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":13},[9],{"measure":10,"description":11,"timeFrame":12},"diagnostic performance of exercise ECG across the four predefined groups.","Differences in ECG response patterns will be compared according to the presence of LVH and obstructive CAD. Multivariable analysis will be performed to identify independent ECG predictors associated with obstructive CAD and inducible ischemia.","From enrollment through completion of all diagnostic evaluations, assessed up to 3 months after enrollment.",null,{"allocation":13,"interventionModel":13,"interventionModelDescription":13,"primaryPurpose":13,"observationalModel":15,"timePerspective":16,"maskingInfo":13},"COHORT","PROSPECTIVE","In this prospective study, consecutive patients undergoing evaluation for suspected coronary artery disease will undergo exercise ECG testing (ExECG), transthoracic echocardiography (TTE), stress cardiac magnetic resonance (CMR), and coronary computed tomography angiography (CCTA).\n\nPatients will be stratified into four groups according to the presence or absence of LVH and obstructive CAD:\n\nLVH with obstructive CAD LVH without obstructive CAD No LVH with obstructive CAD No LVH without obstructive CAD\n\nLVH will be defined by standard echocardiographic criteria, while obstructive CAD will be assessed by CCTA. Stress CMR will serve as the reference standard for inducible myocardial ischemia.\n\nExercise ECG parameters will include conventional ST-segment criteria as well as dynamic indices during exercise and recovery. Associations between ECG findings and imaging-defined phenotypes will be evaluated, and predictors of CAD-related ischemia will be identified.\n\nResults The study will assess the diagnostic performance of exercise ECG across the four predefined groups. Differences in ECG response patterns will be compared according to the presence of LVH and obstructive CAD. Multivariable analysis will be performed to identify independent ECG predictors associated with obstructive CAD and inducible ischemia.","consecutive patients undergoing evaluation for suspected coronary artery disease will undergo exercise ECG testing (ExECG), transthoracic echocardiography (TTE), stress cardiac magnetic resonance (CMR), and coronary computed tomography angiography (CCTA).\n\nPatients will be stratified into four groups according to the presence or absence of LVH and obstructive CAD:\n\nLVH with obstructive CAD LVH without obstructive CAD No LVH with obstructive CAD No LVH without obstructive CAD",[20,22,24,26],{"label":21,"type":13,"description":21,"interventionNames":13},"LVH with obstructive CAD",{"label":23,"type":13,"description":23,"interventionNames":13},"LVH without obstructive CAD",{"label":25,"type":13,"description":25,"interventionNames":13},"No LVH with obstructive CAD",{"label":27,"type":13,"description":27,"interventionNames":13},"No LVH without obstructive CAD",[29],{"facility":30,"status":31,"city":32,"state":33,"zip":34,"country":35,"countryCode":36,"cosmosGeoPoint":37,"geoPoint":42,"contacts":43},"Azienda Ospedaliero-Universitaria Pisana","RECRUITING","Pisa","PI","56124","Italy","IT",{"type":38,"coordinates":39},"Point",[40,41],10.4036,43.70853,{"lat":41,"lon":40},[44,49,52,55,57,59,61,63,65,67,69,71],{"name":45,"role":46,"phone":47,"phoneExt":13,"email":48},"Mattia Alberti, MD, PhD candidate","CONTACT","+39 3770805335","mattia.alberti@phd.unipi.it",{"name":50,"role":46,"phone":13,"phoneExt":13,"email":51},"Morrone Doralisa, MD, PhD, Associate Professor","doralisa.morrone@unipi.it",{"name":53,"role":54,"phone":13,"phoneExt":13,"email":13},"Riccardo Canonaco, MD","SUB_INVESTIGATOR",{"name":56,"role":54,"phone":13,"phoneExt":13,"email":13},"Simona Chiusolo, MD",{"name":58,"role":54,"phone":13,"phoneExt":13,"email":13},"Simona Buralli, MD",{"name":60,"role":54,"phone":13,"phoneExt":13,"email":13},"Stefano Taddei, MD, Full Professor",{"name":62,"role":54,"phone":13,"phoneExt":13,"email":13},"Emanuele Neri, MD, Full Professor",{"name":64,"role":54,"phone":13,"phoneExt":13,"email":13},"Giovanni Donato Aquaro, MD, PhD, Associate Professor",{"name":66,"role":54,"phone":13,"phoneExt":13,"email":13},"Lorenzo Faggioni, MD, Associate Professor",{"name":68,"role":54,"phone":13,"phoneExt":13,"email":13},"Doralisa Morrone, MD, PhD, Associate Professor",{"name":70,"role":54,"phone":13,"phoneExt":13,"email":13},"Raffaele De Caterina, MD, PhD, Full Professor",{"name":72,"role":54,"phone":13,"phoneExt":13,"email":13},"Pietro Lucii, MD",{"type":74,"investigatorFullName":75,"investigatorTitle":76,"investigatorAffiliation":5,"oldNameTitle":13,"oldOrganization":13},"PRINCIPAL_INVESTIGATOR","Mattia Alberti","MD, PhDs","100658073","can-exercise-electrocardiography-discriminate-hypertensive-heart-disease-from-obstructive-coronary-artery-disease-a-multimodality-imaging-study-100658073",false,"NCT07847463","Can Exercise Electrocardiography Discriminate Hypertensive Heart Disease From Obstructive Coronary Artery Disease? A Multimodality Imaging Study","HYSTERESIS","Inclusion Criteria:\n\n* Patients with CAD and LVH\n\nExclusion Criteria:\n\n* Patients with RBBB","ALL","18 Years","99 Years",{"count":88,"type":89},30,"ESTIMATED","12 Months","OBSERVATIONAL","To evaluate the ability of exercise ECG to discriminate between hypertensive heart disease-related and CAD-related abnormalities",[94,95],"Obstructive Coronary Artery Disease","Left Ventricular Hypertrophy",[97,98,99,100,101,102,103],"exercise ECG","LVH","CCTA","Stress CMR","CAD","transthoracic echocardiography","TTE","2026-09-25",{"date":106,"type":107},"2026-09-29","ACTUAL",{"date":109,"type":107},"2026-09-01",{"date":111,"type":89},"2029-09-01",{"name":5,"class":6},1]