[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100651050":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":18,"centralContacts":25,"locations":32,"responsibleParty":50,"collaborators":53,"id":56,"slug":57,"hasResults":58,"nctId":59,"briefTitle":60,"officialTitle":61,"acronym":62,"eligibilityCriteria":63,"healthyVolunteers":58,"sex":64,"minAge":65,"maxAge":66,"enrollmentInfo":67,"targetDuration":18,"studyType":70,"phases":71,"briefSummary":73,"conditions":74,"keywords":80,"overallStatus":90,"whyStopped":18,"lastUpdateSubmitDate":91,"lastUpdatePostDateStruct":92,"startDateStruct":95,"completionDateStruct":97,"leadSponsor":99,"locationsCount":100},{"fullName":5,"class":6},"Aveiro University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Cognitive rehabilitation intervention","EXPERIMENTAL","Participants allocated to this arm will receive the CanCOG® cognitive rehabilitation intervention in addition to usual care. Following baseline assessment (2 weeks before the intervention), participants will attend the intervention over a 6-week period and complete study assessments 2 weeks after the intervention and at 3- and 6-month follow-up time points. Participants will be asked to complete neuropsychological and psychosocial assessments at each evaluation point. A subset of participants (10-15) may also be invited to participate in a semi-structured interview to explore the acceptability of the intervention, perceived benefits, barriers to participation, and overall satisfaction with the program and study procedures.",[13],"Behavioral: CanCOG® - Cogntive Rehabilitation in Cancer",{"label":15,"type":16,"description":17,"interventionNames":18},"Treatment-as-usual","NO_INTERVENTION","Participants allocated to this arm will continue to receive the usual care and support available through their healthcare providers and will not receive the CanCOG® intervention during the study period. Participants will complete the same schedule of neuropsychological and psychosocial assessments as the intervention group at baseline, post-intervention, and at 3- and 6-month follow-up time points.",null,[20],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":18},"BEHAVIORAL","CanCOG® - Cogntive Rehabilitation in Cancer","CanCOG® is a structured cognitive rehabilitation program designed for cancer survivors experiencing cancer-related cognitive impairment (CRCI). The intervention is delivered in person in small groups of 3 to 9 participants by a trained professional and consists of six weekly sessions of 90 minutes each over six consecutive weeks. The program combines psychoeducation about CRCI, cognitive training exercises targeting domains such as attention, memory, and executive functioning, and compensatory strategy training to support everyday cognitive functioning and self-management of cognitive difficulties.",[9],[26],{"name":27,"role":28,"phone":29,"phoneExt":30,"email":31},"Sofia A Marques-Fernandes, M.Sc.","CONTACT","965252831","00351","sofiafernandes6@ua.pt",[33],{"facility":34,"status":18,"city":35,"state":18,"zip":36,"country":37,"countryCode":38,"cosmosGeoPoint":39,"geoPoint":44,"contacts":45},"University of Aveiro","Aveiro","3810-193","Portugal","PT",{"type":40,"coordinates":41},"Point",[42,43],-8.64643,40.64575,{"lat":43,"lon":42},[46,48],{"name":27,"role":28,"phone":47,"phoneExt":18,"email":31},"00351965252831",{"name":27,"role":49,"phone":18,"phoneExt":18,"email":18},"PRINCIPAL_INVESTIGATOR",{"type":49,"investigatorFullName":51,"investigatorTitle":52,"investigatorAffiliation":5,"oldNameTitle":18,"oldOrganization":18},"Sofia Alexandra Marques Fernandes","Principal Investigator",[54],{"name":55,"class":6},"Foundation for Science and Technology, Portugal","100651050","cancog-pilot-trial-of-cognitive-rehabilitation-for-cancer-survivors-100651050",false,"NCT07755839","CanCOG®: Pilot Trial of Cognitive Rehabilitation for Cancer Survivors","CanCOG® - Cognitive Rehabilitation in Cancer: A Protocol for a Multicenter Pilot Randomized Controlled Trial With Non-central Nervous System Cancer Survivors","CanCOG®","Inclusion Criteria:\n\n* Adults aged 18 to 65 years whose native language is European Portuguese;\n* Diagnosis of cancer not involving the central nervous system (non-CNS cancer);\n* Disease stage I to III;\n* Completion of primary cancer treatment at least 6 months and no more than 5 years prior to enrollment (with the exception of ongoing hormone therapy and immunotherapy);\n* Score \\\u003C 51 on the Perceived Cognitive Abilities subscale of the FACT-Cog v3. Stable psychiatric and neurological medication regimen for at least 3 months prior to enrollment;\n* Educational level equal to or higher than the 3rd year of primary education;\n* Ability to read and write in Portuguese and provide informed consent to participate.\n\nExclusion Criteria:\n\n* Diagnosis of current severe psychiatric disorders (e.g., schizophrenia, psychosis, bipolar disorder, major depressive disorder, or attention-deficit\u002Fhyperactivity disorder);\n* Diagnosis of communication disorders;\n* Diagnosis of neurodevelopmental disorders or other severe medical conditions (e.g., history of stroke, encephalitis, dementia or neurodegenerative disease, epilepsy, or traumatic brain injury);\n* Presence of metastases or other tumors;\n* History of substance abuse (alcohol or drugs);\n* Current or prior participation in another cognitive rehabilitation intervention.","ALL","18 Years","65 Years",{"count":68,"type":69},60,"ESTIMATED","INTERVENTIONAL",[72],"NA","Cancer-related cognitive impairment (CRCI) affects a large proportion of non-central nervous system cancer survivors and can negatively impact cognitive functioning and daily life. Cognitive rehabilitation has shown promising results in addressing these difficulties. The goal of this pilot randomized controlled trial is to evaluate the feasibility, acceptability, and preliminary efficacy of the CanCOG®- Cognitive Rehabilitation in Cancer program in Portuguese adult cancer survivors with CRCI.\n\nAdult non-central nervous system cancer survivors (n=60) will be randomly assigned to receive either the CanCOG® intervention or treatment as usual.\n\nCanCOG® is a structured cognitive rehabilitation program designed to help cancer survivors manage cognitive difficulties through cognitive training exercises, psychoeducation, and compensatory strategy training. The program consists of six weekly sessions of 1 hour and 30 minutes each, delivered over six consecutive weeks. Sessions are administered in person in small groups (3-9 participants) and are led by a trained professional.\n\nThe main focus of the study is to assess feasibility outcomes, including recruitment, retention, adherence to the intervention, and completion of study assessments, as well as acceptability and participant satisfaction.\n\nThe study will also explore preliminary effects of the intervention on cognitive functioning (both perceived and objective), symptoms of anxiety and depression, and quality of life. Participants will complete assessments at baseline (2 weeks after the intervention), 2 weeks after the intervention, and at 3- and 6-month follow-ups. Some participants (10-15) will also take part in interviews to provide feedback on their experience with the program.",[75,76,77,78,79],"Cancer-related Cognitive Impairment","Cancer-related Cognitive Dysfunction","Cancer-related Cognitive Difficulties","Depression and Anxiety Symptoms","Quality of Life",[81,82,83,84,85,86,87,88,89],"cancer","cancer survivors","cognitive rehabilitation","cognition","non-pharmacological interventions","RCT","Pilot study","crci","cancer-related cognitive impairment","NOT_YET_RECRUITING","2026-08-07",{"date":93,"type":94},"2026-08-10","ACTUAL",{"date":96,"type":69},"2026-09",{"date":98,"type":69},"2028-05",{"name":5,"class":6},1]