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A prospective cohort of 3,000 women aged 40-60 will be recruited, with each partner contributing 500 participants.",[13],{"name":14,"role":15,"phone":16,"phoneExt":10,"email":17},"Primary Care - OSIs Research Unit","CONTACT","(+34)943006086","unidadinvestigaciongip@osakidetza.eus",[19,37,52,69,84,97],{"facility":20,"status":21,"city":22,"state":10,"zip":10,"country":23,"countryCode":24,"cosmosGeoPoint":25,"geoPoint":30,"contacts":31},"Keralty SAS","NOT_YET_RECRUITING","Bogotá","Colombia","CO",{"type":26,"coordinates":27},"Point",[28,29],-74.08175,4.60971,{"lat":29,"lon":28},[32],{"name":33,"role":15,"phone":34,"phoneExt":35,"email":36},"Kelly R Chacon","(+57)6252111","5714599","krchacon@keralty.com",{"facility":38,"status":21,"city":39,"state":10,"zip":10,"country":40,"countryCode":41,"cosmosGeoPoint":42,"geoPoint":46,"contacts":47},"Magdalena - Klinika Za Kardiovaskularne Bolesti Medicinskog Fakultetasveucilista J.J. 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Its aim is to develop a personalized prevention approach based on state-of-the-art artificial intelligence models for cardiovascular risk stratification in women aged 40-60 years. These models are trained using large amounts of multi-source data and complemented by digital self-assessment and self-management tools. The CARAMEL consortium brings together a diverse group of 25 organizations, including technology companies and research centers, clinical institutions, as well as experts in ethics, law, and communication.\n\nThe CARAMEL-OS study is an observational study aimed at prospectively completing the proposed personalized cardiovascular risk stratification model for women aged 40-60 years that will be developed during the earlier phases of the overall CARAMEL project (https:\u002F\u002Fwww.caramel-project.eu\u002F).\n\nThe study has a purely observational design, and patient stratification will not entail any clinical intervention. The data collected will be used to complete the design of the personalized stratification model, as well as to develop and validate the performance of the predictive models in an independent prospective cohort, distinct from the retrospective cohort initially used. The performance of the models developed using retrospective data will be assessed in terms of accuracy, discrimination, calibration, and other relevant metrics. In addition, the study will enable the development of new predictive models with short-term prediction horizons, incorporating additional variables that are not available retrospectively.\n\nThe study population will be recruited in four European Union countries: Croatia, Spain (Andalusia and The Basque Country - Gipuzkoa), Greece and Lithuania; and in Colombia. A prospective cohort of 3,000 women aged 40-60 will be recruited, with each partner contributing 500 participants.",[156,157,158,159,160,161],"Perimenopause","Menopause","Cardiovascular (CV) Risk","Women (Between 30 to 60 Years Old)","Cardiovascular Disease Risk Factor","Artificial Intelligence (Al)",[163,158,156,157,164,165],"Women-specific risk factors","Prediction models","Patient reported outcomes (PROM)","2026-07-06",{"date":168,"type":169},"2026-07-10","ACTUAL",{"date":171,"type":169},"2026-03-16",{"date":173,"type":151},"2028-11",{"name":5,"class":6},6]