[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100647986":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":25,"centralContacts":30,"locations":40,"responsibleParty":57,"collaborators":25,"id":61,"slug":62,"hasResults":63,"nctId":64,"briefTitle":65,"officialTitle":66,"acronym":25,"eligibilityCriteria":67,"healthyVolunteers":63,"sex":68,"minAge":69,"maxAge":70,"enrollmentInfo":71,"targetDuration":25,"studyType":74,"phases":75,"briefSummary":77,"conditions":78,"keywords":80,"overallStatus":89,"whyStopped":25,"lastUpdateSubmitDate":90,"lastUpdatePostDateStruct":91,"startDateStruct":94,"completionDateStruct":96,"leadSponsor":98,"locationsCount":99},{"fullName":5,"class":6},"Penn State University","OTHER",[8,15],{"label":9,"type":10,"description":11,"interventionNames":12},"Peanut Butter-Usual Diet","EXPERIMENTAL","In the first period, participants will be provided with 43 g\u002Fday of peanut butter with instructions to consume it at breakfast (or the first meal of the day). In the second period, participants will be instructed to continue their usual intake.",[13,14],"Other: Peanut butter","Other: Usual diet",{"label":16,"type":17,"description":18,"interventionNames":19},"Usual Diet-Peanut Butter","ACTIVE_COMPARATOR","In the first period, participants will be instructed to continue their usual intake. In the second period, participants will be provided with 43 g\u002Fday of peanut butter with instructions to consume it at breakfast (or the first meal of the day).",[13,14],[21,26],{"type":6,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"Peanut butter","Intake of 43 g\u002Fday of peanut butter as part of breakfast (or the first meal of the day)",[9,16],null,{"type":6,"name":27,"description":28,"armGroupLabels":29,"otherNames":25},"Usual diet","Continue intake of usual diet.",[9,16],[31,36],{"name":32,"role":33,"phone":34,"phoneExt":25,"email":35},"Kristina Petersen, PhD","CONTACT","+1 814 865 7206","kup63@psu.edu",{"name":37,"role":33,"phone":38,"phoneExt":25,"email":39},"Stacey Meily","+1 814 863 8622","sas117@psu.edu",[41],{"facility":42,"status":25,"city":43,"state":44,"zip":45,"country":46,"countryCode":47,"cosmosGeoPoint":48,"geoPoint":53,"contacts":54},"The Pennsylvania State University","University Park","Pennsylvania","16802","United States","US",{"type":49,"coordinates":50},"Point",[51,52],-77.85639,40.80201,{"lat":52,"lon":51},[55],{"name":32,"role":33,"phone":56,"phoneExt":25,"email":35},"+1 814-865 7206",{"type":58,"investigatorFullName":59,"investigatorTitle":60,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"PRINCIPAL_INVESTIGATOR","Kristina Petersen PhD, APD, FAHA","Associate Professor","100647986","cardiometabolic--cognitive-effects-of-peanut-butter-in-prediabetes-100647986",false,"NCT07714096","Cardiometabolic & Cognitive Effects of Peanut Butter in Prediabetes","Peanut Butter Glycemic Control, Cognition and Cardiovascular Health","Inclusion Criteria:\n\n* Age 40-65 years\n* BMI 25 to 40 kg\u002Fm2\n* HbA1c 5.7-6.4%\n* Low habitual intake of peanut butter (\\\u003C0.5 Tablespoons\u002Fday on average)\n* Have a smartphone device or be willing to use one provided by the study\n\nExclusion Criteria:\n\n* Hemoglobin \\\u003C13.2 g\u002FdL for men or \\\u003C 11.7 g\u002FdL for women at screening\n* Fasting triglycerides \\>350 mg\u002FdL at screening\n* LDL-cholesterol ≥190 mg\u002FdL assessed by the Martin-Hopkins equation at screening\n* ≥10% change in body weight within the 6 months prior to enrollment\n* Blood pressure \\>140\u002F90 mmHg at screening\n* Diagnosed type 1 or type 2 diabetes\n* Takes any (prescription or over-the-counter) anti-hypertensive, lipid-lowering, glucose-lowering or body weight altering drugs\n* Intake of supplements that affect the outcomes of interest (i.e., lipids, blood pressure, glucose, body weight, and microbiome) and are unwilling to cease during the study period.\n* Unwilling to refrain from starting to take any supplements, vitamins, nutritional products, or health foods that are not prescribed by a doctor for the duration of the study\n* Self-reported history of diagnosed liver, kidney, or autoimmune disease\n* Self-reported history of a prior cardiovascular event (e.g., stroke, heart attack)\n* Self-reported history of diagnosed neurological disease (e.g. Alzheimer's Disease, Parkinson's Disease, Multiple Sclerosis)\n* Current pregnancy or intention of pregnancy within the next 12 months\n* Lactation within the prior 6 months\n* Peanut allergy\u002Fintolerance\u002Fsensitivity\u002Fdislike\n* Antibiotic use within the prior four weeks\n* Oral steroid use within the prior four weeks\n* Use of tobacco or nicotine-containing products within the past 6 months\n* History of cancer at any site within the past 10 years (eligible if ≥10 years without recurrence) or non-melanoma skin cancer within the past 5 years (eligible if ≥5 years without recurrence)\n* Participation in another clinical trial within 60 days of baseline\n* Currently following a restricted or weight-loss diet\n* Prior bariatric surgery\n* Intake of \\>14 alcoholic drinks\u002Fweek and\u002For not willing to avoid alcohol consumption for 48 hours prior to test visits\n* Does not speak and\u002For understand English\n* Unwilling to refrain from donating blood and\u002For plasma during the study\n* Weight \\\u003C110 lb\n* Unwilling to contact study staff before enrolling in other health-related research and avoid participating in any research that may interfere with this study\n* For individuals taking thyroid medication: abnormal thyroid stimulated hormone (TSH) concentration, or change in dose of thyroid medication within the last 6 months\n* Principal Investigator discretion related to the potential participant's ability to adhere to the study requirements, including being able to come to attend visits","ALL","40 Years","65 Years",{"count":72,"type":73},56,"ESTIMATED","INTERVENTIONAL",[76],"NA","The purpose of this study is to look at the effect of consuming peanut butter at breakfast on blood sugar control, cognitive function, and heart disease risk factors in middle-aged adults with prediabetes.",[79],"Prediabetes",[81,82,83,84,85,86,87,88],"diet","nutrition","peanut butter","cognition","heart disease","glycemic control","cardiovascular disease","diabetes","NOT_YET_RECRUITING","2026-07-15",{"date":92,"type":93},"2026-07-20","ACTUAL",{"date":95,"type":73},"2027-01-18",{"date":97,"type":73},"2028-10-31",{"name":5,"class":6},1]