[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100652055":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":11,"centralContacts":29,"locations":35,"responsibleParty":52,"collaborators":11,"id":55,"slug":56,"hasResults":57,"nctId":58,"briefTitle":59,"officialTitle":60,"acronym":61,"eligibilityCriteria":62,"healthyVolunteers":57,"sex":63,"minAge":64,"maxAge":11,"enrollmentInfo":65,"targetDuration":11,"studyType":68,"phases":69,"briefSummary":71,"conditions":72,"keywords":77,"overallStatus":38,"whyStopped":11,"lastUpdateSubmitDate":82,"lastUpdatePostDateStruct":83,"startDateStruct":86,"completionDateStruct":87,"leadSponsor":89,"locationsCount":90},{"fullName":5,"class":6},"Ruijin Hospital","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"CCTA-Based CABG","EXPERIMENTAL",null,[13],"Procedure: CCTA-based CABG",{"label":15,"type":16,"description":11,"interventionNames":17},"CAG-Based CABG","ACTIVE_COMPARATOR",[18],"Procedure: CAG-based CABG",[20,25],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":11},"PROCEDURE","CCTA-based CABG","Surgical planning based solely on CCTA-derived data, including diameter stenosis (DS), area stenosis (AS), CT-derived fractional flow reserve (CT-FFR), LV:RV perfusion index, plaque characterization, 3D reconstruction of target vessels, and collateral circulation of chronic total occlusions (CTO) and so on.\n\nCCTA performed using photon-counting CT or conventional CT (≥64-slice, preferably ≥256-slice), following a standardized acquisition protocol. Images are transferred to an independent core laboratory for quantitative analysis and standardized reporting.\n\nThe operating surgeon will not have access to CAG.",[9],{"type":21,"name":26,"description":27,"armGroupLabels":28,"otherNames":11},"CAG-based CABG","Surgical planning following standard practice using invasive coronary angiography(CAG). Angiograms obtained using a flat-panel detector system with standardized projections. The results of CAG are interpreted by the operating surgeon.The operating surgeon will not have access to CCTA.",[15],[30],{"name":31,"role":32,"phone":33,"phoneExt":11,"email":34},"Yunpeng Zhu, MD","CONTACT","0086-02164370045","zyp12220@rjh.com.cn",[36],{"facility":37,"status":38,"city":39,"state":11,"zip":11,"country":40,"countryCode":41,"cosmosGeoPoint":42,"geoPoint":47,"contacts":48},"Ruijin Hospital Shanghai Jiao Tong University School of Medicine","RECRUITING","Shanghai","China","CN",{"type":43,"coordinates":44},"Point",[45,46],121.45806,31.22222,{"lat":46,"lon":45},[49,50],{"name":31,"role":32,"phone":33,"phoneExt":11,"email":34},{"name":31,"role":51,"phone":11,"phoneExt":11,"email":11},"PRINCIPAL_INVESTIGATOR",{"type":51,"investigatorFullName":53,"investigatorTitle":54,"investigatorAffiliation":5,"oldNameTitle":11,"oldOrganization":11},"Zhu yunpeng","Professor and Director of Clinical Research, Department of Cardiovascular Surgery","100652055","ccta-based-vs-cag-based-cabg-a-multicenter-pragmatic-non-inferiority-trial-100652055",false,"NCT07769008","CCTA-Based vs CAG-Based CABG: A Multicenter Pragmatic Non-Inferiority Trial","Coronary Computed Tomography Angiography-Based Versus Coronary Angiography-Based Coronary Artery Bypass Grafting: A Multicenter Pragmatic Non-Inferiority Randomized Controlled Trial","CtaCAB","Inclusion Criteria:\n\n* Referred to CABG treatment\n\nExclusion Criteria:\n\n* Under the age of 18 years\n* Unable to provide informed consent\n* Emergency CABG\n* Redo-CABG\n* Prior PCI with coronary stent implantation\n* Cardiogenic shock\n* Unable to undergo CAG or CCTA examination or deemed unsuitable by the investigator, such as:\n\nKnown allergy to iodinated contrast media; Active hyperthyroidism or uncontrolled thyroid disease; Estimated glomerular filtration rate (eGFR) \\\u003C 30 mL\u002Fmin\u002F1.73 m²; Atrial fibrillation with rapid ventricular response or severe arrhythmias not amenable to rate control;\n\n* Pregnancy, lactation, or childbearing potential without effective contraception in female participants\n* Concurrent participation in another interventional trial","ALL","18 Years",{"count":66,"type":67},826,"ESTIMATED","INTERVENTIONAL",[70],"NA","The goal of this clinical trial is to find out if using a non-invasive heart scan (called coronary computed tomography angiography, or CCTA) to plan coronary artery bypass grafting (CABG) works as well as the standard invasive approach (called coronary angiography, or CAG) for people with blocked heart arteries.\n\nThe main questions it aims to answer are:\n\nDo people who have surgery planned with the non-invasive heart scan have similar health outcomes at 1 year as those who have surgery planned with the standard invasive approach? How does the non-invasive approach compare in terms of heart attacks, strokes, unplanned repeat procedures, and longer hospital stays? Researchers will compare two groups of participants. One group will have their surgery planned using only the CCTA . The other group will have their surgery planned using only the CAG. Both groups will undergo the CABG per local protocol.\n\nParticipants will:\n\nBe randomly assigned (like flipping a coin) to one of the two planning approaches Undergo CABG as scheduled Return for follow-up visits at sugery days, 7 days, 1 month, 6 months, and 1 year after surgery Have a follow-up CCTA scan at 7 days and 1 year to check if the new bypass grafts are working well",[73,74,75,76],"Coronary Artery Disease","Coronary Artery Bypass Grafting","Coronary Computed Tomography Angiography","Coronary Angiography (CAG)",[78,79,80,81],"Major Adverse Cardiovascular Events (MACE)","Coronary Artery Bypass Grafting (CABG)","Coronary Computed Tomography Angiography(CCTA)","Coronary Angiography(CAG)","2026-08-17",{"date":84,"type":85},"2026-08-19","ACTUAL",{"date":82,"type":85},{"date":88,"type":67},"2029-08",{"name":5,"class":6},1]