[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100652941":3},{"organization":4,"armGroups":7,"interventions":28,"overallOfficials":38,"centralContacts":42,"locations":51,"responsibleParty":67,"collaborators":70,"id":77,"slug":78,"hasResults":79,"nctId":80,"briefTitle":81,"officialTitle":82,"acronym":83,"eligibilityCriteria":84,"healthyVolunteers":79,"sex":85,"minAge":86,"maxAge":12,"enrollmentInfo":87,"targetDuration":12,"studyType":90,"phases":91,"briefSummary":93,"conditions":94,"keywords":99,"overallStatus":108,"whyStopped":12,"lastUpdateSubmitDate":109,"lastUpdatePostDateStruct":110,"startDateStruct":113,"completionDateStruct":115,"leadSponsor":117,"locationsCount":118},{"fullName":5,"class":6},"Duke Kunshan University","OTHER",[8,13,19,24],{"label":9,"type":10,"description":11,"interventionNames":12},"Control Group","NO_INTERVENTION","Participants continue routine community-based stroke and chronic disease management, including usual follow-up and medication adherence or health education provided by community healthcare professionals. They do not receive the structured CEEEC-II physical, nutrition, or AI-enabled cognitive enrichment program.",null,{"label":14,"type":15,"description":16,"interventionNames":17},"Behavioral: Multicomponent Physical and Nutrition Enrichment","EXPERIMENTAL","Participants receive a 12-week upgraded physical and nutrition enrichment program comprising eight physician-led Vitality Camp sessions and four volunteer-led reinforcement activities. The program integrates age-appropriate aerobic, resistance, balance, and flexibility exercises, Baduanjin-based movements, practical nutrition education, and between-session practice support.",[18],"Behavioral: Physical Enrichment",{"label":20,"type":15,"description":21,"interventionNames":22},"Behavioral: AI-Enabled Large-Screen Cognitive Enrichment","Participants receive a 12-week cognitive enrichment program comprising eight physician-led Vitality Camp sessions and four volunteer-led reinforcement activities. Health education is integrated with age-adapted games delivered through an AI-enabled interactive large screen to engage memory, attention, processing speed, visuospatial ability, and executive function, with between-session practice support.",[23],"Behavioral: Cognitive Enrichment",{"label":25,"type":15,"description":26,"interventionNames":27},"Participants receive a 12-week cognitive enrichment program comprising eight physician-led Vitality","Participants receive both 12-week enrichment components: the upgraded physical and nutrition program and the AI-enabled large-screen cognitive program. Delivery comprises eight physician-led Vitality Camp sessions, four volunteer-led reinforcement activities, and between-session practice support.",[18,23],[29,34],{"type":30,"name":31,"description":32,"armGroupLabels":33,"otherNames":12},"BEHAVIORAL","Physical Enrichment","A 12-week community-based program delivered through eight physician-led Vitality Camp sessions and four volunteer-led reinforcement activities. Content includes age-appropriate aerobic, resistance, balance, and flexibility exercises, Baduanjin-based movements, practical nutrition education, and supported practice between sessions.",[14,25],{"type":30,"name":35,"description":36,"armGroupLabels":37,"otherNames":12},"Cognitive Enrichment","A 12-week community-based program delivered through eight physician-led Vitality Camp sessions and four volunteer-led reinforcement activities. Health education is combined with age-adapted games presented on an AI-enabled interactive large screen to engage memory, attention, processing speed, visuospatial ability, and executive function, with supported practice between sessions.",[20,25],[39],{"name":40,"affiliation":5,"role":41},"Lijing Yan, Professor","PRINCIPAL_INVESTIGATOR",[43,48],{"name":44,"role":45,"phone":46,"phoneExt":12,"email":47},"Yikang Yao, Graduate Student","CONTACT","+86-18962917333","yikang.yao@duke.edu",{"name":40,"role":45,"phone":49,"phoneExt":12,"email":50},"+86-512-3665-7057","lijing.yan@duke.edu",[52],{"facility":53,"status":12,"city":54,"state":55,"zip":56,"country":57,"countryCode":58,"cosmosGeoPoint":59,"geoPoint":64,"contacts":65},"Participating Community Health Service Centers in Kunshan","Kunshan","Jiangsu","215300","China","CN",{"type":60,"coordinates":61},"Point",[62,63],120.95431,31.37762,{"lat":63,"lon":62},[66],{"name":40,"role":45,"phone":49,"phoneExt":12,"email":50},{"type":41,"investigatorFullName":68,"investigatorTitle":69,"investigatorAffiliation":5,"oldNameTitle":12,"oldOrganization":12},"Lijing Yan","Professor",[71,73,75],{"name":72,"class":6},"Beijing Tiantan Hospital",{"name":74,"class":6},"Kunshan Hospital of Traditional Chinese Medicine",{"name":76,"class":6},"Shanghai Jiao Tong University School of Medicine","100652941","ceeec-ii-a-12-week-physical-and-cognitive-enrichment-extension-study-in-older-stroke-survivors-with-multimorbidity-100652941",false,"NCT07778771","CEEEC-II: A 12-Week Physical and Cognitive Enrichment Extension Study in Older Stroke Survivors With Multimorbidity","A 12-Week, Multicenter, Open-Label, 2×2 Factorial, Cluster-Assigned Extension Study of Upgraded Physical and AI-Enabled Large-Screen Cognitive Enrichment for Older Stroke Survivors With Multimorbidity in Kunshan, China","CEEEC-II","Inclusion Criteria:\n\n* Completed the endpoint assessment of the preceding CEEEC Phase I trial (NCT06975501) and remains under management at a participating community health service station in Kunshan.\n* Age 60 years or older.\n* Hospital-confirmed ischemic or hemorrhagic stroke in a stable stage, with no new or worsening neurological deficit within the previous 3 months.\n* Registered hypertension and\u002For type 2 diabetes mellitus; other comorbid conditions are permitted.\n* Willing and able to participate in the 12-week community-based extension program and complete baseline and endpoint assessments.\n* Able to travel to the community site independently or with a cane or walker; not dependent on a wheelchair for attendance.\n* Short Physical Performance Battery total score \\>=3, or able to maintain a supported side-by-side standing position for 10 seconds when the total score is \\\u003C3.\n* Able to communicate in Mandarin Chinese or the Kunshan dialect and able to recognize Arabic numerals.\n* Corrected vision sufficient to identify large characters at approximately 40 cm and at least one upper limb able to complete touchscreen selection.\n* Resides in the participating community and has no plan to move away during the study period.\n* Provides written informed consent specifically for CEEEC-II.\n\nExclusion Criteria:\n\n* Life-threatening disease or another condition associated with an expected survival of less than 6 months.\n* A new stroke, transient ischemic attack, acute coronary event, or hospitalization for decompensated heart failure within the previous 3 months.\n* Uncontrolled resting blood pressure (systolic \\>=180 mmHg or diastolic \\>=110 mmHg after repeated measurement) until clinically reassessed and controlled.\n* Extreme glycemic instability, including fasting blood glucose \\>16.7 mmol\u002FL or severe hypoglycemia requiring assistance within the previous month, until clinically reassessed.\n* An absolute contraindication to unsupervised community exercise or another medical condition judged by the study clinician to make participation unsafe.\n* Unable to walk to the community site even with a cane or walker, or dependent on a wheelchair for attendance.\n* A severe musculoskeletal, neurological, visual, hearing, cognitive, psychiatric, or communication impairment that prevents safe participation or valid completion of study procedures.\n* Unable to recognize Arabic numerals or unable to complete touchscreen selection with either upper limb.\n* Current participation in another structured physical, cognitive, or nutrition intervention study that may contaminate the assigned intervention.\n* Any other reason documented by the study clinician as making the individual unsuitable for participation.","ALL","60 Years",{"count":88,"type":89},365,"ESTIMATED","INTERVENTIONAL",[92],"NA","CEEEC-II is a 12-week, community-based, prospective extension study conducted in 32 community health service stations in Kunshan, China. It will invite older stroke survivors with hypertension and\u002For type 2 diabetes who participated in the preceding CEEEC Phase I trial (NCT06975501) to provide new informed consent and complete Phase II eligibility and baseline assessments. Participants will remain in the physical enrichment, cognitive enrichment, combined enrichment, or usual-care arm assigned to their community cluster in Phase I; no new randomization will occur in CEEEC-II. The upgraded program includes eight physician-led Vitality Camp sessions and four volunteer-led reinforcement activities. The physical component integrates aerobic, resistance, balance, flexibility, Baduanjin, and nutrition education. The cognitive component integrates health education with age-adapted games delivered through an AI-enabled interactive large screen. The primary objective is to evaluate the marginal effect of the cognitive enrichment factor on intrinsic capacity at 12 weeks.",[95,96,97,98],"Stroke","Hypertension","Type 2 Diabetes Mellitus (T2DM)","Multimorbidity",[100,101,102,103,104,105,106,107],"Intrinsic Capacity","Older Adults","Community Health Services","Environmental Enrichment","Cognitive Training","Physical Exercise","Multicomponent Intervention","Cluster-Assigned Extension Study","NOT_YET_RECRUITING","2026-08-18",{"date":111,"type":112},"2026-08-21","ACTUAL",{"date":114,"type":89},"2026-08-31",{"date":116,"type":89},"2027-01-03",{"name":5,"class":6},1]