[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100656271":3},{"organization":4,"outcomesModule":7,"designInfo":27,"detailedDescription":26,"studyPopulation":30,"armGroups":31,"interventions":36,"overallOfficials":26,"centralContacts":42,"locations":48,"responsibleParty":65,"collaborators":26,"id":69,"slug":70,"hasResults":71,"nctId":72,"briefTitle":73,"officialTitle":74,"acronym":75,"eligibilityCriteria":76,"healthyVolunteers":71,"sex":77,"minAge":26,"maxAge":26,"enrollmentInfo":78,"targetDuration":81,"studyType":82,"phases":26,"briefSummary":83,"conditions":84,"keywords":87,"overallStatus":93,"whyStopped":26,"lastUpdateSubmitDate":94,"lastUpdatePostDateStruct":95,"startDateStruct":98,"completionDateStruct":100,"leadSponsor":102,"locationsCount":103},{"fullName":5,"class":6},"Ankara City Hospital Bilkent","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":26},[9],{"measure":10,"description":11,"timeFrame":12},"Prevalence of Cervical Spinal Cord Signal Abnormalities Including Myelomalacia","The proportion of participants with cervical spinal cord signal abnormalities identified on cervical magnetic resonance imaging (MRI), including intramedullary T2-weighted signal abnormalities and findings consistent with myelomalacia, will be determined. The prevalence will be calculated as the number of participants with these MRI findings divided by the total number of enrolled participants with evaluable cervical MRI examinations.","At the initial clinical evaluation (baseline)",[14,17,20,23],{"measure":15,"description":16,"timeFrame":12},"Planned Treatment Strategy","The treatment strategy selected during routine clinical care will be recorded for each participant. Management will be categorized as interventional pain procedure, medical treatment without intervention, referral for surgical evaluation, or other clinically appropriate management.",{"measure":18,"description":19,"timeFrame":12},"Clinical and Radiological Factors Associated With Interventional Treatment Selection","The association between predefined clinical and radiological variables and the decision to plan an interventional pain procedure will be evaluated. Variables will include Hoffmann sign, motor deficit, hyperreflexia, Babinski sign, clonus, gait abnormality, central canal stenosis, spinal cord compression, intramedullary signal abnormality, and myelomalacia.",{"measure":21,"description":22,"timeFrame":12},"Association Between Hoffmann Sign and Cervical Spinal Cord Signal Abnormalities","The relationship between Hoffmann sign status and cervical spinal cord abnormalities on MRI will be evaluated. The frequency of spinal cord signal abnormalities and myelomalacia will be compared between participants with positive and negative Hoffmann signs.",{"measure":24,"description":25,"timeFrame":12},"Referral for Surgical Evaluation","The proportion of participants referred for neurosurgical or spine surgical evaluation following clinical and radiological assessment will be determined, and factors associated with referral will be explored.",null,{"allocation":26,"interventionModel":26,"interventionModelDescription":26,"primaryPurpose":26,"observationalModel":28,"timePerspective":29,"maskingInfo":26},"COHORT","PROSPECTIVE","The study population will consist of 400 consecutive adult patients presenting to the tertiary Pain Medicine Clinic of Ankara Bilkent City Hospital with cervical radicular pain. Participants will be prospectively enrolled during routine clinical evaluation. Clinical and neurological examination findings, cervical MRI characteristics, and the treatment strategy selected by the treating physician will be recorded. No diagnostic or therapeutic intervention will be assigned by the study protocol.",[32],{"label":33,"type":26,"description":33,"interventionNames":34},"Patients With Cervical Radicular Pain",[35],"Diagnostic Test: Clinical and Cervical MRI Assessment",[37],{"type":38,"name":39,"description":40,"armGroupLabels":41,"otherNames":26},"DIAGNOSTIC_TEST","Clinical and Cervical MRI Assessment","Participants will undergo routine clinical and neurological evaluation, including assessment of the Hoffmann sign and other neurological findings, together with evaluation of cervical magnetic resonance imaging (MRI) findings. Cervical MRI findings, including spinal canal stenosis, spinal cord compression, intramedullary signal abnormalities, and myelomalacia, will be recorded. All assessments are performed as part of routine clinical care. No diagnostic procedure or treatment is assigned by the study protocol.",[33],[43],{"name":44,"role":45,"phone":46,"phoneExt":26,"email":47},"Ülkü Sabuncu, Assoc prof","CONTACT","905337085212","sabuncuulku@gmail.com",[49],{"facility":50,"status":26,"city":51,"state":26,"zip":52,"country":53,"countryCode":26,"cosmosGeoPoint":54,"geoPoint":59,"contacts":60},"Ankara Bilkent City Hospital","Ankara","06680","Turkey (Türkiye)",{"type":55,"coordinates":56},"Point",[57,58],32.85427,39.91987,{"lat":58,"lon":57},[61],{"name":62,"role":45,"phone":63,"phoneExt":64,"email":47},"Ülkü Sabuncu, Assoc Prof","90312 5526000","102-103",{"type":66,"investigatorFullName":67,"investigatorTitle":68,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"PRINCIPAL_INVESTIGATOR","Ülkü Sabuncu","Assoc Prof","100656271","cervical-spinal-cord-signal-abnormalities-in-patients-with-cervical-radicular-pain-100656271",false,"NCT07823426","Cervical Spinal Cord Signal Abnormalities in Patients With Cervical Radicular Pain","Prevalence of Cervical Spinal Cord Signal Abnormalities and Determinants of Treatment Selection in Patients With Cervical Radicular Pain: A Prospective Cohort Study","CSCS","Inclusion Criteria:\n\n* Age 18 years or older\n* Presentation to the pain clinic with cervical radicular pain\n* Clinical symptoms and\u002For examination findings consistent with cervical nerve root involvement\n* Availability of a cervical magnetic resonance imaging (MRI) examination suitable for evaluation\n* Completion of standardized neurological examination at the initial visit\n* Ability and willingness to provide written informed consent\n\nExclusion Criteria:\n\n* Previous cervical spine surgery\n* Acute cervical spine trauma\n* Known cervical spinal malignancy\n* Active spinal infection\n* Known inflammatory, demyelinating, or other non-degenerative spinal cord disease\n* Severe cognitive impairment or communication difficulty preventing reliable clinical assessment\n* Inadequate or non-diagnostic cervical MRI quality\n* Refusal to participate","ALL",{"count":79,"type":80},400,"ESTIMATED","1 Day","OBSERVATIONAL","This prospective observational study aims to determine the prevalence of cervical spinal cord signal abnormalities, including myelomalacia, among adult patients presenting to a tertiary pain clinic with cervical radicular pain.\n\nA total of 400 consecutive patients will be enrolled. Clinical and neurological examination findings, including the Hoffmann sign and other findings suggestive of cervical spinal cord involvement, will be recorded together with cervical magnetic resonance imaging (MRI) findings obtained as part of routine clinical care.\n\nThe primary outcome is the prevalence of cervical spinal cord signal abnormalities, including myelomalacia, on cervical MRI. Secondary outcomes include the treatment strategy selected during routine clinical care, clinical and radiological factors associated with treatment selection, the relationship between the Hoffmann sign and cervical spinal cord abnormalities, and referral for surgical evaluation.\n\nThis is an observational study. Participation in the study will not determine or alter diagnostic or treatment decisions, which will be made by the treating physician according to routine clinical practice.",[85,86],"Cervical Radiculopathy","Cervical Myelomalacia",[88,89,90,91,92],"Cervical Radicular Pain","Cervical Spinal Cord Signal Abnormality","Myelomalacia","Spinal Cord Compression","Hoffman","NOT_YET_RECRUITING","2026-09-15",{"date":96,"type":97},"2026-09-16","ACTUAL",{"date":99,"type":80},"2026-10-01",{"date":101,"type":80},"2027-03-31",{"name":5,"class":6},1]