[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100464994":3},{"organization":4,"armGroups":7,"interventions":31,"overallOfficials":10,"centralContacts":56,"locations":63,"responsibleParty":522,"collaborators":10,"id":526,"slug":527,"hasResults":528,"nctId":529,"briefTitle":530,"officialTitle":530,"acronym":531,"eligibilityCriteria":532,"healthyVolunteers":528,"sex":533,"minAge":534,"maxAge":10,"enrollmentInfo":535,"targetDuration":538,"studyType":539,"phases":10,"briefSummary":540,"conditions":541,"keywords":10,"overallStatus":66,"whyStopped":10,"lastUpdateSubmitDate":548,"lastUpdatePostDateStruct":549,"startDateStruct":552,"completionDateStruct":554,"leadSponsor":556,"locationsCount":557},{"fullName":5,"class":6},"Beijing Tiantan Hospital","OTHER",[8,14,22,27],{"label":9,"type":10,"description":11,"interventionNames":12},"Medicine Overuse Headache\u002FNew Daily Persistent Headache",null,"The first 18 months were followed up once a month,then followed up once at the 24th month,follow-up visits were made annually after 24 months",[13],"Behavioral: Medicine Overuse Headache\u002FNew Daily Persistent Headache",{"label":15,"type":10,"description":16,"interventionNames":17},"Chronic Migraine","The patients were followed up at 1, 2, 3, 6, 9, 12, 18 and 24 months,then follow-up visits were made annually",[18,19,20,21],"Behavioral: Episodic Migraine and Chronic Migraine","Drug: Yangxue Qingnao Granules (Pills)","Biological: Erenumab","Biological: Eptinezumab",{"label":23,"type":10,"description":24,"interventionNames":25},"Patients with other types of primary headache","The patients were followed up at 3, 6, 9months",[26],"Behavioral: Patients with other types of primary headache",{"label":28,"type":10,"description":29,"interventionNames":30},"Episodic migraine","The patients were followed up at 1, 2, 3, 6, 9, 12, 18 and 24 months,then follow-up visits were made annually.",[19,20,21],[32,36,40,43,48,53],{"type":33,"name":9,"description":34,"armGroupLabels":35,"otherNames":10},"BEHAVIORAL","At the end of the 24th month visit, the patient is free to choose whether to conduct a face-to-face visit once a year until death.",[9],{"type":33,"name":37,"description":38,"armGroupLabels":39,"otherNames":10},"Episodic Migraine and Chronic Migraine","long-term follow-up",[15],{"type":33,"name":23,"description":41,"armGroupLabels":42,"otherNames":10},"No collection Brain imaging、Cognitive function test、Biological sample",[23],{"type":44,"name":45,"description":46,"armGroupLabels":47,"otherNames":10},"DRUG","Yangxue Qingnao Granules (Pills)","Participants who, in routine clinical practice, were prescribed Yangxue Qingnao Granules\u002FPills for acute headache relief and\u002For preventive management were enrolled. Treatment initiation, dosing, frequency, and duration were determined by the treating physician and the patient and were not assigned by the study protocol. During the 12-week observation period, participants were followed and outcomes were recorded, including relief of up to four headache episodes (for those using the medication for acute treatment) and longitudinal symptom measures at weeks 4, 8, and 12 (for those receiving preventive management).",[15,28],{"type":49,"name":50,"description":51,"armGroupLabels":52,"otherNames":10},"BIOLOGICAL","Erenumab","Participants who received eptinezumab for migraine prophylaxis in routine clinical practice were included. Treatment decisions (including whether to initiate eptinezumab, the selected dose \\[e.g., 100 mg or 300 mg\\], infusion interval, and duration) were made by the treating physician in consultation with the patient, and were not assigned by the study protocol. Patients were followed prospectively\u002Fretrospectively according to routine clinic visits, with outcome assessments captured at approximately 4-week intervals during the 12-week observation window (and additional follow-up when available).",[15,28],{"type":49,"name":54,"description":51,"armGroupLabels":55,"otherNames":10},"Eptinezumab",[15,28],[57],{"name":58,"role":59,"phone":60,"phoneExt":61,"email":62},"Yong Gang Wang, Doctor","CONTACT","15010066622","086","w100yg@163.com",[64,77,85,95,100,105,110,119,124,133,141,146,155,164,173,178,187,195,204,213,216,224,232,237,242,251,260,268,273,278,286,294,299,304,313,322,330,339,347,356,361,370,378,387,392,400,409,418,427,432,440,448,456,461,469,477,480,488,497,506,514],{"facility":65,"status":66,"city":67,"state":68,"zip":10,"country":69,"countryCode":70,"cosmosGeoPoint":71,"geoPoint":76,"contacts":10},"Anqing Municipal 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College",{"type":72,"coordinates":144},[138,139],{"lat":139,"lon":138},{"facility":147,"status":66,"city":148,"state":149,"zip":10,"country":69,"countryCode":70,"cosmosGeoPoint":150,"geoPoint":154,"contacts":10},"The Second Hospital of Lanzhou University","Lanzhou","Gansu",{"type":72,"coordinates":151},[152,153],103.83987,36.05701,{"lat":153,"lon":152},{"facility":156,"status":66,"city":157,"state":158,"zip":10,"country":69,"countryCode":70,"cosmosGeoPoint":159,"geoPoint":163,"contacts":10},"Shenzhen Second People's Hospital","Shenzhen","Guangdong",{"type":72,"coordinates":160},[161,162],114.0683,22.54554,{"lat":162,"lon":161},{"facility":165,"status":66,"city":166,"state":167,"zip":10,"country":69,"countryCode":70,"cosmosGeoPoint":168,"geoPoint":172,"contacts":10},"The First Affiliated Hospital of Guangxi University of Chinese 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University","Nanjing",{"type":72,"coordinates":326},[327,328],118.77778,32.06167,{"lat":328,"lon":327},{"facility":331,"status":66,"city":332,"state":333,"zip":10,"country":69,"countryCode":70,"cosmosGeoPoint":334,"geoPoint":338,"contacts":10},"Jiujiang First People's Hospital","Jiujiang","Jiangxi",{"type":72,"coordinates":335},[336,337],116.00206,29.70475,{"lat":337,"lon":336},{"facility":340,"status":66,"city":341,"state":333,"zip":10,"country":69,"countryCode":70,"cosmosGeoPoint":342,"geoPoint":346,"contacts":10},"The First Affiliated Hospital of Nanchang University","Nanchang",{"type":72,"coordinates":343},[344,345],115.85306,28.68396,{"lat":345,"lon":344},{"facility":348,"status":66,"city":349,"state":350,"zip":10,"country":69,"countryCode":70,"cosmosGeoPoint":351,"geoPoint":355,"contacts":10},"The First Hospital of Jilin University","Changchun","Jilin",{"type":72,"coordinates":352},[353,354],125.32278,43.88,{"lat":354,"lon":353},{"facility":357,"status":66,"city":349,"state":350,"zip":10,"country":69,"countryCode":70,"cosmosGeoPoint":358,"geoPoint":360,"contacts":10},"The Second Hospital of Jilin University",{"type":72,"coordinates":359},[353,354],{"lat":354,"lon":353},{"facility":362,"status":66,"city":363,"state":364,"zip":10,"country":69,"countryCode":70,"cosmosGeoPoint":365,"geoPoint":369,"contacts":10},"Ansteel Group General Hospital","Anshan","Liaoning",{"type":72,"coordinates":366},[367,368],122.99,41.12361,{"lat":368,"lon":367},{"facility":371,"status":66,"city":372,"state":364,"zip":10,"country":69,"countryCode":70,"cosmosGeoPoint":373,"geoPoint":377,"contacts":10},"Huludao Central 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Hospital","Nanchong",{"type":72,"coordinates":465},[466,467],106.08473,30.79508,{"lat":467,"lon":466},{"facility":470,"status":66,"city":471,"state":421,"zip":10,"country":69,"countryCode":70,"cosmosGeoPoint":472,"geoPoint":476,"contacts":10},"Panzhihua Central Hospital","Panzhihua",{"type":72,"coordinates":473},[474,475],101.71276,26.58509,{"lat":475,"lon":474},{"facility":478,"status":66,"city":479,"state":421,"zip":10,"country":69,"countryCode":70,"cosmosGeoPoint":10,"geoPoint":10,"contacts":10},"Siyang Hospital","Siyang",{"facility":481,"status":66,"city":482,"state":421,"zip":10,"country":69,"countryCode":70,"cosmosGeoPoint":483,"geoPoint":487,"contacts":10},"Zigong First People's Hospital","Zigong",{"type":72,"coordinates":484},[485,486],104.77689,29.34162,{"lat":486,"lon":485},{"facility":489,"status":66,"city":490,"state":491,"zip":10,"country":69,"countryCode":70,"cosmosGeoPoint":492,"geoPoint":496,"contacts":10},"Xinjiang Production and Construction Corps Hospital","Ürümqi","Xinjiang",{"type":72,"coordinates":493},[494,495],87.60046,43.80096,{"lat":495,"lon":494},{"facility":498,"status":66,"city":499,"state":500,"zip":10,"country":69,"countryCode":70,"cosmosGeoPoint":501,"geoPoint":505,"contacts":10},"The Second Affiliated Hospital of Zhejiang University School of Medicine","Hangzhou","Zhejiang",{"type":72,"coordinates":502},[503,504],120.16142,30.29365,{"lat":504,"lon":503},{"facility":507,"status":66,"city":508,"state":500,"zip":10,"country":69,"countryCode":70,"cosmosGeoPoint":509,"geoPoint":513,"contacts":10},"Huzhou Central Hospital","Huzhou",{"type":72,"coordinates":510},[511,512],120.0933,30.8703,{"lat":512,"lon":511},{"facility":515,"status":66,"city":516,"state":500,"zip":10,"country":69,"countryCode":70,"cosmosGeoPoint":517,"geoPoint":521,"contacts":10},"The First Affiliated Hospital of Wenzhou Medical University","Wenzhou",{"type":72,"coordinates":518},[519,520],120.66682,27.99942,{"lat":520,"lon":519},{"type":523,"investigatorFullName":524,"investigatorTitle":525,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Yonggang.wang","MD","100464994","china-headache-disorders-registry-100464994",false,"NCT05334927","China HeadAche DIsorders RegiStry","CHAIRS","Inclusion Criteria:\n\n1. Age ≥ 12 years old,Any gender;\n2. The first onset age of primary headache was less than 50 years old(Age \\\u003C65 years at first diagnosis of chronic migraine);\n3. patients with primary headache (migraine, tension headache and other types of primary headache) or primary headache complicated with MOH according to ICHD-3;\n4. Sign the informed consent form.\n\nExclusion Criteria:\n\n1. According to the ICHD-3 diagnostic criteria, there are still headaches directly related to secondary factors (except drug overuse) at the time of enrollment;\n2. Those who cannot be diagnosed as primary headache or primary headache combined with medication overuse headache according to ICHD-3;\n3. According to DSM-V diagnostic criteria, patients with severe mental diseases (such as schizophrenia, mental disorders associated with mental retardation, etc.);\n4. Patients with severe organic diseases, such as malignant tumors, and the expected survival time is less than 1 year;\n5. Pregnant,planning pregnancy or Lactating women;\n6. Subjects participating in other clinical trials;\n7. Unable to cooperate to complete the follow-up due to geographical or other reasons","ALL","12 Years",{"count":536,"type":537},10000,"ESTIMATED","1 Month","OBSERVATIONAL","It is planned to include 10000 patients. In the China HeadAche DIsorders RegiStry CHAIRS）, patients aged over 12 years with primary headache and medication-overuse headache(MOH) were collected. The biomarkers, imaging features, cognition, genetic characteristics, ocial and demographic data, medical data, therapeutics used, and outcome of headache-related diseases were studied, and long-term follow-up was planned.",[542,543,544,545,546,547],"Headache Disorders, Primary","Migraine","New Daily Persistent Headache","Medication Overuse Headache","Tension-Type Headache","Trigeminal Autonomic Cephalalgia","2026-07-09",{"date":550,"type":551},"2026-07-10","ACTUAL",{"date":553,"type":551},"2022-08-29",{"date":555,"type":537},"2032-12-31",{"name":5,"class":6},61]