[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100556125":3},{"organization":4,"outcomesModule":7,"designInfo":42,"detailedDescription":52,"studyPopulation":45,"armGroups":53,"interventions":64,"overallOfficials":74,"centralContacts":78,"locations":87,"responsibleParty":105,"collaborators":108,"id":118,"slug":119,"hasResults":120,"nctId":121,"briefTitle":122,"officialTitle":123,"acronym":45,"eligibilityCriteria":124,"healthyVolunteers":125,"sex":126,"minAge":127,"maxAge":128,"enrollmentInfo":129,"targetDuration":45,"studyType":132,"phases":133,"briefSummary":135,"conditions":136,"keywords":45,"overallStatus":89,"whyStopped":45,"lastUpdateSubmitDate":138,"lastUpdatePostDateStruct":139,"startDateStruct":142,"completionDateStruct":144,"leadSponsor":146,"locationsCount":147},{"fullName":5,"class":6},"Cedars-Sinai Medical Center","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":37},[9],{"measure":10,"description":11,"timeFrame":12},"Completion Rate of Follow-up Visits","We will continuously track the rate of 3-month and 6-month follow-up completion as followed: actual follow-ups completed \u002F expected follow-ups to be completed.","3 Month, 6 Month",[14,18,21,25,29,33],{"measure":15,"description":16,"timeFrame":17},"Height","Participant baseline height is self-reported in inches.","Baseline",{"measure":19,"description":20,"timeFrame":17},"Demographics","Demographic questionnaire will be used to capture date of birth, sex and gender identity, race, ethnicity, socioeconomic status (education, household income, marital status, employment status) and household composition (e.g., multigenerational, children).",{"measure":22,"description":23,"timeFrame":24},"Drivers of preference, retention, and adherence","Our quantitative analytic approach will make it possible to compare CHOICE and RANDOM study follow-up completion, adherence, and weight loss among Non-Hispanic White and among those who identify to an ethnic and\u002For racial minoritized group. Quantitative analyses, however, do not make it possible to contextualize drivers that may influence relative preference, retention, and adherence. Using semi-structured interviews (Appendix A), we will explore the depth of personal beliefs and experiences, cultural contexts, social dynamics, social support systems, and household factors that may influence affect participants' preferences and sustained engagement. This knowledge will inform personalized behavior change strategies that are sensitive to the diverse needs of participants' social context.","Baseline, 6 Month",{"measure":26,"description":27,"timeFrame":28},"Weight","Weight is measured using the Bluetooth enabled scales based on standard practices (e.g., empty pockets). Weight loss will be operationalized as the difference between weight at baseline, 3-month and 6-month.","Baseline, 3 Month, 6 Month",{"measure":30,"description":31,"timeFrame":32},"Completion Rate of Weight Self-monitoring","Completion rate of weight self-monitoring is defined as the frequency of weekly body weight entries recorded. The outcome is calculated as the percentage of entries with a recorded weight out of the total number of weeks in the 6-month intervention period.","From baseline to end of treatment at 6 months",{"measure":34,"description":35,"timeFrame":36},"Completion Rate of days with recorded dietary self-monitoring","Completion rate of the days with recorded dietary self-monitoring is calculated as the proportion of prescribed days of dietary-self monitoring successfully completed by the participant. The protocol prescribes dietary self-monitoring daily over 6 months, equivalent to about 182 days. Adherence for each participant is calculated as the number of completed days of self-monitoring logs divided by the total number of prescribed days.","From intervention start to the end of treatment at 6 months",[38],{"measure":39,"description":40,"timeFrame":41},"Physical activity","We will leverage data conferred by the WW program to physical activity (type, duration and intensity) via the WW mobile app or online website.","From enrollment to the end of treatment at 6 months",{"allocation":43,"interventionModel":44,"interventionModelDescription":45,"primaryPurpose":46,"observationalModel":45,"timePerspective":45,"maskingInfo":47},"NON_RANDOMIZED","PARALLEL",null,"TREATMENT",{"masking":48,"maskingDescription":45,"whoMasked":49},"DOUBLE",[50,51],"INVESTIGATOR","OUTCOMES_ASSESSOR","Since we initiated recruitment for the AVOID\u002FRESIST trial (IRB STUDY00001652: AVOID-RESIST), we have noted that some participants have a strong initial inclination for one of the self-regulatory strategies. Some individuals have clearly expressed which strategy they believed would work for them, while others have voiced dislike or skepticism for an assigned intervention component. While attrition in the last 18 months (12.5%) is comparable to trials of similar size and scope, over 56% (n=18) of withdrawals were explicitly (n=3) or tangentially (n=15) related to intervention assignment.\n\nThis pilot study (CHOICE) seeks to leverage our ongoing R01 to test whether participants' active choice of behavior change pathways and strategies leads to better adherence, retention, and engagement. Women, and men with overweight or obesity (BMI between 25-45 kg\u002Fm2) will be enrolled in the WW digital program for 6 months. R01 participants will continue to be randomized to one of the 4 study arms: (1) WW alone, (2) WW + AVOID, (3) WW + RESIST, (4) WW + AVOID + RESIST. CHOICE participants will be asked to choose which self-regulatory strategy (AVOID or RESIST) they want to receive to promote behavior change consistent with WW recommendations.",[54,59],{"label":55,"type":6,"description":56,"interventionNames":57},"WW + Home modification and grocery delivery (AVOID)","WW + modification of home food environment + online grocery shopping and delivery\n\nArm assignment is selected by participant.",[58],"Behavioral: AVOID",{"label":60,"type":6,"description":61,"interventionNames":62},"WW + Inhibitory control training (RESIST)","WW + daily gamified inhibitory control training\n\nArm assignment is selected by participant.",[63],"Behavioral: RESIST",[65,70],{"type":66,"name":67,"description":68,"armGroupLabels":69,"otherNames":45},"BEHAVIORAL","AVOID","Behavioral: Home food environment and grocery delivery (AVOID) Participants will receive coaching (Zoom and\u002For email\u002Ftext) to modify their home food environment and alter cues to promote healthy food choices\n\nBehavioral: WW Participants assigned to all arms will receive of coaching (Zoom and\u002For email\u002Ftext) and commercially-available weight management program focusing on diet, physical activity and mindset skills.",[55],{"type":66,"name":71,"description":72,"armGroupLabels":73,"otherNames":45},"RESIST","Behavioral: Inhibitory control training (RESIST) Participants assigned to RESIST will receive coaching (Zoom and\u002For email\u002Ftext) and gamified inhibitory control training.\n\nBehavioral: WW Participants assigned to all arms will receive coaching (Zoom and\u002For email\u002Ftext) and commercially-available weight management program focusing on diet, physical activity and mindset skills.",[60],[75],{"name":76,"affiliation":5,"role":77},"Sarah Salvy, PhD","PRINCIPAL_INVESTIGATOR",[79,84],{"name":80,"role":81,"phone":82,"phoneExt":45,"email":83},"Julissa Ruiz, BS","CONTACT","(310) 602-4169","julissa.ruiz@cshs.org",{"name":85,"role":81,"phone":45,"phoneExt":45,"email":86},"Sarah-Jeanne Salvy, PhD","sarah.salvy@cshs.org",[88],{"facility":5,"status":89,"city":90,"state":91,"zip":92,"country":93,"countryCode":94,"cosmosGeoPoint":95,"geoPoint":100,"contacts":101},"RECRUITING","Beverly Hills","California","90211","United States","US",{"type":96,"coordinates":97},"Point",[98,99],-118.40036,34.07362,{"lat":99,"lon":98},[102,103,104],{"name":80,"role":81,"phone":45,"phoneExt":45,"email":83},{"name":85,"role":81,"phone":45,"phoneExt":45,"email":86},{"name":85,"role":77,"phone":45,"phoneExt":45,"email":45},{"type":77,"investigatorFullName":106,"investigatorTitle":107,"investigatorAffiliation":5,"oldNameTitle":45,"oldOrganization":45},"Sarah Salvy","Professor of Medicine",[109,111,113,116],{"name":110,"class":6},"University of California, Riverside",{"name":112,"class":6},"Northeastern University",{"name":114,"class":115},"WW International Inc","INDUSTRY",{"name":117,"class":6},"The University of Tennessee, Knoxville","100556125","choice-to-avoid-or-resist-100556125",false,"NCT06521021","CHOICE to AVOID or RESIST","CHOICE to AVOID or RESIST: Evaluating Participants' Choice of Self-regulatory Strategy on Weight Management Outcomes: A Pilot Study.","Inclusion Criteria:\n\n* Age 18 years or older\n* BMI between 25-45 kg\u002Fm2\n* Read, write, and speak English with acceptable visual acuity\n\nExclusion Criteria:\n\n* Currently enrolled in weight loss interventions or undergoing bariatric surgery\n* Pregnant women\n* Individuals for whom weight loss may be contraindicated (e.g., unstable coronary artery disease, end-stage disease, active cancer treatment, uncontrolled insulin-dependent diabetes, portal hypertension, drug\u002Falcohol abuse)\n* Individuals who have pacemakers or other electronic medical device implantations\n* Individuals with severe cognitive delays or visual\u002Fhearing impairment\n* Individuals who are unable or unwilling to complete the study assessments \u002F measurements\n* Individuals currently subscribed to a meal delivery service who are unwilling to pause their subscription for the duration of the study",true,"ALL","18 Years","80 Years",{"count":130,"type":131},60,"ESTIMATED","INTERVENTIONAL",[134],"NA","This trials will formally test whether participants' active choice of self-regulatory strategies (AVOID or RESIST) leads to greater adherence to weight management strategies by comparing the CHOICE arms to the randomized arms of the parent intervention, AVOID\u002FRESIST (IRB STUDY00001652: AVOID-RESIST).",[137],"Overweight and Obesity","2026-09-17",{"date":140,"type":141},"2026-09-22","ACTUAL",{"date":143,"type":141},"2026-06-01",{"date":145,"type":131},"2027-07-01",{"name":5,"class":6},1]