[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100658775":3},{"organization":4,"outcomesModule":7,"designInfo":15,"detailedDescription":11,"studyPopulation":18,"armGroups":19,"interventions":11,"overallOfficials":23,"centralContacts":31,"locations":40,"responsibleParty":59,"collaborators":62,"id":66,"slug":67,"hasResults":68,"nctId":69,"briefTitle":70,"officialTitle":70,"acronym":11,"eligibilityCriteria":71,"healthyVolunteers":68,"sex":72,"minAge":73,"maxAge":74,"enrollmentInfo":75,"targetDuration":11,"studyType":78,"phases":11,"briefSummary":79,"conditions":80,"keywords":82,"overallStatus":43,"whyStopped":11,"lastUpdateSubmitDate":86,"lastUpdatePostDateStruct":87,"startDateStruct":90,"completionDateStruct":92,"leadSponsor":94,"locationsCount":95},{"fullName":5,"class":6},"The University of Texas Health Science Center, Houston","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":11,"otherOutcomes":11},[9,13],{"measure":10,"description":11,"timeFrame":12},"Change in anti-factor Xa (anti-FXa) levels",null,"4 hours after the 3rd LMWH dose (T0), then every 6 hours (T6, T12, T18)",{"measure":14,"description":11,"timeFrame":12},"Change in Antithrombin III (AT3) activity",{"allocation":11,"interventionModel":11,"interventionModelDescription":11,"primaryPurpose":11,"observationalModel":16,"timePerspective":17,"maskingInfo":11},"COHORT","PROSPECTIVE","The study will be conducted at HCA Houston Northwest Medical Center and will include adult trauma patients admitted to the Trauma ICU and Trauma Surgical Floor",[20],{"label":21,"type":11,"description":22,"interventionNames":11},"Hospitalized Trauma Patients Receiving LMWH Chemoprophylaxis","Hospitalized trauma patients receiving low-molecular-weight heparin (LMWH) chemoprophylaxis as part of routine clinical care. Participants will have anti-FXa levels and antithrombin III (AT3) activity measured at predefined time points to evaluate potential circadian variation in these measures.",[24,27],{"name":25,"affiliation":5,"role":26},"Evaline W Kihara, MSN, APRN, AGACNP-BC, CCRN","PRINCIPAL_INVESTIGATOR",{"name":28,"affiliation":29,"role":30},"Shiree Berry, MD","HCA Houston NW Medical center- Trauma Medical Director","STUDY_DIRECTOR",[32,36],{"name":25,"role":33,"phone":34,"phoneExt":11,"email":35},"CONTACT","(713) 500-6362","Evaline.W.Kihara@uth.tmc.edu",{"name":37,"role":33,"phone":38,"phoneExt":11,"email":39},"Nikhil Padhye, PhD","(713) 500-2035","Nikhil.S.Padhye@uth.tmc.edu",[41],{"facility":42,"status":43,"city":44,"state":45,"zip":46,"country":47,"countryCode":48,"cosmosGeoPoint":49,"geoPoint":54,"contacts":55},"HCA Houston Northwest Medical Center","RECRUITING","Houston","Texas","77090","United States","US",{"type":50,"coordinates":51},"Point",[52,53],-95.36327,29.76328,{"lat":53,"lon":52},[56,57],{"name":25,"role":33,"phone":34,"phoneExt":11,"email":35},{"name":58,"role":33,"phone":38,"phoneExt":11,"email":39},"Nikhil Padhye",{"type":26,"investigatorFullName":60,"investigatorTitle":61,"investigatorAffiliation":5,"oldNameTitle":11,"oldOrganization":11},"Evaline Kihara","Acute Care Nurse Practitioner",[63],{"name":64,"class":65},"Sigma Theta Tau International Grant; Jerold B. Katz Endowment Fund","UNKNOWN","100658775","circadian-variation-of-anti-factor-xa-in-hospitalized-trauma-patients-100658775",false,"NCT07856641","Circadian Variation of Anti-Factor Xa in Hospitalized Trauma Patients","Inclusion Criteria:\n\n* Inpatient admission for acute traumatic injury ≥72 hours\n* Prescribed LMWH subcutaneous for VTE chemoprophylaxis\n\nExclusion Criteria:\n\n* Pregnancy\n* Brain hemorrhage or non-survivable injury\n* Chronic Kidney disease ≥ 3b estimated Glomerular Filtration Rate (eGFR) less than 30 interferes with coagulation\n* Chronic liver failure\n\n  •-Acute stimulant use of cocaine and methamphetamine\n* Active VTE or ongoing anticoagulation at admission\n* History of coagulopathy or inherited bleeding disorders\n* Chronic alcohol as defined as a documented diagnosis of alcohol use disorder or alcohol consumption exceeding established risk thresholds (men \\>14 drinks\u002Fweek; women \\>7 drinks\u002Fweek) within the prior 3-6 months\n* Unmanaged psychiatric conditions as defined as diagnosed psychiatric disorder with evidence of inadequate or no active treatment or documented poor symptom control\n* Neurologic injury involving hypothalamic or circadian regulatory centers","ALL","18 Years","80 Years",{"count":76,"type":77},40,"ESTIMATED","OBSERVATIONAL","The purpose of this study is to determine whether a circadian rhythm exists in anti-FXa levels and AT3 activity in hospitalized trauma patients receiving low-molecular-weight heparin (LMWH) chemoprophylaxis",[81],"Circadian Variation in Anti-Factor Xa (Anti-FXa) Activity",[83,84,85],"Blood thinner","circadian rhythm","Venous thromboembolism (VTE)","2026-09-28",{"date":88,"type":89},"2026-10-02","ACTUAL",{"date":91,"type":89},"2026-08-26",{"date":93,"type":77},"2028-03-26",{"name":5,"class":6},1]