[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100646635":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":11,"centralContacts":11,"locations":11,"responsibleParty":28,"collaborators":11,"id":32,"slug":33,"hasResults":34,"nctId":35,"briefTitle":36,"officialTitle":37,"acronym":11,"eligibilityCriteria":38,"healthyVolunteers":34,"sex":39,"minAge":40,"maxAge":11,"enrollmentInfo":41,"targetDuration":11,"studyType":44,"phases":45,"briefSummary":47,"conditions":48,"keywords":53,"overallStatus":62,"whyStopped":11,"lastUpdateSubmitDate":63,"lastUpdatePostDateStruct":64,"startDateStruct":67,"completionDateStruct":69,"leadSponsor":71,"locationsCount":11},{"fullName":5,"class":6},"Assiut University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"standard postoperative TKR rehabilitation (hospital protocol)","ACTIVE_COMPARATOR",null,[13],"Other: standard postoperative TKR rehabilitation",{"label":15,"type":16,"description":11,"interventionNames":17},"Circulatory Exercise Protocol (in addition to standard rehab)","EXPERIMENTAL",[18],"Other: Standard Rehabilitation Plus Circulatory Exercise",[20,24],{"type":6,"name":21,"description":22,"armGroupLabels":23,"otherNames":11},"standard postoperative TKR rehabilitation","Participants will receive standard postoperative total knee replacement rehabilitation according to the local hospital protocol, including early mobilization, ROM exercises, quadriceps activation, ambulation training, and standard pain\u002Fedema management as clinically indicated.",[9],{"type":6,"name":25,"description":26,"armGroupLabels":27,"otherNames":11},"Standard Rehabilitation Plus Circulatory Exercise","Participants will receive standard postoperative rehabilitation plus a circulatory exercise protocol including supine leg elevation with ankle pump and knee extension, and seated knee extension with alternating ankle dorsiflexion. The exercise will be performed at approximately 15 cycles\u002Fminute, 10 sets of 1 minute, 60 seconds rest between sets, twice daily for 14 postoperative days.",[15],{"type":29,"investigatorFullName":30,"investigatorTitle":31,"investigatorAffiliation":5,"oldNameTitle":11,"oldOrganization":11},"PRINCIPAL_INVESTIGATOR","Mariam ibrahim","Physical Therapist, PhD","100646635","circulatory-exercise-after-total-knee-replacement-100646635",false,"NCT07688642","Circulatory Exercise After Total Knee Replacement","Boosting Venous Return After Knee Replacement: Effects of a Novel Circulatory Exercise on Early Postoperative Inflammation - A Randomized Controlled Trial","Inclusion Criteria:\n\n* Adults ≥ 18 years undergoing elective unilateral primary TKR for osteoarthritis.\n* Able to provide informed consent.\n* Able to perform the exercise (cognitively and physically) prior to discharge.\n\nExclusion Criteria:\n\n* Preexisting peripheral vascular disease with severe ischemia or venous insufficiency that limits exercise.\n* Contraindication to early active movement per surgeon (e.g., complex surgical fixation limiting motion if present).\n* Severe neurological or cognitive impairment preventing instruction adherence.\n* Inability to comply with follow-up.","ALL","18 Years",{"count":42,"type":43},68,"ESTIMATED","INTERVENTIONAL",[46],"NA","Total knee replacement is commonly associated with early postoperative inflammation, edema, pain, and reduced mobility. This randomized controlled trial will evaluate whether adding a simple circulatory exercise program to standard postoperative rehabilitation reduces early limb edema and inflammatory response after unilateral primary total knee replacement. Participants will be randomized to standard rehabilitation alone or standard rehabilitation plus seated and supine knee-extension exercises with alternating ankle dorsiflexion. The primary endpoint is change in limb edema measured by standardized limb circumference at postoperative day 14.",[49,50,51,52],"Total Knee Replacement","Knee Osteoarthritis","Postoperative Edema","Postoperative Inflammation",[54,55,56,57,58,59,60,61],"Total knee arthroplasty","Total knee replacement","Circulatory exercise","Venous return","Ankle pump exercise","Postoperative edema","Postoperative inflammation","Rehabilitation","NOT_YET_RECRUITING","2026-07-03",{"date":65,"type":66},"2026-07-07","ACTUAL",{"date":68,"type":43},"2026-06-16",{"date":70,"type":43},"2027-05-16",{"name":5,"class":6}]