[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100647312":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":32,"centralContacts":45,"locations":26,"responsibleParty":53,"collaborators":56,"id":60,"slug":61,"hasResults":62,"nctId":63,"briefTitle":64,"officialTitle":65,"acronym":26,"eligibilityCriteria":66,"healthyVolunteers":62,"sex":67,"minAge":68,"maxAge":69,"enrollmentInfo":70,"targetDuration":26,"studyType":73,"phases":74,"briefSummary":76,"conditions":77,"keywords":82,"overallStatus":91,"whyStopped":26,"lastUpdateSubmitDate":92,"lastUpdatePostDateStruct":93,"startDateStruct":96,"completionDateStruct":98,"leadSponsor":100,"locationsCount":26},{"fullName":5,"class":6},"University of Sao Paulo","OTHER",[8,15],{"label":9,"type":10,"description":11,"interventionNames":12},"Regenfast Gel Application Test Side","EXPERIMENTAL","Palatal side randomized to receive a single topical application of polynucleotide and hyaluronic acid gel (Regenfast, 0.3 ml) immediately after subepithelial connective tissue graft (SCTG) harvesting in the first surgical session. The contralateral side receives no intervention. SCTG is harvested again from the same site after 9 weeks for histological and immunohistochemical analyses.",[13,14],"Drug: polynucleotide and hyaluronic acid gel","Procedure: subepithelial connective tissue graft harvesting",{"label":16,"type":17,"description":18,"interventionNames":19},"No Intervention - Control Side","ACTIVE_COMPARATOR","Contralateral palatal side receiving no topical intervention after SCTG harvesting in the first surgical session. SCTG is harvested again from the same site after 9 weeks. This arm serves as control for both the healing time comparison (baseline vs 9 weeks) and the biomaterial effect comparison.",[14],[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DRUG","polynucleotide and hyaluronic acid gel","Single topical application of polynucleotide and hyaluronic acid gel (Regenfast, 0.3 ml) to the palatal donor site immediately after subepithelial connective tissue graft harvesting in the first surgical session, before suturing.",[9],null,{"type":28,"name":29,"description":30,"armGroupLabels":31,"otherNames":26},"PROCEDURE","subepithelial connective tissue graft harvesting","Bilateral subepithelial connective tissue graft harvesting from the palatal donor site using the double incision technique (Harris, 2003) with a standardized 1.5 mm guide scalpel, under local anesthesia (2% lidocaine with 1:100,000 epinephrine). Performed in two surgical sessions with a 9-week interval.",[16,9],[33,37,41],{"name":34,"affiliation":35,"role":36},"Marcella B Kahn, DDS, MS Candidate","Faculdade de Odontologia de Ribeirão Preto, Universidade de São Paulo (FORP-USP)","PRINCIPAL_INVESTIGATOR",{"name":38,"affiliation":39,"role":40},"Michel Reis Messora, DDS, MS, PhD","Faculdade de Odontologia de Ribeirão Preto, Universidade de São Paulo (FORP-USP) Role: Study Chair","STUDY_CHAIR",{"name":42,"affiliation":43,"role":44},"Sergio Kahn, DDS, MS, PhD","Instituto Kahn Odontologia, Rio de Janeiro","STUDY_DIRECTOR",[46,51],{"name":47,"role":48,"phone":49,"phoneExt":26,"email":50},"Marcella Kahn, DDS, MS Candidate","CONTACT","+5521988483846","mbkahn@usp.br",{"name":38,"role":48,"phone":26,"phoneExt":26,"email":52},"m.messora@forp.usp.br",{"type":36,"investigatorFullName":54,"investigatorTitle":55,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"Marcella Kahn","MSc Student, Periodontics Postgraduate Program",[57],{"name":58,"class":59},"Instituto Kahn Odontologia","UNKNOWN","100647312","clinical-and-histological-evaluation-of-subepithelial-connective-tissue-graft-maturation-at-different-healing-timepoints-with-and-without-topical-application-of-a-polynucleotide--and-hyaluronic-acid-based-gel-100647312",false,"NCT07708051","Clinical and Histological Evaluation of Subepithelial Connective Tissue Graft Maturation at Different Healing Timepoints, With and Without Topical Application of a Polynucleotide- and Hyaluronic Acid-Based Gel","Clinical and Histological Evaluation of Subepithelial Connective Tissue Graft Maturation at Different Healing Timepoints, With and Without Topical Application of a Polynucleotide- and Hyaluronic Acid-Based Gel: A Randomized, Blinded, Controlled Clinical Trial With a Split-Mouth Design","Inclusion Criteria:\n\n* Age between 18 and 60 years\n* Good general systemic health\n* Presence of multiple bilateral gingival recessions with indication for root coverage\n\nExclusion Criteria:\n\n* Smoking of any intensity\n* Pregnancy or lactation\n* Oral lesions or alterations in the palatal mucosa\n* Previous history of graft harvesting from the donor area\n* Continuous use of medications that interfere with the inflammatory response, such as corticosteroids or immunosuppressants\n* Autoimmune diseases, coagulation disorders, or other systemic conditions affecting wound healing","ALL","18 Years","60 Years",{"count":71,"type":72},15,"ESTIMATED","INTERVENTIONAL",[75],"NA","This study evaluates whether a 9-week healing interval is sufficient for subepithelial connective tissue graft (SCTG) maturation after palatal harvesting, and whether topical application of a polynucleotide and hyaluronic acid gel (Regenfast®) improves tissue quality. This is a randomized, blinded, controlled clinical trial with a split-mouth design involving 15 participants. Each participant undergoes bilateral SCTG harvesting from the palate in two surgical sessions 9 weeks apart. In the first session, one randomized side receives a single topical application of Regenfast® after graft removal; the contralateral side serves as control. Standardized tissue fragments (3×3 mm, 1.5 mm thickness) are collected from each graft for histological (HE, Picrosirius Red) and immunohistochemical analyses. Comparisons are made between grafts collected at baseline and after 9 weeks, and between sides treated with or without the gel.",[78,79,80,81],"Gingival Recession, Generalized","Gingival Recession, Localized","Wound Healing","Palate; Wound",[83,84,85,86,87,88,89,90],"Subepithelial connective tissue graft","Palatal donor site","Wound healing","Gingival Recession","Hyaluronic acid","Polynucleotides","Split-mouth clinical trial","Histological analysis","NOT_YET_RECRUITING","2026-07-13",{"date":94,"type":95},"2026-07-16","ACTUAL",{"date":97,"type":72},"2026-07",{"date":99,"type":72},"2027-02-27",{"name":5,"class":6}]