[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100652430":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":31,"centralContacts":36,"locations":26,"responsibleParty":46,"collaborators":26,"id":49,"slug":50,"hasResults":51,"nctId":52,"briefTitle":53,"officialTitle":54,"acronym":26,"eligibilityCriteria":55,"healthyVolunteers":51,"sex":56,"minAge":57,"maxAge":58,"enrollmentInfo":59,"targetDuration":26,"studyType":62,"phases":63,"briefSummary":65,"conditions":66,"keywords":71,"overallStatus":76,"whyStopped":26,"lastUpdateSubmitDate":77,"lastUpdatePostDateStruct":78,"startDateStruct":81,"completionDateStruct":83,"leadSponsor":85,"locationsCount":26},{"fullName":5,"class":6},"Cairo University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Calcium Hydroxide-Iodoform Paste + LSTR","EXPERIMENTAL","Participants assigned to this arm will receive lesion sterilization and tissue repair (LSTR) treatment using calcium hydroxide-iodoform paste as the antimicrobial material. The treatment will be performed according to the standardized clinical protocol, followed by clinical and radiographic evaluation during the 12-month follow-up period.",[13],"Drug: Calcium Hydroxide, Iodoform, paste",{"label":15,"type":16,"description":17,"interventionNames":18},"Modified Triple Antibiotic Paste + LSTR","ACTIVE_COMPARATOR","Participants assigned to this arm will receive lesion sterilization and tissue repair (LSTR) treatment using modified triple antibiotic paste as the antimicrobial material. The treatment will be performed according to the standardized clinical protocol, followed by clinical and radiographic evaluation during the 12-month follow-up period.",[19],"Drug: modified triple antibiotic paste",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DRUG","Calcium Hydroxide, Iodoform, paste","Calcium hydroxide-iodoform paste will be used as the antimicrobial material for lesion sterilization and tissue repair (LSTR) treatment of necrotic primary molars. Following access to the pulp chamber and the clinical procedures specified in the study protocol, the paste will be placed into the prepared pulp chamber\u002Fcanal orifices according to the standardized LSTR technique. The tooth will then be restored according to the study protocol. Participants will undergo clinical and radiographic follow-up for 12 months to assess treatment success.",[9],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"modified triple antibiotic paste","Modified triple antibiotic paste will be used as the antimicrobial material for lesion sterilization and tissue repair (LSTR) treatment of necrotic primary molars. The paste will be prepared and applied according to the standardized formulation and clinical protocol specified in the study. Following access to the pulp chamber and the clinical procedures specified in the study protocol, the paste will be placed according to the LSTR technique. The tooth will then be restored according to the study protocol. Participants will undergo clinical and radiographic follow-up for 12 months to assess treatment success.",[15],[32],{"name":33,"affiliation":34,"role":35},"Prof.Dr.Rania Abdullah Nasr, PhD","Faculty of dentistry , Cairo university , Cairo , Giza , Egypt , 12613","PRINCIPAL_INVESTIGATOR",[37,42],{"name":38,"role":39,"phone":40,"phoneExt":26,"email":41},"Yasmine Gamal Hafez Dawood Ghazaly, B.D.S faculty of dentistry","CONTACT","+201204444443","yasmine.ghazaly@dentistry.cu.edu.eg",{"name":43,"role":39,"phone":44,"phoneExt":26,"email":45},"Prof.Dr.Osama EL Shahawy Chief supervisor, PhD","+201005634755","osama.shahawy@dentistry.cu.edu.eg",{"type":35,"investigatorFullName":47,"investigatorTitle":48,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"Yasmine Gamal Hafez Dawood Ghazaly","Master's Student, Department of Pediatric Dentistry","100652430","clinical-and-radiographic-success-of-calcium-hydroxide-iodoform-paste-versus-modified-triple-antibiotic-paste-for-necrotic-primary-molars-in-children-100652430",false,"NCT07773805","Clinical and Radiographic Success of Calcium Hydroxide-Iodoform Paste Versus Modified Triple Antibiotic Paste for Necrotic Primary Molars in Children","Assessment of the Clinical and Radiographic Success of Calcium Hydroxide Iodoform Paste Versus Modified Triple Antibiotic Paste for the Treatment of Necrotic Primary Molars Using LSTR Technique: A Randomized Clinical Trial","Inclusion Criteria:\n\n* Pediatric patients aged 4-7 years\n* Positive parental informed consent\n* Restorable necrotic mandibular second primary molars with peri-radicular\u002Ffurcal involvement and\u002For pathologic root resorption (external or internal one-third to two-thirds of the root)\n* Presence of chronic apical abscess or sinus tract or furcation radiolucency\n\nExclusion Criteria:\n\n* Medically compromised patient\n* Children with a known allergy to any of the components being utilized\n* Molars near exfoliation\n* Molars with severely resorbed roots more than two thirds, indicated for extraction\n* Molar with insufficient coronal structure disabling proper coronal seal\n* Presence of a periapical or interradicular radiolucent area which could compromise the permanent tooth bud","ALL","4 Years","7 Years",{"count":60,"type":61},50,"ESTIMATED","INTERVENTIONAL",[64],"NA","This randomized clinical trial aims to compare the clinical and radiographic success of calcium hydroxide-iodoform paste and modified triple antibiotic paste when used for the treatment of necrotic primary molars in children using the lesion sterilization and tissue repair (LSTR) technique. The study will include children aged 4-7 years with restorable necrotic mandibular second primary molars. Participants will be randomly assigned to receive LSTR treatment with either calcium hydroxide-iodoform paste or modified triple antibiotic paste. Clinical and radiographic findings will be assessed during follow-up over 12 months to determine the success of each treatment. The study hypothesis is that there will be a difference in the clinical and radiographic success between the two treatment materials when used with the LSTR technique",[67,68,69,70],"Dental Pulp Necrosis","Periapical Diseases","Dental Caries","Primary Teeth",[72,67,73,74,75],"Lesion Sterilization and Tissue Repair","Calcium Hydroxide-Iodoform Paste","Modified Triple Antibiotic Paste","Necrotic Primary Teeth","NOT_YET_RECRUITING","2026-08-16",{"date":79,"type":80},"2026-08-19","ACTUAL",{"date":82,"type":61},"2027-01",{"date":84,"type":61},"2028-01",{"name":5,"class":6}]