[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100658570":3},{"organization":4,"outcomesModule":7,"designInfo":33,"detailedDescription":35,"studyPopulation":36,"armGroups":32,"interventions":32,"overallOfficials":32,"centralContacts":37,"locations":43,"responsibleParty":353,"collaborators":32,"id":355,"slug":356,"hasResults":357,"nctId":358,"briefTitle":359,"officialTitle":359,"acronym":360,"eligibilityCriteria":361,"healthyVolunteers":357,"sex":362,"minAge":363,"maxAge":32,"enrollmentInfo":364,"targetDuration":32,"studyType":367,"phases":32,"briefSummary":368,"conditions":369,"keywords":371,"overallStatus":380,"whyStopped":32,"lastUpdateSubmitDate":381,"lastUpdatePostDateStruct":382,"startDateStruct":385,"completionDateStruct":387,"leadSponsor":389,"locationsCount":390},{"fullName":5,"class":6},"Assistance Publique - Hôpitaux de Paris","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":32},[9],{"measure":10,"description":11,"timeFrame":12},"Number and percentage of participants by type of polyneuropathy","Participants will be classified as having genetic or inflammatory polyneuropathy according to the diagnosis documented in their medical records. The number and percentage of participants in each category will be reported.","At inclusion, based on the diagnosis documented in the medical record.",[14,17,21,24,28],{"measure":15,"description":16,"timeFrame":12},"Number and percentage of participants by polyneuropathy subtype","The number and percentage of participants in each genetic or inflammatory polyneuropathy subtype, as documented in the medical records, will be reported.",{"measure":18,"description":19,"timeFrame":20},"Demographic characteristics of patients","Description of demographic characteristics of patients with genetic or inflammatory polyneuropathies, including age, sex and other available demographic data.","At baseline, corresponding to the date of inclusion in the study, using data available in the medical record up to that date.",{"measure":22,"description":23,"timeFrame":20},"Geographical distribution of patients","Description of the geographical distribution of patients with genetic or inflammatory polyneuropathies included in participating centers in France.",{"measure":25,"description":26,"timeFrame":27},"Number and percentage of participants by electrophysiological neuropathy pattern","The electrophysiological neuropathy pattern documented in the medical record will be classified as axonal, demyelinating or mixed. The number and percentage of participants in each category will be reported.","At inclusion, based on electrophysiological examinations available in the medical record.",{"measure":29,"description":30,"timeFrame":31},"Genetic abnormalities","Description of genetic abnormalities identified in patients with genetic or inflammatory polyneuropathies, when genetic analysis results are available in the medical records.","At baseline, corresponding to the date of inclusion in the study, using genetic data available in the medical record up to that date.",null,{"allocation":32,"interventionModel":32,"interventionModelDescription":32,"primaryPurpose":32,"observationalModel":34,"timePerspective":6,"maskingInfo":32},"COHORT","To describe the clinical, electrophysiological, and genetic characteristics of genetic and inflammatory peripheral neuropathies in detail in order to advance our understanding of these rare and disabling diseases. This detailed description is also necessary with a view to the future use of innovative treatments. In recent years, there have indeed been spectacular advances in the field of genetic therapies (siRNA, antisense oligonucleotides, gene therapy) and next-generation immunosuppressive therapies (complement inhibitors, anti-FcRN), all of which are applicable in the short- to medium-term for genetic and inflammatory polyneuropathies.\n\nThis is a multicenter, prospective-retrospective study using data collected as part of routine clinical care.The objectives are as follows:\n\n* Describe the different subtypes of genetic and inflammatory pyneuropathies in France\n* Describe the demographic characteristics\n* Describe the geographic distribution\n* Describe the electrophysiological findings\n* Describe the genetic abnormalities","Adults diagnosed with genetic or inflammatory polyneuropathy and followed in participating neurology centers in France.",[38],{"name":39,"role":40,"phone":41,"phoneExt":32,"email":42},"Andoni ECHANIZ-LAGUNA","CONTACT","+33(0)145212677","andoni.echaniz-laguna@aphp.fr",[44,59,71,82,94,106,118,130,142,154,166,178,189,201,213,225,237,249,261,272,284,293,305,317,329,341],{"facility":45,"status":32,"city":46,"state":32,"zip":32,"country":47,"countryCode":48,"cosmosGeoPoint":49,"geoPoint":54,"contacts":55},"CHU Amiens-Picardie - Site Sud","Amiens","France","FR",{"type":50,"coordinates":51},"Point",[52,53],2.3,49.9,{"lat":53,"lon":52},[56],{"name":57,"role":40,"phone":32,"phoneExt":32,"email":58},"Philippe-Edouard MERLE","merle.philippe@chu-amiens.fr",{"facility":60,"status":32,"city":61,"state":32,"zip":32,"country":47,"countryCode":48,"cosmosGeoPoint":62,"geoPoint":66,"contacts":67},"CHU Angers","Angers",{"type":50,"coordinates":63},[64,65],-0.55202,47.47156,{"lat":65,"lon":64},[68],{"name":69,"role":40,"phone":32,"phoneExt":32,"email":70},"Julien CASSEREAU","JuCassereau@chu-angers.fr",{"facility":72,"status":32,"city":73,"state":32,"zip":32,"country":47,"countryCode":48,"cosmosGeoPoint":74,"geoPoint":78,"contacts":79},"Hôpital Pellegrin, CHU Bordeaux","Bordeaux",{"type":50,"coordinates":75},[76,77],-0.58046,44.84124,{"lat":77,"lon":76},[80],{"name":81,"role":40,"phone":32,"phoneExt":32,"email":32},"Guilhem SOLE",{"facility":83,"status":32,"city":84,"state":32,"zip":32,"country":47,"countryCode":48,"cosmosGeoPoint":85,"geoPoint":89,"contacts":90},"Hôpital Morvan, CHU Brest","Brest",{"type":50,"coordinates":86},[87,88],-4.48628,48.39029,{"lat":88,"lon":87},[91],{"name":92,"role":40,"phone":32,"phoneExt":32,"email":93},"Steeve GENESTET","steeve.genestet@chu-brest.fr",{"facility":95,"status":32,"city":96,"state":32,"zip":32,"country":47,"countryCode":48,"cosmosGeoPoint":97,"geoPoint":101,"contacts":102},"Hôpital Pierre Wertheimer, HCL","Bron",{"type":50,"coordinates":98},[99,100],4.91303,45.73865,{"lat":100,"lon":99},[103],{"name":104,"role":40,"phone":32,"phoneExt":32,"email":105},"Juliette SVAHN","juliette.svahn@chu-lyon.fr",{"facility":107,"status":32,"city":108,"state":32,"zip":32,"country":47,"countryCode":48,"cosmosGeoPoint":109,"geoPoint":113,"contacts":114},"Hôpital Gabriel-Montpied, CHU Clermont-Ferrand","Clermont-Ferrand",{"type":50,"coordinates":110},[111,112],3.08682,45.77969,{"lat":112,"lon":111},[115],{"name":116,"role":40,"phone":32,"phoneExt":32,"email":117},"Frédéric TAITHE","ftaithe@chu-clermontferrand.fr",{"facility":119,"status":32,"city":120,"state":32,"zip":32,"country":47,"countryCode":48,"cosmosGeoPoint":121,"geoPoint":125,"contacts":126},"Hôpital François Mitterrand, CHU Dijon","Dijon",{"type":50,"coordinates":122},[123,124],5.01391,47.31344,{"lat":124,"lon":123},[127],{"name":128,"role":40,"phone":32,"phoneExt":32,"email":129},"Agnès JACQUIN-PIQUES","agnes.jacquin-piques@chu-dijon.fr",{"facility":131,"status":32,"city":132,"state":32,"zip":32,"country":47,"countryCode":48,"cosmosGeoPoint":133,"geoPoint":137,"contacts":138},"Centre Hospitalier Annecy Genevois","Épagny",{"type":50,"coordinates":134},[135,136],6.08302,45.93584,{"lat":136,"lon":135},[139],{"name":140,"role":40,"phone":32,"phoneExt":32,"email":141},"Océane BOUCHOT","obouchot@ch-annecygenevois.fr",{"facility":143,"status":32,"city":144,"state":32,"zip":32,"country":47,"countryCode":48,"cosmosGeoPoint":145,"geoPoint":149,"contacts":150},"Hôpital Raymond-Poincaré","Garches",{"type":50,"coordinates":146},[147,148],2.18232,48.84226,{"lat":148,"lon":147},[151],{"name":152,"role":40,"phone":32,"phoneExt":32,"email":153},"Edouard BERLING","edouard.berling@aphp.fr",{"facility":155,"status":32,"city":156,"state":32,"zip":32,"country":47,"countryCode":48,"cosmosGeoPoint":157,"geoPoint":161,"contacts":162},"CHU Grenoble - Site Sud","Grenoble",{"type":50,"coordinates":158},[159,160],5.71479,45.17869,{"lat":160,"lon":159},[163],{"name":164,"role":40,"phone":32,"phoneExt":32,"email":165},"Emmeline LAGRANGE","ELagrange@chu-grenoble.fr",{"facility":167,"status":32,"city":168,"state":32,"zip":32,"country":47,"countryCode":48,"cosmosGeoPoint":169,"geoPoint":173,"contacts":174},"CHU de la Réunion - GH Sud Réunion - Saint-Pierre","La Réunion",{"type":50,"coordinates":170},[171,172],1.98063,43.48994,{"lat":172,"lon":171},[175],{"name":176,"role":40,"phone":32,"phoneExt":32,"email":177},"Ariane CHOUMERT","ariane.choumert@chu-reunion.fr",{"facility":179,"status":32,"city":180,"state":32,"zip":32,"country":47,"countryCode":48,"cosmosGeoPoint":181,"geoPoint":185,"contacts":186},"Hôpital Bicêtre","Le Kremlin-Bicêtre",{"type":50,"coordinates":182},[183,184],2.36073,48.81471,{"lat":184,"lon":183},[187],{"name":188,"role":40,"phone":32,"phoneExt":32,"email":42},"Andoni ECHANI-LAGUNA",{"facility":190,"status":32,"city":191,"state":32,"zip":32,"country":47,"countryCode":48,"cosmosGeoPoint":192,"geoPoint":196,"contacts":197},"Hôpital Salengro, CHU de Lille","Lille",{"type":50,"coordinates":193},[194,195],3.05512,50.63391,{"lat":195,"lon":194},[198],{"name":199,"role":40,"phone":32,"phoneExt":32,"email":200},"Céline TARD","celine.tard@chu-lille.fr",{"facility":202,"status":32,"city":203,"state":32,"zip":32,"country":47,"countryCode":48,"cosmosGeoPoint":204,"geoPoint":208,"contacts":209},"Hôpital Dupuytren, CHU Limoges","Limoges",{"type":50,"coordinates":205},[206,207],1.24759,45.83362,{"lat":207,"lon":206},[210],{"name":211,"role":40,"phone":32,"phoneExt":32,"email":212},"Laurent MAGY","laurent.magy@chu-limoges.fr",{"facility":214,"status":32,"city":215,"state":32,"zip":32,"country":47,"countryCode":48,"cosmosGeoPoint":216,"geoPoint":220,"contacts":221},"Hôpital de la Timone, AP-HM","Marseille",{"type":50,"coordinates":217},[218,219],5.38107,43.29695,{"lat":219,"lon":218},[222],{"name":223,"role":40,"phone":32,"phoneExt":32,"email":224},"Shahram ATTARIAN","shahram.attarian@ap-hm.fr",{"facility":226,"status":32,"city":227,"state":32,"zip":32,"country":47,"countryCode":48,"cosmosGeoPoint":228,"geoPoint":232,"contacts":233},"F-Esselin@Chu-Montpellier.Fr","Montpellier",{"type":50,"coordinates":229},[230,231],3.87635,43.61093,{"lat":231,"lon":230},[234],{"name":235,"role":40,"phone":32,"phoneExt":32,"email":236},"Florence ESSELIN","f-esselin@chu-montpellier.fr",{"facility":238,"status":32,"city":239,"state":32,"zip":32,"country":47,"countryCode":48,"cosmosGeoPoint":240,"geoPoint":244,"contacts":245},"CHU Nantes - Hôtel-Dieu - Hôpital Mère-Enfant","Nantes",{"type":50,"coordinates":241},[242,243],-1.55336,47.21725,{"lat":243,"lon":242},[246],{"name":247,"role":40,"phone":32,"phoneExt":32,"email":248},"Yann PEREON","Yann.Pereon@univ-nantes.fr",{"facility":250,"status":32,"city":251,"state":32,"zip":32,"country":47,"countryCode":48,"cosmosGeoPoint":252,"geoPoint":256,"contacts":257},"Hôpital Pasteur, CHU Nice","Nice",{"type":50,"coordinates":253},[254,255],7.26608,43.70313,{"lat":255,"lon":254},[258],{"name":259,"role":40,"phone":32,"phoneExt":32,"email":260},"Sabrina SACCONI","SACCONI.S@chu-nice.fr",{"facility":262,"status":32,"city":263,"state":32,"zip":32,"country":47,"countryCode":48,"cosmosGeoPoint":264,"geoPoint":268,"contacts":269},"Hôpital Universitaire Carémeau, CHU Nîmes","Nîmes",{"type":50,"coordinates":265},[266,267],4.35788,43.83665,{"lat":267,"lon":266},[270],{"name":271,"role":40,"phone":32,"phoneExt":32,"email":32},"Ioana Maria ION",{"facility":273,"status":32,"city":274,"state":32,"zip":32,"country":47,"countryCode":48,"cosmosGeoPoint":275,"geoPoint":279,"contacts":280},"Hôpital Ambroise Paré","Paris",{"type":50,"coordinates":276},[277,278],2.3488,48.85341,{"lat":278,"lon":277},[281],{"name":282,"role":40,"phone":32,"phoneExt":32,"email":283},"Pierre LOZERON","pierre.lozeron@aphp.fr",{"facility":285,"status":32,"city":274,"state":32,"zip":32,"country":47,"countryCode":48,"cosmosGeoPoint":286,"geoPoint":288,"contacts":289},"Hôpital La Pitié-Salpetrière",{"type":50,"coordinates":287},[277,278],{"lat":278,"lon":277},[290],{"name":291,"role":40,"phone":32,"phoneExt":32,"email":292},"Tanya STOJKOVIC","tanya.stojkovic@aphp.fr",{"facility":294,"status":32,"city":295,"state":32,"zip":32,"country":47,"countryCode":48,"cosmosGeoPoint":296,"geoPoint":300,"contacts":301},"Hôpital Maison Blanche, CHU Reims","Reims",{"type":50,"coordinates":297},[298,299],4.02853,49.26526,{"lat":299,"lon":298},[302],{"name":303,"role":40,"phone":32,"phoneExt":32,"email":304},"Maxime KIRCHHOFER","mkirchhofer@chu-reims.fr",{"facility":306,"status":32,"city":307,"state":32,"zip":32,"country":47,"countryCode":48,"cosmosGeoPoint":308,"geoPoint":312,"contacts":313},"Hôpital Charles-Nicolle, CHU Rouen","Rouen",{"type":50,"coordinates":309},[310,311],1.09932,49.44313,{"lat":311,"lon":310},[314],{"name":315,"role":40,"phone":32,"phoneExt":32,"email":316},"Anne-Laure BEDAT-MILLET","anne-laure.millet@chu-rouen.fr",{"facility":318,"status":32,"city":319,"state":32,"zip":32,"country":47,"countryCode":48,"cosmosGeoPoint":320,"geoPoint":324,"contacts":325},"Hôpital de Hautepierre, Hôpitaux Universitaires de Strasbourg","Strasbourg",{"type":50,"coordinates":321},[322,323],7.74553,48.58392,{"lat":323,"lon":322},[326],{"name":327,"role":40,"phone":32,"phoneExt":32,"email":328},"Jean-Baptiste CHANSON","jean-baptiste.chanson@chru-strasbourg.fr",{"facility":330,"status":32,"city":331,"state":32,"zip":32,"country":47,"countryCode":48,"cosmosGeoPoint":332,"geoPoint":336,"contacts":337},"Hôpital Rangueil, CHU Toulouse","Toulouse",{"type":50,"coordinates":333},[334,335],1.44367,43.60426,{"lat":335,"lon":334},[338],{"name":339,"role":40,"phone":32,"phoneExt":32,"email":340},"Pascal CINTAS","cintas.p@chu-toulouse.fr",{"facility":342,"status":32,"city":343,"state":32,"zip":32,"country":47,"countryCode":48,"cosmosGeoPoint":344,"geoPoint":348,"contacts":349},"Hôpital Bretonneau CHRU de Tours","Tours",{"type":50,"coordinates":345},[346,347],0.70398,47.39484,{"lat":347,"lon":346},[350],{"name":351,"role":40,"phone":32,"phoneExt":32,"email":352},"Stéphane BELTRAN","s.beltran@chu-tours.fr",{"type":354,"investigatorFullName":32,"investigatorTitle":32,"investigatorAffiliation":32,"oldNameTitle":32,"oldOrganization":32},"SPONSOR","100658570","clinical-electrophysiological-and-genetic-characteristics-of-hereditary-and-inflammatory-polyneuropathies-in-france-100658570",false,"NCT07851844","Clinical, Electrophysiological and Genetic Characteristics of Hereditary and Inflammatory Polyneuropathies in France","POLYFRA","Inclusion Criteria:\n\n* Adult patients aged 18 years or older.\n* Patients with a diagnosis of genetic or inflammatory polyneuropathy, confirmed by complementary examinations performed as part of routine care, including genetic, biological and\u002For electrophysiological tests.\n\nExclusion Criteria:\n\n\\- Patient opposition to the use of their routine care data for research purposes.","ALL","18 Years",{"count":365,"type":366},1000,"ESTIMATED","OBSERVATIONAL","To describe the clinical, electrophysiological, and genetic characteristics of patients with genetic and inflammatory polyneuropathies in France.",[370],"Genetic and Inflammatory Polyneuropathies",[372,373,374,375,376,377,378,379],"Rare Diseases","Genetic Testing","Electrophysiology","Chronic Inflammatory Demyelinating Polyradiculoneuropathy","Charcot-Marie-Tooth Disease","Inflammatory Neuropathy","Hereditary Neuropathy","Polyneuropathy","NOT_YET_RECRUITING","2026-09-25",{"date":383,"type":384},"2026-10-01","ACTUAL",{"date":386,"type":366},"2026-11-01",{"date":388,"type":366},"2036-11-01",{"name":5,"class":6},26]