[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100557107":3},{"organization":4,"outcomesModule":7,"designInfo":32,"detailedDescription":35,"studyPopulation":36,"armGroups":31,"interventions":31,"overallOfficials":37,"centralContacts":41,"locations":49,"responsibleParty":423,"collaborators":425,"id":429,"slug":430,"hasResults":431,"nctId":432,"briefTitle":433,"officialTitle":434,"acronym":435,"eligibilityCriteria":436,"healthyVolunteers":431,"sex":437,"minAge":438,"maxAge":439,"enrollmentInfo":440,"targetDuration":31,"studyType":443,"phases":31,"briefSummary":444,"conditions":445,"keywords":31,"overallStatus":52,"whyStopped":31,"lastUpdateSubmitDate":447,"lastUpdatePostDateStruct":448,"startDateStruct":451,"completionDateStruct":453,"leadSponsor":455,"locationsCount":456},{"fullName":5,"class":6},"FROM- Fondazione per la Ricerca Ospedale di Bergamo- ETS","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":31},[9],{"measure":10,"description":11,"timeFrame":12},"Overall survival according to the presence of cytopenias at diagnosis","Obtained by medical health records normally filled out in clinical practice","At diagnosis during the baseline",[14,17,19,21,23,25,27,29],{"measure":15,"description":11,"timeFrame":16},"Frequency and types of cytopenias","At baseline; 1 year follow-up.",{"measure":18,"description":11,"timeFrame":16},"Treatments response and duration (according to modified IWG-MRT and ELN 2013 criteria, overall and by presence of cytopenias",{"measure":20,"description":11,"timeFrame":16},"Incidence of major CV events (thrombosis and bleeding), overall and by presence of cytopenias and treatments received",{"measure":22,"description":11,"timeFrame":16},"Incidence of disease progressions (MF accelerated phase, MF blast phase\u002Facute myeloid leukemia (AML)), overall and by presence of cytopenias and treatments received",{"measure":24,"description":11,"timeFrame":16},"Incidence of secondary neoplasia, overall, by site and by presence of cytopenias and treatments received",{"measure":26,"description":11,"timeFrame":16},"Incidence of infections, overall and by presence of cytopenias and treatments received",{"measure":28,"description":11,"timeFrame":16},"Incidence of adverse events (AEs) of interest, overall, by type, severity and treatments received",{"measure":30,"description":11,"timeFrame":16},"Incidence of death, overall, by cause and by presence of cytopenias and treatments received",null,{"allocation":31,"interventionModel":31,"interventionModelDescription":31,"primaryPurpose":31,"observationalModel":33,"timePerspective":34,"maskingInfo":31},"CASE_CONTROL","RETROSPECTIVE","Myeloproliferative neoplasms (MPNs) are rare bone marrow disorders characterized by clonal proliferation of hematopoietic cell lineages, and include polycythemia vera (PV), essential thrombocythemia (ET), and myelofibrosis (MF). MF has worse prognosis, with main causes of death including acute leukemia transformation, comorbid conditions, and consequences of cytopenia. MF is characterized by progressive anemia, bone marrow fibrosis, and extramedullary hematopoiesis with splenomegaly. Moreover, the disease is associated with a heavy symptom burden including night sweats, fever, bone pain, and weight loss and worsening the quality of life.\n\nOn the beginning of 2013 the European Registry for Myeloproliferative Neoplasms (ERNEST) observational study was launched and approved by several IRBs of European hematological centers. The study focused on overt Primary (PMF) and Secondary myelofibrosis (SMF; i.e., post-Essential Thrombocythemia myelofibrosis (post-ET MF) and post-polycythemia (post-PV MF)) and aimed at describing the clinical epidemiology of large series of patients observed in clinical practice. This research was justified as the landscape of both pathophysiological and clinical knowledge in MPNs was rapidly evolving, prompting to revise diagnostic criteria, prognostication and therapy recommendations.\n\nERNEST retrospectively enrolled 1292 patients in whom the proposed prognostic models were confirmed to differentiate treatments in clinical practice, while ERNEST-2 reported results on critical events observed in 1010 of these cases during a median follow-up period of 5.4 years.4,5 The two studies closed in December 2022.\n\nIn the last decade, new diagnostic and prognostic findings have been accumulated and the availability of new approved drugs, based on results of several new clinical trials, influenced the therapy decision making in the real-world clinical practice. Therefore, the continuation of observational studies in present ERNEST-3 on large multicenter case series of patients with MF is timely and might refine the results of clinical trials.\n\nThe purpose of this study observational retrospective\u002Fprospective study is to gain information on MF associated cytopenias that represent a significant challenge in the contemporary patients with MF. Currently, there are few agents aimed at treating cytopenic MF, including immunomodulatory drugs, hypomethylating agents, and JAK inhibitors such as momelotinib and pacritinib, and development of new agents specifically tailored to this patient population remains an unmet need. Therefore, this study can provide data on these patients, focusing on clinical status, quality of life, comorbidities, and treatment results over time.","Patients with a 2016- or 2022-WHO confirmed diagnosis of MF established from 01\u002F01\u002F2018 to 31\u002F12\u002F2027 will be enrolled into the study.\n\nPatients with primary and secondary to ET and PV myelofibrosis, annotated for genetic and histological features, in relation to the presence of baseline (i.e., at MF diagnosis) or treatment-related cytopenias (i.e., reduced count of blood cells manifesting as anemia, thrombocytopenia and\u002For neutropenia).",[38],{"name":39,"affiliation":5,"role":40},"TIZIANO BARBUI, MD","STUDY_DIRECTOR",[42,46],{"name":39,"role":43,"phone":44,"phoneExt":31,"email":45},"CONTACT","0352675134","tbarbui@fondazionefrom.it",{"name":47,"role":43,"phone":31,"phoneExt":31,"email":48},"FENILI","sperimentazioni@fondazionefrom.it",[50,68,84,97,110,126,140,154,165,182,196,207,218,232,247,261,274,289,300,315,326,339,352,367,380,395,410],{"facility":51,"status":52,"city":53,"state":31,"zip":31,"country":54,"countryCode":55,"cosmosGeoPoint":56,"geoPoint":61,"contacts":62},"Hematology Center after Prof.R.H. Yeolyan","RECRUITING","Yerevan","Armenia","AM",{"type":57,"coordinates":58},"Point",[59,60],44.5126,40.17765,{"lat":60,"lon":59},[63,65],{"name":31,"role":43,"phone":31,"phoneExt":31,"email":64},"badikyanmaria@gmail.com",{"name":66,"role":67,"phone":31,"phoneExt":31,"email":31},"Maria Badikyan, MD","PRINCIPAL_INVESTIGATOR",{"facility":69,"status":70,"city":71,"state":31,"zip":31,"country":72,"countryCode":73,"cosmosGeoPoint":74,"geoPoint":78,"contacts":79},"University Hospital Halle Department of Hematology\u002FOncology","NOT_YET_RECRUITING","Halle","Germany","DE",{"type":57,"coordinates":75},[76,77],11.97947,51.48158,{"lat":77,"lon":76},[80,82],{"name":31,"role":43,"phone":31,"phoneExt":31,"email":81},"haifa.al-ali@uk-halle.de",{"name":83,"role":67,"phone":31,"phoneExt":31,"email":31},"Haifa Kathrin Al-Ali, MD",{"facility":85,"status":52,"city":86,"state":31,"zip":31,"country":72,"countryCode":73,"cosmosGeoPoint":87,"geoPoint":91,"contacts":92},"University Medicine Hannover","Hanover",{"type":57,"coordinates":88},[89,90],9.73322,52.37052,{"lat":90,"lon":89},[93,95],{"name":31,"role":43,"phone":31,"phoneExt":31,"email":94},"florian.heidel@uni-greifswald.de",{"name":96,"role":67,"phone":31,"phoneExt":31,"email":31},"Florian Heidel, MD",{"facility":98,"status":52,"city":99,"state":31,"zip":31,"country":72,"countryCode":73,"cosmosGeoPoint":100,"geoPoint":104,"contacts":105},"University Clinic for Hematology, Oncology, Hemostaseology and Palliative Care Johannes Wesling Medical Center Minden UKRUB, University of Bochum","Minden",{"type":57,"coordinates":101},[102,103],8.91455,52.28953,{"lat":103,"lon":102},[106,108],{"name":31,"role":43,"phone":31,"phoneExt":31,"email":107},"martin.griesshammer@muehlenkreiskliniken.de",{"name":109,"role":67,"phone":31,"phoneExt":31,"email":31},"Martin Griesshammer, MD",{"facility":111,"status":52,"city":112,"state":31,"zip":113,"country":114,"countryCode":115,"cosmosGeoPoint":116,"geoPoint":120,"contacts":121},"A.S.O. SS. Antonio e Biagio e C.Arrigo, SC Ematologia","Alessandria","15121","Italy","IT",{"type":57,"coordinates":117},[118,119],8.61007,44.90924,{"lat":119,"lon":118},[122,125],{"name":123,"role":43,"phone":31,"phoneExt":31,"email":124},"Monia Marchetti","monia.marchetti@ospedale.al.it",{"name":123,"role":67,"phone":31,"phoneExt":31,"email":31},{"facility":127,"status":52,"city":128,"state":31,"zip":31,"country":114,"countryCode":115,"cosmosGeoPoint":129,"geoPoint":133,"contacts":134},"ASST Papa Giovanni XXIII, SC Ematologia","Bergamo",{"type":57,"coordinates":130},[131,132],9.66721,45.69601,{"lat":132,"lon":131},[135,138],{"name":136,"role":43,"phone":31,"phoneExt":31,"email":137},"Maria Luisa Ferrari","mlferrari@fondazionefrom.it",{"name":139,"role":67,"phone":31,"phoneExt":31,"email":31},"Federico Lussana, MD",{"facility":141,"status":52,"city":142,"state":31,"zip":31,"country":114,"countryCode":115,"cosmosGeoPoint":143,"geoPoint":147,"contacts":148},"Policlinico S. Orsola - Malpighi, Unità di Ematologia","Bologna",{"type":57,"coordinates":144},[145,146],11.33875,44.49381,{"lat":146,"lon":145},[149,152],{"name":150,"role":43,"phone":31,"phoneExt":31,"email":151},"Valerio Michelucci","valeria.michelucci@studio.unibo.it",{"name":153,"role":67,"phone":31,"phoneExt":31,"email":31},"Francesca Palandri, MD",{"facility":155,"status":52,"city":156,"state":31,"zip":31,"country":114,"countryCode":115,"cosmosGeoPoint":157,"geoPoint":161,"contacts":162},"Azienda Ospedaliero - Universitaria \"Policlinico Vittorio Emanuele\" - PO Gaspare Rodolico, Dipartimento di ematologia con Trapianto di midollo Osseo","Catania",{"type":57,"coordinates":158},[159,160],15.07041,37.49223,{"lat":160,"lon":159},[163],{"name":164,"role":67,"phone":31,"phoneExt":31,"email":31},"Giuseppe Palumbo, MD",{"facility":166,"status":52,"city":167,"state":31,"zip":31,"country":114,"countryCode":115,"cosmosGeoPoint":168,"geoPoint":172,"contacts":173},"AOU Careggi di Firenze, Divisione di Ematologia","Florence",{"type":57,"coordinates":169},[170,171],11.24626,43.77925,{"lat":171,"lon":170},[174,177,179],{"name":175,"role":43,"phone":31,"phoneExt":31,"email":176},"Chiara Paoli","chiara.paoli@unifi.it",{"name":178,"role":67,"phone":31,"phoneExt":31,"email":31},"Alessandro M Vannucchi, MD",{"name":180,"role":181,"phone":31,"phoneExt":31,"email":31},"Paola Guglielmelli, MD","SUB_INVESTIGATOR",{"facility":183,"status":52,"city":184,"state":31,"zip":31,"country":114,"countryCode":115,"cosmosGeoPoint":185,"geoPoint":189,"contacts":190},"ASST Grande Ospedale Metropolitano Niguarda, Divisione di Ematologia","Milan",{"type":57,"coordinates":186},[187,188],12.59836,42.78235,{"lat":188,"lon":187},[191,194],{"name":192,"role":43,"phone":31,"phoneExt":31,"email":193},"Mattia La Monica","mattia.lamonica@ospedaleniguarda.it",{"name":195,"role":67,"phone":31,"phoneExt":31,"email":31},"Marianna Caramella, MD",{"facility":197,"status":52,"city":184,"state":31,"zip":31,"country":114,"countryCode":115,"cosmosGeoPoint":198,"geoPoint":200,"contacts":201},"Fondazione IRCCS Ca' Granda - Ospedale Maggiore Policlinico, Ematologia",{"type":57,"coordinates":199},[187,188],{"lat":188,"lon":187},[202,205],{"name":203,"role":43,"phone":31,"phoneExt":31,"email":204},"Silvia Artuso","silvia.artuso@policlinico.mi.it",{"name":206,"role":67,"phone":31,"phoneExt":31,"email":31},"Alessandra Iurlo, MD",{"facility":208,"status":52,"city":184,"state":31,"zip":31,"country":114,"countryCode":115,"cosmosGeoPoint":209,"geoPoint":211,"contacts":212},"Ospedale San Raffaele, Unità Operativa di Ematologia e Trapianto Midollo Osseo",{"type":57,"coordinates":210},[187,188],{"lat":188,"lon":187},[213,216],{"name":214,"role":43,"phone":31,"phoneExt":31,"email":215},"Antonella Danese","danese.antonella@hsr.it",{"name":217,"role":67,"phone":31,"phoneExt":31,"email":31},"Daniele Sannipoli, MD",{"facility":219,"status":52,"city":220,"state":31,"zip":31,"country":114,"countryCode":115,"cosmosGeoPoint":221,"geoPoint":225,"contacts":226},"Fondazione IRCCS San Gerardo dei Tintori","Monza",{"type":57,"coordinates":222},[223,224],9.27246,45.58005,{"lat":224,"lon":223},[227,230],{"name":228,"role":43,"phone":31,"phoneExt":31,"email":229},"Alessia Picozzi","alessia.picozzihsg@gmail.com",{"name":231,"role":67,"phone":31,"phoneExt":31,"email":31},"Elena Elli, MD",{"facility":233,"status":52,"city":234,"state":31,"zip":31,"country":114,"countryCode":115,"cosmosGeoPoint":235,"geoPoint":239,"contacts":240},"Azienda Ospedaliera Universitaria Federico II, Divisione di Ematologia","Naples",{"type":57,"coordinates":236},[237,238],14.26811,40.85216,{"lat":238,"lon":237},[241,243,245],{"name":31,"role":43,"phone":31,"phoneExt":31,"email":242},"giadamc@gmail.com",{"name":31,"role":43,"phone":31,"phoneExt":31,"email":244},"novypugliese@yahoo.it",{"name":246,"role":67,"phone":31,"phoneExt":31,"email":31},"Fabrizio Pane, MD",{"facility":248,"status":52,"city":249,"state":31,"zip":31,"country":114,"countryCode":115,"cosmosGeoPoint":250,"geoPoint":254,"contacts":255},"Azienda Ospedaliero Universitaria Maggiore della Carità, SCDU Ematologia","Novara",{"type":57,"coordinates":251},[252,253],8.62118,45.44694,{"lat":253,"lon":252},[256,259],{"name":257,"role":43,"phone":31,"phoneExt":31,"email":258},"Clara Deambrogi","clara.deambrogi@med.uniupo.it",{"name":260,"role":67,"phone":31,"phoneExt":31,"email":31},"Andrea Patriarca, MD",{"facility":262,"status":52,"city":263,"state":31,"zip":31,"country":114,"countryCode":115,"cosmosGeoPoint":264,"geoPoint":268,"contacts":269},"Fondazione IRCCS Policlinico San Matteo, Divisione di Ematologia","Pavia",{"type":57,"coordinates":265},[266,267],9.15917,45.19205,{"lat":267,"lon":266},[270,272],{"name":31,"role":43,"phone":31,"phoneExt":31,"email":271},"cto-oh@smatteo.pv.it",{"name":273,"role":67,"phone":31,"phoneExt":31,"email":31},"ELisa Rumi, MD",{"facility":275,"status":52,"city":276,"state":31,"zip":31,"country":114,"countryCode":115,"cosmosGeoPoint":277,"geoPoint":281,"contacts":282},"Fondazione Policlinico Universitario A. Gemelli - Università Cattolica del Sacro Cuore, UCSC Ematologia","Roma",{"type":57,"coordinates":278},[279,280],11.10642,44.99364,{"lat":280,"lon":279},[283,285,287],{"name":31,"role":43,"phone":31,"phoneExt":31,"email":284},"giulia.desantis@policlinicogemelli.it",{"name":31,"role":43,"phone":31,"phoneExt":31,"email":286},"denise.soldati@policlinicogemelli.it",{"name":288,"role":67,"phone":31,"phoneExt":31,"email":31},"Valerio De Stefano, MD",{"facility":290,"status":52,"city":276,"state":31,"zip":31,"country":114,"countryCode":115,"cosmosGeoPoint":291,"geoPoint":293,"contacts":294},"Policlinico Umberto I, Dipartimento Ematologia, Oncologia e Dermatologia",{"type":57,"coordinates":292},[279,280],{"lat":280,"lon":279},[295,298],{"name":296,"role":43,"phone":31,"phoneExt":31,"email":297},"Antonella Mosca","a.mosca@bce.uniroma1.it",{"name":299,"role":67,"phone":31,"phoneExt":31,"email":31},"Massimo Breccia, MD",{"facility":301,"status":70,"city":302,"state":31,"zip":303,"country":114,"countryCode":115,"cosmosGeoPoint":304,"geoPoint":308,"contacts":309},"A.O.U. Città della Salute e della Scienza di Torino - Ospedale Molinette- S.C. Ematologia U","Torino","10126",{"type":57,"coordinates":305},[306,307],11.99138,44.88856,{"lat":307,"lon":306},[310,313],{"name":311,"role":43,"phone":31,"phoneExt":31,"email":312},"Francesca Pirillo","francescapirillo.ospedale@gmail.com",{"name":314,"role":67,"phone":31,"phoneExt":31,"email":31},"Giulia Benevolo, Dr",{"facility":316,"status":70,"city":317,"state":31,"zip":31,"country":114,"countryCode":115,"cosmosGeoPoint":318,"geoPoint":322,"contacts":323},"Ospedale Cardinale G. Panico","Tricase",{"type":57,"coordinates":319},[320,321],18.35421,39.93018,{"lat":321,"lon":320},[324],{"name":325,"role":67,"phone":31,"phoneExt":31,"email":31},"Anna Mele, MD",{"facility":327,"status":52,"city":328,"state":31,"zip":31,"country":114,"countryCode":115,"cosmosGeoPoint":329,"geoPoint":333,"contacts":334},"Azienda Ospedaliera Universitaria Integrata - Ospedale Borgo Roma, Unità di Ematologia","Verona",{"type":57,"coordinates":330},[331,332],10.9938,45.43854,{"lat":332,"lon":331},[335,337],{"name":31,"role":43,"phone":31,"phoneExt":31,"email":336},"massimiliano.bonifacio@univr.it",{"name":338,"role":67,"phone":31,"phoneExt":31,"email":31},"Massimiliano Bonifacio, MD",{"facility":340,"status":52,"city":341,"state":31,"zip":31,"country":114,"countryCode":115,"cosmosGeoPoint":342,"geoPoint":346,"contacts":347},"Azienda ULSS 8 Berica - Ospedale San Bortolo, Divisione di Ematologia","Vicenza",{"type":57,"coordinates":343},[344,345],11.5475,45.54672,{"lat":345,"lon":344},[348,350],{"name":31,"role":43,"phone":31,"phoneExt":31,"email":349},"studiclinici.ematologia@aulss8.veneto.it",{"name":351,"role":67,"phone":31,"phoneExt":31,"email":31},"Giuseppe Carli, MD",{"facility":353,"status":52,"city":354,"state":31,"zip":31,"country":355,"countryCode":356,"cosmosGeoPoint":357,"geoPoint":361,"contacts":362},"Department of Hematology, University Hospital, Jagiellonian University Medical College","Krakow","Poland","PL",{"type":57,"coordinates":358},[359,360],19.93658,50.06143,{"lat":360,"lon":359},[363,365],{"name":31,"role":43,"phone":31,"phoneExt":31,"email":364},"weronika.lebowa@doctoral.uj.edu.pl",{"name":366,"role":67,"phone":31,"phoneExt":31,"email":31},"Weronika Lebowa, MD",{"facility":368,"status":52,"city":369,"state":31,"zip":31,"country":355,"countryCode":356,"cosmosGeoPoint":370,"geoPoint":374,"contacts":375},"Department and Clinic of Haematology, Blood Neoplasms, and Bone Marrow Transplantation, Wroclaw Medical University","Wroclaw",{"type":57,"coordinates":371},[372,373],17.03006,51.10286,{"lat":373,"lon":372},[376,378],{"name":31,"role":43,"phone":31,"phoneExt":31,"email":377},"marta.sobas@gmail.com",{"name":379,"role":67,"phone":31,"phoneExt":31,"email":31},"Marta Sobas, MD",{"facility":381,"status":52,"city":382,"state":31,"zip":31,"country":383,"countryCode":384,"cosmosGeoPoint":385,"geoPoint":389,"contacts":390},"Department of Hematology and Bone Marrow Transplantation, Fundeni Clinical Institute","Bucharest","Romania","RO",{"type":57,"coordinates":386},[387,388],26.10626,44.43225,{"lat":388,"lon":387},[391,393],{"name":31,"role":43,"phone":31,"phoneExt":31,"email":392},"daniel_coriu@yahoo.com",{"name":394,"role":67,"phone":31,"phoneExt":31,"email":31},"Daniel Coriu",{"facility":396,"status":52,"city":397,"state":31,"zip":31,"country":398,"countryCode":399,"cosmosGeoPoint":400,"geoPoint":404,"contacts":405},"Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS) - Hospital Clinic","Barcelona","Spain","ES",{"type":57,"coordinates":401},[402,403],2.15899,41.38879,{"lat":403,"lon":402},[406,408],{"name":31,"role":43,"phone":31,"phoneExt":31,"email":407},"AALVAR@clinic.cat",{"name":409,"role":67,"phone":31,"phoneExt":31,"email":31},"Alberto Alvarez-Larran, MD",{"facility":411,"status":52,"city":412,"state":31,"zip":31,"country":398,"countryCode":399,"cosmosGeoPoint":413,"geoPoint":417,"contacts":418},"Hematology and Hemotherapy Department, 12 de Octubre University Hospital","Madrid",{"type":57,"coordinates":414},[415,416],-3.70256,40.4165,{"lat":416,"lon":415},[419,421],{"name":31,"role":43,"phone":31,"phoneExt":31,"email":420},"gonzalo.carreno.gomeztarragona@gmail.com",{"name":422,"role":67,"phone":31,"phoneExt":31,"email":31},"Gonzalo Carreno Gomez-Tarragona, MD",{"type":424,"investigatorFullName":31,"investigatorTitle":31,"investigatorAffiliation":31,"oldNameTitle":31,"oldOrganization":31},"SPONSOR",[426],{"name":427,"class":428},"GlaxoSmithKline","INDUSTRY","100557107","clinical-epidemiology-in-contemporary-patients-with-myelofibrosis-100557107",false,"NCT06533813","Clinical Epidemiology in Contemporary Patients With Myelofibrosis.","Clinical Epidemiology in Contemporary Patients With Myelofibrosis (ERNEST-3): A European LeukemiaNet (ELN) Observational Study","ERNEST-3","Inclusion Criteria:\n\n* Diagnosis of primary myelofibrosis (PMF) or secondary (i.e., post-ET\u002FPV MF) myelofibrosis according to 2016- or 2022-WHO criteria ascertained between 01\u002F01\u002F2018 and 31\u002F12\u002F2027\n* Age ≥ 18 years\n* Signed informed consent where applicable, in line with current European General Data Protection Regulation (GDPR) directives\n\nExclusion Criteria:\n\n* Diagnosis of early\u002Fprefibrotic primary myelofibrosis\n* Concurrent participation to interventional clinical trials in MF","ALL","18 Years","100 Years",{"count":441,"type":442},617,"ESTIMATED","OBSERVATIONAL","Multicenter retrospective and prospective European observational study. At each site, all consecutive patients with a 2016- or 2022 World Health Organization (WHO) confirmed diagnosis of myelofibrosis (MF) established from 01\u002F01\u002F2018 to 31\u002F12\u002F2027 will be enrolled into the study. Yearly follow-up updates will be scheduled until the end of data collection on 31\u002F12\u002F2028 or until the last available patient visit, whichever comes first. At least 1 year of follow-up will be ensured from the last patient enrolled.",[446],"Myelofibrosis","2026-07-08",{"date":449,"type":450},"2026-07-09","ACTUAL",{"date":452,"type":450},"2024-10-14",{"date":454,"type":442},"2028-12-31",{"name":5,"class":6},27]