[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100648789":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":11,"centralContacts":11,"locations":28,"responsibleParty":40,"collaborators":11,"id":42,"slug":43,"hasResults":44,"nctId":45,"briefTitle":46,"officialTitle":47,"acronym":11,"eligibilityCriteria":48,"healthyVolunteers":49,"sex":50,"minAge":51,"maxAge":52,"enrollmentInfo":53,"targetDuration":11,"studyType":56,"phases":57,"briefSummary":59,"conditions":60,"keywords":63,"overallStatus":67,"whyStopped":11,"lastUpdateSubmitDate":68,"lastUpdatePostDateStruct":69,"startDateStruct":72,"completionDateStruct":74,"leadSponsor":76,"locationsCount":77},{"fullName":5,"class":6},"Marmara University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Group 1 (Guided Biofilm Therapy + Phosphoric Acid Etching + Pit and Fissure Sealant)","ACTIVE_COMPARATOR",null,[13],"Device: Device: Guided Biofilm Therapy with erythritol",{"label":15,"type":10,"description":11,"interventionNames":16},"Group 2: Conventional Polishing + Phosphoric Acid Etching + Pit and Fissure Sealant",[17],"Device: Device: Conventional Polishing",[19,24],{"type":20,"name":21,"description":22,"armGroupLabels":23,"otherNames":11},"DEVICE","Device: Guided Biofilm Therapy with erythritol","Permanent first molars assigned to Group 1 will receive occlusal surface cleaning using the AIRFLOW® Prophylaxis Master device (EMS, Switzerland) with AIRFLOW® Plus Powder containing approximately 99% erythritol and a particle size of approximately 14 μm. The powder will be applied for 5 seconds from a distance of approximately 2 mm under suction. The tooth surface will then be etched with 37% phosphoric acid for 15 seconds, followed by the application of Clinpro™ Sealant (3M ESPE, USA), which will be light-cured for 15 seconds.",[9],{"type":20,"name":25,"description":26,"armGroupLabels":27,"otherNames":11},"Device: Conventional Polishing","Permanent first molars assigned to Group 2 will receive occlusal surface cleaning using conventional polishing with a rotary prophylaxis brush. The tooth surface will then be etched with 37% phosphoric acid for 15 seconds, followed by the application of Clinpro™ Sealant (3M ESPE, USA), which will be light-cured for 15 seconds.",[15],[29],{"facility":5,"status":11,"city":30,"state":31,"zip":32,"country":33,"countryCode":11,"cosmosGeoPoint":34,"geoPoint":39,"contacts":11},"Istanbul","Maltepe","34384","Turkey (Türkiye)",{"type":35,"coordinates":36},"Point",[37,38],28.94966,41.01384,{"lat":38,"lon":37},{"type":41,"investigatorFullName":11,"investigatorTitle":11,"investigatorAffiliation":11,"oldNameTitle":11,"oldOrganization":11},"SPONSOR","100648789","clinical-evaluation-of-the-retention-of-fissure-sealants-applied-following-guided-biofilm-therapy-and-conventional-polishing-100648789",false,"NCT07725133","Clinical Evaluation of the Retention of Fissure Sealants Applied Following Guided Biofilm Therapy and Conventional Polishing","Clinical Evaluation of the Retention of Fissure Sealants Applied Following Guided Biofilm Therapy and Conventional Polishing: A Split-Mouth Randomized Clinical Trial","Inclusion Criteria:\n\n* Children aged 6-10 years presenting to the Department of Pediatric Dentistry, Marmara University Faculty of Dentistry, for routine dental treatment.\n* Systemically healthy individuals classified as ASA I.\n* Children who are cooperative and able to maintain communication throughout the clinical procedure.\n* Presence of at least two comparable permanent first molars with unrestored occlusal surfaces that are either caries-free or have initial lesions limited to the pit and fissure level.\n\nExclusion Criteria:\n\n* Individuals with systemic diseases (e.g., diabetes, epilepsy, cardiovascular diseases), classified as ASA II or higher.\n\nIndividuals who have used antibiotics, anti-inflammatory drugs, or immunosuppressive medications within the past 3 months.\n\n* Children who are unable to communicate due to emotional, psychological, or developmental disorders.\n* Individuals with previously placed pit and fissure sealants on their permanent first molars.\n* Presence of deep carious lesions, restorations, or structural defects such as molar-incisor hypomineralization (MIH) in the teeth planned for inclusion in the study.",true,"ALL","6 Years","10 Years",{"count":54,"type":55},80,"ESTIMATED","INTERVENTIONAL",[58],"NA","This randomized split-mouth clinical trial will compare two methods of occlusal surface cleaning before pit and fissure sealant placement in children aged 6-10 years.\n\nIn each participant, eligible permanent first molars will receive either erythritol-based Guided Biofilm Therapy or conventional rotary-brush polishing before phosphoric acid etching and placement of the same resin-based sealant. Each child will receive both interventions on opposite sides of the mouth.\n\nThe sealants will be followed for up to 36 months to determine whether the surface-cleaning method influences sealant retention and clinical performance. Procedure-related discomfort will also be compared between the two methods.",[61,62],"Pit and Fissure Sealant Retention","Dental Caries",[64,65,66],"guided biofilm therapy","airflowing","fissure sealant","NOT_YET_RECRUITING","2026-07-21",{"date":70,"type":71},"2026-07-24","ACTUAL",{"date":73,"type":55},"2026-07-20",{"date":75,"type":55},"2029-10-20",{"name":5,"class":6},1]