[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100647338":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":25,"centralContacts":29,"locations":35,"responsibleParty":55,"collaborators":21,"id":59,"slug":60,"hasResults":61,"nctId":62,"briefTitle":63,"officialTitle":64,"acronym":65,"eligibilityCriteria":66,"healthyVolunteers":67,"sex":68,"minAge":69,"maxAge":70,"enrollmentInfo":71,"targetDuration":21,"studyType":74,"phases":75,"briefSummary":77,"conditions":78,"keywords":81,"overallStatus":83,"whyStopped":21,"lastUpdateSubmitDate":84,"lastUpdatePostDateStruct":85,"startDateStruct":88,"completionDateStruct":90,"leadSponsor":92,"locationsCount":93},{"fullName":5,"class":6},"October 6 University","OTHER",[8,14],{"label":9,"type":6,"description":10,"interventionNames":11},"Milled resin composite restorations fabricated using subtractive manufacturing from CAD\u002FCAM blocks.","Subtractive Manufacturing, the control group will utilize restorations fabricated via subtractive manufacturing, specifically by milling from industrially fabricated blocks of nanohybrid composite. This method is the established gold standard for producing CAD\u002FCAM resin composite restorations. It is known for creating restorations with excellent mechanical properties, high density, and predictable clinical performance due to the optimized, industrial-grade polymerization of the blocks. These materials, which include polymer-infiltrated ceramic networks (PICNs) and resin nanoceramics, were developed to combine the favorable properties of both ceramics and resin composites, offering a biomimetic alternative to traditional glass-ceramics.",[12,13],"Other: Milled resin composite restorations fabricated using subtractive manufacturing from CAD\u002FCAM blocks.","Other: Three dimensionally (3D) printed resin composite restorations fabricated using additive manufacturing",{"label":15,"type":6,"description":16,"interventionNames":17},"Three dimensionally (3D) printed resin composite restorations fabricated using additive manufacturi","Additive Manufacturing, the intervention group will feature restorations fabricated via 3D printing. This technology is more time and cost-efficient, more accurate, and could provide a considerable alternative to the currently applied CNC milling, reduced material waste, and the ability to create complex geometries with high precision. Recent studies have shown that 3D-printed restorations can achieve promising results in terms of marginal and internal fit, which are critical for clinical longevity. This has spurred the development of novel, ceramic-filled hybrid materials specifically engineered for permanent 3D-printed restorations. Manufacturers of these materials claim high dimensional stability, flexural strength, and a modulus suitable for definitive restorations (e.g., Bego; VarseoSmile Triniq technical product data sheet). However, there is a lack of clinical data to support these claims.",[12,13],[19,22],{"type":6,"name":9,"description":10,"armGroupLabels":20,"otherNames":21},[9,15],null,{"type":6,"name":23,"description":16,"armGroupLabels":24,"otherNames":21},"Three dimensionally (3D) printed resin composite restorations fabricated using additive manufacturing",[9,15],[26],{"name":27,"affiliation":5,"role":28},"Mohsen Hussein Abielhassan, • Professor, Conservative Dent","STUDY_DIRECTOR",[30],{"name":31,"role":32,"phone":33,"phoneExt":21,"email":34},"Yara Ahmed Elgammal, Assistant Lecturer","CONTACT","+201157564592","yara.elgammal.dent@o6u.edu.eg",[36],{"facility":37,"status":21,"city":38,"state":21,"zip":39,"country":40,"countryCode":41,"cosmosGeoPoint":42,"geoPoint":47,"contacts":48},"October city, October 6 university","Giza","12556","Egypt","EG",{"type":43,"coordinates":44},"Point",[45,46],31.20861,30.00944,{"lat":46,"lon":45},[49,51],{"name":31,"role":32,"phone":50,"phoneExt":21,"email":34},"01157564592",{"name":52,"role":32,"phone":53,"phoneExt":21,"email":54},"Monaliza Maher Abdelaziz, Assistant Professor","01001400248","monalizamaher.dent@o6u.edu.eg",{"type":56,"investigatorFullName":57,"investigatorTitle":58,"investigatorAffiliation":5,"oldNameTitle":21,"oldOrganization":21},"PRINCIPAL_INVESTIGATOR","Yara Ahmed Elgammal","Assistant lecturer, Conservative Dentistry Department, Faculty of Dentistry, October 6 University, Egypt.","100647338","clinical-performance-and-fit-of-3d-printed-versus-milled-endocrowns-an-18-month-trial-100647338",false,"NCT07708077","Clinical Performance and Fit of 3D-Printed Versus Milled Endocrowns: An 18-Month Trial","Clinical Performance and Restoration Fit of 3D-Printed Versus Milled Biomimetic Resin Composite Endocrowns: 18-Month Randomized Clinical Trial.","Endocrowns","Inclusion Criteria:\n\n\\- Patient-Related Criteria\n\n1. Age: Between 20 and 40 years.\n2. Oral Hygiene: Good oral hygiene, evidenced by low plaque and gingival index scores.\n3. Willingness to attend regular follow-up visits during the study period\n\n   \\- Tooth-Related Criteria\n4. Endodontic Quality: High-quality root canal treatment with no clinical or radiographic signs of pathology.\n5. Tooth Type: A permanent molar tooth requiring an endocrown after successful root canal treatment.\n6. Located in functional occlusion and opposing natural teeth in stable occlusal contact with the restored tooth.\n7. Teeth free from cracks, fractures, or internal resorption; supporting tissues without structural defects that may compromise restoration success\n\nExclusion Criteria:\n\n\\- Patient-Related Criteria\n\n1. Parafunctional Habits: Severe bruxism, clenching, or other parafunctional habits.\n2. Allergies: to any study materials (e.g., resin composites, bonding agents).\n3. Patients with systemic diseases contraindicate elective dental treatment (e.g., uncontrolled diabetes)\n\n   \\- Tooth-Related Criteria\n4. Insufficient Tooth Structure: Less than 2mm of circumferential sound denting height or deep, unrestorable.\n5. Tooth opposes prosthetic restoration.\n6. Teeth with a history of fixed prosthetic restorations (previous crowns, inlays\u002Fonlays, or bridge restorations)\n7. Periodontal Issues: Active periodontal disease, excessive mobility (\\> Grade 1, or a hopeless long-term prognosis.",true,"ALL","20 Years","40 Years",{"count":72,"type":73},52,"ESTIMATED","INTERVENTIONAL",[76],"NA","The goal of this clinical trial is to learn whether 3D-printed resin composite endocrowns perform as well as milled resin composite endocrowns in restoring endodontically treated teeth. It will also learn how well the restorations fit over time.\n\nThe main questions it aims to answer are:\n\nDo 3D-printed endocrowns and milled endocrowns show different clinical performance? Do 3D-printed endocrowns and milled endocrowns differ in restoration fit over 18 months?\n\nResearchers will compare two fabrication methods:\n\nAdditive manufacturing: 3D-printed resin composite endocrowns. Subtractive manufacturing: milled resin composite endocrowns.\n\nParticipants will:\n\nBe recruited from the Conservative Dentistry Department, Faculty of Dentistry, October 6 University.\n\nReceive tooth preparation after confirmation of satisfactory root canal treatment.\n\nHave their teeth prepared using standardized endocrown guidelines by one calibrated operator.\n\nHave digital scans taken of the prepared tooth, opposing arch, and bite registration.\n\nHave restorations designed digitally and then assigned randomly to one of the two groups.\n\nReceive a temporary restoration until the final endocrown is ready.\n\nHave the final restoration tried in for fit, contacts, and occlusion before cementation.\n\nHave a baseline post-cementation scan taken for fit assessment.\n\nReturn for follow-up visits at baseline, 6 months, 12 months, and 18 months.\n\nBe evaluated at each visit using Modified FDI criteria and 3D digital superimposition for fit analysis.",[79,80],"Clinical Performance of Endodontically Treated Teeth Restored With Endocrowns","Restoration Fit of Endodontically Treated Teeth With Endocrowns",[82],"3D-printed endocrown, Milled endocrown, Biomimetic resin composite, Endodontically treated molar, Clinical performance, Restoration fit and 18-month follow-up.","NOT_YET_RECRUITING","2026-07-17",{"date":86,"type":87},"2026-07-21","ACTUAL",{"date":89,"type":73},"2026-11-01",{"date":91,"type":73},"2028-12-01",{"name":5,"class":6},1]