[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100649122":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":26,"centralContacts":26,"locations":26,"responsibleParty":31,"collaborators":26,"id":35,"slug":36,"hasResults":37,"nctId":38,"briefTitle":39,"officialTitle":40,"acronym":26,"eligibilityCriteria":41,"healthyVolunteers":37,"sex":42,"minAge":43,"maxAge":44,"enrollmentInfo":45,"targetDuration":26,"studyType":48,"phases":49,"briefSummary":51,"conditions":52,"keywords":54,"overallStatus":63,"whyStopped":26,"lastUpdateSubmitDate":64,"lastUpdatePostDateStruct":65,"startDateStruct":68,"completionDateStruct":70,"leadSponsor":72,"locationsCount":26},{"fullName":5,"class":6},"Cairo University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Two-bottle HEMA-free Universal Adhesive","EXPERIMENTAL","Restoration of anterior cervical carious lesions using G2-Bond Universal (GC Corporation) in self-etch mode followed by Beautifil II LS composite resin.",[13],"Device: G2-Bond Universal",{"label":15,"type":16,"description":17,"interventionNames":18},"One-bottle HEMA-free Universal Adhesive","ACTIVE_COMPARATOR","Restoration of anterior cervical carious lesions using BeautiBond Xtreme Universal Adhesive (Shofu) in self-etch mode followed by Beautifil II LS composite resin.",[19],"Device: BeautiBond Xtreme Universal Adhesive",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DEVICE","G2-Bond Universal","Two-bottle HEMA-free universal adhesive system used in self-etch mode for restoring anterior cervical carious lesions according to the manufacturer's instructions.",[9],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"BeautiBond Xtreme Universal Adhesive","One-bottle HEMA-free universal adhesive system (Shofu Inc.) used in self-etch mode for restoring anterior cervical carious lesions according to the manufacturer's instructions.",[15],{"type":32,"investigatorFullName":33,"investigatorTitle":34,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"PRINCIPAL_INVESTIGATOR","Mariam Salem","MSc Candidate in Restorative dentistry","100649122","clinical-performance-of-two-hema-free-universal-adhesive-systems-100649122",false,"NCT07731061","Clinical Performance of Two HEMA-Free Universal Adhesive Systems","Clinical Performance of One-Bottle Versus Two-Bottle HEMA- Free Universal Adhesives in Restoring Anterior Cervical Carious Lesions: A 12-Month Randomized Controlled Trial","Inclusion Criteria:\n\n. Patients aged from 18 to 55 years.\n\n* Patients with cervical carious lesions on the labial surfaces of anterior teeth.\n* Lesions classified as ICDAS 3 and 4.\n* Patients with good general health.\n* Patients able and willing to attend the follow-up visits at baseline, 6 months and 12 months.\n\nExclusion Criteria:\n\n* Patients with severe or chronic periodontal disease.\n\n  * Patients with poor oral hygiene or uncontrolled plaque accumulation.\n  * Patients with bruxism or other parafunctional habits that may affect restoration survival.\n  * Non-vital teeth.\n  * Fractured or cracked teeth.\n  * Teeth with defective existing cervical restorations.\n  * Root caries extending beyond the restorative indication of the study.\n  * Pregnant or lactating patients.\n  * Patients with known allergy or hypersensitivity to any component of the adhesive systems or restorative material used in the study.\n  * Patients unable to attend the scheduled follow-up visits.","ALL","18 Years","55 Years",{"count":46,"type":47},50,"ESTIMATED","INTERVENTIONAL",[50],"NA","This randomized controlled clinical trial aims to compare the 12-month clinical performance of two HEMA-free universal adhesive systems for restoring anterior cervical carious lesions. Participants will be randomly allocated (1:1) to receive restorations using either a two-bottle HEMA-free universal adhesive (G2-Bond Universal) or a one-bottle HEMA-free universal adhesive (BeautiBond Xtreme), both applied in self-etch mode. The primary outcome is restoration retention, while secondary outcomes include marginal adaptation, marginal discoloration, and postoperative sensitivity, evaluated at baseline (24 hours), 6 months, and 12 months using the modified USPHS criteria.",[53],"Cervical Caries",[55,56,57,58,59,60,61,62,23],"HEMA-Free Universal Adhesive","Cervical Carious Lesions","Modified USPHS","Universal Adhesive","Randomized Clinical Trial","Restorative Dentistry","One-step versus two-step HEMA free adhesives","BeautiBond Xtreme","NOT_YET_RECRUITING","2026-07-28",{"date":66,"type":67},"2026-07-30","ACTUAL",{"date":69,"type":47},"2026-11",{"date":71,"type":47},"2028-01",{"name":5,"class":6}]