[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100649488":3},{"organization":4,"armGroups":7,"interventions":23,"overallOfficials":47,"centralContacts":52,"locations":61,"responsibleParty":99,"collaborators":29,"id":101,"slug":102,"hasResults":103,"nctId":104,"briefTitle":105,"officialTitle":105,"acronym":29,"eligibilityCriteria":106,"healthyVolunteers":103,"sex":107,"minAge":108,"maxAge":29,"enrollmentInfo":109,"targetDuration":29,"studyType":112,"phases":113,"briefSummary":115,"conditions":116,"keywords":29,"overallStatus":118,"whyStopped":29,"lastUpdateSubmitDate":119,"lastUpdatePostDateStruct":120,"startDateStruct":123,"completionDateStruct":125,"leadSponsor":127,"locationsCount":128},{"fullName":5,"class":6},"Medical University of Warsaw","OTHER",[8,17],{"label":9,"type":10,"description":11,"interventionNames":12},"Entire Papilla Preservation Technique (EPPT) + EMD","ACTIVE_COMPARATOR","Participants receive periodontal regenerative surgery using the Entire Papilla Preservation Technique (EPPT) combined with enamel matrix derivative (EMD). After flap elevation and defect debridement, root surface conditioning with EDTA is performed, followed by application of enamel matrix derivative and placement of bone substitute material as needed. Flaps are repositioned and sutured for primary closure.",[13,14,15,16],"Procedure: Entire Papilla Preservation Technique (EPPT)","Other: EDTA root conditioning","Drug: Enamel Matrix Derivative (EMD)- Emdogain","Other: Bone substitute - Bio Oss Collagen",{"label":18,"type":19,"description":20,"interventionNames":21},"Entire Papilla Preservation Technique (EPPT) + EMD+ SCTG","EXPERIMENTAL","Participants receive periodontal regenerative surgery using the Entire Papilla Preservation Technique (EPPT) combined with enamel matrix derivative (EMD) and subepithelial connective tissue graft (SCTG). After flap elevation and defect debridement, root surface conditioning with EDTA is performed, followed by application of enamel matrix derivative and placement of bone substitute material. A subepithelial connective tissue graft is harvested and placed at the defect site prior to flap closure.",[13,14,15,22,16],"Procedure: Subepithelial Connective Tissue Graft (SCTG)",[24,30,34,39,43],{"type":25,"name":26,"description":27,"armGroupLabels":28,"otherNames":29},"PROCEDURE","Entire Papilla Preservation Technique (EPPT)","A microsurgical periodontal regenerative technique aimed at preserving the interdental papilla. The procedure includes flap elevation, defect debridement, root surface conditioning, application of regenerative materials, and primary wound closure.",[9,18],null,{"type":6,"name":31,"description":32,"armGroupLabels":33,"otherNames":29},"EDTA root conditioning","Application of EDTA gel to the root surface to remove the smear layer and enhance regenerative outcomes.",[9,18],{"type":35,"name":36,"description":37,"armGroupLabels":38,"otherNames":29},"DRUG","Enamel Matrix Derivative (EMD)- Emdogain","A biologically active material applied to the root surface after EDTA conditioning to promote periodontal regeneration.",[9,18],{"type":25,"name":40,"description":41,"armGroupLabels":42,"otherNames":29},"Subepithelial Connective Tissue Graft (SCTG)","An autogenous connective tissue graft harvested from the palate and placed at the surgical site to enhance soft tissue thickness and stability.",[18],{"type":6,"name":44,"description":45,"armGroupLabels":46,"otherNames":29},"Bone substitute - Bio Oss Collagen","A xenogeneic bone graft material used to support bone regeneration within the intrabony defect.",[9,18],[48],{"name":49,"affiliation":50,"role":51},"Bartłomiej Górski","Depatrment of Periodontology and Oral Mucosa Diseases, Medical University of Warsaw, Warsaw","STUDY_CHAIR",[53,58],{"name":54,"role":55,"phone":56,"phoneExt":29,"email":57},"Małgorzata Wyszyńska-Pomian","CONTACT","+48 504006984","malgorzata.wyszynska@wum.edu.pl",{"name":49,"role":55,"phone":59,"phoneExt":29,"email":60},"+48221166431","bartlomiej.gorski@wum.edu.pl",[62,74,87],{"facility":63,"status":29,"city":64,"state":64,"zip":65,"country":66,"countryCode":67,"cosmosGeoPoint":68,"geoPoint":73,"contacts":29},"Department of Periodontology and Oral Mucosa Diseases, Medical University of Warsaw, Warsaw","Warsaw","00-246","Poland","PL",{"type":69,"coordinates":70},"Point",[71,72],21.01178,52.22977,{"lat":72,"lon":71},{"facility":75,"status":29,"city":76,"state":29,"zip":77,"country":66,"countryCode":67,"cosmosGeoPoint":78,"geoPoint":82,"contacts":83},"Department of Integrated Dentistry, University of Białystok","Bialystok","15276",{"type":69,"coordinates":79},[80,81],23.16433,53.13333,{"lat":81,"lon":80},[84],{"name":85,"role":55,"phone":29,"phoneExt":29,"email":86},"Anna Skurska","annaskurska@wp.pl",{"facility":88,"status":29,"city":89,"state":29,"zip":29,"country":66,"countryCode":67,"cosmosGeoPoint":90,"geoPoint":94,"contacts":95},"Department of Periodontology, Pomeranian Medical University Contact","Szczecin",{"type":69,"coordinates":91},[92,93],14.55302,53.42894,{"lat":93,"lon":92},[96],{"name":97,"role":55,"phone":29,"phoneExt":29,"email":98},"Monika Machoy","monika.machoy@pum.edu.pl",{"type":100,"investigatorFullName":29,"investigatorTitle":29,"investigatorAffiliation":29,"oldNameTitle":29,"oldOrganization":29},"SPONSOR","100649488","clinical-radiographic-and-volumetric-evaluation-of-the-entire-papilla-preservation-technique-with-and-without-connective-tissue-graft-in-the-treatment-of-periodontal-intraosseous-defects-100649488",false,"NCT07737834","Clinical, Radiographic and Volumetric Evaluation of the Entire Papilla Preservation Technique With and Without Connective Tissue Graft in the Treatment of Periodontal Intraosseous Defects.","Inclusion Criteria:\n\n* Age ≥ 18 years,\n* Good compliance and good oral hygiene\n* Systemically healthy\n* Isolated two intrabony defects of more than 3 mm depth, combined with more than 6 mm probing depth and attachment loss (stage III\u002FIV periodontitis) and an intrabony radiographic defect depth (DD) ≥ 3 mm, as evaluated on a digital periapical radiograph\n* The associated tooth should either maintain normal pulp vitality or should have undergone root canal therapy for at least 6 months before.\n\nExclusion Criteria:\n\n* Full-mouth plaque score ≥ 20% (O'Leary et al 1972)\n* Full-mouth bleeding score ≥ 20% (Cortellini et al 1995)\n* Smoking\n* Systemic diseases that would adversely influence wound healing\n* Medications interfering with post-operative wound healing\n* Pregnant and lactating females\n* Previous periodontal surgery in the examined area\n* III-degree mobility\n* Furcation involvement\n* Pulpal pathology or inadequate endodontic treatment","ALL","18 Years",{"count":110,"type":111},30,"ESTIMATED","INTERVENTIONAL",[114],"NA","This study is to assess the impact of implementing subepithelial connective tissue graft (SCTG) in the treatment of periodontal intrabony defects with Entire Papilla Preservation Technique (EPPT) on the clinical and radiographic results after 6 and 12 months.",[117],"Intrabony Periodontal Defect","NOT_YET_RECRUITING","2026-07-28",{"date":121,"type":122},"2026-07-30","ACTUAL",{"date":124,"type":111},"2026-08-01",{"date":126,"type":111},"2027-11-30",{"name":5,"class":6},3]