[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100556969":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":24,"centralContacts":28,"locations":12,"responsibleParty":38,"collaborators":42,"id":50,"slug":51,"hasResults":52,"nctId":53,"briefTitle":54,"officialTitle":55,"acronym":12,"eligibilityCriteria":56,"healthyVolunteers":52,"sex":57,"minAge":58,"maxAge":12,"enrollmentInfo":59,"targetDuration":12,"studyType":62,"phases":63,"briefSummary":65,"conditions":66,"keywords":68,"overallStatus":70,"whyStopped":12,"lastUpdateSubmitDate":71,"lastUpdatePostDateStruct":72,"startDateStruct":75,"completionDateStruct":76,"leadSponsor":78,"locationsCount":12},{"fullName":5,"class":6},"Xiangtan Central Hospital","OTHER",[8,13],{"label":9,"type":10,"description":11,"interventionNames":12},"usual care group","NO_INTERVENTION","Patients in this group will receive usual medical care for heart failure.",null,{"label":14,"type":15,"description":16,"interventionNames":17},"targeted intervention group","EXPERIMENTAL","Patients in this group, besides usal medical care for heart failure, will receive targeted therapy: correct hypoalbuminemia, anemia or hyponatremia, and try to enhance medication to lower NT-proBNP, CRP, NYHA Classification, to add diuretics for patients with higher RADs, multidiscipline intervention for patients complicating COPD, and actively reperfusion for ischemic HFpEF patients.",[18],"Other: Targeted intervention based on risk factors",[20],{"type":6,"name":21,"description":22,"armGroupLabels":23,"otherNames":12},"Targeted intervention based on risk factors","Correct hypoalbuminemia, anemia or hyponatremia, and try to enhance medication to lower NT-proBNP, CRP, NYHA Classification, to add diuretics for patients with higher RADs, multidiscipline intervention for patients complicating COPD, and actively reperfusion for ischemic HFpEF patients.",[14],[25],{"name":26,"affiliation":5,"role":27},"Hong Xia, PH.D","STUDY_CHAIR",[29,34],{"name":30,"role":31,"phone":32,"phoneExt":12,"email":33},"Jianping Zeng, PH.D","CONTACT","073158214998","xhjiang2@hnust.edu.cn",{"name":35,"role":31,"phone":36,"phoneExt":12,"email":37},"Yunlong Zhu, PH.D","073158286303","zhuyunlong@hnu.edu.cn",{"type":39,"investigatorFullName":40,"investigatorTitle":41,"investigatorAffiliation":5,"oldNameTitle":12,"oldOrganization":12},"PRINCIPAL_INVESTIGATOR","Jianping Zeng","Dean, Xiangtan Central Hospital ,Director of cardiovascular clinic, Clinical Professor",[43,46,48],{"name":44,"class":45},"The First People's Hospital of Xiangtan City","UNKNOWN",{"name":47,"class":45},"The Xiangtan People's Hospital",{"name":49,"class":45},"The Xiangxiang People's Hospital","100556969","clinical-study-of-active-intervention-in-high-risk-hfpef-patients-100556969",false,"NCT06532019","Clinical Study of Active Intervention in High-risk HFpEF Patients","Randomized Multicenter Clinical Trial in Heart Failure Patients With Preserved Ejection Fraction (HFpEF) at Intermediate and High Risk of All-cause Death","Inclusion Criteria:\n\n* Discharged HFpEF patients with risk score \\> or equal 200.37.\n\nExclusion Criteria:\n\n* Patients with a life expectancy of less than 1-year due to malignancy.","ALL","18 Years",{"count":60,"type":61},924,"ESTIMATED","INTERVENTIONAL",[64],"NA","Based on inclusion and exclusion criteria, this experiment plans to include 924 Heart Failure with Preserved Ejection Fraction(HFpEF) patients with increased risk of all-cause death. The enrolled patients will divided into usual care group (n=462) and targeted intervention group (n=462) in a 1:1 ratio. The usual care patients will receive routine heart failure treatment. Patients in targeted intervention group, on top of routine therapy for heart failure, will receive further therapy targeting therapy to correct hypoalbuminemia, anemia or hyponatremia, and try to enhance medication to lower N-terminal pro brain natriuretic peptide (NT-proBNP), C-reactive protein(CRP), New York Heart Association(NYHA )Classification, to add diuretics for patients with higher right ventricular diameters(RADs),multidiscipline intervention for patients complicating chronic obstructive pulmonary disease(COPD), and actively reperfusion for ischemic HFpEF patients. The incidence of all-cause death will be compared after 3 years follow-up.The primary endpoint is the occurrence of all-cause mortality events during the follow-up period.",[67],"Heart Failure With Preserved Ejection Fraction",[69],"all-cause mortality","NOT_YET_RECRUITING","2024-07-31",{"date":73,"type":74},"2024-08-01","ACTUAL",{"date":73,"type":61},{"date":77,"type":61},"2028-08-01",{"name":5,"class":6}]