[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100652678":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":23,"centralContacts":24,"locations":30,"responsibleParty":47,"collaborators":23,"id":49,"slug":50,"hasResults":51,"nctId":52,"briefTitle":53,"officialTitle":54,"acronym":23,"eligibilityCriteria":55,"healthyVolunteers":51,"sex":56,"minAge":57,"maxAge":23,"enrollmentInfo":58,"targetDuration":23,"studyType":61,"phases":62,"briefSummary":64,"conditions":65,"keywords":23,"overallStatus":70,"whyStopped":23,"lastUpdateSubmitDate":71,"lastUpdatePostDateStruct":72,"startDateStruct":75,"completionDateStruct":77,"leadSponsor":79,"locationsCount":80},{"fullName":5,"class":6},"Shanghai Mental Health Center","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Closed-loop Group","EXPERIMENTAL","Before stimulation:\n\nThe researchers measure the participant's Resting Motor Threshold (RMT) and assess their craving using VAS before and after view a methamphetamine-related video.\n\nThe participants complete SST.\n\nDuring the stimulation phase, participants will:\n\nFirst undergo a training phase, during which EEG will be recorded while they perform a cue-reactivity task to identify neural signatures and calculate stimulation thresholds.\n\nThen perform the cue-reactivity task again, and real-time EEG features will be used to trigger TMS in a closed-loop mode.\n\nAfter the stimulation, participants will:\n\nThe researchers again assess their craving using VAS before and after viewing a methamphetamine-related video.\n\nThe participants again complete the SST. The researchers record adverse reactions and adverse events, and evaluate the blinding effect, through a Blinding Assessment Questionnaire.",[13],"Device: Closed-loop Theta-Burst Stimulation (TBS) Targeting rPO",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":20},"DEVICE","Closed-loop Theta-Burst Stimulation (TBS) Targeting rPO","Participants receive theta-burst stimulation (TBS) over the right parietal-occipital cortex (rPO), triggered by real time by EEG signals recorded during a cue-reactivity task. This closed-loop protocol aims to deliver stimulation precisely during neural states associated with cue-induced reactivity.",[9],[21,22],"EEG-TMS","Closed-loop rPO-TBS",null,[25],{"name":26,"role":27,"phone":28,"phoneExt":23,"email":29},"Min Zhao, PhD","CONTACT","+86 18017311005","drminzhao@smhc.org.cn",[31],{"facility":32,"status":23,"city":33,"state":34,"zip":35,"country":36,"countryCode":37,"cosmosGeoPoint":38,"geoPoint":43,"contacts":44},"Shanghai Mental Health Center, 200030","Shanghai","Shanghai Municipality","200000","China","CN",{"type":39,"coordinates":40},"Point",[41,42],121.45806,31.22222,{"lat":42,"lon":41},[45],{"name":26,"role":27,"phone":46,"phoneExt":23,"email":29},"18017311005",{"type":48,"investigatorFullName":23,"investigatorTitle":23,"investigatorAffiliation":23,"oldNameTitle":23,"oldOrganization":23},"SPONSOR","100652678","closed-loop-tbs-targeting-rpo-for-the-core-clinical-features-of-the-methamphetamine-use-disorder-100652678",false,"NCT07775807","Closed-loop TBS Targeting rPO for the Core Clinical Features of the Methamphetamine Use Disorder","A Pilot Single-Arm Study of Closed-Loop TBS Theta-Burst Stimulation Targeting the Right Parietal-Occipital Cortex for Core Clinical Features of Methamphetamine Use Disorder","Inclusion Criteria:\n\n* Aged 18 years old or older, ....with at least 9 years of education (junior high school or above) or able to fully understand the task.\n* Meets DSM-5 for mild\u002Fsevere amphetamine-type substance use disorder.\n* History of amphetamine-type substance use for no less than 1 year, with use at least once per week.\n* Has not received pharmacological treatment for substance use.\n\nExclusion Criteria:\n\n* Presence of any organic disease, or diagnosis of any other psychiatric disorder according to DSM-5 (e.g., bipolar disorder, major depression disorder).\n* Contraindications to TMS, as assessed by the Transcranial Magnetic Stimulation Adult Safety Screen (TASS).\n* Inability to complete assessments, treatment procedures, or follow-up due to cognitive or behavioral limitations.","ALL","18 Years",{"count":59,"type":60},5,"ESTIMATED","INTERVENTIONAL",[63],"NA","The goal of this clinical trial is to evaluate whether closed-loop theta-burst stimulation (TBS) targeting the right parietal-occipital cortex (rPO) can improve core clinical symptoms in individuals with methamphetamine use disorder (MUD), such as cue-reactivity and impaired inhibitory control.\n\nThe main questions it aims to answer are:\n\nCan closed-loop rPO-TBS significantly reduce cue-reactivity, as measured by a Visual Analog Scale (VAS) and a cue-reactivity task? Does closed-loop stimulation enhance cognitive control, assessed by performance on the Stop Signal Task (SST)?\n\nResearchers will administer closed loop TBS to determine whether it can improve the core symptoms of MUD.\n\nParticipants will:\n\nComplete a single closed-loop sessions. Receive theta-burst stimulation targeting the right parietal-occipital cortex while complete the cue-reactivity task.\n\nUndergo cue-reactivity assessment using a Visual Analog Scale (VAS) and complete the Stop Signal Task (SST) before and after the stimulation session.",[66,67,68,69],"Methamphetamine Use Disorder","Substance Use Disorder","Cue-reactivity","Craving","NOT_YET_RECRUITING","2026-08-16",{"date":73,"type":74},"2026-08-20","ACTUAL",{"date":76,"type":60},"2026-08",{"date":78,"type":60},"2026-12",{"name":5,"class":6},1]