[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100657708":3},{"organization":4,"outcomesModule":7,"designInfo":30,"detailedDescription":33,"studyPopulation":34,"armGroups":35,"interventions":29,"overallOfficials":39,"centralContacts":44,"locations":29,"responsibleParty":50,"collaborators":29,"id":54,"slug":55,"hasResults":56,"nctId":57,"briefTitle":58,"officialTitle":59,"acronym":29,"eligibilityCriteria":60,"healthyVolunteers":56,"sex":61,"minAge":62,"maxAge":29,"enrollmentInfo":63,"targetDuration":29,"studyType":66,"phases":29,"briefSummary":67,"conditions":68,"keywords":72,"overallStatus":79,"whyStopped":29,"lastUpdateSubmitDate":80,"lastUpdatePostDateStruct":81,"startDateStruct":84,"completionDateStruct":86,"leadSponsor":88,"locationsCount":29},{"fullName":5,"class":6},"Assiut University","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":29},[9],{"measure":10,"description":11,"timeFrame":12},"Prevalence of cognitive impairment","Proportion of participants with cognitive impairment defined as a Montreal Cognitive Assessment (MoCA) score less than 26.","Baseline",[14,17,20,23,26],{"measure":15,"description":16,"timeFrame":12},"Mean MoCA score","Mean Montreal Cognitive Assessment (MoCA) score (range 0-30, higher scores indicate better cognition)..",{"measure":18,"description":19,"timeFrame":12},"Mean Katz ADL score","Mean Katz Index of Independence in Activities of Daily Living score (range 0-6, higher scores indicate greater independence).",{"measure":21,"description":22,"timeFrame":12},"Mean Lawton IADL score","Mean Lawton Instrumental Activities of Daily Living score (range 0-8, higher scores indicate greater independence)",{"measure":24,"description":25,"timeFrame":12},"Proportion with impaired activities of daily living","Proportion of participants with impaired Katz ADL score.",{"measure":27,"description":28,"timeFrame":12},"Proportion with impaired instrumental activities of daily living","Proportion of participants with impaired Lawton IADL score.",null,{"allocation":29,"interventionModel":29,"interventionModelDescription":29,"primaryPurpose":29,"observationalModel":31,"timePerspective":32,"maskingInfo":29},"CASE_ONLY","CROSS_SECTIONAL","Cognitive impairment is common among older adults with cancer and may affect treatment adherence and independence. This observational study will include adults aged 65 years or older with confirmed hematologic malignancies who are currently receiving chemotherapy.\n\nParticipants will undergo cognitive assessment using the Montreal Cognitive Assessment (MoCA) and functional assessment using the Katz Index of Activities of Daily Living (ADL) and Lawton Instrumental Activities of Daily Living (IADL).","Older adults aged 65 years or older with confirmed hematologic malignancies receiving chemotherapy at Assiut University Hospitals.",[36],{"label":37,"type":29,"description":38,"interventionNames":29},"Single cohort: Older adults with hematologic malignancies","Adults aged 65 years or older with hematologic malignancies receiving chemotherapy who will undergo cognitive and functional assessment.",[40],{"name":41,"affiliation":42,"role":43},"Soher M kasem, prof","Internal Medicine Department, Assiut University Hospitals","STUDY_CHAIR",[45],{"name":46,"role":47,"phone":48,"phoneExt":29,"email":49},"Kholoud K Fawzy, Resident","CONTACT","01009850621","khloud.18313604@med.aun.edu.eg",{"type":51,"investigatorFullName":52,"investigatorTitle":53,"investigatorAffiliation":5,"oldNameTitle":29,"oldOrganization":29},"PRINCIPAL_INVESTIGATOR","Khloud Khaled Fawzy Kotby","Resident Physician, Department of Internal Medicine - Geriatrics","100657708","cognitive-impairment-in-older-adults-with-hematologic-malignancies-100657708",false,"NCT07842679","Cognitive Impairment in Older Adults With Hematologic Malignancies","Prevalence of Cognitive Impairment and Its Association With Activities of Daily Living Among Older Adults With Hematologic Malignancies Receiving Chemotherapy","Inclusion Criteria:\n\n* \\- Age 65 years or older\n* Confirmed diagnosis of hematologic malignancy\n* Currently receiving chemotherapy\n* Able to communicate and participate in cognitive assessment\n* Written informed consent\n\nExclusion Criteria:\n\n* \\- Previously diagnosed dementia before the diagnosis of malignancy\n* Delirium at the time of assessment\n* Severe visual or hearing impairment interfering with cognitive testing\n* History of major neurological disorders affecting cognition\n* Severe psychiatric illness affecting cognitive assessment\n* Critically ill patients unable to complete study assessment","ALL","65 Years",{"count":64,"type":65},120,"ESTIMATED","OBSERVATIONAL","This cross-sectional study aims to determine the prevalence of cognitive impairment and evaluate its relationship with activities of daily living among older adults with hematologic malignancies receiving chemotherapy.",[69,70,71],"Cognitive Impairment","Hematologic Malignancies","Chemotherapy Effect",[73,74,75,76,77,78],"Cognitive impairment","Hematologic malignancies","Assiut","MoCA","Activities of daily living","Older adults","NOT_YET_RECRUITING","2026-09-24",{"date":82,"type":83},"2026-09-28","ACTUAL",{"date":85,"type":65},"2026-09-26",{"date":87,"type":65},"2028-02-25",{"name":5,"class":6}]