[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100646352":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":31,"centralContacts":36,"locations":41,"responsibleParty":57,"collaborators":26,"id":59,"slug":60,"hasResults":61,"nctId":62,"briefTitle":63,"officialTitle":64,"acronym":26,"eligibilityCriteria":65,"healthyVolunteers":61,"sex":66,"minAge":67,"maxAge":26,"enrollmentInfo":68,"targetDuration":26,"studyType":71,"phases":72,"briefSummary":74,"conditions":75,"keywords":77,"overallStatus":80,"whyStopped":26,"lastUpdateSubmitDate":81,"lastUpdatePostDateStruct":82,"startDateStruct":85,"completionDateStruct":87,"leadSponsor":89,"locationsCount":90},{"fullName":5,"class":6},"VA Office of Research and Development","FED",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Cognitive ENhancement Training (COGENT)","EXPERIMENTAL","Participants will be Veterans assigned to the active cognitive training program, Cognitive ENhancement Training (COGENT).",[13],"Behavioral: COGENT (Cognitive ENhancement Training)",{"label":15,"type":16,"description":17,"interventionNames":18},"Sham Training (ST)","SHAM_COMPARATOR","Participants will be Veterans assigned to the sham training comparator (ST), a non-training cognitive program matched for time and memory demands.",[19],"Behavioral: ST (Sham Training)",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"BEHAVIORAL","COGENT (Cognitive ENhancement Training)","COGENT is a computer-administered cognitive training program and consists of a modified working memory capacity task. COGENT was designed to contain high interference across trials, and requires participants to consistently, actively manage control over working memory interference. By requiring repeated practice with utilization of interference control across trials, COGENT is thought to enhance plasticity of cognitive systems used to manage how information enters and subsequently is removed from working memory, leading to improved performance over time.",[9],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"ST (Sham Training)","The sham training (ST) requires participants to remember the same total number of items as in COGENT; however, this training contains relatively less proactive interference across trials and is designed to be an \"inert\" version of the experimental program. The sham training condition will allow us to evaluate differences based on the proposed working memory interference training element, rather than general elements of the task (e.g., regular staff contact, contact time, general computer interface time).",[15],[32],{"name":33,"affiliation":34,"role":35},"Jessica A Bomyea, PhD","VA San Diego Healthcare System, San Diego, CA","PRINCIPAL_INVESTIGATOR",[37],{"name":33,"role":38,"phone":39,"phoneExt":26,"email":40},"CONTACT","(858) 642-3720","jessica.bomyea@va.gov",[42],{"facility":34,"status":26,"city":43,"state":44,"zip":45,"country":46,"countryCode":47,"cosmosGeoPoint":48,"geoPoint":53,"contacts":54},"San Diego","California","92161-0002","United States","US",{"type":49,"coordinates":50},"Point",[51,52],-117.16472,32.71571,{"lat":52,"lon":51},[55,56],{"name":33,"role":38,"phone":39,"phoneExt":26,"email":40},{"name":33,"role":35,"phone":26,"phoneExt":26,"email":26},{"type":58,"investigatorFullName":26,"investigatorTitle":26,"investigatorAffiliation":26,"oldNameTitle":26,"oldOrganization":26},"SPONSOR","100646352","cognitive-training-for-functioning-in-ptsd-100646352",false,"NCT07693686","Cognitive Training for Functioning in PTSD","Cognitive Training to Address Functioning and Symptoms in Veterans With Posttraumatic Stress Disorder","Inclusion Criteria:\n\n* diagnosis of PTSD\n* presence of subjective cognitive complaints\n* fluent in English\n* willing to attend assessment and treatment sessions\n\nExclusion Criteria:\n\n* past year history of psychotic or bipolar I disorders\n* past year history of severe alcohol or substance use disorder\n* history of severe traumatic brain injury or other known neurological condition that may be associated with cognitive dysfunction\n* acute suicidality necessitating immediate clinical intervention (within past 3 months)\n* presence of circumstances that require imminent intervention prior to other treatment (e.g., current domestic abuse)\n* plans for medication changes within the study timeframe\n* current or planned evidence-based psychotherapy for PTSD within the study timeframe\n* plans for changes to other psychosocial therapy within the study timeframe\n* presence of life-threatening or unstable medical conditions","ALL","18 Years",{"count":69,"type":70},176,"ESTIMATED","INTERVENTIONAL",[73],"NA","The proposed study will test a novel, computerized treatment for posttraumatic stress disorder (PTSD) to determine if it helps Veterans functionally recover as measured by reduced cognitive disability and PTSD symptoms. To do so, investigators will evaluate the effects of a cognitive training program that is designed to improve people's ability to manage information in working memory. Investigators will measure self-reported symptoms and disability alongside day-to-day cognition and functioning. The project support the VA Office of Research and Development's mission to improve Veteran participation in their lives and community by determining if this new approach can improve recovery from trauma and exploring for whom the intervention works.",[76],"Posttraumatic Stress Disorder",[78,79],"Posttraumatic stress disorder","traumatic stress","NOT_YET_RECRUITING","2026-07-14",{"date":83,"type":84},"2026-07-16","ACTUAL",{"date":86,"type":70},"2027-07-01",{"date":88,"type":70},"2030-03-31",{"name":5,"class":6},1]